Standout Papers
- A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q (1994)
- Structural repertoire of the human VH segments (1992)
- HAPPY mapping of a YAC reveals alternative haplotypes in the human immunoglobulin VHlocus (1993)
- The repertoire of human germline vH sequences reveals about fifty groups of VH segments with different hypervariable loops (1992)
- A Complete Map of the Human Immunoglobulin VH Locus (1995)
- The Imprint of Somatic Hypermutation on the Repertoire of Human Germline V Genes (1996)
- Human immunoglobulin VH and D segments on chromosomes 15q11.2 and 16p11.2 (1994)
- Transcription of the SV40 Genome in Transformed Cells and during Lytic Infection (1970)
- Comparison of the Human Germline and Rearranged VH Repertoire Reveals Complementarity between Germline Variability and Somatic Mutation (1995)
Citation Impact
Citing Papers
Antibody Recognition of a Highly Conserved Influenza Virus Epitope
2009 Science
The use of mRNA display to select high-affinity protein-binding peptides
2001 StandoutNobel
AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts
2002 StandoutScienceNobel
Diversification, not use, of the immunoglobulin VH gene repertoire is restricted in DiGeorge syndrome.
1993 StandoutNobel
Characteristics of Sequences Around Individual Nucleotide Substitutions in IgVH Genes Suggest Different GC and AT Mutators
1999
The human olfactory receptor gene family
2004 StandoutNobel
The creation of diversity in the human immunoglobulin Vλ repertoire
1997
Non-stochastic utilization of Ig V region genes in unselected human peripheral B cells
1996
Small binding proteins selected from a combinatorial repertoire of knottins displayed on phage
1998 StandoutNobel
Cloning and sequencing of human immunoglobulin λ. gene segments
1993 StandoutNobel
Pattern of usage and somatic hypermutation in the VH5 gene segments of a patient with asthma: Implications for IgE
1997
Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vλ repertoire
1999 StandoutNobel
Retargeting serum immunoglobulin with bispecific diabodies
1997 StandoutNobel
Crystal Structure of HEL4, a Soluble, Refoldable Human VH Single Domain with a Germ-line Scaffold
2004 StandoutNobel
Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme
1996
Microarrays of cells expressing defined cDNAs
2001 Nature
PDB-based protein loop prediction: parameters for selection and methods for optimization
1997 StandoutNobel
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
2009
Somatic insertions and deletions shape the human antibody repertoire 1 1Edited by J. Karn
1999 StandoutNobel
A genome-wide comparison of recent chimpanzee and human segmental duplications
2005 StandoutNatureNobel
Molecular characterization of human antibodies to bacterial antigens: Utilization of the less frequently expressed VH2 and VH6 heavy chain variable region gene families
1993
A new mathematical model for relative quantification in real-time RT-PCR
2001 Standout
Antigen Specificity and High Affinity Binding Provided by One Single Loop of a Camel Single-domain Antibody
2001
Biophysical Properties of Human Antibody Variable Domains
2002
Designing and optimizing library selection strategies for generating high-affinity antibodies
1997
Recent duplication, domain accretion and the dynamic mutation of the human genome
2001
Insertions and deletions in hypervariable loops of antibody heavy chains contribute to molecular diversity
1998
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Proteomics: new perspectives, new biomedical opportunities
2000
Mimicking Somatic Hypermutation: Affinity Maturation of Antibodies Displayed on Bacteriophage Using a Bacterial Mutator Strain
1996 StandoutNobel
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Antibody VH Domains as Small Recognition Units
1995
[5] Screening of phage antibody libraries
1996 StandoutNobel
Organization of the Human Immunoglobulin Heavy-Chain Locus
1996
The human immunoglobulin VH repertoire
1995
By-passing immunisation
1992 StandoutNobel
Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library
1996
An Antibody Fragment from a Phage Display Library Competes for Ligand Binding to the Low Density Lipoprotein Receptor Family and Inhibits Rhinovirus Infection
1995 StandoutNobel
Thermodynamically Stable Aggregation-Resistant Antibody Domains through Directed Evolution
2008 StandoutNobel
Structure and function of immunoglobulins
2010
Molecular Characterization of Variable Heavy and Light Chain Regions of Five HIV Type 1-Specific Human Monoclonal Antibodies*
1994
Building Antibodies from their Genes
1992 StandoutNobel
Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes
1994
Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift.
1992 StandoutNobel
By–Passing Immunization: Building High Affinity Human Antibodies by Chain Shuffling
1992 StandoutNobel
Human Antibody Fragments Specific for Human Blood Group Antigens from a Phage Display Library
1993 StandoutNobel
‘Camelising’ human antibody fragments: NMR studies on VH domains
1994
The mosaic that is our genome
2003 StandoutNatureNobel
Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, “minor” D segments or D-D recombination 1 1Edited By J. Karn
1997 StandoutNobel
Revealing the world of RNA interference
2004 StandoutNatureNobel
A directory of human germ‐line Vχ segments reveals a strong bias in their usage
1994 StandoutNobel
Segmental Duplications: Organization and Impact Within the Current Human Genome Project Assembly
2001
‘Omic’ approaches for unraveling signaling networks
2002
Anatomy of the antibody molecule
1994
In vitro selection from protein and peptide libraries
1994
Amino acid insertions and deletions contribute to diversify the human Ig repertoire
1998
A Complete Preimmune Human VH3 Repertoirea
1995
Proteomics to study genes and genomes
2000 StandoutNature
Guiding the Selection of Human Antibodies from Phage Display Repertoires to a Single Epitope of an Antigen
1994 StandoutNobel
Synthetic human antibodies and a strategy for protein engineering
1998 StandoutNobel
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Combinatorial protein reagents to manipulate protein function
2000
Maturation of an Antibody Response Is Governed by Modulations in Flexibility of the Antigen-Combining Site
2000
Complement recruitment using bispecific diabodies
1997 StandoutNobel
Phage antibodies against an unstable hapten: Oxygen sensitive reduced flavin
1996 StandoutNobel
Analysis of Heavy and Light Chain Pairings Indicates that Receptor Editing Shapes the Human Antibody Repertoire
1999 StandoutNobel
Towards the Design of an Antibody that Recognises a Given Protein Epitope
1999 StandoutNobel
Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes
1998
Standard conformations for the canonical structures of immunoglobulins 1 1Edited by I. A. Wilson
1997
Segmental Duplications: Organization and Impact Within the Current Human Genome Project Assembly
2001
Biogenesis of mRNA: Genetic Regulation in Mammalian Cells
1973 Science
Solution Structure of a Llama Single-Domain Antibody with Hydrophobic Residues Typical of the VH/VL Interface
2002
The Genome of Simian Virus 40
1977 StandoutNobel
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Biosynthesis of transfer RNA in Escherichia coli
1975 StandoutNobel
RNA-peptide fusions for the in vitro selection of peptides and proteins
1997 StandoutNobel
Idiotypic vaccination against human B-cell lymphoma. Rescue of variable region gene sequences from biopsy material for assembly as single-chain Fv personal vaccines
1994 StandoutNobel
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
2013 StandoutScienceNobel
An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA
1977 StandoutNobel
Antibody fragments from a ‘single pot’ phage display library as immunochemical reagents.
1994 StandoutNobel
Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope
1997 StandoutScienceNobel
Structural Insights into the Evolution of an Antibody Combining Site
1997 Science
Comparison of the Efficiency of Moloney Murine Leukaemia Virus (M-MuLV) Reverse Transcriptase, RNase H--M-MuLV Reverse Transcriptase and Avian Myeloblastoma Leukaemia Virus (AMV) Reverse Transcriptase for the Amplification of Human Immunoglobulin Genes
1998
"Diabodies": small bivalent and bispecific antibody fragments.
1993 StandoutNobel
Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes
1998
Isolation of high affinity human antibodies directly from large synthetic repertoires.
1994
Local mutagenesis: a method for generating viral mutants with base substitutions in preselected regions of the viral genome.
1978 StandoutNobel
Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.
1993
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
2011 StandoutScienceNobel
De Novo Computational Design of Retro-Aldol Enzymes
2008 StandoutScienceNobel
Efficient construction of a large nonimmune phage antibody library: The production of high-affinity human single-chain antibodies to protein antigens
1998
Human DNA Repair Genes
2001 StandoutScienceNobel
The Complete Nucleotide Sequence of the Human Immunoglobulin Heavy Chain Variable Region Locus
1998 StandoutNobel
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.
1993 Nobel
Critical Analysis of Antibody Catalysis
2000
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Somatic hypermutation
1995 Nobel
Human anti-self antibodies with high specificity from phage display libraries.
1993
Elicitation of structure-specific antibodies by epitope scaffolds
2010 StandoutNobel
Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease
1998
A simple physical model for binding energy hot spots in protein–protein complexes
2002 StandoutNobel
The structural repertoire of the human V kappa domain.
1995
Works of Gerald Walter being referenced
Protein arrays for gene expression and molecular interaction screening
2000
The Imprint of Somatic Hypermutation on the Repertoire of Human Germline V Genes
1996 StandoutNobel
HAPPY mapping of a YAC reveals alternative haplotypes in the human immunoglobulin VHlocus
1993 StandoutNobel
The repertoire of human germline vH sequences reveals about fifty groups of VH segments with different hypervariable loops
1992 StandoutNobel
Structural repertoire of the human VH segments
1992 StandoutNobel
Phage diabody repertoires for selection of large numbers of bispecific antibody fragments
1996
Protein Microarrays for Gene Expression and Antibody Screening
1999
A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q
1994 StandoutNobel
Transcription of the SV40 Genome in Transformed Cells and during Lytic Infection
1970 StandoutNobel
Human immunoglobulin VH and D segments on chromosomes 15q11.2 and 16p11.2
1994 StandoutNobel