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Citing Papers
Augmenting neurotransmitter release by enhancing the apparent Ca 2+ affinity of synaptotagmin 1
2005 StandoutNobel
Expression and function of bradykinin receptors in microglia
2003
Characteristics and function of Ca2+ — and inositol 1,4,5-trisphosphate-releasable stores of Ca2+ in neurons
1992
Inhibition of the ω-conotoxin-sensitive calcium current by distinct G proteins
1992 StandoutNobel
Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release
2004
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
2009 StandoutNature
Ng-nitro-l-arginine reduces nonadrenergic, noncholinergic relaxations of human gut
1992
Nucleotide signalling during inflammation
2014 StandoutNature
Soluble Aβ Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors
2011
Purinergic Signaling in the Airways
2012
Identification and Cloning of Centaurin-α
1996
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Differential Localization and pH Dependency of Phosphoinositide 1,4,5‐IP3, 1,3,4,5‐IP4 and IP6 Receptors in Rat and Human Brains
1994
Calcium signalling in glial cells
1996
Cell death and proliferation in acute slices and organotypic cultures of mammalian CNS
2009
Purinergic regulation of the immune system
2016
The function of inositol high polyphosphate binding proteins
1997
The Role of Ionotropic Glutamate Receptors in Childhood Neurodevelopmental Disorders: Autism Spectrum Disorders and Fragile X Syndrome
2014
Thrombin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia
2001
Serine proteases and brain damage – is there a link?
2000
Identification of genes expressed in C. elegans touch receptor neurons
2002 StandoutNatureNobel
Inositol Pentakis- and Hexakisphosphate Metabolism Adds Versatility to the Actions of Inositol Polyphosphates Novel Effects on Ion Channels and Protein Traffic
1996
Microglia response and P2 receptor participation in oxygen/glucose deprivation-induced cortical damage
2005
A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
1996 StandoutNature
Mitochondrial ligand inhibits store‐operated calcium influx and COX‐2 production in human microglia
2006
Cellular Distribution and Functions of P2 Receptor Subtypes in Different Systems
2004
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Expression of proteinase-activated receptors in mouse microglial cells
2003
Lewis Acid Mediated Regioselective Ring Opening of Benzylglycidol with Dibenzyl Phosphate: Short and Attractive Synthesis of Dihydroxyacetone Phosphate
2006
Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection
2015
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
2010 StandoutNature
The L-Arginine-Nitric Oxide Pathway
1993 Standout
C2-domains, Structure and Function of a Universal Ca2+-binding Domain
1998 StandoutNobel
Targeting proteinase-activated receptors: therapeutic potential and challenges
2012
Endothelins-1/3 and endothelin-A/B receptors expressing glial cells with special reference to activated microglia in experimentally induced cerebral ischemia in the adult rats
2010
Thrombin Induces NO Release from Cultured Rat Microglia via Protein Kinase C, Mitogen-activated Protein Kinase, and NF-κB
2000
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Cerebellar neurons and glia respond differentially to endothelins and sarafotoxin S6b
1992
The birth and postnatal development of purinergic signalling
2010
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Protease-activated receptors: novel PARtners in innate immunity
2007
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Inositol trisphosphate and calcium signalling
1993 StandoutNature
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
2009 StandoutNobel
Mammalian COP9 signalosome
2009
Purinergic signalling in the nervous system: an overview
2008
Analysis by mRNA levels of the expression of six G protein α-subunit genes in mammalian cells and tissues
1991
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy
2006
The Hallmarks of Aging
2013 Standout
Intracellular calcium release mediated by two muscarinic receptor subtypes
1988 StandoutNobel
New developments on the role of NMDA receptors in Alzheimer's disease
2011
Calcium signalling: Past, present and future
2005
G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions
2012
The Microglia-activating Potential of Thrombin
2004
Activation of mouse microglial cells affects P2 receptor signaling
2000
Protective Effect of Amiodarone but Not N-Desethylamiodarone on Postischemic Hearts through the Inhibition of Mitochondrial Permeability Transition
2003
Unraveling thrombin's true microglia‐activating potential: markedly disparate profiles of pharmaceutical‐grade and commercial‐grade thrombin preparations
2005
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
2013 Standout
Pharmacological profiles of cloned mammalian P2Y-receptor subtypes
2005
Thrombin‐Induced Activation of Cultured Rodent Microglia
2000
Structure and function of inositol triphosphate receptors
1991
ADP is a potent inhibitor of human platelet plasma membrane adenylate cyclase
1979 StandoutNatureNobel
The Activation of Carboxylic Acids via Self-Assembly Asymmetric Organocatalysis: A Combined Experimental and Computational Investigation
2016 StandoutNobel
Synthesis of Oxacycles Employing the Oxa‐Pictet–Spengler Reaction: Recent Developments and New Prospects
2011
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Alpha-Adrenergic Receptor Subtypes
1980 StandoutNobel
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Inositol phosphate receptors and calcium disposition in the brain
1992
Long-term activation of capacitative Ca2+ entry in mouse microglial cells
1998
Expression cloning of an ATP receptor from mouse neuroblastoma cells.
1993 StandoutNobel
Bradykinin-induced rapid breakdown of phosphatidylinositol 4,5-bisphosphate in neuroblastoma X glioma hybrid NG108-15 cells.
1984
Analysis of gene expression in single live neurons.
1992
Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.
1983
Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor
1989 StandoutNatureNobel
β 2 -Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
1998 StandoutNobel
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
2009 StandoutNobel
Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides
1990 StandoutScience
Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II.
1994
Inositol trisphosphate, a novel second messenger in cellular signal transduction
1984 StandoutNature
The role of hormone receptors and GTP-regulatory proteins in membrane transduction
1980 StandoutNatureNobel
Bradykinin stimulates GTP hydrolysis in NG108‐15 membranes by a high‐affinity, pertussis toxin‐insensitive GTPase
1986
Catalytic Enantioselective Conversion of Epoxides to Thiiranes
2016 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Pain regulation by non-neuronal cells and inflammation
2016 StandoutScience
G Proteins and Regulation of Adenylyl Cyclase
1989 StandoutNobel
Anatomy of cerebellar Purkinje cells in the rat determined by a specific immunohistochemical marker
1984
Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.
1987 StandoutNobel
Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.
1994
Molecular Biology of Learning: Modulation of Transmitter Release
1982 StandoutScienceNobel
Acute Tissue Damage After Injections of Thrombin and Plasmin into Rat Striatum
2001
The GTP-binding protein, Go9 regulates neuronal calcium channels
1987 Nature
Membrane current responses of NG108‐15 mouse neuroblastoma x rat glioma hybrid cells to bradykinin.
1988
Differential regulation of amounts of the guanine-nucleotide-binding proteins Gi and Go in neuroblastoma x glioma hybrid cells in response to dibutyryl cyclic AMP.
1988
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Multiple neurokinin receptors: Recent developments
1988
De novo synthesis of the enantiomers Ins(1,2,3,4)P4 and Ins(1,2,3,6)P4—regiospecificity of their enzymatic dephosphorylation
2000
Activation of P2X7 receptors in glial satellite cells reduces pain through downregulation of P2X3 receptors in nociceptive neurons
2008
Modulation of Neuronal Signal Transduction Systems by Extracellular ATP
1988
Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron
2012 StandoutNobel
Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by alpha receptors.
1979
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Glial Calcium: Homeostasis and Signaling Function
1998
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
2007
Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters†
1976 Nature
Atrial Natriuretic Factors Stimulate Accumulation and Efflux of Cyclic GMP in C6–2B Rat Glioma and PC12 Rat Pheochromocytoma Cell Cultures
1987 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses
2001 StandoutScienceNobel
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Diversity in NMDA Receptor Composition
2012
Nitrated Confined Imidodiphosphates Enable a Catalytic Asymmetric Oxa-Pictet–Spengler Reaction
2016 StandoutNobel
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
Purinoceptors on Neuroglia
2009
Metabotropic NMDA receptor function is required for β-amyloid–induced synaptic depression
2013
Synapsins: Mosaics of Shared and Individual Domains in a Family of Synaptic Vesicle Phosphoproteins
1989 StandoutScienceNobel
c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis
2003
G protein involvement in receptor-effector coupling.
1988 StandoutNobel
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin
1984 StandoutNobel
The glial voltage-gated sodium channel: cell- and tissue-specific mRNA expression.
1992
Protease-Activated Receptors: Contribution to Physiology and Disease
2004
Proteinase-Activated Receptors: Transducers of Proteinase-Mediated Signaling in Inflammation and Immune Response
2004
Physiology of Microglia
2011 Standout
Diversity of G Proteins in Signal Transduction
1991 StandoutScience
Works of Georg Reiser being referenced
Mechanism of toxicity of the branched‐chain fatty acid phytanic acid, a marker of Refsum disease, in astrocytes involves mitochondrial impairment
2006
Glial perspectives of metabolic states during cerebral hypoxia—calcium regulation and metabolic energy
2004
Thrombin Signaling in the Brain: The Role of Protease-Activated Receptors
2003
Four subtypes of protease‐activated receptors, co‐expressed in rat astrocytes, evoke different physiological signaling
2001
High‐affinity inositol 1,3,4,5‐tetrakisphosphate receptor from cerebellum: solubilization, partial purification and characterization
1990
[Ca2+]i oscillations in single rat glioma cells induced by thrombin through activation of cell surface receptors
1995
Memantine (1-amino-3,5-dimethyladamantane) blocks the serotonin-induced depolarization response in a neuronal cell line
1988
Activity of protein kinase C is necessary for sustained thrombin-induced [Ca 2+ ] i oscillations in rat glioma cells
1996
Proteinase‐activated receptors, nucleotide P2Y receptors, and μ‐opioid receptor‐1B are under the control of the type I transmembrane proteins p23 and p24A in post‐Golgi trafficking
2011
A novel, specific binding protein assay for quantitation of intracellular inositol 1,3,4,5‐tetrakisphosphate (InsP4) using a high‐affinity InsP4 receptor from cerebellum
1989
Antioxidative activity of the olive oil constituent hydroxy-1-aryl-isochromans in cells and cell-free systems
2009
The role of the Ca2+‐sensitive tyrosine kinase Pyk2 and Src in thrombin signalling in rat astrocytes
2003
Peptide-Specific Antibodies Indicate Species Heterogeneity of a 42-kDa High-Affinity Inositol 1,3,4,5-Tetrakisphosphate Receptor Protein from Brain
1995
Four different types of protease‐activated receptors are widely expressed in the brain and are up‐regulated in hippocampus by severe ischemia
2001
Characteristics of thrombin-induced calcium signals in rat astrocytes
1997
Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors
2002
Protease‐activated receptor‐1 protects rat astrocytes from apoptotic cell death via JNK‐mediated release of the chemokine GRO/CINC‐1
2006
Desensitisation of protease‐activated receptor‐1 (PAR‐1) in rat astrocytes: evidence for a novel mechanism for terminating Ca2+ signalling evoked by the tethered ligand
2000
Ca2+ ‐ and Nitric Oxide‐Dependent Stimulation of Cyclic GMP Synthesis in Neuronal Cell Line Induced by P2‐Purinergic/Pyrimidinergic Receptor
1995
Swelling of mitochondria in cultured rat hippocampal astrocytes is induced by high cytosolic Ca2+ load, but not by mitochondrial depolarization
2002
Characterization of [35S]‐ATPαS and [3H]‐α,β‐MeATP binding sites in rat brain cortical synaptosomes: regulation of ligand binding by divalent cations
1997
Characterization of a high‐affinity Ins‐P4 (inositol 1,3,4,5‐tetrakisphosphate) receptor from brain by an anti‐peptide antiserum
1995
Fluorescent ε-ATP analogues for probing physicochemical properties of proteins. Synthesis, biochemical evaluation, and sensitivity to properties of the medium
2004
Co-existence of two types of [Ca2+]i-inducing protease-activated receptors (PAR-1 and PAR-2) in rat astrocytes and C6 glioma cells
1998
Characterization of a substance P receptor activating a cation permeability in neuronal cell lines
1988
ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells
2003
Protease-activated receptors in the brain: Receptor expression, activation, and functions in neurodegeneration and neuroprotection
2007
Protease-activated receptor-1 induces generation of new microglia in the dentate gyrus of traumatised hippocampal slice cultures
2007
ATP-Induced Oscillations of Cytosolic Ca2+ Activity in Cultured Astrocytes from Rat Brain are Modulated by Medium Osmolarity Indicating a Control of [Ca2+]i Oscillations by Cell Volume
1997
Jab1, a Novel Protease-activated Receptor-2 (PAR-2)-interacting Protein, Is Involved in PAR-2-induced Activation of Activator Protein-1
2006
[Ca2+]i oscillations induced by bradykinin in rat glioma cells associated with Ca2+ store-dependent Ca2+ influx are controlled by cell volume and by membrane potential
1996
Physiological evidence for a P2Y receptor responsive to diadenosine polyphosphates in human lung via Ca2+ release studies in bronchial epithelial cells
2001
Subtype specific internalization of P2Y1 and P2Y2 receptors induced by novel adenosine 5′‐O‐(1‐boranotriphosphate) derivatives
2004
High‐affinity peripheral benzodiazepine receptor ligand, PK11195, regulates protein phosphorylation in rat brain mitochondria under control of Ca2+
2005
Focal ischemia induces expression of protease-activated receptor1 (PAR1) and PAR3 on microglia and enhances PAR4 labeling in the penumbra
2006
Endothelin Induces a Rise of Inositol 1,4,5‐Trisphosphate, Inositol 1,3,4,5‐Tetrakisphosphate Levels and of Cytosolic Ca2+ Activity in Neural Cell Lines
1990
Endothelin and a Ca2+ ionophore raise cyclic GMP levels in a neuronal cell line via formation of nitric oxide
1990
Diastereoselectivity of the P2Y11 nucleotide receptor: mutational analysis
2008
Distinct mono- and dinucleotide-specific P2Y receptors in A549 lung epithelial cells: Different control of arachidonic acid release and nitric oxide synthase expression
2006
p24A, a Type I Transmembrane Protein, Controls ARF1-dependent Resensitization of Protease-activated Receptor-2 by Influence on Receptor Trafficking
2007
Pharmacological characterisation of metabotropic glutamatergic and purinergic receptors linked to Ca2+ signalling in hippocampal astrocytes
1998
Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors
2010
Translocation between membranes and cytosol of p42IP4, a specific inositol 1,3,4,5‐tetrakisphosphate/phosphatidylinositol 3,4,5‐trisphosphate‐receptor protein from brain, is induced by inositol 1,3,4,5‐tetrakisphosphate and regulated by a membrane‐associated 5‐phosphatase
1999
The effect of atriopeptin III on membrane potential and intracellular Ca++-activity in rat glioma cells
1985
The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations
2000
[26] Culture and characteristics of hormone-responsive neuroblastoma x glioma hybrid cells
1985
Dibutyryl cAMP treatment of neuroblastoma-glioma hybrid cells results in selective increase in cAMP-receptor protein (R-I) as measured by monospecific antibodies.
1983
Disruption of actin cytoskeleton in cultured rat astrocytes suppresses ATP- and bradykinin-induced [Ca2+]i oscillations by reducing the coupling efficiency between Ca2+ release, capacitative Ca2+ entry, and store refilling
2000
Molecular Recognition in Purinergic Receptors. 2. Diastereoselectivity of the h-P2Y1-Receptor
2004
Bradykinin induces hyperpolarizations in rat glioma cells and in neuroblastoma × glioma hybrid cells
1982
Alanine‐(87)‐threonine polymorphism impairs signaling and internalization of the human P2Y11 receptor, when co‐expressed with the P2Y1 receptor
2014
Measurements of adenosine 3′:5′‐cyclic monophosphate and membrane potential in neuroblastoma X glioma hybrid cells: Opiates and adrenergic agonists cause effects opposite to those of postaglandin E1
1975
Adenosine 5‘-O-(1-Boranotriphosphate) Derivatives as Novel P2Y1 Receptor Agonists
2002
Human bronchial epithelial cells express PAR-2 with different sensitivity to thermolysin
2002
Distinct Ca 2+ thresholds determine cytochrome c release or permeability transition pore opening in brain mitochondria
2001
A chimeric rat brain P2Y1 receptor tagged with green-fluorescent protein: High-affinity ligand recognition of adenosine diphosphates and triphosphates and selectivity identical to that of the wild-type receptor
2000
Hetero-oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptor
2007
Calcium-induced permeability transition in rat brain mitochondria is promoted by carbenoxolone through targeting connexin43
2010
Desensitization of P2U receptor in neuronal cell line. Different control by the agonists ATP and UTP, as demonstrated by single-cell Ca2+ responses
1996
Bradykinin causes a transient rise of intracellular Ca2+-activity in cultured neural cells
1985
Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis
2007
P 2U nucleotide receptor activation in rat glial cell line induces [Ca 2+ ] i oscillations which depend on cytosolic pH
1996
Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on lon transport
1983
Enzyme-Assisted Total Synthesis of the Optical Antipodes d -myo-Inositol 3,4,5-Trisphosphate and d -myo-Inositol 1,5,6-Trisphosphate: Aspects of Their Structure−Activity Relationship to Biologically Active Inositol Phosphates
1999
Purification of a high-affinity inositol 1,3,4,5-tetrakisphosphate receptor from brain
1991
Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: Localization, expression and participation in neurodegenerative diseases
2008
Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways
2002