Standout Papers
- Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression (2013)
- Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long‐term intermittent hypoxia (2016)
- Heterozygous HIF‐1α deficiency impairs carotid body‐mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia (2006)
- HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity (2007)
- ROS Signaling in Systemic and Cellular Responses to Chronic Intermittent Hypoxia (2007)
- Transcriptional responses to intermittent hypoxia (2008)
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
H 2 S mediates O 2 sensing in the carotid body
2010
Chemoreceptor Hypersensitivity, Sympathetic Excitation, and Overexpression of ASIC and TASK Channels Before the Onset of Hypertension in SHR
2009
Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia
2008
Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity
2004
Downregulation of c-MYC Protein Levels Contributes to Cancer Cell Survival under Dual Deficiency of Oxygen and Glucose
2010
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Inherent variations in CO-H 2 S-mediated carotid body O 2 sensing mediate hypertension and pulmonary edema
2014
Genetic and Functional Studies Implicate HIF1 α as a 14q Kidney Cancer Suppressor Gene
2011 StandoutNobel
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
2018 StandoutScienceNobel
Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis
2012 StandoutNobel
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
EglN2 associates with the NRF 1‐ PGC 1α complex and controls mitochondrial function in breast cancer
2015 StandoutNobel
Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia
2004
HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression
2014 StandoutNobel
Differential expressions and roles of hypoxia-inducible factor-1alpha, -2alpha and -3alpha in the rat carotid body during chronic and intermittent hypoxia.
2008
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
2011 StandoutNobel
G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth
2009 StandoutNobel
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis
2009 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy
2010 StandoutNobel
Regulation of hypoxia‐inducible factor‐α isoforms and redox state by carotid body neural activity in rats
2014 StandoutNobel
The interplay between MYC and HIF in cancer
2007
FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis
2010 StandoutNobel
Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease
2016
Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism
2009
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Biology of hypoxia-inducible factor-2α in development and disease
2008
HIF-1α induces MXI1 by alternate promoter usage in human neuroblastoma cells
2009
Chronic Intermittent Hypoxia Alters Local Respiratory Circuit Function at the Level of the preBötzinger Complex
2016
MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent Mechanisms
2010
Activation of nitric oxide synthase gene expression by hypoxia in central and peripheral neurons
1996
Induction of HIF‐1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR
2008 StandoutNobel
Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1α heterozygous-null mice after burn wounding
2010 StandoutNobel
MYC on the Path to Cancer
2012 Standout
Hypoxia, HIF1 and glucose metabolism in the solid tumour
2008
HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
2008
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer
2008 StandoutNobel
Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1
2007 StandoutNobel
HIF-1: upstream and downstream of cancer metabolism
2009 StandoutNobel
Identification of non-coding genetic variants in samples from hypoxemic respiratory disease patients that affect the transcriptional response to hypoxia
2016
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
2008 StandoutNobel
HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo
2007 StandoutNobel
HIF-1 and ventilatory acclimatization to chronic hypoxia
2008
The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia
2017 StandoutNobel
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Divergent roles of reactive oxygen species in the responses of perinatal adrenal chromaffin cells to hypoxic challenges
2010
Molecular Signatures of Obstructive Sleep Apnea in Adults: A Review and Perspective
2009
The Interplay Between MYC and HIF in the Warburg Effect
2008
Tumor Cell Metabolism: Cancer's Achilles' Heel
2008 Standout
Ca2+/Calmodulin Kinase-dependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia
2004 StandoutNobel
Neonatal Intermittent Hypoxia Leads to Long-Lasting Facilitation of Acute Hypoxia-Evoked Catecholamine Secretion From Rat Chromaffin Cells
2009
Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism
2008
Xanthine Oxidase Mediates Hypoxia-Inducible Factor-2α Degradation by Intermittent Hypoxia
2013
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Increased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C
2007
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy
2009
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
2008
Developmental programming of O2 sensing by neonatal intermittent hypoxia via epigenetic mechanisms
2012
Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
2011
Increased sympathetic activity in rats submitted to chronic intermittent hypoxia
2006
The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma
2010
Reactive oxygen species contribute to sleep apnea-induced hypertension in rats
2007
Hypoxia-Inducible Factor 1α Determines Gastric Cancer Chemosensitivity via Modulation of p53 and NF-κB
2010
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance
2018
Hypoxia‐inducible factor 1 mediates increased expression of NADPH oxidase‐2 in response to intermittent hypoxia
2011 StandoutNobel
Adaptive Depression in Synaptic Transmission in the Nucleus of the Solitary Tract after In Vivo Chronic Intermittent Hypoxia: Evidence for Homeostatic Plasticity
2007
HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism and Proliferation
2007
Sensing hypoxia: physiology, genetics and epigenetics
2013
Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆
2009
HIF-1α Activation by Intermittent Hypoxia Requires NADPH Oxidase Stimulation by Xanthine Oxidase
2015 StandoutNobel
PIEZO2 in sensory neurons and urothelial cells coordinates urination
2020 StandoutNatureNobel
Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice
2009
miR‐210: More than a silent player in hypoxia
2011
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body
2012
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Regulation of Metabolism by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2
2013 StandoutNobel
Mitochondria and cancer
2012 Standout
NADPH Oxidase-Dependent Regulation of T-Type Ca2+Channels and Ryanodine Receptors Mediate the Augmented Exocytosis of Catecholamines from Intermittent Hypoxia-Treated Neonatal Rat Chromaffin Cells
2010
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism
2010
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
2009
Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation
2009
Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways
2009 StandoutNobel
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
2012 StandoutNobel
Oxygen homeostasis
2009 StandoutNobel
Mechanisms of acute oxygen sensing by the carotid body: Lessons from genetically modified animals
2007
Myc’s broad reach
2008
Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4
2013 StandoutNobel
Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection
2009
Pattern-Specific Sustained Activation of Tyrosine Hydroxylase by Intermittent Hypoxia: Role of Reactive Oxygen Species-Dependent Downregulation of Protein Phosphatase 2A and Upregulation of Protein Kinases
2009
NADPH Oxidase 2 Mediates Intermittent Hypoxia-Induced Mitochondrial Complex I Inhibition: Relevance to Blood Pressure Changes in Rats
2010
LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer
2009
Clues from cell metabolism
2010 StandoutNatureNobel
Peripheral chemoreceptors in health and disease
2004
Dyslipidemia and Atherosclerosis Induced by Chronic Intermittent Hypoxia Are Attenuated by Deficiency of Stearoyl Coenzyme A Desaturase
2008
Life with Oxygen
2007 StandoutScienceNobel
The von Hippel-Lindau Chuvash mutation in mice causes carotid-body hyperplasia and enhanced ventilatory sensitivity to hypoxia
2013
Effects of Aging and Hypoxia-Inducible Factor-1 Activity on Angiogenic Cell Mobilization and Recovery of Perfusion After Limb Ischemia
2007 StandoutNobel
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Hypoxia-Inducible Factor 1 and Cardiovascular Disease
2013 StandoutNobel
Ontogeny of O2 and CO2//H+ chemosensitivity in adrenal chromaffin cells: role of innervation
2014
DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity
2017 StandoutNobel
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1
2007 StandoutNobel
Neonatal intermittent hypoxia impairs neuronal nicotinic receptor expression and function in adrenal chromaffin cells
2010
Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss
2010 StandoutScienceNobel
Effects of different acute hypoxic regimens on tissue oxygen profiles and metabolic outcomes
2011
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
pVHL: A Multipurpose Adaptor Protein
2008
Complementary roles of gasotransmitters CO and H2S in sleep apnea
2017 StandoutNobel
Pathophysiology of Sleep Apnea
2010 Standout
The role of hypoxia‐inducible factors in carotid body (patho) physiology
2018 StandoutNobel
HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury
2010 StandoutNobel
Hypoxia-Induced Pulmonary Vascular Remodeling
2006
Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway
2015 StandoutNobel
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
2009 StandoutNobel
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
2012 StandoutNobel
H 2 S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea
2016 StandoutNobel
Works of Ganesh Kumar being referenced
Intermittent hypoxia degrades HIF-2α via calpains resulting in oxidative stress: Implications for recurrent apnea-induced morbidities
2009
Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression
2013 StandoutNobel
Intermittent Hypoxia‐Mediated Plasticity of Acute O2 Sensing Requires Altered Red‐Ox Regulation by HIF‐1 and HIF‐2
2009
Central and peripheral factors contributing to obstructive sleep apneas
2013
Regulation of Neuronal Nitric Oxide Synthase Gene Expression by Hypoxia
1996
Systemic and Cellular Responses to Intermittent Hypoxia: Evidence for Oxidative Stress and Mitochondrial Dysfunction
2003
Mechanisms of sympathetic activation and blood pressure elevation by intermittent hypoxia
2010
Heterozygous HIF‐1α deficiency impairs carotid body‐mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
2006 StandoutNobel
Role of oxidative stress‐induced endothelin‐converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia
2013
CARDIOVASCULAR ALTERATIONS BY CHRONIC INTERMITTENT HYPOXIA: IMPORTANCE OF CAROTID BODY CHEMOREFLEXES
2005
Transcriptional responses to intermittent hypoxia
2008 StandoutNobel
Chronic intermittent hypoxia induces hypoxia‐evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress
2006
Facilitation of dopamine and acetylcholine release by intermittent hypoxia in PC12 cells: involvement of calcium and reactive oxygen species
2004
HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity
2007 StandoutNobel
Systemic, cellular and molecular analysis of chemoreflex‐mediated sympathoexcitation by chronic intermittent hypoxia
2006
Altered carotid body function by intermittent hypoxia in neonates and adults: Relevance to recurrent apneas
2007
Substance P and mitochondrial oxygen consumption: Evidence for a direct intracellular role for the peptide
1989
Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome
2015
Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS
2010
Role of oxidative stress in intermittent hypoxia‐induced immediate early gene activation in rat PC12 cells
2004
Peptidases of the peripheral chemoreceptors: biochemical, immunological, in vitro hydrolytic studies and electron microscopic analysis of neutral endopeptidase-like activity of the carotid body
1997
Oxidative stress in the systemic and cellular responses to intermittent hypoxia
2004
Peripheral Chemoreception and Arterial Pressure Responses to Intermittent Hypoxia
2015
NADPH Oxidase Is Required for the Sensory Plasticity of the Carotid Body by Chronic Intermittent Hypoxia
2009
Enhanced Neuropeptide Y Synthesis During Intermittent Hypoxia in the Rat Adrenal Medulla: Role of Reactive Oxygen Species–Dependent Alterations in Precursor Peptide Processing
2010
ROS Signaling in Systemic and Cellular Responses to Chronic Intermittent Hypoxia
2007 StandoutNobel
Sympatho-adrenal activation by chronic intermittent hypoxia
2012
Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long‐term intermittent hypoxia
2016 StandoutNobel
Endothelin-1 mediates attenuated carotid baroreceptor activity by intermittent hypoxia
2011
Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: Implications for recurrent apneas
2003