Citation Impact
Citing Papers
Suppression of Skeletal Muscle Turnover in Cancer Cachexia: Evidence from the Transcriptome in Sequential Human Muscle Biopsies
2012
In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker
2003 StandoutNobel
Thymocyte K<sup>+</sup>, Na<sup>+</sup> and Water Balance During Dexamethasone- and Etoposide-Induced Apoptosis
2005
Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome
2013
Interaction of Hydroxylated Collagen IV with the von Hippel-Lindau Tumor Suppressor
2007 StandoutNobel
Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)
2016
Lysosomes in iron metabolism, ageing and apoptosis
2008
Expression of the ubiquitin-proteasome pathway and muscle loss in experimental cancer cachexia
2005
Why do cancers have high aerobic glycolysis?
2004 Standout
Down-Regulation of Na+/K+ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
2013 Standout
Omics/systems biology and cancer cachexia
2016
The Role of PPAR Ligands in Controlling Growth‐Related Gene Expression and their Interaction with Lipoperoxidation Products
2008
Molecular pathways leading to loss of skeletal muscle mass in cancer cachexia – can findings from animal models be translated to humans?
2016
International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels
2005 StandoutNobel
Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon‐26 adenocarcinoma
2004
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
2009 Standout
Interleukin‐15 is able to suppress the increased DNA fragmentation associated with muscle wasting in tumour‐bearing rats
2004
Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions
2013 StandoutNature
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
2003 StandoutNobel
Calcium's Role in Mechanotransduction during Muscle Development
2014 Standout
Intracellular trafficking and degradation of unassociated proα2 chains of collagen type I
2004
4-Hydroxynonenal and PPARγ ligands affect proliferation, differentiation, and apoptosis in colon cancer cells
2007
The Influence of Macromolecular Crowding and Macromolecular Confinement on Biochemical Reactions in Physiological Media
2001 Standout
Physiology of Cell Volume Regulation in Vertebrates
2009
Prevention and treatment of cancer cachexia: New insights into an old problem
2005
Autophagy as a cell death and tumor suppressor mechanism
2004 Standout
Cancer drug resistance: an evolving paradigm
2013 Standout
IGF-1 Modulates N and L Calcium Channels in a PI 3-Kinase-Dependent Manner
1997
Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation
2002
The biology and function of fibroblasts in cancer
2016 Standout
4‐Hydroxynonenal: A membrane lipid oxidation product of medicinal interest
2007
Indomethacin preserves muscle mass and reduces levels of E3 ligases and TNF receptor type 1 in the gastrocnemius muscle of tumor‐bearing mice
2004
Cellular survival: a play in three Akts
1999 Standout
Celastrols as Inducers of the Heat Shock Response and Cytoprotection
2004 Standout
The pivotal role of cytokines in muscle wasting during cancer
2005
Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells
2008
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Ubiquitin Ligase Activity of TFIIH and the Transcriptional Response to DNA Damage
2005 StandoutNobel
Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”
2010 Standout
Mechanisms of skeletal muscle depletion in wasting syndromes: role of ATP-ubiquitin-dependent proteolysis
2003
Lysosomes in cell death
2004
Cancer-associated cachexia
2018 Standout
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 Standout
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
Understanding and Managing Cancer Cachexia
2003
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
2000 Standout
Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
2014 Nature
Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth
2014
Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia
2015
Induction of autophagy and inhibition of tumorigenesis by beclin 1
1999 StandoutNature
STAT3 in the systemic inflammation of cancer cachexia
2016
Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death
2008
Complex mutual regulation of facilitates chromatin transcription (FACT) subunits on both mRNA and protein levels in human cells
2013
Growth inhibition and differentiation induction in murine erythroleukemia cells by 4-hydroxynonenal
2001
Disrupted Skeletal Muscle Mitochondrial Dynamics, Mitophagy, and Biogenesis during Cancer Cachexia: A Role for Inflammation
2017
Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
2013 Standout
Role of Intracellular pH in Proliferation, Transformation, and Apoptosis
1997
Autophagic proteolysis: control and specificity
1997
Role of Activin A and Myostatin in Human Cancer Cachexia
2015
Sarcopenia
2019 Standout
Testis-specific HMG-domain protein alters the responses of cells to cisplatin
2002
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
4-hydroxynonenal and regulation of cell cycle: effects on the pRb/E2F pathway
2004
Waste management—Cytokines, growth factors and cachexia
2006
Cathepsin D—Many functions of one aspartic protease
2008
Increased expression of proteasome subunits in skeletal muscle of cancer patients with weight loss
2004
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
Regulation of protein degradation in normal and transformed human bronchial epithelial cells in culture
1992
Role of TNF receptor 1 in protein turnover during cancer cachexia using gene knockout mice
1998
Gefitinib (?Iressa?, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells
2004
Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
2017
4-Hydroxynonenal affects pRb/E2F pathway in HL-60 human leukemic cells
2002
Cancer cachexia: A systematic literature review of items and domains associated with involuntary weight loss in cancer
2011
Determination of the lipid peroxidation product trans-4-hydroxy-2-nonenal in biological samples by high-performance liquid chromatography and combined capillary column gas chromatography—negative-ion chemical ionisation mass spectrometry
1989
Inflammatory burden and amino acid metabolism in cancer cachexia
2008
Autophagy in cell death: an innocent convict?
2005 Standout
Ubiquitin gene expression is increased in skeletal muscle of tumour‐bearing rats
1994
Cisplatin-induced apoptosis of mesothelioma cells is affected by potassium ion flux modulator amphotericin B and bumetanide
2001
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis
2016
Autophagy: process and function
2007 Standout
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
2016 StandoutNobel
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival
2010
Interaction of aldehydes derived from lipid peroxidation and membrane proteins
2013
Adaptation of the ubiquitin-proteasome proteolytic pathway in cancer cachexia
1999
The role of the ubiquitin/proteasome system in cellular responses to radiation
2003
Protein breakdown in cancer cachexia
2015
Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins
2013 StandoutNobel
Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells
2005
Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways
2012
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
Inhibition of D1, D2, and a cyclin expression in HL-60 cells by the lipid peroxydation product 4-hydroxynonenal
1999
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
1991 Standout
Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy
2004
Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance
2003 Standout
Habitual Myofibrillar Protein Synthesis Is Normal in Patients with Upper GI Cancer Cachexia
2014
The Free Radical Theory of Aging Matures
1998 Standout
New strategies to overcome cancer cachexia: from molecular mechanisms to the 'Parallel Pathway'
2008
Advanced Glycation End Products
2006 Standout
Apoptosis: A Review of Programmed Cell Death
2007 Standout
Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.
1994
NF-κB–mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia
2013
The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer
2010
New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
2009 Standout
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
2003 StandoutNobel
Apg9p/Cvt7p Is an Integral Membrane Protein Required for Transport Vesicle Formation in the Cvt and Autophagy Pathways
2000 StandoutNobel
Lipid Peroxidation and Cancer: A Critical Reconsideration
1989
Fluorescent Sensors for Measuring Metal Ions in Living Systems
2014 Standout
The pathogenesis and treatment of cardiac atrophy in cancer cachexia
2015
Valproic acid attenuates skeletal muscle wasting by inhibiting C/EBPβ-regulated atrogin1 expression in cancer cachexia
2016
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Effects of systemic inhibition of prostaglandin production on protein metabolism in tumor-bearing rats
1989
Quantitative changes in the lysosomal vacuolar system of rat hepatocytes during short-term starvation
1986
Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia
2013
Anticachectic Effects of Formoterol
2004
Cancer Cachexia in the Age of Obesity: Skeletal Muscle Depletion Is a Powerful Prognostic Factor, Independent of Body Mass Index
2013 Standout
T cell exclusion, immune privilege, and the tumor microenvironment
2015 StandoutScience
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal
2014 Standout
Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma
1995
Signaling mechanism of tumor cell‐induced up‐regulation of E3 ubiquitin ligase UBR2
2013
Intracellular protein degradation.
1990
Sarcopenia: European consensus on definition and diagnosis
2010 Standout
Functional Significance of Cell Volume Regulatory Mechanisms
1998 Standout
Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes
1996
4-Hydroxy-alkenals interaction with purified microtubular protein
1985
Nutritional State and the Swelling-Induced Inhibition of Proteolysis in Perfused Rat Liver
1996
Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy
2012
Akt-Dependent Potentiation of L Channels by Insulin-Like Growth Factor-1 Is Required for Neuronal Survival
1999
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Gabriella Bonelli being referenced
Protein turnover states of tumour cells and host tissues in an experimental model.
1986
Intracellular free iron and acidic pathways mediate TNF-induced death of rat hepatoma cells
2005
ANTICYTOKINE TREATMENT PREVENTS THE INCREASE IN THE ACTIVITY OF ATP-UBIQUITIN- AND CA2+-DEPENDENT PROTEOLYTIC SYSTEMS IN THE MUSCLE OF TUMOUR-BEARING RATS
2002
Effects of simvastatin administration in an experimental model of cancer cachexia
2003
Decreased expression of the high-mobility group protein T160 by antisense RNA impairs the growth of mouse fibroblasts
1997
Effect of two aliphatic aldehydes, methylglyoxal and 4-hydroxypentenal, on the growth of Yoshida ascites hepatoma AH-130
1989
Muscle myostatin signalling is enhanced in experimental cancer cachexia
2008
Deacetylase Inhibitors Modulate the Myostatin/Follistatin Axis without Improving Cachexia in Tumor-Bearing Mice
2009
Muscle Wasting and Impaired Myogenesis in Tumor Bearing Mice Are Prevented by ERK Inhibition
2010
Anti-cytokine strategies for the treatment of cancer-related anorexia and cachexia
2010
Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation
2005
Intracellular Ionic Variations in the Apoptotic Death of L Cells by Inhibitors of Cell Cycle Progression
1995
Autophagic Degradation Contributes to Muscle Wasting in Cancer Cachexia
2013
Increased Muscle Proteasome Activity Correlates With Disease Severity in Gastric Cancer Patients
2003
IGF-1 is downregulated in experimental cancer cachexia
2006
Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells
2012
Muscle atrophy in experimental cancer cachexia: Is the IGF‐1 signaling pathway involved?
2009
Differential targeting and processing of procathepsin D in normal and transformed murine 3T3 fibroblasts
1997
Effect of 4-hydroxynonenal on cell cycle progression and expression of differentiation-associated antigens in HL-60 cells
1996
Increase in Ceramide Level Alters the Lysosomal Targeting of Cathepsin D prior to Onset of Apoptosis in HT-29 Colon Cancer Cells
2002
Expression of protein kinase C ?1 confers resistance to TNF?- and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells
2001
Effect of methylglyoxal on tumour microtubular protein
1985
Control of cell protein catabolism in rat liver. Effects of starvation and administration of cycloheximide
1982
Aliphatic aldehydes inhibit the proliferative response of human peripheral blood lymphocytes to phytohemagglutinin and alloantigens
1987
Two currents activated by epidermal growth factor in EGFR-T17 fibroblasts
1992
Regulation of lysosomal cysteine-proteinase activities in 3T3 and SV-3T3 cells*
1986
Inhibition of colchicine binding to rat liver tubulin by aldehydes and by linoleic acid hydroperoxide
1977
Regulation of protein turnover versus growth state. Studies on the mechanism(s) of initiation of acidic vacuolar proteolysis in cells of stationary ascites hepatoma
1988
Regulation of protein turnover versus growth state
1988
Early development of protein metabolic perturbations in the liver and skeletal muscle of tumour-bearing rats. A model system for cancer cachexia
1987
Endosomal-Lysosomal Proteolysis Mediates Death Signalling by TNFα, Not by Etoposide, in L929 Fibrosarcoma Cells: Evidence for an Active Role of Cathepsin D
2002
Regulation of protein turnover versus growth state. III. Growth cessation is associated with activation of autophagy in Yoshida ascites hepatoma AH-340.
1988