Citation Impact
Citing Papers
Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O 2 activation
2019 StandoutNobel
Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex
2008
Molecular properties of mammalian proteins that interact with cGMP: protein kinases, cation channels, phosphodiesterases, and multi-drug anion transporters
2005
Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5
2008
Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4
2008 StandoutNobel
Crystal structure of a laccase from Melanocarpus albomyces with an intact trinuclear copper site
2002
Mechanisms of Thrombus Formation
2008 Standout
Multicopper oxidase involvement in both Mn(II) and Mn(III) oxidation during bacterial formation of MnO2
2012
Recent applications of protein crystallography and structure-guided drug design
2005
Structure–Function Studies of a Melanocarpus albomyces Laccase Suggest a Pathway for Oxidation of Phenolic Compounds
2009
Multiple Elements Jointly Determine Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases 4 and 7
2005
Spectral and Kinetic Properties of the Fet3 Protein fromSaccharomyces cerevisiae, a Multinuclear Copper Ferroxidase Enzyme
1998
Selective PDE inhibitors as novel treatments for respiratory diseases
2012
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
The Long and Short of Vascular Smooth Muscle Phosphodiesterase-4 As a Putative Therapeutic Target
2005
Genetic Defects in Copper Metabolism
2003
Intramolecular electron transfer in laccases
2011
Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use
2006 Standout
Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α
2007 StandoutNobel
Function and molecular evolution of multicopper blue proteins
2005
Substrate and Dioxygen Binding to the Endospore Coat Laccase from Bacillus subtilis
2004
Biomimetic Modeling of Copper Complexes: A Study of Enantioselective Catalytic Oxidation on D‐(+)‐Catechin and L‐(−)‐Epicatechin with Copper Complexes
2008
Crystal structure of the type-2 Cu depleted laccase from Coprinus dnereus at 2.2 Å resolution
1998
Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source
2013
New insights into structure-function relationships in nitrogenase: a 1.6 Å resolution X-ray crystallographic study of Klebsiella pneumoniae MoFe-protein
1999
Balancing Acts
2004 Standout
Mutations at Asp112 adjacent to the trinuclear Cu center in CueO as the proton donor in the four‐electron reduction of dioxygen
2006
New approaches to molecular cancer therapeutics
2006
Ca2+-calmodulin-dependent phosphodiesterase (PDE1): Current perspectives
2005
Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice
2004
cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action
2010 Standout
Fragment-based lead discovery: a chemical update
2006
Leishmania major thialysine Nε‐acetyltransferase: Identification of amino acid residues crucial for substrate binding
2005
When analoging is not enough: scaffold discovery in medicinal chemistry
2010
Copper transport
1998
Recent Developments in Fragment-Based Drug Discovery
2008
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode
2009
The chemical biology of copper
1998
Transforming fragments into candidates: small becomes big in medicinal chemistry
2009
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Copper-binding motifs in catalysis, transport, detoxification and signaling
1997
O2 Reduction to H2O by the multicopper oxidases
2008
DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts
2000 StandoutNobel
Features and development of Coot
2010 Standout
Oxygen Binding, Activation, and Reduction to Water by Copper Proteins
2001
Structure-Function Analysis of the Cuprous Oxidase Activity in Fet3p from Saccharomyces cerevisiae
2007
Crystal Structure of a Two-domain Multicopper Oxidase
2009
Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells
2015 Standout
Phosphodiesterase-5 Gln817 Is Critical for cGMP, Vardenafil, or Sildenafil Affinity
2006
Crystal Structure of a Laccase from the FungusTrametes versicolor at 1.90-Å Resolution Containing a Full Complement of Coppers
2002
A Labile Regulatory Copper Ion Lies Near the T1 Copper Site in the Multicopper Oxidase CueO
2003
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin
2002
Reduction of Unusual Iron-Sulfur Clusters in the H2-sensing Regulatory Ni-Fe Hydrogenase from Ralstonia eutropha H16
2005
Multiple Conformations of Phosphodiesterase-5
2006
Targeted suppression of the ferroxidase and iron trafficking activities of the multicopper oxidase Fet3p from Saccharomyces cerevisiae
2003
Regulation of premeiotic S phase and recombination-related double-strand DNA breaks during meiosis in fission yeast
2001 StandoutNobel
Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development
2005
Fragment-based lead discovery: leads by design
2005
A decade of fragment-based drug design: strategic advances and lessons learned
2007
Cuprous oxidase activity of yeast Fet3p and human ceruloplasmin: implication for function
2003
Cdk6–cyclin D3 activity in murine ES cells is resistant to inhibition by p16INK4a
2004
A crystallographic and spectroscopic study on the effect of X-ray radiation on the crystal structure of Melanocarpus albomyces laccase
2006
On the Relationship between the Characteristics of Bilirubin Oxidases and O2 Cathodes Based on Their “Wiring”
2002
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
CERULOPLASMIN METABOLISM AND FUNCTION
2002
3d Transition Metals for C–H Activation
2018 Standout
Fluorine in medicinal chemistry
2007 Standout
Cyclic GMP-Hydrolyzing Phosphodiesterases
2008
Spectroscopic and Electronic Structure Studies of the Trinuclear Cu Cluster Active Site of the Multicopper Oxidase Laccase: Nature of Its Coordination Unsaturation
2005
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Cu and Cu-Based Nanoparticles: Synthesis and Applications in Catalysis
2016 Standout
Geometric and Electronic Structure/Function Correlations in Non-Heme Iron Enzymes
1999 Standout
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
The pKBHX Database: Toward a Better Understanding of Hydrogen-Bond Basicity for Medicinal Chemists
2009
Spectroscopic Demonstration of a Large Antisymmetric Exchange Contribution to the Spin-Frustrated Ground State of a D3 Symmetric Hydroxy-Bridged Trinuclear Cu(II) Complex: Ground-to-Excited State Superexchange Pathways
2004
Multicopper Oxidases and Oxygenases
1996 Standout
A Tris(μ-hydroxy)tricopper(II) Complex as a Model of the Native Intermediate in Laccase and Its Relationship to a Binuclear Analogue
2005
Structure and Spectroscopy of Copper−Dioxygen Complexes
2004 Standout
Copper Active Sites in Biology
2014 Standout
Recombinant Expression and Functional Characterization of Human Hephaestin: A Multicopper Oxidase with Ferroxidase Activity
2005
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct
2009
Synthetic Analogues of the Active Sites of Iron−Sulfur Proteins
2003
An Oxygen Cathode Operating in a Physiological Solution
2002
Recent Advances in Transition Metal Catalyzed Oxidation of Organic Substrates with Molecular Oxygen
2005 Standout
A comparative analysis of the spin state distribution of in vitro and in vivo mutants of PsaC. A biochemical argument for the sequence of electron transfer in Photosystem I as FX → FA → FB → ferredoxin/flavodoxin
1999
Chemistry of Iron Sulfides
2007 Standout
Discovery of Imidazo[1,5-a]pyrido[3,2-e]pyrazines as a New Class of Phosphodiesterase 10A Inhibitiors
2010
Systematic Perturbation of the Trinuclear Copper Cluster in the Multicopper Oxidases: The Role of Active Site Asymmetry in Its Reduction of O2 to H2O
2010
Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore
2010 Standout
Design and NMR-Based Screening of LEF, a Library of Chemical Fragments with Different Local Environment of Fluorine
2009
Spectroscopic and Magnetic Studies of Human Ceruloplasmin: Identification of a Redox-Inactive Reduced Type 1 Copper Site
1998
Occurrence, Classification, and Biological Function of Hydrogenases: An Overview
2007 Standout
Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux
1999
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
Nature of the Intermediate Formed in the Reduction of O2 to H2O at the Trinuclear Copper Cluster Active Site in Native Laccase
2002
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, β-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5
2006
Mechanism of Nitrogen Fixation by Nitrogenase: The Next Stage
2014 Standout
Reactivity of Dioxygen−Copper Systems
2004
Spectroscopic Analysis of the Trinuclear Cluster in the Fet3 Protein from Yeast, a Multinuclear Copper Oxidase
2000
Crystal Structure of a Four-Copper Laccase Complexed with an Arylamine: Insights into Substrate Recognition and Correlation with Kinetics,
2002
Three-dimensional structure of cyanobacterial photosystem I at 2.5 Å resolution
2001 StandoutNature
Decay of the Peroxide Intermediate in Laccase: Reductive Cleavage of the O−O Bond
2001
Aerobic Copper-Catalyzed Organic Reactions
2013 Standout
Structural Basis of the Ferrous Iron Specificity of the Yeast Ferroxidase, Fet3p
2006
Cyclic nucleotide phosphodiesterases in Drosophila melanogaster
2005
Spectroscopy and Reactivity of the Type 1 Copper Site in Fet3p from Saccharomyces cerevisiae: Correlation of Structure with Reactivity in the Multicopper Oxidases
2001
Bacteriogenic Manganese Oxides
2009
Spectroscopic and Kinetic Studies of Perturbed Trinuclear Copper Clusters: The Role of Protons in Reductive Cleavage of the O−O Bond in the Multicopper Oxidase Fet3p
2007
Recent Advances on Phosphodiesterase 4 Inhibitors for the Treatment of Asthma and Chronic Obstructive Pulmonary Disease
2008
Reaction Mechanisms of the Multicopper Oxidase CueO from Escherichia coli Support Its Functional Role as a Cuprous Oxidase
2010
Electronic structures of exchange coupled trigonal trimeric Cu(II) complexes: Spin frustration, antisymmetric exchange, pseudo-A terms, and their relation to O2 activation in the multicopper oxidases
2006
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
The copper-iron connection in biology: Structure of the metallo-oxidase Fet3p
2005
Aromatic Trifluoromethylation with Metal Complexes
2011 Standout
Redox cycling and kinetic analysis of single molecules of solution-phase nitrite reductase
2011 StandoutNobel
Research on Soluble Metal Sulfides: From Polysulfido Complexes to Functional Models for the Hydrogenases
2003
Advances in Copper Complexes as Anticancer Agents
2013 Standout
Electrochemical Glucose Sensors and Their Applications in Diabetes Management
2008 Standout
Spectroscopic Characterization and O2 Reactivity of the Trinuclear Cu Cluster of Mutants of the Multicopper Oxidase Fet3p
2002
Electronic Structure of the Peroxy Intermediate and Its Correlation to the Native Intermediate in the Multicopper Oxidases: Insights into the Reductive Cleavage of the O−O Bond
2007
Protein Radicals in Enzyme Catalysis
1998 Standout
Mössbauer and EPR Characterization of the S = 9/2 Mixed-Valence Fe(II)Fe(III) Cluster in the Cryoreduced R2 Subunit of Escherichia coli Ribonucleotide Reductase
2000
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
A Trinuclear Intermediate in the Copper-Mediated Reduction of O 2 : Four Electrons from Three Coppers
1996 Science
Mechanistic Studies on Synthetic Fe−S-Based Clusters and Their Relevance to the Action of Nitrogenases
2005 StandoutNobel
Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling
2007 Standout
Catalytic Asymmetric Protonation of Silyl Ketene Imines
2013 StandoutNobel
Copper-related diseases: From chemistry to molecular pathology
2009
Great Metalloclusters in Enzymology
2002
Synthetic models for biological trinuclear copper clusters. Trinuclear and binuclear complexes derived from an octadentate tetraamine-tetrabenzimidazole ligand
1998
Structure–function relationships of copper-containing nitrite reductases
1999
Point Mutations at the Type I Cu Ligands, Cys457 and Met467, and at the Putative Proton Donor, Asp105, in Myrothecium verrucaria Bilirubin Oxidase and Reactions with Dioxygen
2005
Ferrous Binding to the Multicopper OxidasesSaccharomyces cerevisiaeFet3p and Human Ceruloplasmin: Contributions to Ferroxidase Activity
2004
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
2008 Standout
Frozen Density Functional Free Energy Simulations of Redox Proteins: Computational Studies of the Reduction Potential of Plastocyanin and Rusticyanin
2003 StandoutNobel
Proton-Coupled Electron Transfer
2012 Standout
Biomimetic Hydrogen Evolution: MoS2Nanoparticles as Catalyst for Hydrogen Evolution
2005 Standout
Geometric and electronic structure differences between the type 3 copper sites of the multicopper oxidases and hemocyanin/tyrosinase
2009
Structure and Chemistry of Cytochrome P450
2005 Standout
Crystal structure and electron transfer kinetics of CueO, a multicopper oxidase required for copper homeostasis in Escherichia coli
2002
Works of G.L. Card being referenced
A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
2004
A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
2004
Remote access to crystallography beamlines at SSRL: novel tools for training, education and collaboration
2010
Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases
2004
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design
2005
Overcoming inhibitions: subversion of CKI function by viral cyclins
1999
Crystallization and preliminary X-ray studies of nitrogenase component 1 (the MoFe protein) from Klebsiella pneumoniae
1997
The Crystal Structure of Rv1347c, a Putative Antibiotic Resistance Protein from Mycobacterium tuberculosis, Reveals a GCN5-related Fold and Suggests an Alternative Function in Siderophore Biosynthesis
2005
A Molecular Model for the Triplicated A Domains of Human Factor VIII Based on the Crystal Structure of Human Ceruloplasmin
1997
The "prismane" protein resolved: X-ray structure at 1.7 Å and multiple spectroscopy of two novel 4Fe clusters
1998
The X-ray structure of human serum ceruloplasmin at 3.1 Å: nature of the copper centres
1996
An X-ray structural study of human ceruloplasmin in relation to ferroxidase activity
1997