Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
2002 StandoutScienceNobel
PDE4 cAMP-specific phosphodiesterases
2001
Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4
2008 StandoutNobel
Functional diversity of helper T lymphocytes
1996 StandoutNature
Regional anesthesia in the anticoagulated patient: Defining the risks (the second ASRA Consensus Conference on Neuraxial Anesthesia and Anticoagulation)
2003
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1
1994 StandoutNature
Salbutamol reduces pulmonary neutrophil sequestration of platelet-activating factor in humans.
1996
Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons
1992
Complementary and alternative medicine in cardiovascular disease: a review of biologically based approaches
2004
Idiopathic pulmonary fibrosis
2017 Standout
Immediate and Late Airway Response of Allergic Rhinitis Patients to Segmental Antigen Challenge: Characterization of Eosinophil and Mast Cell Mediators
1991
Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family
2000
Substituted furans as inhibitors of the PDE4 enzyme
1999
Immediate and Long-term Hemodynamic and Clinical Effects of Sildenafil in Patients With Pulmonary Arterial Hypertension Receiving Vasodilator Therapy
2003
Atopic dermatitis
2003 Standout
Eosinophil function in health and disease
1995
Treatment of Pulmonary Arterial Hypertension
2004 Standout
Eosinophilia
1998
The Acute Respiratory Distress Syndrome
2000 Standout
Herb-drug interactions
2000 Standout
Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use
2006 Standout
Inhibition of PDGF, VEGF and FGF signalling attenuates fibrosis
2007
Pulmonary fibrosis: pathogenesis, etiology and regulation
2009 Standout
MECHANISMS OF INCREASED AIRWAY MICROVASCULAR PERMEABILITY: ROLE IN AIRWAY INFLAMMATION AND OBSTRUCTION
1995
Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part II)
1994
Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial
2016
2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults
2009 Standout
Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials
2011 Standout
Nonresolving Inflammation
2010 Standout
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
2017 Standout
Inhibition of airway hyperresponsiveness and pulmonary inflammation by roflumilast and other PDE4 inhibitors
2005
Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma
1997 Standout
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
2007 Standout
The Immunobiology of Eosinophils
1991
The sentinel role of the airway epithelium in asthma pathogenesis
2011
Asthma
2017 Standout
Reactive Oxygen Species as Mediators in Asthma
2001
Alveolar Macrophages as Orchestrators of COPD
2004
Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part I)
1994
Adenosine in Bronchoalveolar Lavage Fluid in Asthma
1993
The interaction between salmeterol and β2‐adrenoceptor agonists with higher efficacy on guinea‐pig trachea and human bronchus in vitro
1994
Asthma
2001 Standout
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
2016 Standout
Tadalafil: A Long-Acting Phosphodiesterase-5 Inhibitor for the Treatment of Pulmonary Arterial Hypertension
2011
Pre-eclampsia
2010 Standout
Traditional Chinese medicine
2008 Standout
β-adrenoceptors on smooth muscle, nerves and inflammatory cells
1993
Cyclic nucleotide phosphodiesterases
2001
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
2002
Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung
1991 Nature
Indirect airway challenges
2003
Airway Mucus Function and Dysfunction
2010 Standout
Theophylline: Potential antiinflammatory effects in nocturnal asthma
1996
Type 5 phosphodiesterase inhibition in heart failure and pulmonary hypertension
2004
Platelet-activating factor stimulates a rapid accumulation of inositol (1,4,5)trisphosphate in guinea pig eosinophils: Relationship to calcium mobilization and degranulation
1991
Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension
2015 Standout
Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis
2001
Ginkgo biloba
1992
A Comparison of Low-Dose Inhaled Budesonide plus Theophylline and High-Dose Inhaled Budesonide for Moderate Asthma
1997
Idiopathic pulmonary fibrosis
2011 Standout
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
1994 Standout
The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis
2004
Theophylline, a new inducer of apoptosis in B‐CLL: role of cyclic nucleotides
1995
Herbal Medicines and Perioperative Care
2001 Standout
Eosinophils: Biology and Role in Disease
1995
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
1993 Standout
Pulmonary hypertension: inhaled nitric oxide, sildenafil and natriuretic peptides
2005
Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
2009
Beta2 adrenergic receptors in asthma: A current perspective
1992
Formation and inactivation of endogenous cannabinoid anandamide in central neurons
1994 StandoutNature
Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development
2005
Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial
2002
Identification of the platelet ADP receptor targeted by antithrombotic drugs
2001 StandoutNatureNobel
β-Arrestin-2 regulates the development of allergic asthma
2003 StandoutNobel
Positive benefits of theophylline in a randomized, double‐blind, parallel‐group, placebo‐controlled study of low‐dose, slow‐release theophylline in the treatment of COPD for 1 year
2006
Asthma
2000 Standout
Pirfenidone Modulates Airway Responsiveness, Inflammation, and Remodeling after Repeated Challenge
2006
Oxidative Stress in Chronic Obstructive Pulmonary Disease
1997 Standout
Transforming Growth Factor- β Expression in Mucosal Biopsies in Asthma and Chronic Bronchitis
1997
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
2012 Standout
Activation of A3 adenosine receptors on human eosinophils elevates intracellular calcium
1996 StandoutNobel
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
2003
Expression cloning of an ATP receptor from mouse neuroblastoma cells.
1993 StandoutNobel
Solid phase parallel synthesis of highly substituted thiophene derivatives and identification of novel phosphodiesterase-4 (PDE-4) inhibitors
1999
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Platelet-activating factor.
1990 Standout
An Essential Role of Mast Cells in the Development of Airway Hyperresponsiveness in a Murine Asthma Model
2000
Combination Therapy with Oral Sildenafil and Inhaled Iloprost for Severe Pulmonary Hypertension
2002
Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation.
1994
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
2001 StandoutScience
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils
1997 StandoutNobel
Phosphodiesterase 4D is required for β 2 adrenoceptor subtype-specific signaling in cardiac myocytes
2005 StandoutNobel
Structure-based discovery of β 2 -adrenergic receptor ligands
2009 StandoutNobel
Inflammation and the mechanism of action of anti‐inflammatory drugs
1987 Nobel
G PROTEIN–COUPLED RECEPTOR KINASES
1998 StandoutNobel
β-Arrestin-2 regulates the development of allergic asthma
2003 StandoutNobel
The Acute Respiratory Distress Syndrome
1996 Standout
Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor
2001
The Sympathetic Nerve—An Integrative Interface between Two Supersystems: The Brain and the Immune System
2000 Standout
PDE4D plays a critical role in the control of airway smooth muscle contraction
2003
Section Review: Cardiovascular & Renal: Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiovascular diseases
1995
The Vinylogous Aldol Reaction: A Valuable, Yet Understated Carbon−Carbon Bond-Forming Maneuver
2000 Standout
Aryl−Aryl Bond Formation One Century after the Discovery of the Ullmann Reaction
2002 Standout
ADP Receptors on Platelets
1996
Works of Gordon Dent being referenced
Prosurvival activity for airway neutrophils in severe asthma
2010
PAF-Receptors on eosinophils: identification with a novel ligand, [3H]WEB 2086
1989
Theophylline suppresses human alveolar macrophage respiratory burst through phosphodiesterase inhibition.
1994
Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086 Correlation between receptor binding and function
1989
Effects of a Selective PDE4 Inhibitor, D-22888, on Human Airways and Eosinophils in vitro and Late Phase Allergic Pulmonary Eosinophilia in Guinea Pigs
1998
Effect of Theophylline and Adenosine on Eosinophil Function
1989
Radioligand binding of antagonists of platelet‐activating factor to intact human platelets
1988
Cyclic nucleotide phosphodiesterases in the human lung
1994
Prospects for selective cyclic nucleotide phosphodiesterase inhibitors in the treatment of bronchial asthma
1992
Selective phosphodiesterase inhibitors for the treatment of bronchial asthma and chronic obstructive pulmonary disease
1999
The effect of selective and non‐selective phosphodiesterase inhibitors on allergen‐ and leukotriene C4‐induced contractions in passively sensitized human airways
2000
Activation of guinea pig eosinophil respiratory burst by leukotriene B4: role of protein kinase C
1992
Effect of a Paf antagonist, WEB 2086, on airway microvascular leakage in the guinea‐pig and platelet aggregation in man
1988
[3H]WEB 2086 labels platelet activating factor receptors in guinea pig and human lung
1989
Beta 2 -Adrenergic Receptors on Eosinophils: Binding and Functional Studies
1990
Salmeterol is a competitive antagonist at β-adrenoceptors mediating inhibition of respiratory burst in guinea-pig eosinophils
1993
Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan‐stimulated respiratory burst by ‘type IV’‐selective PDE inhibitors
1991
The Contribution of Interleukin (IL)-4 and IL-13 to the Epithelial–Mesenchymal Trophic Unit in Asthma
2001
Effects of a 5-lipoxygenase inhibitor, ABT-761, on exercise-induced bronchoconstriction and urinary LTE4 in asthmatic patients
1998
Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants
1995
Generation of oxygen free radicals from blood eosinophils from asthma patients after stimulation with PAF or phorbol ester
1990
Eosinophils adhere to and stimulate replication of lung fibroblasts ‘in vitro’
1991
Selective Phosphodiesterase Inhibitors in the Therapy of Asthma
1995
Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors
1994
Hydrogen peroxide contracts human airways in vitro: role of epithelium
1995
Platelet-activating factor induces eosinophil peroxidase release from purified human eosinophils.
1988
Effects of salbutamol on bronchoconstriction, bronchial hyperresponsiveness, and leucocyte responses induced by platelet activating factor in man.
1989
Theophylline and airway inflammation.
1998
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization
1993
Stimulation of degranulation from human eosinophils by platelet-activating factor.
1989
Phosphodiesterase inhibitors: Lily the Pink's medicinal compound for asthma?
1996
EFFECT OF A GINKGOLIDE MIXTURE (BN 52063) IN ANTAGONISING SKIN AND PLATELET RESPONSES TO PLATELET ACTIVATING FACTOR IN MAN
1987