Standout Papers
Citation Impact
Citing Papers
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses
2011
A Topological Analysis of Goldfish Kainate Receptors Predicts Three Transmembrane Segments
1995
Trinitrophenyl-Substituted Nucleotides Are Potent Antagonists Selective for P2X1, P2X3, and Heteromeric P2X2/3 Receptors
1998
Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin‐8 from human eosinophils
2003
A proton-gated cation channel involved in acid-sensing
1997 Nature
Functional Degenerin-containing Chimeras Identify Residues Essential for Amiloride-sensitive Na- Channel Function
1995
Chapter 14 Methods for the Study of Cell Death in the Nematode Caenorhabditis elegans
1995
A New Member of the Amiloride-Sensitive Sodium Channel Family inDrosophila melanogasterPeripheral Nervous System
1998
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Nucleotide signalling during inflammation
2014 StandoutNature
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
Synaptic corelease of ATP and GABA in cultured spinal neurons
1999
P2X purinoceptor is not important in thymocyte apoptosis
1996
TRPV1 shows dynamic ionic selectivity during agonist stimulation
2008
A Potential Role for P2X 7 R in Allergic Airway Inflammation in Mice and Humans
2010
Purinergic Signaling in the Airways
2012
Microglial activation by purines and pyrimidines
2002
A capsaicin-receptor homologue with a high threshold for noxious heat
1999 StandoutNatureNobel
Potassium channels and their evolving gates
1994 Nature
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
A Modulatory Subunit of Acid Sensing Ion Channels in Brain and Dorsal Root Ganglion Cells
1997
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
2008 StandoutNature
Modulatory roles of the adenosine triphosphate P2x-purinoceptor in generation of the persistent nociception induced by subcutaneous bee venom injection in the conscious rat
2000
Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain
1995 StandoutNobel
Molecular Cloning of a Non-inactivating Proton-gated Na+ Channel Specific for Sensory Neurons
1997
Flavonoid-induced reduction of ENaC expression in the kidney of Dahl salt-sensitive hypertensive rat
2004
Roles of the C Termini of α-, β-, and γ-Subunits of Epithelial Na+ Channels (ENaC) in Regulating ENaC and Mediating Its Inhibition by Cytosolic Na+
2001
Extracellular Proteins Needed for C. elegans Mechanosensation
1996 StandoutNobel
A P2X purinoceptor cDNA conferring a novel pharmacological profile
1995
Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans
1994 StandoutNatureNobel
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
Pore loops: An emerging theme in ion channel structure
1995 StandoutNobel
A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans
1995 StandoutNobel
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
2002 StandoutNatureNobel
Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
2004
The Nematode Degenerin UNC-105 Forms Ion Channels that Are Activated by Degeneration- or Hypercontraction-Causing Mutations
1998
Protection from asthma in a high-risk birth cohort by attenuated P2X7 function
2012
The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice
2001
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
2003 StandoutNature
Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel
1995
P2X 7 Receptor Signaling in the Pathogenesis of Smoke-Induced Lung Inflammation and Emphysema
2010
Chemotactic activity of extracellular nucleotideson human immune cells.
2007
P2X receptors as cell-surface ATP sensors in health and disease
2006 Nature
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Neuromodulation by Extracellular ATP and P2X Receptors in the CNS
2012
The Activity of the Epithelial Sodium Channel Is Regulated by Clathrin-mediated Endocytosis
1997
Is pannexin the pore associated with the P2X7 receptor?
2013
Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits
2002
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
2002 StandoutNatureNobel
Role of Extracellular ATP and P1 and P2 Classes of Purinergic Receptors in T‐cell Development and Cytotoxic T Lymphocyte Effector Functions
1995 StandoutNobel
G protein-coupled P2 purinoceptors: from molecular biology to functional responses
1995
A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat
2006
Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na+ channel cell surface expression
2001
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation
2002 StandoutNatureNobel
Molecular Cloning and Functional Expression of a Novel Amiloride-sensitive Na+ Channel
1995
P2Y12Receptor Upregulation in Activated Microglia Is a Gateway of p38 Signaling and Neuropathic Pain
2008
unc-8, a DEG/ENaC Family Member, Encodes a Subunit of a Candidate Mechanically Gated Channel That Modulates C. elegans Locomotion
1997
H+‐Gated Cation Channelsa
1999
Epithelial Na+ channels and stomatin are expressed in rat trigeminal mechanosensory neurons
2000
The menthol receptor TRPM8 is the principal detector of environmental cold
2007 StandoutNatureNobel
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination
1997
Localization of β and γ subunits of ENaC in sensory nerve endings in the rat foot pad
2000
Analgesic profile of intrathecal P2X3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats
2002
Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses
1997 Nature
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Unraveling the modular design of glutamate-gated ion channels
1995
P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production
2000
The changing sensitivity in the life of the nociceptor
1999
Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system.
1998
Cloning and Expression of a Novel Human Brain Na+ Channel
1996
The Mammalian Degenerin MDEG, an Amiloride-sensitive Cation Channel Activated by Mutations Causing Neurodegeneration in Caenorhabditis elegans
1996
A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans
1994 Nature
P2X Receptors as Drug Targets
2012
Serum and Glucocorticoid-regulated Kinase Modulates Nedd4-2-mediated Inhibition of the Epithelial Na+Channel
2002
Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites
1999
Crystal structure of the ATP-gated P2X4 ion channel in the closed state
2009 Nature
Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice
1999
Neurosensory mechanotransduction
2008 StandoutNobel
Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice
2000 Nature
Identification of the platelet ADP receptor targeted by antithrombotic drugs
2001 StandoutNatureNobel
In vivo pathway of thermal hyperalgesia by intrathecal administration of α,β‐methylene ATP in mouse spinal cord: Involvement of the glutamate‐NMDA receptor system
1999
Trimeric Architecture of Homomeric P2X2 and Heteromeric P2X1+2 Receptor Subtypes
2004
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
2002 StandoutNature
Purinergic signalling and disorders of the central nervous system
2008
Acute nociception mediated by hindpaw P2X receptor activation in the rat
1997
What is the hair cell transduction channel?
2006
Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease
2006
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations
1983 Nature
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na + channels
2004 StandoutNobel
Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel
1995
WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.
1996
P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation.
1996
A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain.
1996
Receptor-mediated transcellular transport of immunoglobulin: synthesis of secretory component as multiple and larger transmembrane forms.
1980 StandoutNobel
Activation of human eosinophils via P2 receptors: novel findings and future perspectives
2005
A novel mouse Nedd4 protein suppresses the activity of the epithelial Na + channel
2001
Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases
1979 StandoutNobel
Cachectin and tumour necrosis factor as two sides of the same biological coin
1986 StandoutNatureNobel
Molecular analysis of the unc-54 myosin heavy-chain gene of Caenorhabditis elegans
1981 StandoutNatureNobel
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
1983 Standout
Expression of a chicken chromosomal ovalbumin gene injected into frog oocyte nuclei
1980 StandoutNatureNobel
Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage
1984 StandoutScienceNobel
The 5-HT3Subtype of Serotonin Receptor Contributes to Nociceptive Processing via a Novel Subset of Myelinated and Unmyelinated Nociceptors
2002 StandoutNobel
Nedd4 mediates control of an epithelial Na + channel in salivary duct cells by cytosolic Na +
1998
Purinergic Mechanosensory Transduction and Visceral Pain
2009
Purinergic Receptor Inhibition Prevents the Development of Smoke-Induced Lung Injury and Emphysema
2010
Cell-specific expression of epithelial sodium channel alpha, beta, and gamma subunits in aldosterone-responsive epithelia from the rat: localization by in situ hybridization and immunocytochemistry.
1994
DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature
2001
Two distant clusters of partially homologous small repeats of Epstein-Barr virus are transcribed upon induction of an abortive or lytic cycle of the virus
1983
Transport and Localization of the DEG/ENaC Ion Channel BNaC1α to Peripheral Mechanosensory Terminals of Dorsal Root Ganglia Neurons
2001
ATP P2X Receptor-Mediated Enhancement of Glutamate Release and Evoked EPSCs in Dorsal Horn Neurons of the Rat Spinal Cord
2001
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
2000 StandoutScienceNobel
Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the β-subunit of the amiloride-sensitive epithelial sodium channel
1999
Vanilloid (Capsaicin) Receptors and Mechanisms
1999 Standout
Alphavirus-based expression vectors: strategies and applications.
1996 StandoutNobel
Signaling at Purinergic P2X Receptors
2008
Acid-Evoked Currents in Cardiac Sensory Neurons
1999
Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers.
1995
Heteromultimers of DEG/ENaC subunits form H + -gated channels in mouse sensory neurons
2002
International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.
2001
The role of individual Nedd4–2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels
2002
ATP P2× Receptors and Sensory Synaptic Transmission Between Primary Afferent Fibers and Spinal Dorsal Horn Neurons in Rats
1998
Genetically targeted cell disruption in Caenorhabditis elegans
1997 StandoutNobel
Molecular Basis of Mechanotransduction in Living Cells
2001
Neuropathology of degenerative cell death in Caenorhabditis elegans.
1997 StandoutNobel
Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions.
1979
Comparative biochemical properties of normal and activated human ras p21 protein
1984 Nature
Genetic interactions affecting touch sensitivity in Caenorhabditis elegans.
1996 StandoutNobel
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity
1984 Nature
Membrane topology of the amiloride-sensitive epithelial sodium channel.
1994
Diversity of Channels Generated by Different Combinations of Epithelial Sodium Channel Subunits
1997
ION CHANNELS OF NOCICEPTION
1999
Inflammatory mediators and modulators of pain
2006
Sequence and transmembrane topology of MEC-4, an ion channel subunit required for mechanotransduction in Caenorhabditis elegans.
1996 StandoutNobel
Mechanical Allodynia Caused by Intraplantar Injection of P2X Receptor Agonist in Rats: Involvement of Heteromeric P2X2/3Receptor Signaling in Capsaicin-Insensitive Primary Afferent Neurons
2000
A P2X purinoceptor expressed by a subset of sensory neurons
1995 Nature
Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome.
1996
P2X4: an ATP-activated ionotropic receptor cloned from rat brain.
1996
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Ripped Pocket and Pickpocket, Novel Drosophila DEG/ENaC Subunits Expressed in Early Development and in Mechanosensory Neurons
1998
Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells
1985 StandoutNature
A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism
1997
Isolectin B4-Positive and -Negative Nociceptors Are Functionally Distinct
1999
Transient up-regulation of P2Y2nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes
1997 StandoutNobel
MOLECULAR MODELING OF MECHANOTRANSDUCTION IN THE NEMATODE CAENORHABDITIS ELEGANS
1997
Neuropathology of Degenerative Cell Death inCaenorhabditis elegans
1997 StandoutNobel
BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels
1997
Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
1985 StandoutNatureNobel
Somatic generation of antibody diversity
1983 StandoutNatureNobel
Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release
2017 StandoutNobel
Isolation of a cDNA clone for the human HLA-DR antigen alpha chain by using a synthetic oligonucleotide as a hybridization probe.
1982 StandoutNobel
ATP P2XReceptors Mediate Fast Synaptic Transmission in the Dorsal Horn of the Rat Spinal Cord
1997
ADP Receptors on Platelets
1996
Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes
1980 Standout
Genetics of Sensory Mechanotransduction
2002 StandoutNobel
Interaction Between a Putative Mechanosensory Membrane Channel and a Collagen
1996 Science
Works of Gary Buell being referenced
High‐level Expression of the Human Neurokinin‐1 Receptor in Mammalian Cell Lines using the Semliki Forest Virus Expression System
1994
Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors
2000 Nature
A comparison of the binding characteristics of recombinant P2×1 and P2×2 purinoceptors
1996
ATP-mediated cytotoxicity in microglial cells
1997
Desensitization of the P2X2 receptor controlled by alternative splicing
1997
Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals
1997
Organization of the mouse 5-HT3 receptor gene and functional expression of two splice variants
1994
Contribution of Individual Subunits to the Multimeric P2X2Receptor: Estimates based on Methanethiosulfonate Block at T336C
1999
P2x receptors bring new structure to ligand-gated ion channels
1995
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
1994 StandoutNature
New insights on P2X purinoceptors
1995
Up-Regulation of P2X4Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain
2008
Altered Hippocampal Synaptic Potentiation in P2X4Knock-Out Mice
2006
P2X3 is expressed by DRG neurons that terminate in inner lamina II
1998
Tissue distribution of the P2X7 receptor
1997
Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons
1995 Nature
A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP
1994 Nature
The Permeabilizing ATP Receptor, P2X7
1997
Membrane Topology of an ATP-gated Ion Channel (P2X Receptor)
1998
P2X Receptors: An Emerging Channel Family
1996
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
2005
Ionic permeability of, and divalent cation effects on, two ATP‐gated cation channels (P2X receptors) expressed in mammalian cells.
1996
An antagonist-insensitive P2X receptor expressed in epithelia and brain.
1996
Synthesis of full length cDNAs from four partially purified oviduct mRNAs.
1978
Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry.
1996
Restriction map of the region surrounding the EcoRI site in the pCR1 plasmid and analysis of an inserted ovalbumin gene
1979
Cloning overlapping DNA fragments from the B95-8 strain of Epstein-Barr virus reveals a site of homology to the internal repetition
1981
Radiolabeling of the Rat P2X4 Purinoceptor: Evidence for Allosteric Interactions of Purinoceptor Antagonists and Monovalent Cations with P2X Purinoceptors
1997
P2X1 receptor activation in HL60 cells
1996
Expression of P2X7 purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X7 receptors
2000
Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I.
1978
Domains of P2X receptors involved in desensitization
1996
Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels
1996
Spontaneous Cell Fusion in Macrophage Cultures Expressing High Levels of the P2Z/P2X7 Receptor
1997
Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors).
1995
The Cytolytic P 2Z Receptor for Extracellular ATP Identified as a P 2X Receptor (P2X 7 )
1996 StandoutScience
Cutting Edge: Purinergic Signaling Regulates Radical-Mediated Bacterial Killing Mechanisms in Macrophages Through a P2X7-Independent Mechanism
1999