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Citing Papers
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
2007
From molecular to modular cell biology
1999 StandoutNatureNobel
CDK inhibitors: positive and negative regulators of G1-phase progression
1999 Standout
The p16INK4a/CDKN2A tumor suppressor and its relatives
1998
Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
2001 Nature
Telomeres, the nucleolus and aging
1998
Ordering S phase and M phase in the cell cycle
1994 StandoutNobel
The RB and p53 pathways in cancer
2002 Standout
Replicative senescence: a critical review
2004
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
1995 StandoutNobel
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
1995 Nature
Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis
2014
DNA-guided DNA interference by a prokaryotic Argonaute
2014 Nature
Cyclin dependent kinase regulation
1995
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1
1997
Reversal of human cellular senescence: roles of the p53 and p16 pathways
2003
The p21Cip1 and p27Kip1 CDK `inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
1999
Ink4a/Arf expression is a biomarker of aging
2004
Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle
1995
Cellular senescence in aging and age-related disease: from mechanisms to therapy
2015 Standout
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
1998 Nature
Tumor suppressors and oncogenes in cellular senescence☆
2000
Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species
1999
Inhibitors of the Cip/Kip Family
1998
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.
1995
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
A matter of life and death
2002 Standout
Senescence of human fibroblasts induced by oncogenic Raf
1998 Nobel
Heterochronic Genes Control Cell Cycle Progress and Developmental Competence of C. elegans Vulva Precursor Cells
1996 StandoutNobel
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Involvement of the INK4a/Arf gene locus in senescence
2003
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
1997 StandoutNobel
The Hallmarks of Cancer
2000 Standout
p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast
1995 StandoutNobel
Regulation of cellular senescence by p53
2001
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
2005 Standout
Morphologic and biochemical hallmarks of apoptosis
2000
p16INK4a expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation
2000
A Long Twentieth Century of the Cell Cycle and Beyond
2000 StandoutNobel
Cellular senescence and DNA repair
2006
Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19
1997
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
2006
The Structure of Human Argonaute-2 in Complex with miR-20a
2012
Contribution of p16INK4a to replicative senescence of human fibroblasts
2004
A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen
1995
Senescence and epigenetic dysregulation in cancer
2002
Cancer and ageing: rival demons?
2003
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
1999 Nature
pl9skp1 and p45skp2 are essential elements of the cyclin A-CDK2 S phase kinase
1995
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
2000 Nature
The essence of senescence: Figure 1.
2010 Standout
Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
2013
The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2
1998
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
1997 Standout
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
1998
Regulating S Phase: CDKs, Licensing and Proteolysis
1996 StandoutNobel
Microarray analysis of replicative senescence
1999
Cellular senescence in the glaucomatous outflow pathway
2005
Differential Interaction of the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 with Cyclin A-Cdk2 and Cyclin D2-Cdk4
1997
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
2001 Nature
Origins of G1 arrest in senescent human fibroblasts
1995
The common biology of cancer and ageing
2007 Nature
Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence
2004
Fibrillar Collagen Inhibits Arterial Smooth Muscle Proliferation through Regulation of Cdk2 Inhibitors
1996
G1 phase progression: Cycling on cue
1994 Standout
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Features of replicative senescence induced by direct addition of antennapedia‐p16INK4A fusion protein to human diploid fibroblasts
1998
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Switching and Signaling at the Telomere
2001 StandoutNobel
Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: association with cell senescence and tumour-promoting activities of stromal fibroblasts
2002
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence
2002
Principles of CDK regulation
1995 StandoutNature
Role of Cyclin-Dependent Kinases and Their Inhibitors in Cellular Differentiation and Development
1998
Atherosclerosis — An Inflammatory Disease
1999 Standout
Fast gapped-read alignment with Bowtie 2
2012 Standout
Genes involved in senescence and immortalization
2000
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
Molecular Regulation of Melanocyte Senescence
2002
Inhibitors of mammalian G1 cyclin-dependent kinases.
1995 Standout
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
1994 Standout
A survey of sequence alignment algorithms for next-generation sequencing
2010
A critical role for telomeres in suppressing and facilitating carcinogenesis
2000
Role of the INK4a Locus in Tumor Suppression and Cell Mortality
1996
Inhibitors of histone deacetylase arrest cell cycle and induce apoptosis in cervical carcinoma cells circumventing human papillomavirus oncogene expression
2001 StandoutNobel
Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
2001 Nature
Bacterial Argonaute Samples the Transcriptome to Identify Foreign DNA
2013
A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy
2002
Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
1998
Uncoupling the Senescent Phenotype from Telomere Shortening in Hydrogen Peroxide-Treated Fibroblasts
2001
Regulatory networks defining EMT during cancer initiation and progression
2013 Standout
Replicative senescence in organ transplantation—mechanisms and significance
2002
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies
1998
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27
1995 StandoutScience
Induction of Cell Proliferation in Quiescent NIH 3T3 Cells by Oncogenic c-Raf-1
1997
Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.
1994
Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1
2002
p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells
1998
Identification of a Cyclin-cdk2 Recognition Motif Present in Substrates and p21-Like Cyclin-Dependent Kinase Inhibitors
1996 StandoutNobel
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
1999 StandoutNobel
Effects of p21Waf1/Cip1/Sdi1on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases
2000
Induced Expression of p16INK4a Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes
1999
Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1.
1995
Cooperating oncogenes converge to regulate cyclin/cdk complexes.
1997
Role of p14ARF in Replicative and Induced Senescence of Human Fibroblasts
2001
p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.
1995
Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems
1999 Nobel
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
Requirement of Cyclin E-Cdk2 Inhibition in p16INK4a-Mediated Growth Suppression
1998
Formation of p27-CDK complexes during the human mitotic cell cycle.
1996
Cyclin E-CDK2 is a regulator of p27Kip1.
1997
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity
2009 StandoutNobel
Inhibition of p53-Mediated Growth Arrest by Overexpression of Cyclin-Dependent Kinases
1996
Cyclin-Binding Motifs Are Essential for the Function of p21CIP1
1996
Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts
1999 Standout
Tumor cell senescence in cancer treatment.
2003
The Prognostic Significance of Altered Cyclin-Dependent Kinase Inhibitors in Human Cancer
1999
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Aging and Genome Maintenance: Lessons from the Mouse?
2003 Science
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
1998
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
2007
CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors
1997 Standout
Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts
1997 Science
Retinoblastoma Protein Contains a C-terminal Motif That Targets It for Phosphorylation by Cyclin-cdk Complexes
1999 StandoutNobel
Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts.
1999
Induction of p21WAF1/CIP1 and Inhibition of Cdk2 Mediated by the Tumor Suppressor p16INK4a
1999
Growth factor modulation of p53-mediated growth arrest versus apoptosis.
1995
The signals and pathways activating cellular senescence
2004
Inhibition of cyclin-dependent kinases by p21.
1995
p21 Disrupts the Interaction between cdk2 and the E2F-p130 Complex
1996
Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation.
1996
Early events in DNA replication require cyclin E and are blocked by p21CIP1.
1995
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
1995
Human DNA Repair Genes
2001 StandoutScienceNobel
Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6
1995
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
Transforming Growth Factor β Stabilizes p15INK4B Protein, Increases p15INK4B-cdk4 Complexes, and Inhibits Cyclin D1-cdk4 Association in Human Mammary Epithelial Cells
1997
A Two-Stage, p16INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status
2002
New functional activities for the p21 family of CDK inhibitors.
1997
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Cyclin D-CDK Subunit Arrangement Is Dependent on the Availability of Competing INK4 and p21 Class Inhibitors
1999
Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16ink4
1995
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
1994
Human melanocyte senescence and melanoma susceptibility genes
2003
Trimmomatic: a flexible trimmer for Illumina sequence data
2014 Standout
DNA damage is able to induce senescence in tumor cells in vitro and in vivo.
2002
Works of Greg Hannon being referenced
miR-34 miRNAs provide a barrier for somatic cell reprogramming
2011
Ancestral Roles of Small RNAs: An Ago-Centric Perspective
2010
Deletion of the p16 and p15 Genes in Human Bladder Tumors
1995
p21 Is a Component of Active Cell Cycle Kinases
1994
p21-containing cyclin kinases exist in both active and inactive states.
1994
Updates to the RMAP short-read mapping software
2009
ANALYSIS OF LARGE-SCALE SEQUENCING OF SMALL RNAS
2007
Cloning and characterization of murine p16INK4a and p15INK4b genes.
1995
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
1996
Oncogene-dependent apoptosis is mediated by caspase-9
1998