Standout Papers
Citation Impact
Citing Papers
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
2003 Standout
The human splicing code reveals new insights into the genetic determinants of disease
2014 Science
Triggering a Cell Shape Change by Exploiting Preexisting Actomyosin Contractions
2012 StandoutScienceNobel
SGK196 Is a Glycosylation-Specific O -Mannose Kinase Required for Dystroglycan Function
2013 Science
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
De novo design of self-assembling helical protein filaments
2018 StandoutScienceNobel
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
A conserved protonation-dependent switch controls drug binding in the Abl kinase
2008
Overcoming Redundancy: An RNAi Enhancer Screen for Morphogenesis Genes in Caenorhabditis elegans
2011
An efficient proteomics method to identify the cellular targets of protein kinase inhibitors
2003
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress
2010 StandoutNobel
Atomic model of the type III secretion system needle
2012 StandoutNatureNobel
Signalling scaffolds and local organization of cellular behaviour
2015
In Vivo Imaging Reveals Different Cellular Functions for FGF and Dpp Signaling in Tracheal Branching Morphogenesis
2002
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
2003 Standout
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Following evolutionary paths to protein-protein interactions with high affinity and selectivity
2009
High‐Throughput Screening for Terpene‐Synthase‐Cyclization Activity and Directed Evolution of a Terpene Synthase
2013 StandoutNobel
Transcending the biomarker mindset: deciphering disease mechanisms at the single cell level
2006
Kinase-Selective Enrichment Enables Quantitative Phosphoproteomics of the Kinome across the Cell Cycle
2008
PKA: a portrait of protein kinase dynamics
2003
Wound repair and regeneration
2008 StandoutNature
Plant and Animal Pathogen Recognition Receptors Signal through Non-RD Kinases
2006
Proteasome-Mediated Processing of Nrf1 Is Essential for Coordinate Induction of All Proteasome Subunits and p97
2014
Crystal Structure of the Kinase Domain of WNK1, a Kinase that Causes a Hereditary Form of Hypertension
2004
Rational design of inhibitors that bind to inactive kinase conformations
2006
UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans
2021
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Hierarchical Modeling of Activation Mechanisms in the ABL and EGFR Kinase Domains: Thermodynamic and Mechanistic Catalysts of Kinase Activation by Cancer Mutations
2009
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Haematopoietic stem cells require a highly regulated protein synthesis rate
2014 Nature
Peptide inhibitors of protein kinases—discovery, characterisation and use
2005
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
2014 StandoutNobel
Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
2004 Standout
Conservation, Variability and the Modeling of Active Protein Kinases
2007 StandoutNobel
Targeting cancer with small molecule kinase inhibitors
2008 Standout
Structural Basis for the Recognition of c-Src by Its Inactivator Csk
2008
Pathogenesis of Human Mitochondrial Diseases Is Modulated by Reduced Activity of the Ubiquitin/Proteasome System
2014
Autophosphorylation of Archaeoglobus fulgidus Rio2 and crystal structures of its nucleotide–metal ion complexes
2005
Connecting Cell Behavior to Patterning: Lessons from the Cell Cycle
1997
Terpenoid synthase structures: a so far incomplete view of complex catalysis
2012
Crystal Structure of the TAO2 Kinase Domain
2004
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Characterization of a Conserved Structural Determinant Controlling Protein Kinase Sensitivity to Selective Inhibitors
2004
Catalytic Independent Functions of a Protein Kinase as Revealed by a Kinase-dead Mutant: Study of the Lys72His Mutant of cAMP-dependent Kinase
2005
Crystal Structure of A. fulgidus Rio2 Defines a New Family of Serine Protein Kinases
2004
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Mechanisms of angiogenesis
1997 StandoutNature
Deep learning
2015 StandoutNatureNobel
A Family Portrait of the RIO Kinases
2005
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
A New Tyrosine Phosphorylation Mechanism Involved in Signal Transduction in <i>Bacillus subtilis</i>
2005
A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen
2006
Regulation of proteasome assembly and activity in health and disease
2018
Homing in: Mechanisms of Substrate Targeting by Protein Kinases
2018
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Protein Tyrosine Phosphatases in the Human Genome
2004 Standout
The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases
2014
The Hallmarks of Aging
2013 Standout
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
A General Strategy for Creating “Inactive-Conformation” Abl Inhibitors
2006
Are Complex Behaviors Specified by Dedicated Regulatory Genes? Reasoning from Drosophila
2001 StandoutNobel
Mitogen‐activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment
2006
Rewiring the Specificity of Two-Component Signal Transduction Systems
2008
Programmable design of orthogonal protein heterodimers
2018 StandoutNatureNobel
Structural Basis of Constitutive Activity and a Unique Nucleotide Binding Mode of Human Pim-1 Kinase
2004
mTOR is a key modulator of ageing and age-related disease
2013 Nature
Emerging roles of pseudokinases
2006
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
2005 StandoutNatureNobel
Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals
2007 Standout
Alpha-kinases: analysis of the family and comparison with conventional protein kinases
2003
Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia
2005
Regulation of Protein Kinases
2004
A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy
2016
The plant immune system
2006 StandoutNature
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Deep mutational scanning: a new style of protein science
2014
Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases
2003
Engineering the third wave of biocatalysis
2012 StandoutNature
Mechanism-Based Profiling of Enzyme Families
2006
Supramolecular Interactions Probed by 13C−13C Solid-State NMR Spectroscopy
2010
Protein Conformational Transitions: The Closure Mechanism of a Kinase Explored by Atomistic Simulations
2008
Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination
2016
McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits the Heat-Shock Regulator CtsR
2009 StandoutScienceNobel
Intermediate Filaments: Molecular Structure, Assembly Mechanism, and Integration Into Functionally Distinct Intracellular Scaffolds
2004
Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence
2015
Mechanisms of drug inhibition of signalling molecules
2006 Nature
Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
2010 Standout
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides
2006
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
2003
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
2011 StandoutScience
Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors
2005 Science
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases
2007
High-Throughput Screening of the Yeast Kinome: Identification of Human Serine/Threonine Protein Kinases That Phosphorylate the Hepatitis C Virus NS5A Protein
2004
Genetic Control of Branching Morphogenesis
1999 Science
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Comparative Analysis of Mutant Tyrosine Kinase Chemical Rescue
2009 StandoutNobel
Cell fate choices in Drosophila tracheal morphogenesis
2000
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoformsin vitroandin vivo
2006
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
2018 Science
Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control
2010
Works of Gerard Manning being referenced
The mouse kinome: Discovery and comparative genomics of all mouse protein kinases
2004
Assessment of computational methods for predicting the effects of missense mutations in human cancers
2013
RPN-6 determines C. elegans longevity under proteotoxic stress conditions
2012 Nature
The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress
2009
Evolution of protein kinase signaling from yeast to man
2002
Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases
2008
Genomic overview of protein kinases
2005
The Dictyostelium Kinome—Analysis of the Protein Kinases from a Simple Model Organism
2006
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
2011 Nature
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
Genetic control of epithelial tube fusion during Drosophila tracheal development
1996
The fold of α-synuclein fibrils
2008
Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events
1996
Whole Animal Cell Sorting of Drosophila Embryos
1991 Science