Standout Papers
Citation Impact
Citing Papers
IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation
2001
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response
2013 StandoutNobel
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
2007 StandoutScienceNobel
Complete Replication of Hepatitis C Virus in Cell Culture
2005 StandoutScienceNobel
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Subpolar addition of new cell wall is directed by DivIVA in mycobacteria
2014 StandoutNobel
Soluble IL-6 Receptor Potentiates the Antagonistic Activity of Soluble gp130 on IL-6 Responses
1998
Differences in Wound Healing in Mice with Deficiency of IL-6 versus IL-6 Receptor
2010
Loss of CD4+ T Cell IL-6R Expression during Inflammation Underlines a Role for IL-6 Trans Signaling in the Local Maintenance of Th17 Cells
2010
Functional diversity of helper T lymphocytes
1996 StandoutNature
Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment
1997
Inflammation and cancer
2002 StandoutNature
A role for IL-27p28 as an antagonist of gp130-mediated signaling
2010
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
2006 Standout
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
Enhancement of Th2 response in IL-6-deficient mice immunized with myelin oligodendrocyte glycoprotein
2000
SOCS3 negatively regulates IL-6 signaling in vivo
2003
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate Lymphocytes
2010
An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos
2013
Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase
1999
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling
2009
Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation
1998
Analyzing real-time PCR data by the comparative CT method
2008 Standout
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.
1998 Standout
Interleukin 6 and its Receptor: Ten Years Later
1998
IL-6 as a keystone cytokine in health and disease
2015 Standout
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
2006 StandoutNature
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
2002
Comparison of Activation versus Induction of Unresponsiveness of Virus-Specific CD4+ and CD8+ T Cells upon Acute versus Persistent Viral Infection
1998
Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections
2003
Interleukin-6 Is Crucial for Recall of Influenza-Specific Memory CD4+ T Cells
2008
Mechanisms of Exogenous Antigen Presentation by MHC Class I Molecules in Vitro and in Vivo: Implications for Generating CD8+ T Cell Responses to Infectious Agents, Tumors, Transplants, and Vaccines
1999
Immunity, Inflammation, and Cancer
2010 Standout
Plasma cell differentiation requires the transcription factor XBP-1
2001 Nature
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
2009 StandoutNatureNobel
Affinity maturation of Fab antibody fragments by fluorescent‐activated cell sorting of yeast‐displayed libraries
2003
IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
1998
Robust Antigen Specific Th17 T Cell Response to Group A Streptococcus Is Dependent on IL-6 and Intranasal Route of Infection
2011
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
1999 StandoutNature
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Interleukin‐6 Gene‐Deficient Mice Show Impaired Defense against Pneumococcal Pneumonia
1997
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
2011
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
2001 StandoutNatureNobel
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
2007 StandoutNatureNobel
IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
2000
The tetraspanin web modulates immune-signalling complexes
2005
Origin and physiological roles of inflammation
2008 StandoutNature
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Animal Models for Hepatitis C
2013
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
IL-6 plays a crucial role in the induction phase of myelin oligodendrocyte glycoprotein 35–55 induced experimental autoimmune encephalomyelitis
1999
A genetically humanized mouse model for hepatitis C virus infection
2011 StandoutNatureNobel
Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
1995
Cancer-related inflammation
2008 StandoutNature
Interplay between IFN-γ and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation
2003
Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria
2004 Nature
Cytokines in the generation of immune responses to, and resolution of, virus infection
1994
Interactions between commensal intestinal bacteria and the immune system
2004 Standout
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Dendritic cells process exogenous viral proteins and virus‐like particles for class I presentation to CD8+ cytotoxic T lymphocytes
1996
Serum antibodies against the hepatitis C virus E2 protein mediate antibody-dependent cellular cytotoxicity (ADCC)
2005 StandoutNobel
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
2001 Standout
Induction of Cell Cycle Arrest and B Cell Terminal Differentiation by CDK Inhibitor p18 and IL-6
1997
Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis
2007
Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity
2000
Increased and Long-Term Generation of Dendritic Cells with Reduced Function from IL-6-Deficient Bone Marrow
2004
DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8 + T cells in a spectrum of human MHC I haplotypes
2007 StandoutNobel
In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development
2010
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.
1995
CD81 Is Required for Hepatitis C Virus Glycoprotein-Mediated Viral Infection
2004 StandoutNobel
Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells
1997
Interleukin 6 plays a key role in the development of antigen-induced arthritis
1998
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Differential Regulation of Neutrophil-Activating Chemokines by IL-6 and Its Soluble Receptor Isoforms
2004
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
2005 StandoutScience
Directing Transition from Innate to Acquired Immunity: Defining a Role for IL-6
2005
Cd4+ T Cell Subsets during Virus Infection
2000
ON IMMUNOLOGICAL MEMORY
1996
Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation
2000
IL‐6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo
2013
CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.
1996 Standout
Viral IL-6 Blocks Neutrophil Infiltration during Acute Inflammation
2005
The transcription factor NFATc2 controls IL-6–dependent T cell activation in experimental colitis
2008
Interleukin‐6 limits influenza‐induced inflammation and protects against fatal lung pathology
2013
Elevated Serum Levels of the Soluble Form of gp130, the IL‐6 Signal Transducer, in HTLV‐1 Infection and No Involvement of Alternative Splicing for Its Generation
1998
The IL-6-Soluble IL-6Rα Autocrine Loop of Endothelial Activation as an Intermediate Between Acute and Chronic Inflammation: an Experimental Model Involving Thrombin
2001
IL-6 Controls the Innate Immune Response against Listeria monocytogenes via Classical IL-6 Signaling
2012
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Total Synthesis of (+)-Madindoline A and (−)-Madindoline B, Potent, Selective Inhibitors of Interleukin 6. Determination of the Relative and Absolute Configurations
2000 StandoutNobel
The soluble interleukin 6 receptor: mechanisms of production and implications in disease
2001
Dynamics of Persistent TT Virus Infection, as Determined in Patients Treated with Alpha Interferon for Concomitant Hepatitis C Virus Infection
2001
Recurrent Staphylococcal Cellulitis and Subcutaneous Abscesses in a Child with Autoantibodies against IL-6
2008
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.
1996
Quantitation of Viral Load Using Real-Time Amplification Techniques
2001
Cloning and sequencing of TT virus genotype 6 and expression of antigenic open reading frame 2 proteins
2002
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages
2003
Superantigen overcomes resistance of IL‐6‐deficient mice towards MOG‐induced EAE by a TNFR1 controlled pathway
2001
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP beta-deficient mice.
1996
Replication of Subgenomic Hepatitis C Virus Replicons in Mouse Fibroblasts Is Facilitated by Deletion of Interferon Regulatory Factor 3 and Expression of Liver-Specific MicroRNA 122
2010
Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans.
1996
IL-6 as a drug discovery target
1998
Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection
2011 Science
IL-6 Is Required for Airway Mucus Production Induced by Inhaled Fungal Allergens
2009
Interleukin-6 and the Granulocyte Colony-Stimulating Factor Receptor Are Major Independent Regulators of Granulopoiesis In Vivo But Are Not Required for Lineage Commitment or Terminal Differentiation
1997
The Role of Interleukin-6 in Mucosal IgA Antibody Responses in Vivo
1994 Science
Diverse CD81 Proteins Support Hepatitis C Virus Infection
2006 StandoutNobel
Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling
2007 StandoutNobel
TLR and B Cell Receptor Signals to B Cells Differentially Program Primary and Memory Th1 Responses to Salmonella enterica
2010
Different Domains of CD81 Mediate Distinct Stages of Hepatitis C Virus Pseudoparticle Entry
2006
Although IL-6 Trans-Signaling Is Sufficient To Drive Local Immune Responses, Classical IL-6 Signaling Is Obligate for the Induction of T Cell-Mediated Autoimmunity
2010
Immunological Memory and Protective Immunity: Understanding Their Relation
1996 StandoutScience
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
Defective inflammatory response in interleukin 6-deficient mice.
1994
IL-6-Deficient Mice Are Resistant to Experimental Autoimmune Encephalomyelitis: Roles of IL-6 in the Activation and Differentiation of Autoreactive T Cells
1998
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
1999
Isolation of Multiple TT Virus Genotypes from Spleen Biopsy Tissue from a Hodgkin's Disease Patient: Genome Reorganization and Diversity in the Hypervariable Region
2004 StandoutNobel
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Works of Giulia Freer being referenced
Localization of T Helper Cell Epitopes in the Vesicular Stomatitis Virus: The Nucleoprotein Is Responsible for Serotype Cross-Reactive T Help
1994
Pleiotropic Defects of IL‐6—deficient Mice Including Early Hematopoiesis, T and B Cell Function, and Acute Phase Responses
1995 Nobel
Impaired immune and acute-phase responses in interleukin-6-deficient mice
1994 StandoutNatureNobel
Role of T helper cell precursor frequency on vesicular stomatitis virus neutralizing antibody responses in a T cell receptor β chain transgenic mouse
1995
Induction of protective cytotoxic T cells with viral proteins
1994
Expression of Human CD81 in Transgenic Mice Does Not Confer Susceptibility to Hepatitis C Virus Infection
2002 StandoutNobel
Characterization of T-helper epitopes of the glycoprotein of vesicular stomatitis virus
1994
The Role of Antibody Concentration and Avidity in Antiviral Protection
1997 Science
Qualitative and Quantitative Requirements for CD4+ T Cell-Mediated Antiviral Protection
1999
Molecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of Humans
2001
Involvement of the fadD33 gene in the growth of Mycobacterium tuberculosis in the liver of BALB/c mice
2002
TT virus levels in the plasma of infected individuals with different hepatic and extrahepatic pathology
2001
Vesicular stomatitis virus Indiana glycoprotein as a T-cell-dependent and -independent antigen
1994