Citation Impact
Citing Papers
Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
2010 StandoutScience
PI4P and PI(4,5)P 2 Are Essential But Independent Lipid Determinants of Membrane Identity
2012 Science
Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor
2000 StandoutScience
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
2003 StandoutScienceNobel
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C
2003 StandoutNobel
Sleep Drives Metabolite Clearance from the Adult Brain
2013 StandoutScience
Calcium-dependent Regulation of Protein Kinase D Revealed by a Genetically Encoded Kinase Activity Reporter
2006 StandoutNobel
β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor
2005 StandoutNobel
Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling
2001 Standout
Specificity of G Protein-Coupled Receptor Kinase 6-Mediated Phosphorylation and Regulation of Single-Cell M3 Muscarinic Acetylcholine Receptor Signaling
2003
Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs
1994
G Protein-Coupled Receptor Kinase Function Is Essential for Chemosensation in C. elegans
2004 StandoutNobel
β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation
2002 StandoutNobel
G-protein-coupled Receptor Kinase Specificity for β-Arrestin Recruitment to the β2-Adrenergic Receptor Revealed by Fluorescence Resonance Energy Transfer
2006 StandoutNobel
DNA-based asymmetric catalysis
2010 StandoutNobel
Structure-Activity Relationships of G Protein-Coupled Receptors
1999
Nucleotide signalling during inflammation
2014 StandoutNature
Calcium's Role in Mechanotransduction during Muscle Development
2014 Standout
Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation
2006 StandoutNobel
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Confronting Complexity: the Interlink of Phototransduction and Retinoid Metabolism in the Vertebrate Retina
2001
Newly Synthesized Phosphatidylinositol Phosphates Are Required for Synaptic Norepinephrine but Not Glutamate or γ-Aminobutyric Acid (GABA) Release
1998 StandoutNobel
Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane
2009 StandoutNobel
Synergistic Ca2+ Responses by Gαi- and Gαq-coupled G-protein-coupled Receptors Require a Single PLCβ Isoform That Is Sensitive to Both Gβγ and Gαq
2010
In Vivo Light-induced and Basal Phospholipase C Activity in Drosophila Photoreceptors Measured with Genetically Targeted Phosphatidylinositol 4,5-Bisphosphate-sensitive Ion Channels (Kir2.1)
2004
GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
2010 Standout
Regulation of Kv7 (KCNQ) K+Channel Open Probability by Phosphatidylinositol 4,5-Bisphosphate
2005
Effect of inhibition of aldose reductase on glucose flux, diacylglycerol formation, protein kinase C, and phospholipase A2 activation
1997
BTK Regulates PtdIns-4,5-P2 Synthesis
2003
Functional Control of Cold- and Menthol-Sensitive TRPM8 Ion Channels by Phosphatidylinositol 4,5-Bisphosphate
2005
Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function
2004
Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI
2019 StandoutNobel
Distinct Mesenchymal Alterations in N-Cadherin and E-Cadherin Positive Primary Renal Epithelial Cells
2012
Role of delivery and trafficking of δ-opioid peptide receptors in opioid analgesia and tolerance
2006
α-Latrotoxin Receptor CIRL/Latrophilin 1 (CL1) Defines an Unusual Family of Ubiquitous G-protein-linked Receptors
1998 StandoutNobel
Molecular Engineering of DNA: Molecular Beacons
2008
The TRPM7 channel is inactivated by PIP2 hydrolysis
2002
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
2008 StandoutNature
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
TRP channels as cellular sensors
2003 StandoutNature
Nerve growth factor and neurotrophin-3 enhance neurite outgrowth and up-regulate the levels of messenger RNA for growth-associated protein GAP-43 and Tα1 α-tubulin in cultured adult rat sensory neurones
1995
Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling
2007
Membrane-Proximal Region of the Carboxyl Terminus of the Gonadotropin-Releasing Hormone Receptor (GnRHR) Confers Differential Signal Transduction between Mammalian and Nonmammalian GnRHRs
2004
EMT: 2016
2016 Standout
Calmodulin Controls Synaptic Strength via Presynaptic Activation of Calmodulin Kinase II
2010 StandoutNobel
Metabotropic receptor activation, desensitization and sequestration—II: modelling the dynamics of the pleckstrin homology domain
2003
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
β2-Adrenergic Receptor Signaling and Desensitization Elucidated by Quantitative Modeling of Real Time cAMP Dynamics
2007 StandoutNobel
The role of aldose reductase in the development of diabetic complications
1988
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Non-visual GRKs: are we seeing the whole picture?
2003
Endogenous G Protein-coupled Receptor Kinase 6 Regulates M3 Muscarinic Acetylcholine Receptor Phosphorylation and Desensitization in Human SH-SY5Y Neuroblastoma Cells
2002
Acute changes in short-term plasticity at synapses with elevated levels of neuronal calcium sensor-1
2003
Homo- and Hetero-oligomerization of Thyrotropin-releasing Hormone (TRH) Receptor Subtypes
2002 StandoutNobel
Reduced Cell Surface Expression of CCR5 in CCR5Δ32 Heterozygotes Is Mediated by Gene Dosage, Rather Than by Receptor Sequestration
2002 StandoutNobel
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy
2006
Seven-transmembrane receptors
2002 StandoutNobel
The PI3K Pathway in Human Disease
2017 Standout
Receptor-specific messenger oscillations
2001 Nature
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
2011 StandoutNature
Calcium Signaling
2007 Standout
Mechanism of Proteasomal Degradation of Inositol Trisphosphate Receptors in CHO-K1 Cells
2005
Modulation of chemokine receptor activity through dimerization and crosstalk
2008
NeuralKCNQ(Kv7) channels
2009
Amyotrophic Lateral Sclerosis
2001 Standout
Cell signalling diversity of the Gqα family of heterotrimeric G proteins
2005
Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival
2007 Standout
The Stability of the G Protein-coupled Receptor-β-Arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation
2003 StandoutNobel
Neurotrophic factors and neuro-muscular disease: II. GDNF, other neurotrophic factors, and future directions
1999
Rab3 Superprimes Synaptic Vesicles for Release: Implications for Short-Term Synaptic Plasticity
2006 StandoutNobel
The role of Ca2+ in triggering inositol 1,4,5-trisphosphate receptor ubiquitination
2005
G Protein–Coupled Receptor Oligomerization
2004
Biological robustness
2004
Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
2015 StandoutNobel
Kinetic analysis of receptor-activated phosphoinositide turnover
2003
Structure, Function, and Control of Phosphoinositide-Specific Phospholipase C
2000
TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids
2013 StandoutNobel
Norepinephrine: A Neuromodulator That Boosts the Function of Multiple Cell Types to Optimize CNS Performance
2012
Double-knockout mice for α- and β-synucleins: Effect on synaptic functions
2004 StandoutNobel
Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor
2005 StandoutNobel
A comprehensive pathway map of epidermal growth factor receptor signaling
2005
An Unbiased cDNA Library Prepared from IsolatedAplysiaSensory Neuron Processes Is Enriched for Cytoskeletal and Translational mRNAs
2003 StandoutNobel
Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling
2005 StandoutNobel
Computer Simulation Studies of the Catalytic Mechanism of Human Aldose Reductase
2000 StandoutNobel
The role of the insulin-like growth factors in the central nervous system
1996
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
2009 StandoutNobel
Phospholipase C in Living Cells
2005
Assessment of the Role of the Inositol 1,4,5-Trisphosphate Receptor in the Activation of Transient Receptor Potential Channels and Store-operated Ca2+ Entry Channels
2001
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress
2015 StandoutNobel
Works of Gary B. Willars being referenced
Mechanisms Underlying the Neuronal Calcium Sensor-1-evoked Enhancement of Exocytosis in PC12 Cells
2002
Complexes of the G Protein Subunit Gβ5 with the Regulators of G Protein Signaling RGS7 and RGS9
2000
Insulin and insulin-like growth factor I enhance regeneration in cultured adult rat sensory neurones
1993
Lack of a C-terminal Tail in the Mammalian Gonadotropin-releasing Hormone Receptor Confers Resistance to Agonist-dependent Phosphorylation and Rapid Desensitization
1999
Phosphorylation of the Gq/11-coupled M3-Muscarinic Receptor Is Involved in Receptor Activation of the ERK-1/2 Mitogen-activated Protein Kinase Pathway
2001
Ca2+ signalling by recombinant human CXCR2 chemokine receptors is potentiated by P2Y nucleotide receptors in HEK cells
2002
Cross Talk between P2Y2 Nucleotide Receptors and CXC Chemokine Receptor 2 Resulting in Enhanced Ca2+ Signaling Involves Enhancement of Phospholipase C Activity and Is Enabled by Incremental Ca2+ Release in Human Embryonic Kidney Cells
2003
Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation
2001
Gβ5·RGS7 Inhibits Gαq-mediated Signaling via a Direct Protein-Protein Interaction
2003
Rapid Down-regulation of the Type I Inositol 1,4,5-Trisphosphate Receptor and Desensitization of Gonadotropin-releasing Hormone-mediated Ca2+ Responses in αT3–1 Gonadotropes
2001
Desensitization of Gonadotropin-releasing Hormone Action in αT3-1 Cells Due to Uncoupling of Inositol 1,4,5-Trisphosphate Generation and Ca2+ Mobilization
1996
Complex relationship between Ins(1,4,5)P3 accumulation and Ca2+‐signalling in a human neuroblastoma revealed by cellular differentiation
1999
Differential Regulation of Muscarinic Acetylcholine Receptor-sensitive Polyphosphoinositide Pools and Consequences for Signaling in Human Neuroblastoma Cells
1998
Vasoreactivity and prostacyclin release in streptozotocin‐diabetic rats: effects of insulin or aldose reductase inhibition
1993
C-peptide reverses TGF-β1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy
2008
Pivotal Role for the Cytoplasmic Carboxyl-Terminal Tail of a Nonmammalian Gonadotropin-Releasing Hormone Receptor in Cell Surface Expression, Ligand Binding, and Receptor Phosphorylation and Internalization
1999
Opposite effects of diabetes and galactosaemia on adenosine triphosphatase activity in rat nervous tissue
1987
Proinsulin C-Peptide Antagonizes the Profibrotic Effects of TGF-β1 via Up-Regulation of Retinoic Acid and HGF-Related Signaling Pathways
2010
Heterologous desensitization of both phosphoinositide and Ca2+ signaling in SH-SY5Y neuroblastoma cells: a role for intracellular Ca2+ store depletion?
1995
Pivotal Role for the Cytoplasmic Carboxyl-Terminal Tail of a Nonmammalian Gonadotropin-Releasing Hormone Receptor in Cell Surface Expression, Ligand Binding, and Receptor Phosphorylation and Internalization
1999
Receptor phosphorylation does not mediate cross talk between muscarinic M3and bradykinin B2receptors
1999
Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation
2001
Defects of axonal transport in experimental diabetes that are unrelated to the sorbitol pathway
1987
Does Galactose Feeding Provide a Valid Model of Consequences of Exaggerated Polyol-Pathway Flux in Peripheral Nerve in Experimental Diabetes?
1987
Mechanisms of cross-talk between G-protein-coupled receptors resulting in enhanced release of intracellular Ca2+
2003
Studies of sorbinil on axonal transport in streptozotocin-diabetic rats
1986