Citation Impact
Citing Papers
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility
2003 StandoutNobel
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
Toll Pathway-Dependent Blockade of CD4 + CD25 + T Cell-Mediated Suppression by Dendritic Cells
2003 StandoutScience
Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients
2007 StandoutNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Toll-Like Receptor 4 Signaling by Intestinal Microbes Influences Susceptibility to Food Allergy
2004
Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2
1999 Standout
Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids
2003
Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis
1999
Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin
2001
Toll-Like Receptor-5 and the Innate Immune Response to Bacterial Flagellin
2002
LPS induction of gene expression in human monocytes
2001 Standout
Toll receptors and pathogen resistance
2003
A CD14-independent LPS receptor cluster
2001
Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran
2007
Human Toll-like receptor 4 recognizes host-specific LPS modifications
2002
Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2
1999 Standout
Analysis of Tlr4-Mediated LPS Signal Transduction in Macrophages by Mutational Modification of the Receptor
1999 StandoutNobel
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
Endotoxin can induce MyD88-deficient dendritic cells to support Th2 cell differentiation
2002
Toll signaling pathways in the innate immune response
2000
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
2001 StandoutNature
The Toll receptor family and microbial recognition
2000
Saturated Fatty Acid Activates but Polyunsaturated Fatty Acid Inhibits Toll-like Receptor 2 Dimerized with Toll-like Receptor 6 or 1
2004 Standout
Mouse Toll-like Receptor 4·MD-2 Complex Mediates Lipopolysaccharide-mimetic Signal Transduction by Taxol
2000
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
2005
Evolution of the TIR, Tolls and TLRs: Functional Inferences from Computational Biology
2002 StandoutNobel
Innate Immunity
2000
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
1999 Nature
Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice
2001
Roles of Toll‐like receptors in innate immune responses
2001
IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program
2002
Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections
2001 StandoutNobel
Bacterial Lipopolysaccharide Activates NF-κB through Toll-like Receptor 4 (TLR-4) in Cultured Human Dermal Endothelial Cells
2000
Regulation of Chemokine Expression by Antiinflammatory Cytokines
2002
Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells
2001
Essential role of MD-2 in LPS responsiveness and TLR4 distribution
2002
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Association between Common Toll‐Like Receptor 4 Mutations and Severe Respiratory Syncytial Virus Disease
2004
Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids
2003
The molecular basis of the host response to lipopolysaccharide
2009
Unresponsiveness of MyD88-Deficient Mice to Endotoxin
1999 Standout
Toll-like Receptor-2 Mediates Treponema Glycolipid and Lipoteichoic Acid-induced NF-κB Translocation
2001
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
1999
Toll-like receptors in the induction of the innate immune response
2000 StandoutNature
TAK1 mediates an activation signal from toll‐like receptor(s) to nuclear factor‐κB in lipopolysaccharide‐stimulated macrophages
2000
CD36 is a sensor of diacylglycerides
2005 StandoutNatureNobel
Caenorhabditis elegans: a model genetic host to study Pseudomonas aeruginosa pathogenesis
2000
Toll-like receptors: balancing host resistance with immune tolerance
2003
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
2000
Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition
2001
Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases
2003
The immune response of Drosophila
2003 StandoutNatureNobel
The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol
2001
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
1999 Standout
The biology of Toll-like receptors
2000
Murine TOLL-like Receptor 4 Confers Lipopolysaccharide Responsiveness as Determined by Activation of NFκB and Expression of the Inducible Cyclooxygenase
2000
The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling
2000
The Role of Toll-like Receptors (TLRs) in Bacteria-induced Maturation of Murine Dendritic Cells (DCs)
2001
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Toll-like receptors and innate immunity
2009
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
2000
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Absence of Toll-Like Receptor 4 Explains Endotoxin Hyporesponsiveness in Human Intestinal Epithelium
2001
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
2000
Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88
2000
A Lipopolysaccharide‐Deficient Mutant ofNeisseria meningitidisElicits Attenuated Cytokine Release by Human Macrophages and Signals via Toll‐like Receptor (TLR) 2 but Not via TLR4/MD2
2001
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Toll-like receptors and innate immunity
2001 Standout
Differential Roles of Toll-Like Receptors 2 and 4 in In Vitro Responses of Macrophages toLegionella pneumophila
2004
Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
2000 StandoutNobel
Toll-Like Receptors
2003 Standout
Innate immunity: Lipoproteins take their Toll on the host
1999
Human Toll-Like Receptor 2 Mediates Monocyte Activation byListeria monocytogenes, But Not by Group B Streptococci or Lipopolysaccharide
2000
Involvement of Toll-Like Receptor 4 in Innate Immunity to Respiratory Syncytial Virus
2001
An Essential Role of the NF-κB/Toll-Like Receptor Pathway in Induction of Inflammatory and Tissue-Repair Gene Expression by Necrotic Cells
2001
Toll-like receptor 4-mediated activation of murine mast cells
2001
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Bacterial lipopolysaccharides and innate immunity.
2001
Differential Involvement of BB Loops of Toll-IL-1 Resistance (TIR) Domain-Containing Adapter Proteins in TLR4- versus TLR2-Mediated Signal Transduction
2005
Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex
2000
Toll-Like Receptor 4 Mediates Innate Immune Responses toHaemophilus influenzaeInfection in Mouse Lung
2002
Spontaneous and Continuous Cyclooxygenase-2-Dependent Prostaglandin E2 Production by Stromal Cells in the Murine Small Intestine Lamina Propria: Directing the Tone of the Intestinal Immune Response
2001
Cutting Edge: Inflammatory Signaling by Borrelia burgdorferi Lipoproteins Is Mediated by Toll-Like Receptor 2
1999 Standout
Regulation of Toll-Like Receptor 2 Expression by Macrophages FollowingMycobacterium aviumInfection
2000
Cutting Edge: Gln22 of Mouse MD-2 Is Essential for Species-Specific Lipopolysaccharide Mimetic Action of Taxol
2001
How the immune system works to protect the host from infection: A personal view
2001
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease
2005 StandoutNobel
Rapid Chromatin Remodeling of Toll-Like Receptor 2 Promoter During Infection of Macrophages with Mycobacterium avium
2002
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
2000 StandoutNobel
A genome-wide analysis of immune responses in Drosophila
2001 StandoutNobel
Murine retroviruses activate B cells via interaction with toll-like receptor 4
2002
Cooperation of Toll-Like Receptor 2 and 6 for Cellular Activation by Soluble Tuberculosis Factor andBorrelia burgdorferiOuter Surface Protein A Lipoprotein: Role of Toll-Interacting Protein and IL-1 Receptor Signaling Molecules in Toll-Like Receptor 2 Signaling
2001
Transport of Bacterial Lipopolysaccharide to the Golgi Apparatus
1999
A Novel Pathway Regulating Lipopolysaccharide-Induced Shock by ST2/T1 Via Inhibition of Toll-Like Receptor 4 Expression
2001
The CD14 Ligands Lipoarabinomannan and Lipopolysaccharide Differ in Their Requirement for Toll-Like Receptors
1999
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract
2005 StandoutScience
NFκB and Sp1 Elements Are Necessary for Maximal Transcription of Toll-like Receptor 2 Induced byMycobacterium avium
2001
Signaling Events Induced by Lipopolysaccharide-Activated Toll-Like Receptor 2
1999
Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line
2001
Signaling by Toll-Like Receptor 2 and 4 Agonists Results in Differential Gene Expression in Murine Macrophages
2001
Cutting Edge: Lipopolysaccharide Induces Physical Proximity Between CD14 and Toll-Like Receptor 4 (TLR4) Prior to Nuclear Translocation of NF-κB
2000
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Divergent Response to LPS and Bacteria in CD14-Deficient Murine Macrophages
2000
Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression
2001
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
2000 Standout
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease
2000
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling
2000
MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4
1999 Standout
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Toll-Like Receptor 2 Is Required for Innate, But Not Acquired, Host Defense to Borrelia burgdorferi
2002
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2
2000
Colony-Stimulating Factor-1 Suppresses Responses to CpG DNA and Expression of Toll-Like Receptor 9 but Enhances Responses to Lipopolysaccharide in Murine Macrophages
2002
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis
2006 StandoutNobel
Lipopolysaccharides from Distinct Pathogens Induce Different Classes of Immune Responses In Vivo
2001
Expression of Toll-Like Receptor 2 on γδ T Cells Bearing Invariant Vγ6/Vδ1 Induced by Escherichia coli Infection in Mice
2000
Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
1999
Dendritic Cells Pulsed with Live and DeadLegionella pneumophilaElicit Distinct Immune Responses
2004
The Toll-like Receptor Protein Rp105 Regulates Lipopolysaccharide Signaling in B Cells
2000
Cutting Edge: Cells That Carry A Null Allele for Toll-Like Receptor 2 Are Capable of Responding to Endotoxin
1999
Gene Expressions of Toll-Like Receptor 2, But Not Toll-Like Receptor 4, Is Induced by LPS and Inflammatory Cytokines in Mouse Macrophages
2000
Lipopolysaccharide Endotoxins
2002 Standout
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants ofDrosophila
2000 StandoutNobel
Induction of Cross-Tolerance by Lipopolysaccharide and Highly Purified Lipoteichoic Acid Via Different Toll-Like Receptors Independent of Paracrine Mediators
2001
Endotoxin-Induced Maturation of MyD88-Deficient Dendritic Cells
2001
Requirement for STAT1 in LPS-induced gene expression in macrophages
2001
Protective Roles of Mast Cells Against Enterobacterial Infection Are Mediated by Toll-Like Receptor 4
2001
Toll‐like receptors: molecular mechanisms of the mammalian immune response
2000
Innate Immune Recognition
2002 Standout
Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression
2000
Cutting Edge: Cell Surface Expression and Lipopolysaccharide Signaling Via the Toll-Like Receptor 4-MD-2 Complex on Mouse Peritoneal Macrophages
2000
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
2006 StandoutScienceNobel
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines
2002
Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress
2015 StandoutNobel
Works of Gary Leveque being referenced
Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)
1999 Standout
Cloning and Characterization of the Murine Toll-like Receptor 5 (Tlr5) Gene: Sequence and mRNA Expression Studies in Salmonella-Susceptible MOLF/Ei Mice
2000
Allelic Variation inTLR4Is Linked to Susceptibility toSalmonella entericaSerovar Typhimurium Infection in Chickens
2003