Standout Papers
Citation Impact
Citing Papers
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
2012 StandoutScience
Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS
2018 StandoutNobel
Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells
2010 StandoutScience
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
2012 StandoutScience
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
2020 StandoutNobel
c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response
2010 Science
c‐di‐AMP reports DNA integrity during sporulation in Bacillus subtilis
2011
Protein structure determination using metagenome sequence data
2017 StandoutScienceNobel
Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa
2012
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
2020 StandoutScience
Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses
2013 Science
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
The diverse and expanding role of mass spectrometry in structural and molecular biology
2016
Nmd3 is a structural mimic of eIF 5A, and activates the cp GTP ase Lsg1 during 60S ribosome biogenesis
2017 StandoutNobel
Listeria monocytogenes induces IFNβ expression through an IFI16‐, cGAS‐ and STING‐dependent pathway
2014
Analysis of the role ofBacillus subtilisσMin β‐lactam resistance reveals an essential role for c‐di‐AMP in peptidoglycan homeostasis
2011
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway
2015
YybT Is a Signaling Protein That Contains a Cyclic Dinucleotide Phosphodiesterase Domain and a GGDEF Domain with ATPase Activity
2009
Discovery and engineering of enhanced SUMO protease enzymes
2018 StandoutNobel
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
2015 StandoutNobel
Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution
2024 StandoutNobel
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1
2015
Interaction network containing conserved and essential protein complexes in Escherichia coli
2005 Nature
Engineering precision nanoparticles for drug delivery
2020 Standout
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
2015 StandoutNobel
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
2013
Mycobacterium tuberculosis Rv3586 (DacA) Is a Diadenylate Cyclase That Converts ATP or ADP into c-di-AMP
2012
Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA
2013
The potential of 3′,5′-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant
2010
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
2016 Standout
Cyclic Dinucleotides and the Innate Immune Response
2013
Viral RNA detection by RIG-I-like receptors
2015
Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production
2016
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
2015 Standout
Hallmarks of aging: An expanding universe
2023 Standout
Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein
2015
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
Cytosolic Sensing of Viruses
2013
HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity
2020
Evolutionarily Conserved Roles of the Dicer Helicase Domain in Regulating RNA Interference Processing
2014 StandoutNobel
Identification and characterization of phosphodiesterases that specifically degrade 3′3′-cyclic GMP-AMP
2015
You’ve come a long way: c-di-GMP signaling
2012
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
2016
c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress
2011
Coordinated Regulation of Accessory Genetic Elements Produces Cyclic Di-Nucleotides for V. cholerae Virulence
2012
Bacterial nucleotide-based second messengers
2009
Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses
2014
RIG-I-like receptors and negative-strand RNA viruses: RLRly bird catches some worms
2014
eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences
2015 Standout
Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates
2014
New advances in our understanding of the “unique” RNase L in host pathogen interaction and immune signaling
2016
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Did a discrete event 200,000–100,000 years ago produce modern humans?
2012
Colorectal cancer
2019 Standout
Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors
2014
Dynamical features of thePlasmodium falciparumribosome during translation
2015 StandoutNobel
Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING
2014
Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch
2009
Expanded microbial genome coverage and improved protein family annotation in the COG database
2014
Structures of the human and Drosophila 80S ribosome
2013 Nature
Immunotherapy in colorectal cancer: rationale, challenges and potential
2019
The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling
2014
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Inhibition of the OAS/RNase L pathway by viruses
2015
Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1
2016
The overlapping host responses to bacterial cyclic dinucleotides
2011
Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
2014
Cyclic di‐GMP, an established secondary messenger still speeding up
2011
LtmA, a novel cyclic di-GMP-responsive activator, broadly regulates the expression of lipid transport and metabolism genes in Mycobacterium smegmatis
2012
Mechanistic insight into eukaryotic 60S ribosomal subunit biogenesis by cryo-electron microscopy
2016
Interferons and viruses: an evolutionary arms race of molecular interactions
2015 StandoutNobel
DarR, a TetR-like Transcriptional Factor, Is a Cyclic Di-AMP-responsive Repressor in Mycobacterium smegmatis
2012
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase
2015
Developing genetic tools to exploit Chaetomium thermophilum for biochemical analyses of eukaryotic macromolecular assemblies
2016
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
2016 Standout
Cyclic GMP–AMP signalling protects bacteria against viral infection
2019 Nature
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Translation Initiation Factor eIF3b Contains a Nine-Bladed β-Propeller and Interacts with the 40S Ribosomal Subunit
2014
Quantitative determination of cyclic diguanosine monophosphate concentrations in nucleotide extracts of bacteria by matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry
2008
New fossils from Jebel Irhoud, Morocco and the pan-African origin of Homo sapiens
2017 StandoutNature
Heterocomplex Formation by Arp4 and β-Actin Involved in Integrity of the Brg1 Chromatin Remodeling Complex
2012
Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling
2013
Transcriptional regulation and nuclear reprogramming: roles of nuclear actin and actin-binding proteins
2012 StandoutNobel
Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA
2014
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
Cytoplasmic DNA: sources, sensing, and role in aging and disease
2021
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
2014
Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy
2019
Structural and mechanistic determinants of c-di-GMP signalling
2009
Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer
2016
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
2013 Nature
Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape
2015
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Antibacterial drug discovery in the resistance era
2016 StandoutNature
Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation
2015
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
2014
STING is a direct innate immune sensor of cyclic di-GMP
2011 Nature
Structural basis of ligand binding by a c-di-GMP riboswitch
2009
Structural Insight into the Mechanism of c-di-GMP Hydrolysis by EAL Domain Phosphodiesterases
2010
ATP-Dependent Effector-like Functions of RIG-I-like Receptors
2015 StandoutNobel
Time-tagged ticker tapes for intracellular recordings
2023 StandoutNobel
Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses
2015
Polymorphisms in melanoma differentiation‐associated gene 5 link protein function to clearance of hepatitis C virus
2014 StandoutNobel
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
2009
Facing the Design Challenges of Particle-Based Nanosensors for Metabolite Quantification in Living Cells
2015
Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS
2016
A structural model of the active ribosome-bound membrane protein insertase YidC
2014
Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks
2018
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
2014
cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection
2016
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Surface-Enhanced Raman Spectroscopy for Bioanalysis: Reliability and Challenges
2018 Standout
Biofilm infections, their resilience to therapy and innovative treatment strategies
2012
A bacterial Argonaute with noncanonical guide RNA specificity
2016 StandoutNobel
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger
2013 Standout
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
2015
STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
2015
eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
2018 Standout
Identification of a Streptococcus pyogenes SF370 gene involved in production of c-di-AMP.
2011
Viruses transfer the antiviral second messenger cGAMP between cells
2015 Science
Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING
2015
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
2015
Actin nucleators in the nucleus: an emerging theme
2012
Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20
2018 StandoutNobel
Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II
2018
A Critical and Comparative Review of Fluorescent Tools for Live-Cell Imaging
2016
Characterizing Protein‐Protein Interactions by Sedimentation Velocity Analytical Ultracentrifugation
2008
Cyclic di-nucleotide signaling enters the eukaryote domain
2013
Prevailing Concepts of c-di-GMP Signaling
2009
DNA Repair and Genome Maintenance in Bacillus subtilis
2012
Transmission of innate immune signaling by packaging of cGAMP in viral particles
2015 Science
Great Times for Small Molecules: c-di-AMP, a Second Messenger Candidate in Bacteria and Archaea
2008
Cutting Edge: DNA Sensing via the STING Adaptor in Myeloid Dendritic Cells Induces Potent Tolerogenic Responses
2013
Positive Feedback Regulation of Type I IFN Production by the IFN-Inducible DNA Sensor cGAS
2015
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Thiazole Orange-Induced c-di-GMP Quadruplex Formation Facilitates a Simple Fluorescent Detection of This Ubiquitous Biofilm Regulating Molecule
2011
N‐Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen‐Presenting Cells through Dectin‐1 and Dectin‐2
2018 StandoutNobel
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
2013 Science
ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA
2015
Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways
2017
Works of Gregor Witte being referenced
Paramyxovirus V Proteins Disrupt the Fold of the RNA Sensor MDA5 to Inhibit Antiviral Signaling
2013 Science
DNA polymerase III subunit ties single-stranded DNA binding protein to the bacterial replication machinery
2003
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
2013 StandoutNature
Structural characterization of a eukaryotic chaperone—the ribosome-associated complex
2012
Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth
2011
Structural mechanism of cytosolic DNA sensing by cGAS
2013 Nature
Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP
2011 Nature
Structural biochemistry of nuclear actin‐related proteins 4 and 8 reveals their interaction with actin
2011
cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells
2016
Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates
2008
Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes
2014
Structural basis for sequestration and autoinhibition of cGAS by chromatin
2020 Nature
Sedimentation Velocity Method in the Analytical Ultracentrifuge for the Study of Protein-Protein Interactions
2005
The RIG‐I ATPase domain structure reveals insights into ATP‐dependent antiviral signalling
2011