Standout Papers
Citation Impact
Citing Papers
RelE toxins from Bacteria and Archaea cleave mRNAs on translating ribosomes, which are rescued by tmRNA
2003
Structural insights into peptide bond formation
2002 StandoutNobel
Mechanisms of AIF-Mediated Apoptotic DNA Degradation in Caenorhabditis elegans
2002 Science
Distinctive Roles of PHAP Proteins and Prothymosin-α in a Death Regulatory Pathway
2003 Science
Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice
2004
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis
2003
Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration
2006
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Hypoxic enhancement of exosome release by breast cancer cells
2012
The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
2009 StandoutNobel
Mechanisms of Caspase Activation and Inhibition during Apoptosis
2002 Standout
Complex of Transfer-messenger RNA and Elongation Factor Tu
2001
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi
2002
The SsrA–SmpB system for protein tagging, directed degradation and ribosome rescue
2000
Structure of small protein B: the protein component of the tmRNA-SmpB system for ribosome rescue
2002
Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane
2002
Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction
2002
Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac
2003
Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
2009 Standout
Shotgun Glycopeptide Capture Approach Coupled with Mass Spectrometry for Comprehensive Glycoproteomics
2006
Crystal Structures of the Bacillus stearothermophilus CCA-Adding Enzyme and Its Complexes with ATP or CTP
2002 StandoutNobel
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
2002 Standout
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet
2002
c-Myb and Bcl-x Overexpression Predicts Poor Prognosis in Colorectal Cancer
2001
BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo
2003
pp32/PHAPI determines the apoptosis response of non-small-cell lung cancer
2007
Mammalian mitochondrial IAP binding proteins
2003
Internal protein sequence analysis: Enzymatic digestion for less than 10 μg of protein bound to polyvinylidene difluoride or nitrocellulose membranes
1992
Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
2000 StandoutNatureNobel
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2
2001
Bcl-xES, a BH4- and BH2-containing antiapoptotic protein, delays Bax oligomer formation and binds Apaf-1, blocking procaspase-9 activation
2004
Visualizing the transfer-messenger RNA as the ribosome resumes translation
2010 StandoutNobel
Chemotherapy: targeting the mitochondrial cell death pathway
2002
tmRNA-induced Release of Messenger RNA from Stalled Ribosomes
2005
Bcl-2 and Bcl-xL Inhibit CD95-mediated Apoptosis by Preventing Mitochondrial Release of Smac/DIABLO and Subsequent Inactivation of X-linked Inhibitor-of-Apoptosis Protein
2002
Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents
2004
Structural Basis for the Inhibition of Caspase-3 by XIAP
2001
The mitochondrial ARTS protein promotes apoptosis through targeting XIAP
2004
Resuming translation on tmRNA: a unique mode of determining a reading frame
1999
A matter of life and death
2002 Standout
The dynamic disulphide relay of quiescin sulphydryl oxidase
2012 StandoutNatureNobel
The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP through a Reaper-like Motif
2002
Pharmacological manipulation of Bcl-2 family members to control cell death
2005
Spatial and Temporal Dynamics of Mitochondrial Membrane Permeability Waves during Apoptosis
2009
Mitochondrial Release of Pro-apoptotic Proteins
2004
Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Å Resolution
2000 StandoutNobel
tcBid promotes Ca2+ signal propagation to the mitochondria: control of Ca2+ permeation through the outer mitochondrial membrane
2002
In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis
1992
The Apaf-1 apoptosome: a large caspase-activating complex
2002
Cell Death
2004 Standout
Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria
2002
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
2012 Standout
Smac/DIABLO Selectively Reduces the Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in HeLa Cells
2004
The biochemistry of apoptosis
2000 StandoutNature
A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid
2002
Toxic proteins released from mitochondria in cell death
2004
The involvement of RNA in ribosome function
2002 StandoutNatureNobel
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
2011
The Drosophila DIAP1 Protein Is Required to Prevent Accumulation of a Continuously Generated, Processed Form of the Apical Caspase DRONC
2002
Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions
2003
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
2003
Caspase-independent cell death: leaving the set without the final cut
2008
Contributions of Pseudoknots and Protein SmpB to the Structure and Function of tmRNA in trans-Translation
2004
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
gp130-mediated Signal Transduction in Embryonic Stem Cells Involves Activation of Jak and Ras/Mitogen-activated Protein Kinase Pathways
1996
The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system
1998
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x L , but not Bcl-2, until displaced by BH3-only proteins
2005
Apoptosis-based therapies
2002
Determinants on tmRNA for initiating efficient and precise trans-translation: Some mutations upstream of the tag-encoding sequence of Escherichia coli tmRNA shift the initiation point of trans-translation in vitro
2001
How does tmRNA move through the ribosome?
2002
β-Amyloid-Induced Neuronal Apoptosis Involves c-Jun N-Terminal Kinase-Dependent Downregulation of Bcl-w
2005
Granzyme A Induces Caspase-Independent Mitochondrial Damage, a Required First Step for Apoptosis
2005
Identification of Endogenous SsrA-tagged Proteins Reveals Tagging at Positions Corresponding to Stop Codons
2001
Proteasome-mediated Degradation of Smac during Apoptosis: XIAP Promotes Smac Ubiquitination in Vitro
2002
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
2000 Nature
The pathogenic basis of malaria
2002 StandoutNature
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex
1995 StandoutNobel
IAP proteins: blocking the road to death's door
2002
A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death
2001
SsrA-mediated peptide tagging caused by rare codons and tRNA scarcity
1999
A Central Role for Bid in Granzyme B-induced Apoptosis
2004
IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis
2007
Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization
2003
Transfer-messenger RNA unfolds as it transits the ribosome
2005
Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition
2000 Standout
Mechanism of XIAP-Mediated Inhibition of Caspase-9
2003
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition
2002
Molecular mechanisms of caspase regulation during apoptosis
2004 Standout
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
2003
Three of four pseudoknots in tmRNA are interchangeable and are substitutable with single‐stranded RNAs
2000
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways
2005
NADH Oxidase Activity of Mitochondrial Apoptosis-inducing Factor
2001
Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆
2009
A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif
2000
SmpB, a unique RNA-binding protein essential for the peptide-tagging activity of SsrA (tmRNA)
1999
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1
2002 StandoutNobel
Dysregulation of apoptosis genes in hematopoietic malignancies
2002
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
AMID, an Apoptosis-inducing Factor-homologous Mitochondrion-associated Protein, Induces Caspase-independent Apoptosis
2002
Mitochondrial endonuclease G is important for apoptosis in C. elegans
2001 Nature
Applications of reversible covalent chemistry in analytical sample preparation
2012
A Tripartite Protein Complex with the Potential to Couple Synaptic Vesicle Exocytosis to Cell Adhesion in Brain
1998 StandoutNobel
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
2001 Nature
Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1
2002
Endonuclease G is an apoptotic DNase when released from mitochondria
2001 Nature
A surprising simplicity to protein folding
2000 StandoutNatureNobel
XIAP discriminates between type I and type II FAS-induced apoptosis
2009 Nature
Preservation of Caspase-3 Subunits from Degradation Contributes to Apoptosis Evoked by Lactacystin: Any Single Lysine or Lysine Pair of the Small Subunit Is Sufficient for Ubiquitination
2003
Understanding IAP function and regulation: a view from Drosophila
2000
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
2000 Nature
Structural Basis of Caspase-7 Inhibition by XIAP
2001
Structural basis of IAP recognition by Smac/DIABLO
2000 Nature
Ribosome Structure and the Mechanism of Translation
2002 StandoutNobel
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
2004 StandoutNatureNobel
Structural Analysis of a Functional DIAP1 Fragment Bound to Grim and Hid Peptides
2001
Simultaneous and functional binding of SmpB and EF-Tu·GTP to the alanyl acceptor arm of tmRNA
2001
TNF-α Induces Two Distinct Caspase-8 Activation Pathways
2008
SmpB functions in various steps of trans-translation
2002
The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity
2002
Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template
2004 StandoutNatureNobel
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Mitochondria and cell death: outer membrane permeabilization and beyond
2010 Standout
Mechanisms of Apoptosis
2000
CD95's deadly mission in the immune system
2000 Nature
Induction of p53‐independent apoptosis by the BH3‐only protein ITM2Bs
2004
The biological roles of trans-translation
2002
Caspase Activation Inhibits Proteasome Function during Apoptosis
2004 StandoutNobel
The use of mass spectrometry for the proteomic analysis of glycosylation
2006
Programmed Cell Death in Animal Development and Disease
2011
Structure of the 80S Ribosome from Saccharomyces cerevisiae—tRNA-Ribosome and Subunit-Subunit Interactions
2001 StandoutNobel
Absorption of serotonin (5‐hydroxytryptamine) and histamine by dog platelets
1954
Cyclophilin D, a Component of the Permeability Transition-Pore, Is an Apoptosis Repressor
2004
Maspin Mediates Increased Tumor Cell Apoptosis upon Induction of the Mitochondrial Permeability Transition
2005
Clues from cell metabolism
2010 StandoutNatureNobel
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
1999
Binding of serotonin and other amines by blood platelets
1958
Tryptamine Receptors in the Central Nervous System
1961 StandoutNatureNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis
2004
Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis
2003
The application of targeted mass spectrometry‐based strategies to the detection and localization of post‐translational modifications
2014
Generation and Characterization of Smac/DIABLO-Deficient Mice
2002
Identification of Two GTP-Binding Proteins in the Chloroplast Protein Import Machinery
1994 StandoutScienceNobel
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C
1995 StandoutScienceNobel
A comprehensive investigation of proline fragmentation behavior in low-energy collision-induced dissociation peptide mass spectra
2011
The Renin–Angiotensin System: Inhibition of Converting Enzyme in Isolated Tissues
1970 StandoutNatureNobel
Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry
2004 Standout
3′ Exoribonucleolytic trimming is a common feature of the maturation of small, stable RNAs in Escherichia coli
1998
Protein Analysis by Shotgun/Bottom-up Proteomics
2013
Structural Basis of Caspase Inhibition by XIAP
2001
The Structural Basis of Ribosome Activity in Peptide Bond Synthesis
2000 StandoutScienceNobel
Dynamics and structure of the Bax-Bak complex responsible for releasing mitochondrial proteins during apoptosis
2008
The protein structures that shape caspase activity, specificity, activation and inhibition
2004
Polymer Brushes via Surface-Initiated Controlled Radical Polymerization: Synthesis, Characterization, Properties, and Applications
2009 Standout
Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene
2003
Supplemental Activation Method for High-Efficiency Electron-Transfer Dissociation of Doubly Protonated Peptide Precursors
2006
Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.
1995 StandoutNobel
对含砂低液限占土（CLS）最大干密度问题的探索
2001
Identification and Characterization of Disulfide Bonds in Proteins and Peptides from Tandem MS Data by Use of the MassMatrix MS/MS Search Engine
2007
Probing the structure of the Escherichia coli 10Sa RNA (tmRNA).
1997
Alternating metabolic pathways in NGF-deprived sympathetic neurons affect caspase-independent death
2003
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Visualizing tmRNA Entry into a Stalled Ribosome
2003 StandoutScienceNobel
RIBOSOMES AND TRANSLATION
1997
Studies on the uptake of 5‐hydroxytryptamine by blood platelets
1959
Protein identification using sequential ion/ion reactions and tandem mass spectrometry
2005
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
1993 StandoutNatureNobel
VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release
2001
Exogenous Smac Induces Competence and Permits Caspase Activation in Sympathetic Neurons
2002
5-Hydroxytryptamine in the Circulation of the Dog
1967 StandoutNatureNobel
Protein Targets of Reactive Electrophiles in Human Liver Microsomes
2007
Chaperone rings in protein folding and degradation
1999
The expanding role of mitochondria in apoptosis.
2001 Standout
Controlling the Caspases
2001 Science
Isolation of Components of the Chloroplast Protein Import Machinery
1994 StandoutScienceNobel
A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding
2002
A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death
2004 Science
HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins
2002
Cytochrome C Maintains Mitochondrial Transmembrane Potential and Atp Generation after Outer Mitochondrial Membrane Permeabilization during the Apoptotic Process
2001
Real-time single cell analysis of Smac/DIABLO release during apoptosis
2003
Role of a Peptide Tagging System in Degradation of Proteins Synthesized from Damaged Messenger RNA
1996 Science
Tryptamine receptors
1953
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
Glycobioinformatics: Current strategies and tools for data mining in MS ‐based glycoproteomics
2012
Cytochrome c release from mitochondria proceeds by a two-step process
2002
Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated Lipidic Pore Formation
2009
The Role of Mitochondria in Apoptosis
2009 Standout
Chemical Glycoproteomics
2016 StandoutNobel
Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells
2001
Downregulation of Smac/DIABLO Expression in Renal Cell Carcinoma and Its Prognostic Significance
2004
Works of Gavin E. Reid being referenced
S‐Pyridylethylation of intact polyacrylamide gels and in situ digestion of electrophoretically separated proteins: A rapid mass spectrometric method for identifying cysteine‐containing peptides
1996
Strategies for internal amino acid sequence analysis of proteins separated by polyacrylamide gel electrophoresis
1990
Proteomic analysis of the human colon carcinoma cell line (LIM 1215): Development of a membrane protein database
2000
Peptide mapping and internal sequencing of proteins electroblotted from two-dimensional gels onto polyvinylidene difluoride membranes
1989
Techniques for phosphopeptide enrichment prior to analysis by mass spectrometry
2009
Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins
2000 Standout
C-terminal Extension of Truncated Recombinant Proteins in Escherichia coli with a 10Sa RNA Decapeptide
1995
A two‐dimensional gel database of human colon carcinoma proteins
1997
Tandem mass spectrometry strategies for phosphoproteome analysis
2011
The Disulfide Bond Structure of Plasmodium Apical Membrane Antigen-1
1996
Purification and characterization of a recombinant murine interleukin‐6
1992
Characterization of rat brain stathmin isoforms by two‐dimensional gel electrophoresis‐matrix assisted laser desorption/ionization and electrospray ionizationion trap mass spectrometry
1998
Disulfide Bond Structure and N-Glycosylation Sites of the Extracellular Domain of the Human Interleukin-6 Receptor
1999
‘Top down’ protein characterization via tandem mass spectrometry
2002
ExoCarta 2012: database of exosomal proteins, RNA and lipids
2011
Phosphopeptide Enrichment Using MALDI Plates Modified with High-Capacity Polymer Brushes
2008
Mining a Tandem Mass Spectrometry Database To Determine the Trends and Global Factors Influencing Peptide Fragmentation
2003
Selective identification and quantitative analysis of methionine containing peptides by charge derivatization and tandem mass spectrometry
2005
Charge state dependent fragmentation of gaseous protein ions in a quadrupole ion trap: bovine ferri-, ferro-, and apo-cytochrome c
2002
Ion Parking during Ion/Ion Reactions in Electrodynamic Ion Traps
2001
Affecting Proton Mobility in Activated Peptide and Whole Protein Ions via Lysine Guanidination
2003
Mechanistic Insights into the Multistage Gas-Phase Fragmentation Behavior of Phosphoserine- and Phosphothreonine-Containing Peptides
2008
Evaluation of Gas-Phase Rearrangement and Competing Fragmentation Reactions on Protein Phosphorylation Site Assignment Using Collision Induced Dissociation-MS/MS and MS3
2008
Gas-Phase Concentration, Purification, and Identification of Whole Proteins from Complex Mixtures
2002
Statistical and Mechanistic Approaches to Understanding the Gas-Phase Fragmentation Behavior of Methionine Sulfoxide Containing Peptides
2004
Tandem Mass Spectrometry of Ribonuclease A and B: N-Linked Glycosylation Site Analysis of Whole Protein Ions
2001
Myb expression is higher in malignant human colonic carcinoma and premalignant adenomatous polyps than in normal mucosa.
1992
ON THE PRESENCE IN RABBIT SERUM OF THROMBOTONIN (THROMBOCYTIN OR SEROTONIN)
1952
Source of ‘Serotonin’ in Serum
1951 Nature
PHYSIOLOGICAL ACTIONS OF THE PARTIALLY PURIFIED SERUM VASOCONSTRICTOR (SEROTONIN)
1951