Standout Papers
Citation Impact
Citing Papers
Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells
2019 StandoutNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins
2007
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
2006 StandoutNobel
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
2020 StandoutScienceNobel
Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs
2002 StandoutNobel
The xc− cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance
2008
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Arginine, arginine analogs and nitric oxide production in chronic kidney disease
2006
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice
2010
Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance
2013
CATs and HATs: the SLC7 family of amino acid transporters
2004
Activation of nitric oxide synthase by β2‐adrenoceptors in human umbilical vein endothelium in vitro
1999
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Heme oxygenase–carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide?
1999
HIF-1, O2, and the 3 PHDs
2001 StandoutNobel
Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice
2004
Elevated protein carbonyls as plasma markers of oxidative stress in acute pancreatitis
2003
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
2006 Standout
Gene regulation of heme oxygenase-1 as a therapeutic target
2000
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Hypoxia‐inducible factor as a physiological regulator
2005
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis
2002
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
HIF-1alpha is required for solid tumor formation and embryonic vascularization
1998
HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration
2002
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α
2007 StandoutNobel
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
2012 Standout
Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation
1989
Role of controlled cardiac reoxygenation in reducing nitric oxide production and cardiac oxidant damage in cyanotic infantile hearts.
1994 StandoutNobel
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
2007 StandoutNatureNobel
Sulfasalazine-Induced Reduction of Glutathione Levels in Breast Cancer Cells: Enhancement of Growth-Inhibitory Activity of Doxorubicin
2007
Electrophile Response Element-mediated Induction of the Cystine/Glutamate Exchange Transporter Gene Expression
2002
Where is the blood–brain barrier … really?
2005
Structural and functional aspects of the blood-brain barrier
2003
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Astrocyte–endothelial interactions at the blood–brain barrier
2005 Standout
Perspectives on Oxygen Sensing
1999 StandoutNobel
System Xc−and Apolipoprotein E Expressed by Microglia Have Opposite Effects on the Neurotoxicity of Amyloid-β Peptide 1–40
2006
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia
2010
Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection
2009
The Heme-Bach1 Pathway in the Regulation of Oxidative Stress Response and Erythroid Differentiation
2006
First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
2010
Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis.
1992 StandoutNobel
Expression of heme oxygenase-1 in atherosclerotic lesions.
1998
Life with Oxygen
2007 StandoutScienceNobel
Mammalian Oxygen Sensing, Signalling and Gene Regulation
2000
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
2002 StandoutNobel
Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
2000 StandoutNobel
Fc receptors in antibody‐dependent enhancement of viral infections
2015
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons.
1988 StandoutNobel
Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O 2 ‐regulated gene expression
2002
Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor
1996
PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light
1999
Nongenomic Steroid Action: Controversies, Questions, and Answers
2003
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
2005
Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
2013
The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.
1990 StandoutNobel
Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss
2010 StandoutScienceNobel
Hearts From Rodents Exposed to Intermittent Hypoxia or Erythropoietin Are Protected Against Ischemia-Reperfusion Injury
2003 StandoutNobel
Reduced stress defense in heme oxygenase 1-deficient cells
1997 Nobel
Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor
2002
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
1995 StandoutNobel
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
2002 StandoutNobel
Endothelial NOS and the Blockade of LTP by NOS Inhibitors in Mice Lacking Neuronal NOS
1994 StandoutScienceNobel
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
1997 StandoutNobel
Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels.
1987 StandoutNobel
Hyperglycemia Regulates Hypoxia-Inducible Factor-1α Protein Stability and Function
2004
Adverse Effects of Cigarette Smoke on NO Bioavailability
2006
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice
2009 StandoutNobel
The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF)
2005
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart
2013 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Nitric oxide synthases in mammals
1994 Standout
Works of Giovanni E. Mann being referenced
Effect of Oxygen on Induction of the Cystine Transporter by Bacterial Lipopolysaccharide in Mouse Peritoneal Macrophages
2001
Substrate-dependent regulation of intracellular amino acid concentrations in cultured bovine aortic endothelial cells
1990
Modulation of antioxidant gene expression by 4-hydroxynonenal: atheroprotective role of the Nrf2/ARE transcription pathway
2007
Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations
2011 Standout
Acute oxidative stress modulates secretion and repetitive Ca2+ spiking in rat exocrine pancreas
1999
Expression of stress proteins heme oxygenase‐1 and ‐2 in acute pancreatitis and pancreatic islet βTC3 and acinar AR42J cells
1997
Identification of system y+L as the high-affinity transporter for l-arginine in human platelets: up-regulation of l-arginine influx in uraemia
1999
Induction of cystine transport via system xc− and maintenance of intracellular glutathione levels in pancreatic acinar and islet cell lines
1998
Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells
1991
Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial celll ‐arginine transporter
1992
Role of Oxidative Stress in the Pathogenesis of Acute Pancreatitis
1996
Oxygen- and dioxin-regulated gene expression in mouse hepatoma cells
1997
Modulation of vascular tone by low density lipoproteins: effects on L‐arginine transport and nitric oxide synthesis
1997
Nitric oxide activity in platelets of dengue haemorrhagic fever patients: the apparent paradoxical role of ADMA and l-NMMA
2012
Induction of the antioxidant stress proteins heme oxygenase‐1 and MSP23 by stress agents and oxidised LDL in cultured vascular smooth muscle cells
1995
Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling
2009
HIF‐1 is expressed in normoxic tissue and displays an organ‐specific regulation under systemic hypoxia
2001
Diabetes‐induced activation of system y+ and nitric oxide synthase in human endothelial cells: association with membrane hyperpolarization.
1995
Regulation of Amino Acid and Glucose Transporters in Endothelial and Smooth Muscle Cells
2003
Transport of l -Arginine and the Nitric Oxide Inhibitor NG-Monomethyl-l -Arginine in Human Erythrocytes in Chronic Renal Failure
1997
Expression of amino acid transport systems in cultured human umbilical vein endothelial cells.
1989
Identification of system y
1999
Vitamin C Protects Human Arterial Smooth Muscle Cells Against Atherogenic Lipoproteins
1998
Acute Activation of Maxi-K Channels ( hSlo ) by Estradiol Binding to the β Subunit
1999 Science
Role of Nrf2 in the Regulation of CD36 and Stress Protein Expression in Murine Macrophages
2004
Early activation of the p42/p44 MAPK pathway mediates adenosine‐induced nitric oxide production in human endothelial cells: a novel calcium‐insensitive mechanism
2002