Citation Impact
Citing Papers
p53: puzzle and paradigm.
1996 Standout
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
Wild-Type Human p53 Transactivates the Human Proliferating Cell Nuclear Antigen Promoter
1995
Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes.
1993
A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage
1995 StandoutNobel
Characterization of a translocation within the von Recklinghausen neurofibromatosis region of chromosome 17
1989
Structure of the Histone Acetyltransferase Hat1
1998 StandoutNobel
Crystal Structure of lac Repressor Core Tetramer and Its Implications for DNA Looping
1995 StandoutScienceNobel
Oncogenic forms of p53 inhibit p53-regulated gene expression
1992 Science
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
WAF1, a potential mediator of p53 tumor suppression
1993 Standout
Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
1992 StandoutNobel
Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells
1994
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
p53 in growth control and neoplasia
1996
Tumor spectrum analysis in p53-mutant mice
1994 Standout
Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53
1993 Nature
The Role of the p53 Tumor Suppressor Gene in Squamous Cell Carcinoma of the Head and Neck
1993
DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2
1997 Standout
Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function invivo
1997
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Negative Regulation of Chk2 Expression by p53 Is Dependent on the CCAAT-binding Transcription Factor NF-Y
2004
When Checkpoints Fail
1997 StandoutNobel
Tumor-suppressor p53 and the cell cycle
1993
Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice
1993
The Hallmarks of Cancer
2000 Standout
The role of the E6-p53 interaction in the molecular pathogenesis of HPV
1999
Tumor suppressor genes
1991 Standout
p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1
1995
Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53
1995
COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective
1996
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
1992 Standout
A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations
1990 Standout
P53 Activates Fanconi Anemia Group C Gene Expression
1997
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
DNA damage induces phosphorylation of the amino terminus of p53
1997
p53 Negatively Regulates cdc2 Transcription via the CCAAT-binding NF-Y Transcription Factor
1999
The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis
1994
The p53 tumour suppressor gene
1991 StandoutNature
Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
2006
Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases
1995
p53 negatively regulates the expression of FAT10, a gene upregulated in various cancers
2006
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient mice
1995
Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53
1992
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
p53 function and dysfunction
1992 Standout
Transcriptional activation by p53 correlates with suppression of growth but not transformation
1994
p53 is required for radiation-induced apoptosis in mouse thymocytes
1993 StandoutNature
Cell cycle, CDKs and cancer: a changing paradigm
2009 Standout
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
Gain of function mutations in p53
1993
The specificity of p53 mutation spectra in sunlight induced human cancers
1995
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
Additive effect between NF-κB subunits and p53 protein for transcriptional activation of human p53 promoter
2000
Transcriptional Repression by p53 through Direct Binding to a Novel DNA Element
2001
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
1991 StandoutNatureNobel
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
1994 Standout
Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?
1993
Activation of the cryptic DNA binding function of mutant forms of p53
1993
p53 down‐regulates matrix metalloproteinase‐1 by targeting the communications between AP‐1 and the basal transcription complex
2004
Doing the right thing: feedback control and p53
1993
The tumore suppressor p53
1993
Regulation of the specific DNA binding function of p53
1992
The Bradykinin Type 2 Receptor Is a Target for p53-mediated Transcriptional Activation
2000
Hypermutability and mismatch repair deficiency in RER+ tumor cells
1993 StandoutNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Role of Cysteine Residues in Regulation of p53 Function
1995
Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.
1993
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.
1992
Wild-type p53 binds to the TATA-binding protein and represses transcription.
1992
The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.
1992
Stimulation of polyomavirus DNA replication by wild-type p53 through the DNA-binding site.
1994
p53 Mutations in Human Cancers
1991 StandoutScience
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Analysis of a Protein-Binding Domain of p53
1993
p53-Mediated Repression of Alpha-Fetoprotein Gene Expression by Specific DNA Binding
1999
Cooperating oncogenes converge to regulate cyclin/cdk complexes.
1997
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
1994 StandoutScience
Alternatively Spliced Forms in the Carboxy-Terminal Domain of the p53 Protein Regulate Its Ability to Promote Annealing of Complementary Single Strands of Nucleic Acids
1995
Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression
1992 Science
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Induction of cell growth regulatory genes by p53.
1996
Tumor Suppressor Genes
1991 Science
Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.
1994
p73 Function Is Inhibited by Tumor-Derived p53 Mutants in Mammalian Cells
1999
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53.
1994
Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53.
1996
p53 Domains: Structure, Oligomerization, and Transformation
1994
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.
1994
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
1990 StandoutScience
The p53-mdm-2 autoregulatory feedback loop.
1993 Standout
Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.
1995
Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability
1998
HUMAN TUMOR SUPPRESSOR GENES
1990
PAK1, a gene that can regulate p53 activity in yeast.
1995
Transcriptional control of human p53-regulated genes
2008 Standout
p53-mediated cell death: relationship to cell cycle control.
1993
p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding.
2003
Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.
1993
p53 Transcriptional Activation Mediated by Coactivators TAF II 40 and TAF II 60
1995 Science
Essential role for p53-mediated transcription in E1A-induced apoptosis.
1995
mdm2 expression is induced by wild type p53 activity.
1993
Proteolysis by Calpains: a Possible Contribution to Degradation of p53
1997
The p53 Activation Domain Binds the TATA Box-Binding Polypeptide in Holo-TFIID, and a Neighboring p53 Domain Inhibits Transcription
1993
Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells.
1994
Identification of p53 as a Sequence-Specific DNA-Binding Protein
1991 Science
Wild-type p53 adopts a ‘mutant’-like conformation when bound to DNA.
1993
p53 oligomerization and DNA looping are linked with transcriptional activation.
1994
Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.
1993
Modulation of p53-Mediated Transcriptional Repression and Apoptosis by the Adenovirus E1B 19K Protein
1995
Viral Oncoproteins Discriminate between p53 and the p53 Homolog p73
1998 StandoutNobel
Two Domains of p53 Interact with the TATA-Binding Protein, and the Adenovirus 13S E1A Protein Disrupts the Association, Relieving p53-Mediated Transcriptional Repression
1995
Wild-type alternatively spliced p53: binding to DNA and interaction with the major p53 protein in vitro and in cells.
1994
Crystal Structure of the Tetramerization Domain of the p53 Tumor Suppressor at 1.7 Angstroms
1995 Science
Hot-spot p53 mutants interact specifically with two cellular proteins during progression of the cell cycle.
1994
Functional and physical interaction between p53 and BZLF1: implications for Epstein-Barr virus latency.
1994
Computational Alanine Scanning To Probe Protein−Protein Interactions: A Novel Approach To Evaluate Binding Free Energies
1999
p53 domains: identification and characterization of two autonomous DNA-binding regions.
1993
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Down-regulation of fibronectin gene expression by the p53 tumor suppressor protein.
1996
p53 binds to the TATA-binding protein-TATA complex
1993
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.
1993
Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression
1995
The tumor suppressor p53 regulates its own transcription.
1993
A temperature-sensitive mutant of human p53.
1994
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
1996
Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.
1992
Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness.
1994
The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells
1994
p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.
1991
Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
2000
The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding.
1995
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.
1990
Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.
1994
Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation.
1995
Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation
1995
Multipoint linkage analysis in neurofibromatosis type I: an international collaboration.
1989
Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.
1993
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples
1991 Science
Interaction of p53 with Its Consensus DNA-Binding Site
1995
Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53.
1992
Dynamics and mechanism of cyclobutane pyrimidine dimer repair by DNA photolyase
2011 StandoutNobel
The p53 protein is an unusually shaped tetramer that binds directly to DNA.
1993
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis.
1995
Mapping of the p53 and mdm-2 interaction domains.
1993
Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53
1993
p53 Stimulates Transcription from the Human Transforming Growth Factor α Promoter: a Potential Growth-Stimulatory Role for p53
1995
A simple physical model for binding energy hot spots in protein–protein complexes
2002 StandoutNobel
Another p53 Doppelgänger?
1998 StandoutScienceNobel
Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus
1995
Transcriptional Activation of the Human Epidermal Growth Factor Receptor Promoter by Human p53
1996
Cyclin E Restores p53 Activity in Contact-Inhibited Cells
1995
Works of George E. Farmer being referenced
Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein
1996
Wild-type p53 activates transcription in vitro
1992 Nature
DNA-binding Properties of the p53 Tumor Suppressor Protein
1994
Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis.
1990
Loss of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas.
1989
Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.
1993
Functional Interaction between p53, the TATA-Binding Protein (TBP), and TBP-Associated Factors In Vivo
1996
p53 Inhibits DNA Replication In Vitro in a DNA-Binding-Dependent Manner
1995
Flanking markers for the gene causing von Recklinghausen neurofibromatosis (NF1).
1989