Citation Impact
Citing Papers
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
2003 StandoutNobel
The DNA-damage response in human biology and disease
2009 StandoutNature
Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues.
1990
Identification of a Human Homologue of theSchizosaccharomyces pombe rad17+ Checkpoint Gene
1998
Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family
1997
Cdc2 Phosphorylation of Crb2 Is Required for Reestablishing Cell Cycle Progression after the Damage Checkpoint
1999
Inflammation and cancer
2002 StandoutNature
Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p
1998
Circular chromosome formation in a fission yeast mutant defective in two ATM homologues
1998
Growth Dominance of the Metastatic Cancer Cell: Cellular and Molecular Aspects
1990
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
1995 StandoutNobel
The Molecular Biology of Leukocyte Chemoattractant Receptors
1994
Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
1997
S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe
1998
Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway
1997
The DNA Replication and Damage Checkpoint Pathways Induce Transcription by Inhibition of the Crt1 Repressor
1998
Meiotic DNA replication checkpoint control in fission yeast
1999 StandoutNobel
Reconstitution of an ATM-Dependent Checkpoint that Inhibits Chromosomal DNA Replication following DNA Damage
2000
Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint
1997
Genetic instabilities in human cancers
1998 StandoutNature
rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
1997
Isolation and characterization of kirsten murine sarcoma virus‐transformed mouse keratinocytes resistant to transforming growth factor beta
1990
A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins
1999
A role for ATR in the DNA damage-induced phosphorylation of p53
1999
Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2
1993
ATR: an essential regulator of genome integrity
2008
Involvement of chemokine receptors in breast cancer metastasis
2001 StandoutNature
Pre-meiotic S phase is linked to reductional chromosome segregation and recombination
2001 StandoutNatureNobel
Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1
1997
The Hallmarks of Cancer
2000 Standout
Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses
1998
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
1998
Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase
1998
IP-10, a γ-interferon-inducible protein related to interleukin-8, lacks neutrophil activating properties
1992
Checkpoint Pathways Come of Age
1997 StandoutNobel
Physical Interactions among Human Checkpoint Control Proteins HUS1p, RAD1p, and RAD9p, and Implications for the Regulation of Cell Cycle Progression
2000
A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome
2003
A Human Homologue of the Schizosaccharomyces pombe rad1+ Checkpoint Gene Encodes an Exonuclease
1998
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
2000
Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice
2003
Electron Crystal Structure of the Transcription Factor and DNA Repair Complex, Core TFIIH
2000 StandoutNobel
Human Monocyte Chemoattractant Protein-1 (MCP-1)
1991
Meiotic chromosomes: it takes two to tango
1997
Human and Mouse Homologs of theSchizosaccharomyces pombe rad17Cell Cycle Checkpoint Control Gene
1999
Mitotic DNA damage and replication checkpoints in yeast
1998
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.
1989 Standout
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint
2000
HIV as the cause of AIDS
1996 StandoutNobel
Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage
1998
Switching and Signaling at the Telomere
2001 StandoutNobel
Atherosclerosis — An Inflammatory Disease
1999 Standout
Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis
1993
Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage
1997
TOR signalling and control of cell growth
1997
DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts
2000 StandoutNobel
Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine β and γ proteins
1997
Differential gene expression in migrating renal epithelial cells after wounding
1995
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
Human monocyte chemoattractant protein-1 (MCP-1)
1990
A Human and Mouse Homolog of theSchizosaccharomyces pombe rad1+Cell Cycle Checkpoint Control Gene
1998
Cohesin Rec8 is required for reductional chromosome segregation at meiosis
1999 StandoutNatureNobel
The role of the DNA double-strand break response network in meiosis
2004
Structure of DNA-dependent protein kinase: implications for its regulation by DNA
1999
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
1993 StandoutNobel
Negative control elements of the cell cycle in human tumors
1998 StandoutNobel
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
Synaptonemal complex morphogenesis and sister-chromatid cohesion require Mek1-dependent phosphorylation of a meiotic chromosomal protein
1998
Checkpoints on the road to mitosis
1998
Human and mouse homologs ofSchizosaccharomyces pombe rad1+andSaccharomyces cerevisiae RAD17:linkage to checkpoint control and mammalian meiosis
1998
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK
1999
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
HRad17 Colocalizes with NHP2L1 in the Nucleolus and Redistributes after UV Irradiation
1999
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Crystal structure of interleukin 8: symbiosis of NMR and crystallography.
1991
Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I
1998
The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts
1998
A novel mutant allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints
2000 StandoutNobel
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
Comparison of the NMR solution structure and the x-ray crystal structure of rat metallothionein-2.
1992 StandoutNobel
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Chemokines
1997 Standout
DNA Damage and Replication Checkpoints in Fission Yeast Require Nuclear Exclusion of the Cdc25 Phosphatase via 14-3-3 Binding
1999
Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres
2006 StandoutNobel
Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8.
1991
The Platelet-derived Growth Factor-inducible KC Gene Encodes a Secretory Protein Related to Platelet α-Granule Proteins
1989
The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage
1997
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
2002 StandoutNobel
Molecular piracy of mammalian interleukin-8 receptor type B by herpesvirus saimiri.
1993
The Schizosaccharomyces pombe S-Phase Checkpoint Differentiates Between Different Types of DNA Damage
1998
Identification of three related human GRO genes encoding cytokine functions.
1990
Rfc4 Interacts with Rpa1 and Is Required for Both DNA Replication and DNA Damage Checkpoints in Saccharomyces cerevisiae
2001
Basis for the Checkpoint Signal Specificity That Regulates Chk1 and Cds1 Protein Kinases
1999
The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway
1997
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2
1997 StandoutNobel
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
1998 StandoutScience
Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities.
1991
Wound Healing--Aiming for Perfect Skin Regeneration
1997 StandoutScience
Loss of p 21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm -deficient mice
1997
Human Mig chemokine: biochemical and functional characterization.
1995
Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil-activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity.
1990
Telomere fusions caused by mutating the terminal region of telomeric DNA
2000 StandoutNobel
Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.
2003 StandoutNobel
New Biarsenical Ligands and Tetracysteine Motifs for Protein Labeling in Vitro and in Vivo: Synthesis and Biological Applications
2002 StandoutNobel
Identification of a phorbol ester-repressible v-src-inducible gene.
1989
Analysis of fission yeast DNA structure checkpoints:1996 Fleming Lecture
1998
Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1α (SDF-1α) and SDF-1β are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage
1998 StandoutNobel
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
1993 StandoutScienceNobel
Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines
1989
Cancer Genome Landscapes
2013 StandoutScience
Characterization of Schizosaccharomyces pombeHus1: a PCNA-Related Protein That Associates with Rad1 and Rad9
2000
ATM-dependent Phosphorylation of Human Rad9 Is Required for Ionizing Radiation-induced Checkpoint Activation
2001
Neutrophil-activating peptide 2 and gro/melanoma growth-stimulatory activity interact with neutrophil-activating peptide 1/interleukin 8 receptors on human neutrophils
1991
Brca2 is required for embryonic cellular proliferation in the mouse.
1997 StandoutNobel
Genomic Expression Responses to DNA-damaging Agents and the Regulatory Role of the Yeast ATR Homolog Mec1p
2001
Cdc25 Inhibited In Vivo and In Vitro by Checkpoint Kinases Cds1 and Chk1
1999
ATR and ATRIP: Partners in Checkpoint Signaling
2001 Science
The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint.
1998
Rad53 FHA Domain Associated with Phosphorylated Rad9 in the DNA Damage Checkpoint
1998 Science
Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage
1998 StandoutScience
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
Neutrophil-activating properties of the melanoma growth-stimulatory activity.
1990
Importance of the amino terminus of the interleukin-8 receptor in ligand interactions.
1993
The interleukin-8-related chemotactic cytokines GRO alpha, GRO beta, and GRO gamma activate human neutrophil and basophil leukocytes
1993
Chemokines
1997
Variability of human immunodeficiency virus type 1 group O strains isolated from Cameroonian patients living in France
1995
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory Activity
1990
HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene
1998
RAD1,a Human Structural Homolog of theSchizosaccharomyces pombe RAD1Cell Cycle Checkpoint Gene
1998
Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase
1997 Science
Suppression of tumor formation in vivo by expression of the JE gene in malignant cells.
1991
ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart
1997
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Works of Gail Flaggs being referenced
Atm-dependent interactions of a mammalian Chk1 homolog with meiotic chromosomes
1997
Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest
1998
Molecular Characterization of HIV-1 Isolated from a Serum Collected in 1976: Nucleotide Sequence Comparison to Recent Isolates and Generation of Hybrid HIV
1989
The Schizosaccharomyces pombe rad3 checkpoint gene.
1996
Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.
1988 Nobel
The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.
1996