Citation Impact
Citing Papers
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease
2010 StandoutScience
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
2010 StandoutScience
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
2005 StandoutNobel
The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist
2008 StandoutScience
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Sleep Drives Metabolite Clearance from the Adult Brain
2013 StandoutScience
(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic Acid, a Potent and Selective Agonist at the GluR5 Subtype of Ionotropic Glutamate Receptors. Synthesis, Modeling, and Molecular Pharmacology
2003
A Double-Blind, Placebo-Controlled Study of Memantine in the Treatment of Major Depression
2006
A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression
2006 Standout
Ionotropic and metabotropic glutamate receptor structure and pharmacology
2005
Antidepressant effects of ketamine in depressed patients
2000 Standout
Efficacy of the NMDA-receptor antagonist memantine in patients with chronic phantom limb pain – results of a randomized double-blinded, placebo-controlled trial
2003
Glutamate antagonists and Parkinson's disease: A review of clinical data
1997
Glutamate receptor ion channels
2005 Standout
Glutamate and Depression
2003
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
2010 Standout
Breast cancer expresses functional NMDA receptors
2009
Amyloid beta peptides and glutamatergic synaptic dysregulation
2007
NMDA receptors in clinical neurology: excitatory times ahead
2008
Memantine in Moderate-to-Severe Alzheimer's Disease
2003 Standout
Neuroprotective potential of ionotropic glutamate receptor antagonists
2002
Characterization of the binding of two novel glycine site antagonists to cloned NMDA receptors: evidence for two pharmacological classes of antagonists
2000
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia
2005 Nature
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
2006
20-Oxo-5β-Pregnan-3α-yl Sulfate Is a Use-Dependent NMDA Receptor Inhibitor
2005
Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain
1998
Pretraining and the Function of Hippocampal Long-Term Potentiation
2000 StandoutNobel
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
2011 StandoutNature
β-Amyloid-Stimulated Microglia Induce Neuron Death via Synergistic Stimulation of Tumor Necrosis Factor α and NMDA Receptors
2005
Discovery of (−)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone—A potent NR2B-selective N-methyl d-aspartate (NMDA) antagonist for the treatment of pain
2007
Structural determinants of the blocker binding site in glutamate and NMDA receptor channels
1998
Catalysis for fluorination and trifluoromethylation
2011 StandoutNature
Subunit- and site-specific pharmacology of the NMDA receptor channel
1999
Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist
2001
Decoding ALS: from genes to mechanism
2016 StandoutNature
The chemical biology of clinically tolerated NMDA receptor antagonists
2006
Frequency of gamma oscillations routes flow of information in the hippocampus
2009 StandoutNatureNobel
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
2011 StandoutNature
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Amantadine Inhibits NMDA Receptors by Accelerating Channel Closure during Channel Block
2005
Dose escalating safety study of CNS 5161 HCl, a new neuronal glutamate receptor antagonist (NMDA) for the treatment of neuropathic pain
2007
Memantine binding to a superficial site on NMDA receptors contributes to partial trapping
2009
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer?s disease
2004
Rethinking schizophrenia
2010 StandoutNature
Effects of NMDA receptor antagonists on olfactory learning and memory in the honeybee (Apis mellifera)
2003
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
2012 Standout
An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder
2008
How were new medicines discovered?
2011 Standout
Novel pharmacological targets for the treatment of Parkinson's disease
2006
NMDA receptor antagonists as analgesics: focus on the NR2B subtype
2001
The history of the pharmacology and cloning of ionotropic glutamate receptors and the development of idiosyncratic nomenclature
2008
Determinants of trapping block of N‐methyl‐d ‐aspartate receptor channels
2003
Distribution of an NMDA receptor:GFP fusion protein in sensory neurons is altered by a C-terminal construct
2001
The Return of the Frequency Sweep: Designing Adiabatic Pulses for Contemporary NMR
2001
Alzheimer's Disease
2010 Standout
Memantine in Vascular Dementia
2003
Major Depressive Disorder
2008 Standout
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
2007 StandoutNatureNobel
Glutamate-based therapeutic approaches: NR2B receptor antagonists
2005
Comparative Studies of Anthraquinone- and Anthracene-Tetraamines as Blockers of N-Methyl-d-aspartate Receptors
2006
Interaction of memantine and amantadine with agonist‐unbound NMDA‐receptor channels in acutely isolated rat hippocampal neurons
1998
Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
2013 Standout
Two Blocking Sites of Amino-Adamantane Derivatives in Open N-Methyl-d-Aspartate Channels
1998
Insights into social insects from the genome of the honeybee Apis mellifera
2006 StandoutNature
Dynorphin displaces binding at the glycine site of the NMDA receptor in the rat striatum
2006
The NR2B-specific Interactions of Polyamines and Protons with theN-Methyl-d-aspartate Receptor
1997
Cross-talk between calcium and cAMP-dependent intracellular signaling pathways. Implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar cells.
1995 StandoutNobel
Allosteric modulation of NMDA receptor via elevation of brain glycine and d-serine: The therapeutic potentials for schizophrenia
2008
Memantine Treatment of Complex Regional Pain Syndrome
2007
Endogenous Activation of mGlu5 Metabotropic Glutamate Receptors Contributes to the Development of Nigro-Striatal Damage Induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice
2004
Alzheimer's Disease
2004 Standout
Can patients with chronic neuropathic pain be cured by acute administration of the NMDA receptor antagonist amantadine?
1998
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
2017 StandoutNobel
Molecular Rearrangements of the Extracellular Vestibule in NMDAR Channels during Gating
2002
System Xc−and Apolipoprotein E Expressed by Microglia Have Opposite Effects on the Neurotoxicity of Amyloid-β Peptide 1–40
2006
The Structure of a Mixed GluR2 Ligand-binding Core Dimer in Complex with (S)-Glutamate and the Antagonist (S)-NS1209
2006
Antidepressant-like effects of 1-aminocyclopropanecarboxylic acid and d-cycloserine in an animal model of depression
1996
Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia
2004
The molecular neurobiology of depression
2008 StandoutNature
Modeling of the Pore Domain of the GLUR1 Channel: Homology with K+ Channel and Binding of Channel Blockers
2002
Memantine in severe dementia: results of the9M-best study (benefit and efficacy in severly demented patients during treatment with memantine)
1999
The role of dextromethorphan in pain control
2000
Memantine Blocks α7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons
2005
Memantine Treatment in Patients With Moderate to Severe Alzheimer Disease Already Receiving Donepezil
2004
The NMDA receptor antagonist amantadine reduces surgical neuropathic pain in cancer patients: a double blind, randomized, placebo controlled trial
1998
Specific Functional Effects of Memantine Treatment in Patients with Moderate to Severe Alzheimer’s Disease
2004
Antagonist properties of eliprodil and other NMDA receptor antagonists at rat NR1A/NR2A and NR1A/NR2B receptors expressed in Xenopus oocytes
1997
Pharmacological Implications of Two Distinct Mechanisms of Interaction of Memantine with N-Methyl-d-aspartate-Gated Channels
2005
Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects
2003
Catalytic Asymmetric Additions of Enol Silanes to In Situ Generated Cyclic, AliphaticN‐Acyliminium Ions
2021 StandoutNobel
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
2005
Structural Modifications to anN-Methyl-d-aspartate Receptor Antagonist Result in Large Differences in Trapping Block
2001
Catalytic Enantioselective Reissert-Type Reaction: Development and Application to the Synthesis of a Potent NMDA Receptor Antagonist (−)-L-689,560 Using a Solid-Supported Catalyst
2001
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons.
1988 StandoutNobel
Plasma Cortisol and Progression of Dementia in Subjects With Alzheimer-Type Dementia
2006
Memantine for dementia
2006
NR2B subtype-selective NMDA receptor antagonists: 2001 – 2004
2005
Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons.
1987 StandoutNobel
The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.
1990 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Neuroprotection in emerging psychotic disorders
2007
The Glutamate Receptor Ion Channels
1999 Standout
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Molecular Imaging with PET
2008
Solid-Phase Synthesis of Polyamine Toxin Analogues: Potent and Selective Antagonists of Ca2+-Permeable AMPA Receptors
2002
Structural modifications to an N-methyl-D-aspartate receptor antagonist result in large differences in trapping block.
2001
Bioisosteric Modifications of 2-Arylureidobenzoic Acids: Selective Noncompetitive Antagonists for the Homomeric Kainate Receptor Subtype GluR5
2004
Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels.
1987 StandoutNobel
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
2011 StandoutNobel
Identification of a New Endogenous Metabolite and the Characterization of Its Protein Interactions through an Immobilization Approach
2008 StandoutNobel
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.
1990 Standout
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Spin-Transfer Pathways in Paramagnetic Lithium Transition-Metal Phosphates from Combined Broadband Isotropic Solid-State MAS NMR Spectroscopy and DFT Calculations
2012 StandoutNobel
2-Arylureidobenzoic Acids: Selective Noncompetitive Antagonists for the Homomeric Kainate Receptor Subtype GluR5
2003
Electrochemical synthesis of methyl-3,5,7-trifluoroadamantane-1-carboxylate under recycling use of ionic liquid media
2012
The glutamate receptor ion channels.
1999
N-Hydroxypyrazolyl Glycine Derivatives as SelectiveN-Methyl-d -aspartic Acid Receptor Ligands
2008
Competitive Antagonism of AMPA Receptors by Ligands of Different Classes: Crystal Structure of ATPO Bound to the GluR2 Ligand-Binding Core, in Comparison with DNQX
2002
Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease
1998
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
2000 Standout
Differences in Degree of Trapping of Low-Affinity Uncompetitive N-Methyl-d-aspartic Acid Receptor Antagonists with Similar Kinetics of Block
1999
Trapping Channel Block of NMDA-Activated Responses By Amantadine and Memantine
1997
Computational design of a red fluorophore ligase for site-specific protein labeling in living cells
2014 StandoutNobel
Works of G. Quack being referenced
Novel Systemically Active Antagonists of the Glycine Site of the N-Methyl-d-aspartate Receptor: Electrophysiological, Biochemical and Behavioral Characterization
1997
Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo
1995
Memantine and the amino-alkyl-cyclohexane MRZ 2/579 are moderate affinity uncompetitive NMDA receptor antagonists - in vitro characterisation
2000
Are NMDA antagonistic properties relevant for antiparkinsonianlike activity in rats?—Case of amantadine and memantine
1994
Neuroprotection by memantine against neurodegeneration induced by β-amyloid(1–40)
2002
Neuroprotective and symptomatological action of memantine relevant for alzheimer’s disease — a unified glutamatergic hypothesis on the mechanism of action
2000
Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data
1999
PET studies of 18 F-memantine in healthy volunteers
2002
Amino-alkyl-cyclohexanes are novel uncompetitive NMDA receptor antagonists with strong voltage-dependency and fast blocking kinetics: in vitro and in vivo characterization
1999
Cerebrospinal fluid and serum concentrations of the N-methyl-d-aspartate (NMDA) receptor antagonist memantine in man
1995
Potential Antidepressive Properties of Amantadine, Memantine and Bifemelane
1993
Infusion of (+)-MK-801 and memantine — contrasting effects on radial maze learning in rats with entorhinal cortex lesion
1996
Modulation of NMDA receptors by glycine ? introduction to some basic aspects and recent developments
1998
Therapeutic brain concentration of the NMDA receptor antagonist amantadine
1995
Glutamate in CNS disorders as a target for drug development: an update
1998
Co-administration of memantine and amantadine with sub/suprathreshold doses of L-Dopa restores motor behaviour of MPTP-treated mice
2001
NMDA channel blockers: memantine and amino-aklylcyclohexanes - In vivo characterization
2000
Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization.
1997
Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents — preclinical studies
1997
Proton Resonance Spectroscopy Study of the Effects of L-Ornithine-L-Aspartate on the Development of Encephalopathy, Using Localization Pulses with Reduced Specific Absorption Rate
1994