Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors

Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases