Citation Impact
Citing Papers
RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
2009 StandoutScience
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice
2004
Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis
2008
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases
2013
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
2008 Standout
Neutrophils Suppress Intraluminal NK Cell–Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells
2016
An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins
2020 StandoutNobel
Sequential Activation of Poly(ADP-Ribose) Polymerase 1, Calpains, and Bax Is Essential in Apoptosis-Inducing Factor-Mediated Programmed Necrosis
2007
Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3–mediated pathway
2011
Disclosure of the Culprits: Macrophages—Versatile Regulators of Wound Healing
2013
RIPK3-Mediated Necroptosis Promotes Donor Kidney Inflammatory Injury and Reduces Allograft Survival
2013
Enterocyte-Derived TAK1 Signaling Prevents Epithelium Apoptosis and the Development of Ileitis and Colitis
2008
Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations
2015
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
A Mitochondrial Protein, Bit1, Mediates Apoptosis Regulated by Integrins and Groucho/TLE Corepressors
2004
Hallmarks of Cancer: The Next Generation
2011 Standout
A positive feedback loop between RIP 3 and JNK controls non‐alcoholic steatohepatitis
2014
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis
2013
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Apoptosis and necrosis: Detection, discrimination and phagocytosis
2008
Mechanisms of Caspase Activation and Inhibition during Apoptosis
2002 Standout
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi
2002
Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features
2009
Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
2011 Nature
Caspase inhibition causes hyperacute tumor necrosis factor–induced shock via oxidative stress and phospholipase A2
2003
Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's Disease
2005
Does Autophagy Contribute To Cell Death?
2005
Macrophages Are Essential for the Early Wound Healing Response and the Formation of a Fibrovascular Scar
2013
Death of cortical and striatal neurons induced by mitochondrial defect involves differential molecular mechanisms
2003
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases
2005 Standout
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species
2004
Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis
2008
Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8
2013
Necroptosis and its role in inflammation
2015 StandoutNature
Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
2009 Standout
Inflammation and Cancer: Triggers, Mechanisms, and Consequences
2019 Standout
MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis
2007
Mammalian mitochondrial IAP binding proteins
2003
IL-10 Indirectly Regulates Corneal Lymphangiogenesis and Resolution of Inflammation via Macrophages
2015
A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development
2013
Phagocytosis in atherosclerosis: Molecular mechanisms and implications for plaque progression and stability
2006
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
2010
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 StandoutNature
Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis
2014
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak
2005
The role of macrophages in skin homeostasis
2017
Tumor necrosis factor, cancer and anticancer therapy
2004
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis
2014
Sensitizing Anthrax Lethal Toxin-resistant Macrophages to Lethal Toxin-induced Killing by Tumor Necrosis Factor-α
2003 StandoutNobel
Immune Response Against Dying Tumor Cells
2004
Altered Tumor-Cell Glycosylation Promotes Metastasis
2014
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
2013
CD301b+ Macrophages Are Essential for Effective Skin Wound Healing
2016
Pathogenic and Protective Roles of MyD88 in Leukocytes and Epithelial Cells in Mouse Models of Inflammatory Bowel Disease
2010
Tumor-suppressive Maspin Regulates Cell Response to Oxidative Stress by Direct Interaction with Glutathione S-Transferase
2005
Origins of Metastatic Traits
2013
Inflammation and colorectal cancer: colitis-associated neoplasia
2012
Sensitization to Death Receptor Cytotoxicity by Inhibition of Fas-associated Death Domain Protein (FADD)/Caspase Signaling
2000
Critical Role of Calpain I in Mitochondrial Release of Apoptosis-Inducing Factor in Ischemic Neuronal Injury
2007
Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer
2015
NF- B inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death
2003
Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis
2013
Do inducers of apoptosis trigger caspase-independent cell death?
2005
ERICE, a Novel FLICE-activatable Caspase
1998
HSP90 and the chaperoning of cancer
2005 Standout
Black, White, and Gray: Macrophages in Skin Repair and Disease
2017
The roles of Bid
2002
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
2012 Standout
Smac/DIABLO Selectively Reduces the Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in HeLa Cells
2004
Reactive oxygen species are involved in FasL-induced caspase-independent cell death and inflammatory responses
2008
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
2012
RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome
2011
Necrotic death as a cell fate
2006
Lysosomes in cell death
2004
Role of the gut microbiota in immunity and inflammatory disease
2013 Standout
Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children
2016 Standout
NF-κB Protects Macrophages from Lipopolysaccharide-induced Cell Death
2005
Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts
2003
Cytosolic RIG-I–like helicases act as negative regulators of sterile inflammation in the CNS
2011
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
2007
Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance
2013
Interdigital cell death can occur through a necrotic and caspase-independent pathway
1999
Cell Death in Pancreatitis
2005
IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy
2005 Standout
A long-awaited merger of the pathways mediating host defence and programmed cell death
2014
The Tumor Suppressor RASSF1A and MAP-1 Link Death Receptor Signaling to Bax Conformational Change and Cell Death
2005
Macrophages in Tissue Repair, Regeneration, and Fibrosis
2016 Standout
Expansion and evolution of cell death programmes
2008
More than one way to die: apoptosis, necrosis and reactive oxygen damage
1999
Death receptors in chemotherapy and cancer
2004
Depletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene Expression
2011
Apoptosis-based therapies
2002
Evidence That Caspase-13 Is Not a Human but a Bovine Gene
2001
Cell death by necrosis: towards a molecular definition
2006
Tumor Promotion via Injury- and Death-Induced Inflammation
2011
Mitochondria, the killer organelles and their weapons
2002
Host microbiota constantly control maturation and function of microglia in the CNS
2015 Standout
Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins
2004
Granzyme A Induces Caspase-Independent Mitochondrial Damage, a Required First Step for Apoptosis
2005
RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis
2014
Nitric oxide-induced carbonylation of Bcl-2, GAPDH and ANT precedes apoptotic events in insulin-secreting RINm5F cells
2003
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
2013
Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation
2013
IAP proteins: blocking the road to death's door
2002
Emerging Biological Principles of Metastasis
2017 Standout
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
2014 Nature
Caspase-14 Is a Novel Developmentally Regulated Protease
1998
Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray
2001
Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization
2003
Regulation of apoptosis by endoplasmic reticulum pathways
2003
Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomas
2004
Induction of apoptosis and chemosensitization of mesothelioma cells by Bcl‐2 and Bcl‐xL antisense treatment
2003
Caspase-independent cell death
2005
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits
2008 Nature
Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis
2014 Nature
Influenza Virus PB1-F2 Protein Induces Cell Death through Mitochondrial ANT3 and VDAC1
2005
Calcium, mitochondria and oxidative stress in neuronal pathology
2006
Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways
2011
Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture
2018
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis
2011 Nature
Molecular mechanisms of caspase regulation during apoptosis
2004 Standout
Redundant cell death mechanisms as relics and backups
2005
Tumor necrosis factor signaling
2003 Standout
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
2014
The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
2007
Molecular mechanisms of necroptosis: an ordered cellular explosion
2010 Standout
Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆
2009
Necroptosis in development, inflammation and disease
2016
Enzymes with extra talents: moonlighting functions and catalytic promiscuity
2003
Glycogen Synthase Kinase-3 Mediates Acetaminophen-Induced Apoptosis in Human Hepatoma Cells
2005
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Tumor Necrosis Factor-induced Nonapoptotic Cell Death Requires Receptor-interacting Protein-mediated Cellular Reactive Oxygen Species Accumulation
2004
Mitochondriotoxic compounds for cancer therapy
2006
Necrosis: a specific form of programmed cell death?
2003
The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis
2012
Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL
2013
β-Carbolines induce apoptosis in cultured cerebellar granule neurons via the mitochondrial pathway
2004
XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease
2008 Standout
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule
2000 Standout
Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells
2006
Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress‐induced apoptosis of rat brain astrocytes
2004
The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs
2011
Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway
2008
Heat-shock proteins as regulators of apoptosis
2003
Phosphatidylserine exposure during early primary necrosis (oncosis) in JB6 cells as evidenced by immunogold labeling technique
2004
Cancer-related inflammation
2008 StandoutNature
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair
2015
The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair
2014
Intracellular ATP, a switch in the decision between apoptosis and necrosis
1998
Crossing the endothelial barrier during metastasis
2013
Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration
2013
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Mutational Analysis of the Caenorhabditis elegans Cell-Death Gene ced-3
1999 StandoutNobel
Apoptotic and necrotic cell death induced by death domain receptors
2001
Caspase-independent cell death in T lymphocytes
2003
Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response
2006
A decade of caspases
2003
RIPK3-Mediated Necroptosis Regulates Cardiac Allograft Rejection
2014
Crosstalk between apoptosis, necrosis and autophagy
2013
A Plug Release Mechanism for Membrane Permeation by MLKL
2014
Caspase Activation Inhibits Proteasome Function during Apoptosis
2004 StandoutNobel
Regulation of Tumor Necrosis Factor-Induced, Mitochondria- and Reactive Oxygen Species-Dependent Cell Death by the Electron Flux through the Electron Transport Chain Complex I
1999
Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance
2003
Clues from cell metabolism
2010 StandoutNatureNobel
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα
2010 StandoutNobel
Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma.
2009
Control of Life-or-Death Decisions by RIP1 Kinase
2013
iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
2018
Endonuclease G is required for early embryogenesis and normal apoptosis in mice
2003
Immunometabolism governs dendritic cell and macrophage function
2015 Standout
Apoptosis: A Review of Programmed Cell Death
2007 Standout
In the light of directed evolution: Pathways of adaptive protein evolution
2009 StandoutNobel
Pan-caspase inhibitor zVAD enhances cell death in RAW246.7 macrophages
2001
Cellular and molecular mechanisms in cancer immune escape: a comprehensive review
2013
Platelets guide the formation of early metastatic niches
2014
Distinct Roles of Basal Steady-State and Induced H-Ferritin in Tumor Necrosis Factor-Induced Death in L929 Cells
2005
Altered Hsp90 function in cancer: A unique therapeutic opportunity
2004
Tumor necrosis factor α induces a caspase-independent death pathway in human neutrophils
2003
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death
2002
THE CENTRAL EFFECTORS OF CELL DEATH IN THE IMMUNE SYSTEM
1999
The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment
2007
Inhibition of ADP/ATP Exchange in Receptor-Interacting Protein-Mediated Necrosis
2006
Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity
2011
cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis
2013
Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-α–stimulated neutrophils
2002
Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2
2003
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis
2014
Phagocytosis of Necrotic Cells by Macrophages Is Phosphatidylserine Dependent and Does Not Induce Inflammatory Cytokine Production
2003
Inhibition of proinflammatory and innate immune signaling pathways by a cytomegalovirus RIP1-interacting protein
2008
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
2007 Standout
Susceptibility of Lysosomes to Rupture Is a Determinant for Plasma Membrane Disruption in Tumor Necrosis Factor Alpha-Induced Cell Death
2003
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Virulent Shigella flexneri Causes Damage to Mitochondria and Triggers Necrosis in Infected Human Monocyte-Derived Macrophages
2004
Wound Healing: A Cellular Perspective
2018 Standout
A20: linking a complex regulator of ubiquitylation to immunity and human disease
2012
Apoptosis in Caspase-inhibited Neurons
2001
Apoptosis-inducing factor: vital and lethal
2006
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
The Apoptosis-Necrosis Continuum: Insights from Genetically Altered Mice
2003
The Initial Hours of Metastasis: The Importance of Cooperative Host–Tumor Cell Interactions during Hematogenous Dissemination
2012
Mitochondria as Functional Targets of Proteins Coded by Human Tumor Viruses
2005
Neutrophil Extracellular Traps Kill Bacteria
2004 StandoutScience
Opposing functions of IKKβ during acute and chronic intestinal inflammation
2008
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis
2010
Newcomers in the process of mitochondrial permeabilization
2005
Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice
2014
Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
2009 StandoutNobel
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
2010 StandoutNobel
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
1999
Protein synthesis persists during necrotic cell death
2005
Cell Death and Inflammatory Bowel Diseases: Apoptosis, Necrosis, and Autophagy in the Intestinal Epithelium
2014
Caspase Inhibitors Promote Alternative Cell Death Pathways
2006
Clinically Approved Heterocyclics Act on a Mitochondrial Target and Reduce Stroke-induced Pathology
2004
Activation and Caspase-mediated Inhibition of PARP: A Molecular Switch between Fibroblast Necrosis and Apoptosis in Death Receptor Signaling
2002
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
Myeloid Cell–Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation
2015
Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways
1998
Mitochondrial Oxidative Stress: Implications for Cell Death
2006
An annexin A1–FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions
2014
Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis
2015
The Role of Mitochondria in Apoptosis
2009 Standout
TRP Channels as Sensors of Chemically-Induced Changes in Cell Membrane Mechanical Properties
2019
Ceramide mediates caspase‐independent programmed cell death
2005
Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice
2008
Downregulation of Smac/DIABLO Expression in Renal Cell Carcinoma and Its Prognostic Significance
2004
Works of Geert Loo being referenced
Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells
2015 Science
Lithium Sensitizes Tumor Cells in an NF-κB-independent Way to Caspase Activation and Apoptosis Induced by Tumor Necrosis Factor (TNF)
2001
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet
2002
Enterocyte death and intestinal barrier maintenance in homeostasis and disease
2011
Bcl-2 Family Members as Sentinels of Cellular Integrity and Role of Mitochondrial Intermembrane Space Proteins in Apoptotic Cell Death
2003
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis
2014 Nature
Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria
2001
Death by TNF: a road to inflammation
2022
Identification of a new caspase homologue: caspase-14
1998
IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-κB in the central nervous system
2011
The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation
2011
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
2014 Nature
Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice
2006
The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology
2009
A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid
2002
Toxic proteins released from mitochondria in cell death
2004
Mitochondrial intermembrane proteins in cell death
2003
Differential Signaling to Apoptotic and Necrotic Cell Death by Fas-associated Death Domain Protein FADD
2004
Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma
2007
The Ubiquitin-Editing Protein A20 Prevents Dendritic Cell Activation, Recognition of Apoptotic Cells, and Systemic Autoimmunity
2011
Cathepsin B-Mediated Activation of the Proinflammatory Caspase-11
1998
Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA
2002
Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis
2011
Molecular cloning and identification of murine caspase-8
1998
Characterization of seven murine caspase family members
1997
Caspases are not localized in mitochondria during life or death
2002
Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway
2012
Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential
1999
Signaling to gene activation and cell death by tumor necrosis factor receptors and fas
2002
Disruption of HSP90 Function Reverts Tumor Necrosis Factor-induced Necrosis to Apoptosis
2003
FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation
2011 Nature
Epithelial NEMO links innate immunity to chronic intestinal inflammation
2007 Nature
Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation
2001
A20 controls intestinal homeostasis through cell-specific activities
2014
The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity
2002
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis
2011
Structure/Function Analysis of p55 Tumor Necrosis Factor Receptor and Fas-associated Death Domain
2000
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
2012
Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor
1998
Oligodendrocyte-Specific FADD Deletion Protects Mice from Autoimmune-Mediated Demyelination
2010
Hepatic Tumor Necrosis Factor Signaling and Nuclear Factor-κB: Effects on Liver Homeostasis and Beyond
2007
B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice
2010
Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis
2010
A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection
2012