Citation Impact
Citing Papers
Debrisoquine 4-Hydroxylase: Characterization of a New P450 Gene Subfamily, Regulation, Chromosomal Mapping, and Molecular Analysis of the DA Rat Polymorphism
1987
Calcineurin Inhibitor Nephrotoxicity
2009 Standout
Vascularized and functional human liver from an iPSC-derived organ bud transplant
2013 StandoutNature
Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites
2010
Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications
2003 Standout
Quantitative analysis of complex protein mixtures using isotope-coded affinity tags
1999 Standout
Dose calculation of anticancer drugs: a review of the current practice and introduction of an alternative.
1996 Standout
The genetic polymorphism of debrisoquine/sparteine metabolism—molecular mechanisms
1990
Acute and chronic arsenic toxicity
2003 Standout
Calcium channel blockers protect transplant patients from cyclosporine-induced daily renal hypoperfusion
1993
Drug-Induced Hepatotoxicity
2003 Standout
Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation*
1996
Libraries of hybrid proteins from distantly related sequences
2001 StandoutNobel
Catalytic Assays for Human Cytochrome P450
2003
Acute Renal Failure
1996 Standout
The biochemistry and medical significance of the flavonoids
2002 Standout
Studies on Coumarins and Coumarin-Related Compounds to Determine their Therapeutic Role in the Treatment of Cancer
2004 Standout
Clinical Pharmacokinetics and Pharmacodynamics of Tacrolimus in Solid Organ Transplantation
2004 Standout
Equine Metabolic Syndrome
2010 Standout
Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy
2018 StandoutNobel
Oral fluid collection: The neglected variable in oral fluid testing
2005
Testing for drugs of abuse in saliva and sweat
1998
Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry
2004
Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways
2008 Standout
Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications
2011 Standout
Tobacco Smoke Carcinogens and Lung Cancer
1999 Standout
Human drug metabolism in vitro
1988
Clinical Pharmacology of Tramadol
2004 Standout
The antioxidant and pro-oxidant activities of green tea polyphenols: A role in cancer prevention
2010 Standout
Enzyme induction in the cytochrome P-450 system
1990 Standout
CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A7*1C allele
2005
Cytochrome P450 ω-Hydroxylase Pathway of Tocopherol Catabolism
2002 Standout
Pharmacogenetics – five decades of therapeutic lessons from genetic diversity
2004
Extrahepatic Metabolism of Drugs in Humans
1994
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 Standout
The Use of Therapeutic Drug Monitoring to Optimise Immunosuppressive Therapy
1996
Inhibition and induction of human cytochrome P450 (CYP) enzymes
1998
Antipyrine as a model drug to study hepatic drug-metabolizing capacity
1988
Indolizidine and quinolizidine alkaloids
2004 Standout
Human Cannabinoid Pharmacokinetics
2007 Standout
Apoptosis and necrosis: Mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line
1998
The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature
1993 Standout
Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children
2003 Standout
Aromatase Cytochrome P450, The Enzyme Responsible for Estrogen Biosynthesis*
1994 Standout
Regulation of Human Drug Metabolism by Dietary Factors
1980
Monoclonal antibodies for studies on xenobiotic and endobiotic metabolism
1985
Genes for Cytochrome P-450 and Their Regulatio
1986
Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes.
1985
Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes
1983
Bioactive compounds in seaweed: functional food applications and legislation
2011 Standout
The effect of cigarette smoking on 7‐ethoxyresorufin O‐deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies.
1986
Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene.
1992
Clinical significance of the sparteine/debrisoquine oxidation polymorphism
1989
Variations in Drug Metabolism Due to Genetic Polymorphism
1993
Effect of herbal teas on hepatic drug metabolizing enzymes in rats
2001
Tea consumption modulates hepatic drug metabolizing enzymes in Wistar rats
2001
Tissue distribution of drug-metabolizing enzymes in humans
1988
Pharmacokinetics of metformin after intravenous and oral administration to man
1979
Human UDP-Glucuronosyltransferases: Metabolism, Expression, and Disease
2000 Standout
Cyclosporin exerts a direct fibrogenic effect on human tubulointerstitial cells: roles of insulin-like growth factor I, transforming growth factor beta1, and platelet-derived growth factor.
1999
Genetic variation in the human hepatic cytochrome P-450 system
1987
Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease
1995
Clinical Implications of Enzyme Induction and Enzyme Inhibition
1981
Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.
1985
Applications of isotope dilution‐mass spectrometry in clinical chemistry, pharmacokinetics, and toxicology
1992
Genetically Determined Variability in Acetylation and Oxidation Therapeutic Implications
1985
Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics
1999 StandoutScience
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Immunoquantification of epoxide hydrolase and cytochrome P‐450 isozymes in fetal and adult human liver microsomes
1985
Resistance of the 2,2,2-trifluoroethoxy aryl moiety to the cytochrome P-450 metabolism in rat liver microsomes
1993
Coumarins and Coumarin-Related Compounds in Pharmacotherapy of Cancer
2020 Standout
Human cytochromes P-450
1984
Debrisoquine/sparteine-type polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol.
1986
Works of GC Kahn being referenced
Sex and strain differences in hepatic debrisoquine 4-hydroxylase activity of the rat.
1985
Biphasic O-deethylation of phenacetin and 7-ethoxycoumarin by human and rat liver microsomal fractions
1981
Substrate specificity of the form of cytochrome P-450 catalyzing the 4-hydroxylation of debrisoquine in man.
1983
Assay and characterisation of debrisoquine 4‐hydroxylase activity of microsomal fractions of human liver.
1982
Antipyrine as an in vitro probe of mixed function oxidase activity [proceeding]
1980
A radiometric high-pressure liquid chromatography assay for the simultaneous determination of the three main oxidative metabolites of antipyrine in studies in vitro
1981
Evidence for an enzymatic defect in the 4‐hydroxylation of debrisoquine by human liver.
1981
The selective activation of cytochrome P-450 dependent microsomal hydroxylases in human and rat liver microsomes
1981
Xenobiotic metabolism in the human lung
1980
Differential effects of 3-methylcholanthrene and phenobarbitone treatment on the oxidative metabolism of antipyrinein vitroby microsomal fractions of rat liver
1982
Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens.
1980
Routine Monitoring of Cyclosporine in Whole Blood and in Kidney Tissue Using High Performance Liquid Chromatography
1986
Phenacetin O‐deethylase: an activity of a cytochrome P‐450 showing genetic linkage with that catalysing the 4‐hydroxylation of debrisoquine?
1985
Drug concentration in saliva
1978
Comparison of the in vivo and in vitro rates of formation of the three main oxidative metabolites of antipyrine in man.
1981