Standout Papers
Citation Impact
Citing Papers
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8 + T cells in NOD mice
2008 StandoutNobel
Macromolecular-scale resolution in biological fluorescence microscopy
2006 StandoutNobel
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis
2013 StandoutNobel
Regulatory T Cells
2000 StandoutNobel
In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism
1993
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
B7.1 and B7.2 co-stimulatory molecules regulate crescentic glomerulonephritis
2000
Ro’s Role in RNA Reconnaissance
2005 StandoutNobel
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
2006 StandoutNobel
The Polymyositis-Scleroderma Autoantigen Interacts with the Helix-Loop-Helix Proteins E12 and E47
1997
Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing
1991
RNA travel: Tracks from DNA to cytoplasm
1993 StandoutNobel
During the Early Prediabetic Period in NOD Mice, the Pathogenic CD8+ T-Cell Population Comprises Multiple Antigenic Specificities
2002
The Splicing Factor BBP Interacts Specifically with the Pre-mRNA Branchpoint Sequence UACUAAC
1997 StandoutNobel
Compartmentalization of RNA Processing Factors within Nuclear Speckles
2000
Nopp 140 shuttles on tracks between nucleolus and cytoplasm
1992 StandoutNobel
Updated Clinical Classification of Pulmonary Hypertension
2013 Standout
B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes
2000 Standout
Virus-induced autoantibody response to a transgenic viral antigen
1990 StandoutNatureNobel
Cross-Intron Bridging Interactions in the Yeast Commitment Complex Are Conserved in Mammals
1997 StandoutNobel
The La antigen shuttles between the nucleus and the cytoplasm in CV-1 cells
1989
B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse
2004 StandoutNobel
Antinuclear antibodies (ANAs): Diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity
1988
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus
1990 Nature
B7 Costimulation in the Development of Lupus: Autoimmunity Arises Either in the Absence of B7.1/B7.2 or in the Presence of Anti-B7.1/B7.2 Blocking Antibodies
1999
Autoimmune sera reactive with Sm antigen contain high levels of RNP-like antibodies.
1985
Fractionation of Antibodies against Staphylococcal Nuclease on ‘Sepharose’ Immunoadsorbents
1970 StandoutNatureNobel
Antibodies against distinct nuclear matrix proteins are characteristic for mixed connective tissue disease.
1983
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
2005 StandoutNobel
Fractionation and characterization of human small nuclear ribonucleoproteins containing U1 and U2 RNAs.
1983
The structure of mammalian small nuclear ribonucleoproteins. Identification of multiple protein components reactive with anti-(U1)ribonucleoprotein and anti-Sm autoantibodies.
1984
Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors.
1991
Protein antigens of the RNA-protein complexes detected by anti-SM and anti-RNP antibodies found in serum of patients with systemic lupus erythematosus and related disorders.
1982 StandoutNobel
Isolation of small nuclear ribonucleoproteins containing U1, U2, U4, U5, and U6 RNAs.
1983
Differentiation of antinuclear antibodies giving speckled staining patterns in immunofluorescence
1972
Analysis of Autoimmunity through Experimental Models of Thyroiditis and Allergic Encephalomyelitis
1980
Immunochemistry of staphylococcal nuclease. II. Inhibition and binding studies with sequence fragments
1970 StandoutNobel
Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery.
1991
Small nuclear ribonucleoprotein particle assembly in vivo: Demonstration of a 6S RNA-free core precursor and posttranslational modification
1985 StandoutNobel
Two Novel Classes of Small Ribonucleoproteins Detected by Antibodies Associated with Lupus Erythematosus
1981 Science
Isolation and characterization of nuclear ribonucleoprotein complexes using human anti-nuclear ribonucleoprotein antibodies.
1979
Murine Models of Systemic Lupus Erythematosus
1985
Autoantibodies to Nuclear Antigens (ANA): Their Immunobiology and Medicine
1982
The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis.
1987
Novel Proteinaceous Infectious Particles Cause Scrapie
1982 StandoutScienceNobel
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
2008 StandoutNobel
A multicomponent complex is involved in the splicing of messenger RNA precursors
1985 StandoutNobel
Purification and Properties of Poliovirus
1959
Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components.
1991 StandoutNobel
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
2003 StandoutNobel
Antibodies reacting with ribosomal ribonucleoprotein in connective tissue diseases
1979
A Selective Fractionation of Anti-Lysozyme Antibodies of Different Determinant Specificities
1968
Spliceosomes and Snurposomes
1991 Science
Transfer RNA is an essential component of the ubiquitin- and ATP-dependent proteolytic system.
1985 StandoutNobel
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
2002 StandoutNobel
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
An Immunologic Approach to the Conformational Equilibria of Polypeptides
1972 StandoutNobel
Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus
1993
Definition of the antigenic polypeptides in the Sm and RNP ribonucleoprotein complexes
1981
Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation
2001
Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus
1979
Human U1 and U2 Small Nuclear Ribonucleoproteins Contain Common and Unique Polypeptides
1982
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function
2010 StandoutNobel
The Structure of Sister Minichromosome DNA Before Anaphase in Saccharomyces Cerevisiae
1987 StandoutScienceNobel
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
2000 StandoutNobel
Autoantibodies to the U2 small nuclear ribonucleoprotein in a patient with scleroderma-polymyositis overlap syndrome.
1984
Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies
1992
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
1979 Standout
Molecular characterization of ribonucleoprotein antigens bound by antinuclear antibodies. A diagnostic evaluation
1982
Human autoantibodies reactive with the signal-recognition particle.
1986 StandoutNobel
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit
2008 StandoutNobel
Human U1 and U2 small nuclear ribonucleoproteins contain common and unique polypeptides.
1982
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
2007 StandoutNobel
Compartmentalization within the nucleus: discovery of a novel subnuclear region.
1991
The Biology and Detection of Immune Complexes
1980
Differential Distribution of Factors Involved in Pre-mRNA Processing in the Yeast Cell Nucleus
1990
Pulse labeling of small nuclear ribonucleoproteins in vivo reveals distinct patterns of antigen recognition by human autoimmune antibodies.
1984 StandoutNobel
Psoriasis and Raynaud's Phenomenon Associated with Autoantibodies to U1 and U2 Small Nuclear Ribonucleoproteins
1986
Synthesis and assembly of human small nuclear ribonucleoproteins generated by cell-free translation.
1983
The Ro small cytoplasmic ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNAs.
1984
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Associations between distinct pre-mRNA splicing components and the cell nucleus.
1991
A Three-Dimensional View of Precursor Messenger RNA Metabolism Within the Mammalian Nucleus
1993 Science
Reconstitution of RNAase P activity using inactive subunits from E. coli and HeLa cells
1986 StandoutNobel
Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution.
1991
Antibodies in human serum that precipitate ribonuclease P.
1988 StandoutNobel
Antibodies from patients with connective tissue diseases bind specific subsets of cellular RNA-protein particles.
1982
Identification of fission yeast nuclear markers using random polypeptide fusions with green fluorescent protein
1996 StandoutNobel
Works of Gordon C. Sharp being referenced
Long-term outcome in mixed connective tissue disease: Longitudinal clinical and serologic findings
1999
Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice
1999
Protection against Autoimmune Thyroiditis in Guinea Pigs by Thyroglobulin Antiserum
1974
Antinuclear antibody with distinct specificity for polymyositis.
1977
Differential Susceptibility of Strain 2 and Strain 13 Guinea Pigs to Induction of Experimental Autoimmune Thyroiditis
1975
Cyclophosphamide protection in nzb/nzw disease. Mechanisms and therapeutic regimens
1976
Preparation of Specific Complement-Fixing Antigens from the Three Prototypes of Poliomyelitis Viruses.
1952
Intranuclear localization of snRNP antigens.
1986
Association of Antibodies to Ribonucleoprotein and Sm Antigens with Mixed Connective-Tissue Disease, Systemic Lupus Erythematosus and Other Rheumatic Diseases
1976
Purification and Biochemical Characterization of Nuclear Ribonucleoprotein Antigen using Purified Antibody from Serum of a Patient with Mixed Connective Tissue Disease
1980
Suppression of experimental autoimmune thyroiditis in the guinea pig by pretreatment with thyroglobulin in incomplete Freund's adjuvant
1978
Production of Augmented Experimental Autoimmune Thyroiditis Lesions by Combined Transfer of Antiserum and Lymph Node Cells
1974
Mixed connective tissue disease-an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA)
1972 Standout
The Properties of Thyroglobulin VII. The Immunologic Activity of Thyroglobulin Fragments
1962
B7.2 Has Opposing Roles During the Activation Versus Effector Stages of Experimental Autoimmune Thyroiditis
1999
Antibodies to a nuclear/nucleolar antigen in patients with polymyositis overlap syndromes
1984
Identification of a clinical subset of systemic lupus erythematosus by antibodies to the sm antigen
1979
Anti‐Tissue Antibodies in Rheumatic Disease
1977
Association of autoantibodies to different nuclear antigens with clinical patterns of rheumatic disease and responsiveness to therapy
1971
Molecular relationships between two nuclear antigens, ribonucleoprotein and Sm: purification of active antigens and their biochemical characterization
1981