Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages
2005 StandoutNobel
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
2005 StandoutScience
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
2004 StandoutScience
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 StandoutScienceNobel
Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B
1998
Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells
2002
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Structural Basis for Gating and Activation of RyR1
2016 StandoutNobel
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
A Requirement for Phosphatidylinositol 3-Kinase in Pseudopod Extension
1999
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
1999
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions
2000
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases
2004
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
2002 Standout
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
2009 Standout
Regulation of translation initiation by FRAP/mTOR
2001
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
A role for ATR in the DNA damage-induced phosphorylation of p53
1999
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
1994
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
2004 Standout
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
1994
Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells
1995
Structure of S6 Kinase 1 Determines whether Raptor-mTOR or Rictor-mTOR Phosphorylates Its Hydrophobic Motif Site
2005
FAT: a novel domain in PIK-related kinases
2000
Protein‐Reactive Natural Products
2005
Upstream and downstream of mTOR
2004 Standout
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Control of p70 S6 kinase by kinase activity of FRAP in vivo
1995 Nature
Regulation of Glycogen Synthase in Rat Hepatocytes
1999
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
2000
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Fibrillar Collagen Inhibits Arterial Smooth Muscle Proliferation through Regulation of Cdk2 Inhibitors
1996
Methods in Mammalian Autophagy Research
2010 Standout
Principles of CDK regulation
1995 StandoutNature
Atherosclerosis — An Inflammatory Disease
1999 Standout
Fab Antibody Fragments
2004
Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation
1994
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
2003 StandoutNature
AKT/PKB Signaling: Navigating the Network
2017 Standout
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
A mammalian protein targeted by G1-arresting rapamycin–receptor complex
1994 StandoutNature
lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin
1994 Nature
The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
1995
Insulin Signaling and the Control of PHAS-I Phosphorylation
2001
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton
2004 Standout
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK
1999
Autophagy in immunity and inflammation
2011 StandoutNature
Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability
1998
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
1998
Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
1998 Standout
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.
1998
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
1999 Standout
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Conditional Glycosylation in Eukaryotic Cells Using a Biocompatible Chemical Inducer of Dimerization
2008 StandoutNobel
Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin
2002
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
1999
Telomerase activity, cell proliferation, and cancer
1998 StandoutNobel
Cancer Cell Cycles
1996 StandoutScience
The rate of telomere sequence loss in human leukocytes varies with age
1998 StandoutNobel
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Ribosomal Synthesis of Dehydroalanine-Containing Peptides
2006 StandoutNobel
Integrin Signaling
1999 StandoutScience
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
2001
Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin
1997 Science
Two Motifs in the Translational Repressor PHAS-I Required for Efficient Phosphorylation by Mammalian Target of Rapamycin and for Recognition by Raptor
2003
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.
1994
Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM
2004
Distinct Signaling Events Downstream of mTOR Cooperate To Mediate the Effects of Amino Acids and Insulin on Initiation Factor 4E-Binding Proteins
2005 StandoutNobel
Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage
1998 StandoutScience
Dominant Missense Mutations in a Novel Yeast Protein related to Mammalian Phosphatidylinositol 3-Kinase and VPS34 Abrogate Rapamycin Cytotoxicity
1993
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
Autophagy as a Regulated Pathway of Cellular Degradation
2000 StandoutScience
Effects of Rapamycin on Ryanodine Receptor/Ca 2+ -Release Channels From Cardiac Muscle
1996
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Telomerase regulation during entry into the cell cycle in normal human T cells.
1996 StandoutNobel
The Phosphoinositide 3-Kinase Pathway
2002 StandoutScience
PHOSPHOINOSITIDE KINASES
1998
FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.
1993
The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation
2002
Works of G.J. Brunn being referenced
Reversal of desipramine toxicity in rats using drug-specific antibody Fab' fragment: effects on hypotension and interaction with sodium bicarbonate.
1992
Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes.
1993
Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.
1996
Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes.
1993