Standout Papers
Citation Impact
Citing Papers
Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone
2004
Recognition of the amyloid precursor protein by human γ-secretase
2019 Science
Alzheimer's disease β-amyloid peptides are released in association with exosomes
2006
Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression
2007
Take five—BACE and the γ‐secretase quartet conduct Alzheimer's amyloid β‐peptide generation
2004
Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
2003
Genetic Dissection of the Amyloid Precursor Protein in Developmental Function and Amyloid Pathogenesis
2010 StandoutNobel
Notch signalling controls pancreatic cell differentiation
1999 StandoutNatureNobel
Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice
2011
Indirect Regulation of Presenilins in CREB-mediated Transcription
2009
Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase
2003
The amyloid precursor protein: beyond amyloid.
2006
γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43
2013
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
1998 StandoutNature
Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains
2002
Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
2016 Standout
Notch and neurogenesis
1998
The Lipoprotein Receptor LR11 Regulates Amyloid β Production and Amyloid Precursor Protein Traffic in Endosomal Compartments
2006
Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease
2010 Nature
Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?
2004
A Critical Function for β-Amyloid Precursor Protein in Neuronal Migration Revealed by In Utero RNA Interference
2007
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Gene-Targeting Technologies for the Study of Neurological Disorders
2004
Presynaptic Localization of Neprilysin Contributes to Efficient Clearance of Amyloid-β Peptide in Mouse Brain
2004
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
Estrogen Receptors: How Do They Signal and What Are Their Targets
2007 Standout
Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
2014
Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration
2004 Nobel
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice
2005
Skeletal and CNS Defects in Presenilin-1-Deficient Mice
1997 Nobel
Endoproteolytic Cleavage and Proteasomal Degradation of Presenilin 2 in Transfected Cells
1997
Nuclear Signaling: A Common Function of Presenilin Substrates?
2001
It all sticks together—the APP-related family of proteins and Alzheimer's disease
1999
Three-dimensional structure of human γ-secretase
2014 Nature
Direct Interaction of Alzheimer's Disease-related Presenilin 1 with Armadillo Protein p0071
1999 StandoutNobel
Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis
2008
Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
2000 Nature
Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins
1997
Cleavage of Alzheimer's Amyloid Precursor Protein (APP) by Secretases Occurs after O-Glycosylation of APP in the Protein Secretory Pathway
1998
The presenilins and Alzheimer's disease
1997
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
Uncoupled Packaging of Amyloid Precursor Protein and Presenilin 1 into Coat Protein Complex II Vesicles
2004 StandoutNobel
Presenilin 1 Regulates Epidermal Growth Factor Receptor Turnover and Signaling in the Endosomal-Lysosomal Pathway
2007
Intracellular A-Beta Amyloid, A Sign for Worse Things to Come?
2002
Modeling familial Alzheimer's disease with induced pluripotent stem cells
2011 StandoutNobel
aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation
2002
BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology
2018
Nicastrin binds to membrane-tethered Notch
2001
Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue
1997
Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins
1997
APP Gene Family Alternative Splicing Generates Functionally Related Isoformsa
1996
Aβ localization in abnormal endosomes: association with earliest Aβ elevations in AD and Down syndrome
2004
Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2
2005
Numb Modifies Neuronal Vulnerability to Amyloid β-Peptide in an Isoform-Specific Manner by a Mechanism Involving Altered Calcium Homeostasis
2002
Presenilin-Dependent Gamma-Secretase Activity Modulates Neurite Outgrowth
2002
Molecular Dissection of Domains in Mutant Presenilin 2 That Mediate Overproduction of Amyloidogenic Forms of Amyloid β Peptides
1998
Maturation and Endosomal Targeting of β-Site Amyloid Precursor Protein-cleaving Enzyme
2000
An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos
1998
The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture
2001
β‐amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment
2007
The Transmembrane Aspartates in Presenilin 1 and 2 Are Obligatory for γ-Secretase Activity and Amyloid β-Protein Generation
2000
Cell Surface Presenilin-1 Participates in the γ-Secretase-like Proteolysis of Notch
1999
Variable phenotype of Alzheimer's disease with spastic paraparesis
2001
γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?
2002
Presenilins and Alzheimer's disease
1997
Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP
2005
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease
2005
Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model
2000
Scaffolding microdomains and beyond: the function of reggie/flotillin proteins
2005
Subcellular Distribution and Turnover of Presenilins in Transfected Cells
1998
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome
2002
A Dynamic Relationship between Intracellular and Extracellular Pools of Aβ
2006
Reconstitution of γ-secretase activity
2003
Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
2002
The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein
2006
A common enzyme connects Notch signaling and Alzheimer's disease
2000
Aβ-Generating Enzymes
2000
Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels
2005
Presenilin-1 Forms Complexes with the Cadherin/Catenin Cell–Cell Adhesion System and Is Recruited to Intercellular and Synaptic Contacts
1999
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Post-translational Processing of β-Secretase (β-Amyloid-converting Enzyme) and Its Ectodomain Shedding
2001
Identification of a Novel PSD-95/Dlg/ZO-1 (PDZ)-like Protein Interacting with the C Terminus of Presenilin-1
1999
The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
1998
Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
2000
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members
2004
The Intracellular Domain of the β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-like Manner
2001
Calcium dyshomeostasis and intracellular signalling in alzheimer's disease
2002
Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation
1997
Biochemistry of Amyloid -Protein and Amyloid Deposits in Alzheimer Disease
2012
TANGO1 Facilitates Cargo Loading at Endoplasmic Reticulum Exit Sites
2009 StandoutNobel
Endogenous Presenilin-1 Targets to Endocytic Rather Than Biosynthetic Compartments
2000
Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
1999 Nature
Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation
2004 StandoutNobel
Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP
2001 Nature
TREM2 function impedes tau seeding in neuritic plaques
2019
Deletion of Presenilin 1 Hydrophilic Loop Sequence Leads to Impaired γ-Secretase Activity and Exacerbated Amyloid Pathology
2006
Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis
2009
Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch
2002
The Secreted β-Amyloid Precursor Protein Ectodomain APPsα Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice
2007
The Role of Presenilins in γ-Secretase Activity
2001
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
2000 Nature
Amyloidogenic Processing of Human Amyloid Precursor Protein in Hippocampal Neurons Devoid of Cathepsin D
1996
Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch
2000
Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons
2008 StandoutNobel
Subcellular Topography of Neuronal Aβ Peptide in APPxPS1 Transgenic Mice
2004
Endogenous β-amyloid production in presenilin-deficient embryonic mouse fibroblasts
2001
Regulation of NMDA receptor trafficking by amyloid-β
2005
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Pharmacological Knock-down of the Presenilin 1 Heterodimer by a Novel γ-Secretase Inhibitor
2001
APP Processing and Synaptic Plasticity in Presenilin-1 Conditional Knockout Mice
2001 Nobel
Complex N-linked Glycosylated Nicastrin Associates with Active γ-Secretase and Undergoes Tight Cellular Regulation
2002
Presenilins: Genes for Life and Death
1997
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1
2008
Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects
1999
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
2001
Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons
2004
Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo
2008
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42
2007
Neprilysin-sensitive Synapse-associated Amyloid-β Peptide Oligomers Impair Neuronal Plasticity and Cognitive Function
2006
Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
1998 Nature
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
2006 Standout
Environmental Enrichment Exacerbates Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease
2003
Presenilin mutations in Alzheimer's disease
1998
APP Processing and Synaptic Function
2003
Aspartate Mutations in Presenilin and γ‐Secretase Inhibitors Both Impair Notch1 Proteolysis and Nuclear Translocation with Relative Preservation of Notch1 Signaling
2000
Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
2001
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
2002
The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin
1998
Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein
1998
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
1998
Phosphorylation Regulates Intracellular Trafficking of β-Secretase
2001
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum
2002 StandoutNobel
Intraneuronal Aβ42 Accumulation in Human Brain
2000
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
2017
Degradation of nicastrin involves both proteasome and lysosome
2007
Implication of APP Secretases in Notch Signaling
2001
Increased Aβ42(43) from cell lines expressing presenilin 1 mutations
1998
Expression of human β‐secretase in the mouse brain increases the steady‐state level of β‐amyloid
2002
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
1996 Nature
Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
2005 Standout
Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins
1997
Immature nicastrin stabilizes APH‐1 independent of PEN‐2 and presenilin: identification of nicastrin mutants that selectively interact with APH‐1
2004
Amyloid beta from axons and dendrites reduces local spine number and plasticity
2009
Learning and Memory Deficits in Notch Mutant Mice
2003 StandoutNobel
Localization of presenilin–nicastrin complexes and γ‐secretase activity to the trans‐Golgi network
2003
Longer Forms of Amyloid β Protein: Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase
2005
BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions
2005
A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex
2004
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
A Loss of Function Mutation of Presenilin-2 Interferes with Amyloid β-Peptide Production and Notch Signaling
1999
Production and Actions of Estrogens
2002 Standout
The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex
1998
Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm
1997 Nature
Activation of β2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation
2006
Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
2016
Estrogen Plus Progestin and the Incidence of Dementia and Mild Cognitive Impairment in Postmenopausal Women
2003 Standout
Mutant Human Presenilin 1 Protects presenilin 1 Null Mouse against Embryonic Lethality and Elevates Aβ1–42/43 Expression
1998
Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
2006
Cancer-related inflammation
2008 StandoutNature
Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein
1997
Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Aβ42 in response to tunicamycin
2004
Amyloid, the presenilins and Alzheimer's disease
1997
Processing of β-Amyloid Precursor-like Protein-1 and -2 by γ-Secretase Regulates Transcription
2002
Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex
2003
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Alzheimer's disease: the cholesterol connection
2003
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
2000
Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective
2005
SEC23-SEC31 the Interface Plays Critical Role for Export of Procollagen from the Endoplasmic Reticulum
2012 StandoutNobel
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
1999 StandoutNature
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
1996
The β‐Amyloid Precursor Protein (APP) and Alzheimer's Disease: Does the Tail Wag the Dog?
2002
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain
2003
Notch and Presenilin: a proteolytic mechanism emerges
2001
Protein Topology of Presenilin 1
1996
Expression of Alzheimer’s Disease-associated Presenilin-1 Is Controlled by Proteolytic Degradation and Complex Formation
1998
Localization and Possible Functions of Presenilins in Brain
1998
Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch
2001
Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure
2009 StandoutNobel
The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons
1999 Nobel
Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex
2010
Genetically engineered mouse models of neurodegenerative diseases
2002
Translating cell biology into therapeutic advances in Alzheimer's disease
1999 Nature
Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms
2006
γ-Secretase and its modulators: Twenty years and beyond
2019
The Cleavage Products of Amyloid-β Precursor Protein Are Sorted to Distinct Carrier Vesicles That Are Independently Transported within Neurites
2009
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
2005
Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1
2000
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
2001
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
A γ‐secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish
2002
NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo
2003
Neuronal membrane cholesterol loss enhances amyloid peptide generation
2004
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
Intraneuronal Aβ42 accumulation in Down syndrome brain
2002
Aggresomes: A Cellular Response to Misfolded Proteins
1998 Standout
Neuronal Localization of Presenilin-1 and Association with Amyloid Plaques and Neurofibrillary Tangles in Alzheimer’s Disease
1997
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
The initial substrate-binding site of γ-secretase is located on presenilin near the active site
2005
γ-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation
2003
Disabled-1 Binds to the Cytoplasmic Domain of Amyloid Precursor-Like Protein 1
1999
Light and Electron Microscopic Localization of Presenilin-1 in Primate Brain
1997
HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling
1997
Amyloidogenic Function of the Alzheimer's Disease-Associated Presenilin 1 in the Absence of Endoproteolysis
1999
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
CD147 is a regulatory subunit of the γ-secretase complex in Alzheimer's disease amyloid β-peptide production
2005
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
2003
Alzheimer's disease: a re-examination of the amyloid hypothesis
1998
The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism
2006
MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS
1998
Contrasting Role of Presenilin-1 and Presenilin-2 in Neuronal DifferentiationIn Vitro
1999
γ-Cleavage Is Dependent on ζ-Cleavage during the Proteolytic Processing of Amyloid Precursor Protein within Its Transmembrane Domain
2005
Accelerated A Deposition in APPswe/PS1 E9 Mice with Hemizygous Deletions of TTR (Transthyretin)
2007
BACE overexpression alters the subcellular processing of APP and inhibits Aβ deposition in vivo
2005
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
1999
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation
2000
Low‐density lipoprotein receptor‐related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway
2007
Three-Dimensional Structure of an Independently Folded Extracellular Domain of Human Amyloid-β Precursor Protein,
2004 StandoutNobel
A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor
2019
Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein
2000
Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues
1996
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
A Cargo Receptor Mystery APP arently Solved?
2002 Science
Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology
2012
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
1997
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Evidence That Synaptically Released β-Amyloid Accumulates as Extracellular Deposits in the Hippocampus of Transgenic Mice
2002
C‐terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase‐3β expression
2003
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila
2000
Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins
1998
Alzheimer's Disease--Genotypes, Phenotype, and Treatments
1997 Science
Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes
2003
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
γ-Secretase Cleavage and Binding to FE65 Regulate the Nuclear Translocation of the Intracellular C-Terminal Domain (ICD) of the APP Family of Proteins
2003
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain
2008 StandoutNobel
Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix
1999
Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons
1999
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin
1998
Disruption of Corticocortical Connections Ameliorates Amyloid Burden in Terminal Fields in a Transgenic Model of Aβ Amyloidosis
2002
Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease
1997
The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein
2001
Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans
1998
Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells
1997
APL-1, a Caenorhabditis elegans protein related to the human β-amyloid precursor protein, is essential for viability
2007
Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice
2018
Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ
2001
A Portrait of Alzheimer Secretases--New Features and Familiar Faces
2001 Science
Presenilin-1 regulates neuronal differentiation during neurogenesis
2000
A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP
2002
Sampling the conformational space of the catalytic subunit of human γ-secretase
2015
Proteolytic processing and cell biological functions of the amyloid precursor protein
2000
The Presenilins in Alzheimer's Disease--Proteolysis Holds the Key
1999 Science
Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter
2007
The Alzheimer family of diseases: Many etiologies, one pathogenesis?
1997
Evidence for a physical interaction between presenilin and Notch
1999
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members
2000
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
2001
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
1999
Works of Gopal Thinakaran being referenced
Lack of requirement for Presenilin1 in Notch1 signaling
1999
Spatial Segregation of γ-Secretase and Substrates in DistinctMembraneDomains
2005
Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes
2014
Nicastrin Is Critical for Stability and Trafficking but Not Association of Other Presenilin/γ-Secretase Components
2005
Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease
2016
Metabolism of Presenilins<
2001
Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing
1999
Steady‐state increase of cAMP‐response element binding protein, Rac, and PAK signaling in presenilin‐deficient neurons
2007
Psychosine Accumulates in Membrane Microdomains in the Brain of Krabbe Patients, Disrupting the Raft Architecture
2009
Post-translational Processing and Turnover Kinetics of Presynaptically Targeted Amyloid Precursor Superfamily Proteins in the Central Nervous System
1998
Pathological and physiological functions of presenilins
2006
Trafficking and Proteolytic Processing of APP
2012
Subcellular Localization of Presenilins: Association with a Unique Membrane Pool in Cultured Cells
2000
Amyloid Precursor Protein Trafficking, Processing, and Function
2008
Ectodomain Phosphorylation of β-Amyloid Precursor Protein at Two Distinct Cellular Locations
1997
Presenilin 1 Is Required for Maturation and Cell Surface Accumulation of Nicastrin
2002
Presenilin-1 Regulates Intracellular Trafficking and Cell Surface Delivery of β-Amyloid Precursor Protein
2003
Endoplasmic Reticulum Stress-induced Cysteine Protease Activation in Cortical Neurons
2001
Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression
2000
Mutation Analysis of the Presenilin 1 N-terminal Domain Reveals a Broad Spectrum of γ-Secretase Activity toward Amyloid Precursor Protein and Other Substrates
2010
Novel Regulation of Chondroitin Sulfate Glycosaminoglycan Modification of Amyloid Precursor Protein and Its Homologue, APLP2
1995
Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors
1997
The Nonconserved Hydrophilic Loop Domain of Presenilin (PS) Is Not Required for PS Endoproteolysis or Enhanced Aβ42 Production Mediated by Familial Early Onset Alzheimer's Disease-linked PS Variants
2000
Metabolism of the “Swedish” Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells
1996
A Role for Presenilin 1 in Regulating the Delivery of Amyloid Precursor Protein to the Cell Surface
2002
Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons
1998
Processing of presenilin 1 in brains of patients with Alzheimerʼs disease and controls
1997
Hyperaccumulation of FAD-linked presenilin 1 variants in vivo
1997
Studies on the Metabolism and Biological Function of APLP2a
1996
Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains
1998
PEN-2 and APH-1 Coordinately Regulate Proteolytic Processing of Presenilin 1
2003
Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin
1997
The role of presenilins in Alzheimer’s disease
1999
Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP
1998
Metabolism of the Amyloid Precursor-like Protein 2 in MDCK Cells.
1995
Multiple Effects of Aspartate Mutant Presenilin 1 on the Processing and Trafficking of Amyloid Precursor Protein
2001
Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes
2004
Generation of APLP2 KO Mice and Early Postnatal Lethality in APLP2/APP Double KO Mice
1997
Function and Dysfunction of the Presenilins
1999
Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo
1996
Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides
1998
The role of presenilin cofactors in the γ-secretase complex
2003 Nature
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
1996
Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis
1995
Evidence for phosphorylation and oligomeric assembly of presenilin 1
1997
Presenilins and γ-Secretase Inhibitors Affect Intracellular Trafficking and Cell Surface Localization of the γ-Secretase Complex Components
2004
Nucleotide sequence of the chromosome 14-encodedS182cDNA and revised secondary structure prediction
1995
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides
1999
Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation
1997
Expression and distribution of amyloid precursor protein-like protein-2 in Alzheimer's disease and in normal brain.
1996
Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path
1998
Amyloidogenic processing of β-amyloid precursor protein in intracellular compartments
2006
Biogenesis of γ-secretase early in the secretory pathway
2007 StandoutNobel
Amyloid precursor-like protein 2 (APLP2) is modified by the addition of chondroitin sulfate glycosaminoglycan at a single site.
1994