Citation Impact
Citing Papers
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
2023 StandoutNobel
Acute pro‐inflammatory actions of endothelin‐1 in the guinea‐pig lung: involvement of ETA and ETB receptors
1995
Endothelin antagonism with bosentan: a review of potential applications
1999
Treatment of Pulmonary Arterial Hypertension
2004 Standout
The antisense homology box: A new motif within proteins that encodes biologically active peptides
1995 StandoutNobel
Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons
1994 Standout
Cellular pathophysiology of ischemic acute kidney injury
2011 Standout
Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
2003 Standout
PDGF-Mediated Chemoattraction of Hepatic Stellate Cells by Bile Duct Segments in Cholestatic Liver Injury
2000
White Matter Lesions and Disequilibrium in Older People
1995
Antisense Homology Box-Derived Peptides Represent a New Class of Endothelin Receptor Inhibitors
1998 StandoutNobel
Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.
1998 StandoutNobel
Drugs, their targets and the nature and number of drug targets
2006
DrugBank: a knowledgebase for drugs, drug actions and drug targets
2007 Standout
Dissecting fibrosis: therapeutic insights from the small-molecule toolbox
2015
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
Acute Renal Failure
1996 Standout
DANCE, a Novel Secreted RGD Protein Expressed in Developing, Atherosclerotic, and Balloon-injured Arteries
1999 StandoutNobel
Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors
2007
The Emerging Concept of Vascular Remodeling
1994
Endothelin antagonists
1999
Effect of Carvedilol on Survival in Severe Chronic Heart Failure
2001 Standout
Predicting Drug‐Resistant Mutations of HIV Protease
2007 StandoutNobel
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study
2001 Standout
Endothelin—Biology and disease
2010
Hemodynamic Shear Stress and Its Role in Atherosclerosis
1999 Standout
Migraine — Current Understanding and Treatment
2002 Standout
Phosphorylation and Desensitization of Human Endothelin A and B Receptors
1997 StandoutNobel
Catalytic asymmetric synthesis of chromenes and tetrahydroquinolines via sequential allylic alkylation and intramolecular Heck coupling
2012 StandoutNobel
Idiopathic Pulmonary Fibrosis
2001 Standout
Effects of Ro 47-0203 on endothelin-1 and sarafotoxin S6c-induced contractions of human bronchus and guinea-pig trachea
1996
Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension
2015 Standout
ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
1994
Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice
1994 Standout
Endothelins
1995
Endothelin receptor subtypes and their role in transmembrane signaling mechanisms
1995
Endothelin antagonism in experimental hepatic fibrosis. Implications for endothelin in the pathogenesis of wound healing.
1996
Endothelin antagonist bosentan blocks neurogenic inflammation, but is not effective in aborting migraine attacks
1996
COMMENTARY Endothelins: from laboratory to clinic?
1994
SYMPOSIUM Experimental Biology 1995 Endothelin Receptors: Role in Renal Function and Dysfunction ROLE OF ENDOTHELIN IN RENAL FUNCTION AND DYSFUNCTION
1996
Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors
2007
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
2008 Standout
Ambrisentan, a Non‐peptide Endothelin Receptor Antagonist
2006
The determination and interpretation of the therapeutic index in drug development
2012
Increased Endothelin-1 in Bleomycin-induced Pulmonary Fibrosis and the Effect of an Endothelin Receptor Antagonist
1997
Solid-Phase Synthesis of Aspartic Peptidase Inhibitors: 3-Alkoxy-4-Aryl Piperidines
2001
Iron-Catalyzed Reactions in Organic Synthesis
2004 Standout
Iron Catalysis in Organic Synthesis
2015 Standout
Endothelin-1 Is Involved in Norepinephrine-Induced Ventricular Hypertrophy In Vivo
1996
Cu and Cu-Based Nanoparticles: Synthesis and Applications in Catalysis
2016 Standout
Bioorganometallic Chemistry of Ferrocene
2004 Standout
Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Infliximab, a Chimeric Monoclonal Antibody to Tumor Necrosis Factor-α, in Patients With Moderate-to-Severe Heart Failure
2003 Standout
Styrylsulfonates and ‐Sulfonamides through Pd‐Catalysed Matsuda–Heck Reactions of Vinylsulfonic Acid Derivatives and Arenediazonium Salts
2016
Role of Endogenous Endothelin in Chronic Heart Failure
1997
Current Perspectives on Arterial Stiffness and Pulse Pressure in Hypertension and Cardiovascular Diseases
2003 Standout
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
2016 StandoutNobel
Advances in Transition Metal (Pd,Ni,Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-organometallics as Reaction Partners
2011 Standout
Recent advances in the synthesis of pyrroles by multicomponent reactions
2014 Standout
Synthetic Analogues of Glycosylphosphatidylinositol-Anchored Proteins and Their Behavior in Supported Lipid Bilayers
2007 StandoutNobel
Stereoselektive Alkylierung an C(α) von Serin, Glycerinsäure, Threonin und Weinsäure über heterocyclische Enolate mit exocyclischer Doppelbindung
1987
Asymmetric induction during carbonylation of an optically active organopalladium. A novel and versatile route to enantiomeric glycerides.
1985
G Protein-Coupled Receptors: Functional and Mechanistic Insights Through Altered Gene Expression
1998 StandoutNobel
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
Synthesis of glyceryl ethers in high optical purity via ruthenium catalyzed asymmetric hydrogenation
1991
SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist.
1994
Hemodynamic Effects of Bosentan, an Endothelin Receptor Antagonist, in Patients With Pulmonary Hypertension
2000
Structure-Based Design of β-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease
2013
Chimeric Antigen Receptor Therapy
2018 Standout
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Metal(II) d-Tartrates Catalyzed Asymmetric Ring Opening of Oxiranes with Various Nucleophiles
1988
Inactivation of C5a Anaphylatoxin by a Peptide That Is Complementary to a Region of C5a
2004 StandoutNobel
Fibrosis — A Common Pathway to Organ Injury and Failure
2015 Standout
New Chiral Phosphorus Ligands for Enantioselective Hydrogenation
2003 Standout
Protease Inhibitors: Current Status and Future Prospects
2000
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
From Peptides to Non-Peptide Peptidomimetics: Design and Synthesis of New Piperidine Inhibitors of Aspartic Peptidases
2001
Right Ventricular Function in Cardiovascular Disease, Part I
2008 Standout
Different Mechanisms of Endothelial Dysfunction With Aging and Hypertension in Rat Aorta
1995
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
A Variable Concept for the Preparation of Branched Glycosyl Phosphatidyl Inositol Anchors
2003
Structure and Mechanism of the Pepsin-Like Family of Aspartic Peptidases
2002
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
A Convergent Approach to Coenzyme Q
1999
Metal-Free Multicomponent Syntheses of Pyridines
2014 Standout
Works of Georges Hirth being referenced
Piperidine-renin inhibitors compounds with improved physicochemical properties
1999
Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist
1993 Nature
Substituted piperidines - highly potent renin inhibitors due to induced fit adaptation of the active site
1999
Renin inhibition by substituted piperidines: A novel paradigm for the inhibition of monomeric aspartic proteinases?
1999
In vitro characterisation of Ro 46‐8443, the first non‐peptide antagonist selective for the endothelin ETB receptor
1996
Stereoselektive Totalsynthese von natürlichem Phytol und Phytolderivaten und deren Verwendung zur Herstellung von natürlichem Vitamin K1
1982
The Discovery of Nonpeptide Endothelin Receptor Antagonists. Progression towards Bosentan
1996
Synthèse des (R)‐ et (S)‐O‐isopropylidène‐1,2‐glycérols. Détermination de la pureté optique
1985
Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.
1994
Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from bosentan
1997
Synthese von Glycerylätherphosphatiden 2. Mitteilung Herstellung von 2‐O‐Acetyl‐1‐O‐[(Z)‐9‐octadecenyl] ‐sn‐glyceryl‐3‐phosphorylcholin («Oleyl‐PAF»), des Enantiomeren sowie einiger analoger, ungesättigter Verbindungen
1983
Synthese von Glycerylätherphosphatiden 1. Mitteilung Herstellung von 1‐O‐Octadecyl‐2‐O‐acetyl‐sn‐glyceryl‐3‐phosphorylcholin1 (‘Platelet Activating Factor’), des Enantiomeren sowie einiger analoger Verbindungen
1982