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Citing Papers
Tumor imaging by means of proteolytic activation of cell-penetrating peptides
2004 StandoutNobel
Interactions of thrombospondin with endothelial cells: receptor-mediated binding and degradation.
1987
Role of thrombospondin in mesangial cell growth: Possible existence of an autocrine feedback growth circuit
1994
Thrombospondins: structure and regulation of expression
1992
Matrix metalloproteinases and their inhibitors in connective tissue remodeling
1991 Standout
Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development
1997
Cutaneous Wound Healing
1999 Standout
Completion of the primary structure of the human type IV collagenase preproenzyme and assignment of the gene (CLG4) to the q21 region of chromosome 16
1990
Phosphorylation of Cell Surface Receptors: A Mechanism for Regulating Signal Transduction Pathways
1988 StandoutNobel
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
1998 StandoutNature
Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds.
1994
Thrombospondins
1991
Zinc coordination, function, and structure of zinc enzymes and other proteins
1990
Regulation of Collagenase Gene Expression in Synovial Fibroblastsa
1990
Gelatin Zymography and Substrate Cleavage Assays of Matrix Metalloproteinase-2 in Breast Carcinoma Cells Overexpressing Membrane Type-1 Matrix Metalloproteinase
2002
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
1996 Standout
Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis
2000 StandoutNature
Thrombospondin mediates migration and potentiates platelet‐derived growth factor‐dependent migration of calf pulmonary artery smooth muscle cells
1993 StandoutNobel
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
2004 StandoutNature
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas
1990 Nature
Periluminal Distribution of HIV-Binding Target Cells and Gp340 in the Oral, Cervical and Sigmoid/Rectal Mucosae: A Mapping Study
2015 StandoutNobel
Crystallization and preliminary X-ray analysis of porcine synovial collagenase
1989
Thrombospondin-induced adhesion of human keratinocytes.
1988
Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts
1990
Distinct Populations of Stromal Cells Express Collagenase-3 (MMP-13) and Collagenase-1 (MMP-1) in Chronic Ulcers but Not in Normally Healing Wounds
1997
From tadpole collagenase to a family of matrix metalloproteinases
1988
Thrombospondin as a regulator of angiogenesis
1997
Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members
1989
Signal transduction by receptors with tyrosine kinase activity
1990 Standout
Protease inhibitors: Role and potential therapeutic use in human cancer
1994
Thrombospondin II: Partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans
1992
The Hallmarks of Cancer
2000 Standout
Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
1992 StandoutNature
Metalloproteinases and their inhibitors in matrix remodeling
1990
Role of the N-terminal Catalytic Domain of Angiotensin-converting Enzyme Investigated by Targeted Inactivation in Mice
2004 StandoutNobel
A role for the Drosophila neurogenic genes in mesoderm differentiation
1991 StandoutNobel
Synthesis of truncated amino-terminal trimers of thrombospondin
1991
Specific inhibition of endothelial cell proliferation by thrombospondin
1990
Molecular Mass, Stoichiometry, and Assembly of 20 S Particles
2001 StandoutNobel
The microenvironment of the tumour–host interface
2001 StandoutNature
Growth factors, proteases and protease inhibitors in the maternal—fetaldialogue
1996
Neutrophil thrombospondin receptors are linked to GTP-binding proteins
1996 StandoutNobel
Distinct localization of collagenase and tissue inhibitor of metalloproteinases expression in wound healing associated with ulcerative pyogenic granuloma.
1992
Mechanisms of Matrix Degradation in Rheumatoid Arthritisa
1990
Male–female differences in fertility and blood pressure in ACE-deficient mice
1995 StandoutNatureNobel
Collagens—structure, function, and biosynthesis
2003 Standout
Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development.
1990
Degradative processes of connective tissue proteins with special emphasis on collagenolysis and bone resorption
1988
The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases
1995
Differential Stromal Regulation of MMP-1 Expression in Benign and Malignant Keratinocytes
2001
Type IV collagenases in invasive tumors
1993
Proteolytic activities of human fibroblast collagenase: hydrolysis of a broad range of substrates at a single active site
1990
A matrix metalloproteinase expressed on the surface of invasive tumour cells
1994 StandoutNature
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
1997 StandoutNature
Chinese hamster ovary cell adhesion to human platelet thrombospondin is dependent on cell surface heparan sulfate proteoglycan.
1989
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
1996 StandoutNature
A unique signature identifies a family of zinc‐dependent metallopeptidases
1989
Changing views of the role of matrix metalloproteinases in metastasis
1997
Angiogenesis as a therapeutic target
2005 StandoutNature
Sequence specificity of human skin fibroblast collagenase. Evidence for the role of collagen structure in determining the collagenase cleavage site.
1987
The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.
1986
Matrix Metalloproteinases: Biologic Activity and Clinical Implications
2000
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
1985 StandoutNature
Polymerase Chain Reaction Selects a Novel Disintegrin Proteinase from CD40-Activated Germinal Center Dendritic Cells
1997
Cloning and characterization of human tumor cell interstitial collagenase.
1990
Fluorescent oligopeptide substrates for kinetic characterization of the specificity of Astacus protease
1990
Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: structure and proteolysis by tetanus toxin and botulinal neurotoxins type D and F.
1994 StandoutNobel
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Human Keratinocytes Synthesize and Secrete the Extracellular Matrix Protein, Thrombospondin
1987
The precursor of a metalloendopeptidase from human rheumatoid synovial fibroblasts. Purification and mechanisms of activation by endopeptidases and 4-aminophenylmercuric acetate
1988
An unusual active site identified in a family of zinc metalloendopeptidases.
1992
Autophosphorylation sites on the epidermal growth factor receptor
1984 Nature
Integrins: Versatility, modulation, and signaling in cell adhesion
1992 Standout
Fragments of human fibroblast collagenase. Purification and characterization
1989
Modulation of keratinocyte motility. Correlation with production of extracellular matrix molecules in response to growth promoting and antiproliferative factors.
1988
Structure of the human type IV collagenase gene.
1990
Genetic determinants of neoplastic transformation by the retroviral oncogene v-erbB.
1988 StandoutNobel
A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.
1986
Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors.
1988
Regulation of transmembrane signaling by receptor phosphorylation
1987 StandoutNobel
An endogenous substrate for the insulin receptor-associated tyrosine kinase.
1985
Purification and properties of a small latent matrix metalloproteinase of the rat uterus.
1988
Dynamin I is a Ca(2+)-sensitive phospholipid-binding protein with very high affinity for protein kinase C.
1994 StandoutNobel
Intracellular protein topogenesis
1980 StandoutNobel
The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc
1996 StandoutScience
The Mode of Action of Vitamin K
1974
Thrombospondin Promotes Cell-Substratum Adhesion
1987 Science
Nonphosphorylatable substrate analogs selectively block autophosphorylation and activation of the insulin receptor, epidermal growth factor receptor, and pp60 kinases
1989
Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity.
1985
Protein tyrosine kinase and protein phosphotyrosine phosphatase in normal and psoriatic skin
1984
Characterization of insulin-like growth factor I-stimulated tyrosine kinase activity associated with the beta-subunit of type I insulin-like growth factor receptors of rat liver cells.
1985
Self-phosphorylation enhances the protein-tyrosine kinase activity of the epidermal growth factor receptor.
1985
Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.
1985
The extracellular matrix geneFrem1is essential for the normal adhesion of the embryonic epidermis
2004 StandoutNobel
Purification of the major protein-tyrosine-phosphatases of human placenta.
1988 StandoutNobel
Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines.
1990
Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase
1995
Stable expression of truncated inositol 1,4,5-trisphosphate receptor subunits in 3T3 fibroblasts. Coordinate signaling changes and differential suppression of cell growth and transformation.
1994 StandoutNobel
Wound Healing--Aiming for Perfect Skin Regeneration
1997 StandoutScience
The structural and functional properties of thrombospondin
1986
Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin promote melanoma cell adhesion.
1992
SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages
1989
Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas
1994
A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases that degrades the connective tissue matrix
1987
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
1988 StandoutScience
Human carcinoma cells express receptors for distinct domains of thrombospondin.
1991
Multistage nanoparticle delivery system for deep penetration into tumor tissue
2011 StandoutNobel
Interaction of Human Rheumatoid Synovial Collagenase (Matrix Metalloproteinase 1) and Stromelysin (Matrix Metalloproteinase 3) with Human α2-Macroglobulin and Chicken Ovostatin
1989
A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.
1988
Inhibition of preprotein processing in ascites tumor lysates by incorporation of a leucine analog
1980
Angiotensin-converting enzyme and male fertility
1998 StandoutNobel
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
2002 StandoutScience
Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2.
1998
Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene
1985 StandoutScience
Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity
1993
Human Fibroblast Collagenase-α-Macroglobulin Interactions
1989
Comparison of human stromelysin and collagenase by cloning and sequence analysis
1986
Effects of antithrombospondin monoclonal antibodies on the agglutination of erythrocytes and fixed, activated platelets by purified thrombospondin
1985
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.
1988
Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase
1989
A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.
1990
Monoclonal antibodies that recognize calcium-dependent structures of human thrombospondin. Characterization and mapping of their epitopes.
1986
Thrombospondin-induced attachment and spreading of human squamous carcinoma cells
1986
Control of smooth muscle cell growth by components of the extracellular matrix: autocrine role for thrombospondin.
1986
Interaction of the NG2 chondroitin sulfate proteoglycan with type VI collagen.
1990
The collagenase gene family in humans consists of at least four members
1988
Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.
1990
The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.
1990
Platelet thrombospondin mediates attachment and spreading of human melanoma cells.
1987
H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.
1988
Requirement of Vascular Integrin α v β 3 for Angiogenesis
1994 StandoutScience
Matrix Metalloproteinases: A Review
1993 Standout
Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.
1989
Portion-mixing peptide libraries of quenched fluorogenic substrates for complete subsite mapping of endoprotease specificity.
1994 StandoutNobel
A monoclonal antibody against human thrombospondin inhibits platelet aggregation.
1985
Alteration of epidermal growth factor receptor activity by mutation of its primary carboxyl-terminal site of tyrosine self-phosphorylation.
1988
Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases.
1990
Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1
1994 StandoutScience
Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.
1990
Thrombospondin stimulates motility of human neutrophils.
1990 StandoutNobel
Molecular Biology of Fibronectin
1985
Thrombospondin binds to monocytes-macrophages and mediates platelet-monocyte adhesion.
1987
Characterization of the mouse thrombospondin gene and evaluation of the role of the first intron in human gene expression.
1990
New Perspectives in Cell Adhesion: RGD and Integrins
1987 StandoutScience
Tissue Inhibitor of Metalloproteinase (TIMP-2)
1989
Platelet-derived growth factor and heparin-like glycosaminoglycans regulate thrombospondin synthesis and deposition in the matrix by smooth muscle cells.
1985
Heparin-binding peptides from the type I repeats of thrombospondin. Structural requirements for heparin binding and promotion of melanoma cell adhesion and chemotaxis.
1992
Kinetic parameters of the protein tyrosine kinase activity of EGF-receptor mutants with individually altered autophosphorylation sites.
1988
Thrombospondin-induced tumor cell migration: haptotaxis and chemotaxis are mediated by different molecular domains.
1987
Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia
1992 StandoutScienceNobel
Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation
1988
Works of G.A. Grant being referenced
Epidemiology and clinical significance of cervical erosion in women attending a family planning clinic.
1978
Purification and properties of a gelatin-specific neutral protease from human skin.
1981
Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.
1986
Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin.
1984
D-3-Phosphoglycerate dehydrogenase from chicken liver. II. Chemical and physical properties.
1978
Interaction of epidermal growth factor-dependent protein kinase with endogenous membrane proteins and soluble peptide substrate.
1983
Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2
1993
Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing.
1985
A rat liver protein with potential thrombin activity: Properties and partial purification
1973
The activation of human skin fibroblast procollagenase. Sequence identification of the major conversion products.
1987