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Citing Papers
Improved method for preparation of ubiquitin‐ligated lysozyme as substrate of ATP‐dependent proteolysis
1991
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
Multiubiquitin Chain Binding and Protein Degradation Are Mediated by Distinct Domains within the 26 S Proteasome Subunit Mcb1
1998
Mapping Subunit Contacts in the Regulatory Complex of the 26 S Proteasome
2000
Interaction of hHR23 with S5a
1999
The ATP-dependent HslVU protease from Escherichia coli is a four-ring structure resembling the proteasome
1997
Regulated import and degradation of a cytosolic protein in the yeast vacuole
1991 StandoutNatureNobel
Identification, Purification, and Characterization of a PA700-dependent Activator of the Proteasome
1996
The mechanism and functions of ATP‐dependent proteases in bacterial and animal cells
1992
S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase
1993 Nature
CeMyoD accumulation defines the body wall muscle cell fate during C. elegans embryogenesis
1990 StandoutNobel
Ubiquitinylation and Ubiquitin-dependent Proteolysis in Vertebrate Photoreceptors (Rod Outer Segments)
1996
The multicatalytic proteinase complex, a major extralysosomal proteolytic system
1990
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Specific Interactions between ATPase Subunits of the 26 S Protease
1997
Regulation of enzyme levels by proteolysis: The role of pest regions
1988
Amyloid β-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro
1995
Getting in and out of the proteasome
2000
Structural and Functional Characterizations of the Proteasome-activating Protein PA26 from Trypanosoma brucei
1999
Characterization of Recombinant REGα, REGβ, and REGγ Proteasome Activators
1997
HEC Binds to the Seventh Regulatory Subunit of the 26 S Proteasome and Modulates the Proteolysis of Mitotic Cyclins
1997
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
The ubiquitin pathway for protein degradation
1991 StandoutNobel
CYP2E1 Degradation by in Vitro Reconstituted Systems: Role of the Molecular Chaperone hsp90
2000
The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes
1999
Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination
1992 Nature
Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes
1995 StandoutNobel
In vivo degradation of a transcriptional regulator: The yeast α2 repressor
1990
Homology in Structural Organization BetweenE. coliClpAP Protease and the Eukaryotic 26 S Proteasome
1995
Activity and Regulation of the Centrosome-associated Proteasome
2000
An Archaebacterial ATPase, Homologous to ATPases in the Eukaryotic 26 S Proteasome, Activates Protein Breakdown by 20 S Proteasomes
1999
Nob1p, a new essential protein, associates with the 26S proteasome of growing Saccharomyces cerevisiae cells
2000
Subunits of the regulatory complex of the 26S protease
1995
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
Degradation of 3-Hydroxy-3-methylglutaryl-CoA Reductase in Endoplasmic Reticulum Membranes Is Accelerated as a Result of Increased Susceptibility to Proteolysis
1996 StandoutNobel
Lessons from the discovery ofthe ubiquitin system
1996 StandoutNobel
Inhibition of Ubiquitin-mediated Proteolysis by the Arabidopsis 26 S Protease Subunit S5a
1995
Protein degradation and protection against misfolded or damaged proteins
2003 StandoutNature
Antigen processing by the proteasome
2001
cDNA Cloning, Expression, and Functional Characterization of PI31, a Proline-rich Inhibitor of the Proteasome
2000
Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine
1995 StandoutNatureNobel
Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome
1998
The ATPase activity of purified CDC48p from Saccharomyces cerevisiae shows complex dependence on ATP-, ADP-, and NADH-concentrations and is completely inhibited by NEM
1995
Structural and functional effects of PA700 and modulator protein on proteasomes 1 1Edited by W. Baumeister
1997
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
1997 StandoutNobel
Production of a Specific Major Histocompatibility Complex Class I-restricted Epitope by Ubiquitin-dependent Degradation of Modified Ovalbumin in Lymphocyte Lysate
1997
The Logic of the 26S Proteasome
2017
Sequence analysis of the AAA protein family
1997
Developmental Changes of the 26 S Proteasome in Abdominal Intersegmental Muscles of Manduca sexta during Programmed Cell Death
1995
Enzymes Catalyzing Ubiquitination and Proteolytic Processing of the p105 Precursor of Nuclear Factor κB1
1998
Novel Multiubiquitin Chain Linkages Catalyzed by the Conjugating Enzymes E2EPF and RAD6 Are Recognized by 26 S Proteasome Subunit 5
1996
Ump1p Is Required for Proper Maturation of the 20S Proteasome and Becomes Its Substrate upon Completion of the Assembly
1998
The Human Papillomavirus E7 Oncoprotein Functionally Interacts with the S4 Subunit of the 26 S Proteasome
1997
Recognition of the polyubiquitin proteolytic signal
2000
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
1994 StandoutNobel
Proteasomes: protein degradation machines of the cell
1994
The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases
2014
Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit
1993 Nature
Hybrid Proteasomes
2000
Structural and Functional Characterization of Interaction between Hepatitis B Virus X Protein and the Proteasome Complex
2000
Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental β2m-Dependent Interactions with the Maternal Immune System
2002 StandoutNobel
Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4
2001
Structural basis for the activation of 20S proteasomes by 11S regulators
2000 Nature
Proteolysis, proteasomes and antigen presentation
1992 Nature
The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
1994 Standout
A role for the proteasome regulator PA28α in antigen presentation
1996 Nature
Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase
1998
Specificity of the Ubiquitin Isopeptidase in the PA700 Regulatory Complex of 26 S Proteasomes
1997
Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28
2000
Recognition of Misfolding Proteins by PA700, the Regulatory Subcomplex of the 26 S Proteasome
2000
HIV-1 Tat Inhibits the 20 S Proteasome and Its 11 S Regulator-mediated Activation
1997
Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands
1996
NF-κB p105 Processing via the Ubiquitin-Proteasome Pathway
1998
Regulating protein degradation by ubiquitination
1997
26 S Proteasome-mediated Production of an Authentic Major Histocompatibility Class I-restricted Epitope from an Intact Protein Substrate
1999
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Cut2 proteolysis required for sister-chromatid separation in fission yeast
1996 StandoutNatureNobel
A gradient of bicoid protein in Drosophila embryos
1988 StandoutNobel
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3
1998
Peptide antigen production by the proteasome: complexity provides efficiency
1996
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
The ubiquitin system
2000 StandoutNobel
Characterization of Two Polyubiquitin Binding Sites in the 26 S Protease Subunit 5a
1998
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Ubiquitin-Mediated Pathways for Intracellular Proteolysis
1987
The proteasome activator 11 S REG (PA28) and Class I antigen presentation
1999
Arabidopsis MBP1 gene encodes a conserved ubiquitin recognition component of the 26S proteasome.
1996
The Regulatory Complex of Drosophila melanogaster 26s Proteasomes
2000
Degradation of Ornithine Decarboxylase in Reticulocyte Lysate Is ATP-dependent but Ubiquitin-independent
1989 StandoutNobel
Degradation of nuclear oncoproteins by the ubiquitin system in vitro.
1991 StandoutNobel
Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis
1986 StandoutScience
Natural substrates of the Ubiquitin proteolytic pathway
1991
PEST sequences and regulation by proteolysis
1996
The multicatalytic and 26 S proteases.
1993
Degradation of Proteins with Acetylated Amino Termini by the Ubiquitin System
1989 StandoutScienceNobel
Role of arginine-tRNA in protein degradation by the ubiquitin pathway
1987 StandoutNatureNobel
The Regulatory Particle of the Saccharomyces cerevisiae Proteasome
1998
Post-translational addition of an arginine moiety to acidic NH2 termini of proteins is required for their recognition by ubiquitin-protein ligase.
1990 StandoutNobel
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
1999 Standout
Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme.
1991
Skeletal muscle proteasome can degrade proteins in an ATP-dependent process that does not require ubiquitin.
1989
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.
1990
Ubiquitin C-terminal hydrolase activity associated with the 26 S protease complex.
1993 StandoutNobel
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
1995 StandoutNobel
Dynamic Association of Proteasomal Machinery with the Centrosome
1999
Potential Immunocompetence of Proteolytic Fragments Produced by Proteasomes before Evolution of the Vertebrate Immune System
1997 StandoutNobel
N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion.
1994 StandoutNobel
Skeletal muscle and liver contain a soluble ATP + ubiquitin-dependent proteolytic system
1987
Synthesis and characterization of ubiquitin ethyl ester, a new substrate for ubiquitin carboxyl-terminal hydrolase
1986
Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog
1987 StandoutNobel
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.
1995
Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins.
1990
Purification and characterization of a high molecular weight proteinase (macropain) from human erythrocytes
1986
Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.
1987 StandoutNobel
Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution
1995 ScienceNobel
An ATP-stabilized inhibitor of the proteasome is a component of the 1500-kDa ubiquitin conjugate-degrading complex.
1992
Site of catabolite inactivation
1994 StandoutNatureNobel
Levels of active ubiquitin carrier proteins decline during erythroid maturation.
1988
A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation.
1988 StandoutNobel
Involvement of the Molecular Chaperone Ydj1 in the Ubiquitin-Dependent Degradation of Short-Lived and Abnormal Proteins in Saccharomyces cerevisiae
1996
Proteasomes in the archaea: from structure to function
2000
Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm.
1994
Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates.
1987
The energy utilized in protein breakdown by the ATP-dependent protease (La) from Escherichia coli.
1987
Activation of the multicatalytic protease. The 11 S regulator and 20 S ATPase complexes contain distinct 30-kilodalton subunits
1994
UBIQUITIN-DEPENDENT PROTEIN DEGRADATION
1996
Substrate Binding and Catalysis by Ubiquitin C-Terminal Hydrolases: Identification of Two Active Site Residues
1996
Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).
1992
Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes
1998
The ubiquitin‐mediated proteolytic pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins
1994 StandoutNobel
UBIQUITIN AND THE CONTROL OF PROTEIN FATE IN THE SECRETORY AND ENDOCYTIC PATHWAYS
1998
A ubiquitin C-terminal isopeptidase that acts on polyubiquitin chains. Role in protein degradation.
1992 StandoutNobel
A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits
1998
Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of enolase 1
1998 Nobel
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.
1989 StandoutNobel
Purification of the Xenopus laevis double-stranded RNA adenosine deaminase
1994
Subcellular localization of proteasomes and their regulatory complexes in mammalian cells
2000
Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity.
1990 StandoutNobel
Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.
1991 StandoutNobel
DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES
1999
PA700, an ATP-dependent activator of the 20 S proteasome, is an ATPase containing multiple members of a nucleotide-binding protein family.
1994
The PRE4 gene codes for a subunit of the yeast proteasome necessary for peptidylglutamyl-peptide-hydrolyzing activity. Mutations link the proteasome to stress- and ubiquitin-dependent proteolysis.
1993
THE PROTEASOME
1999 Nobel
In vivo function of the proteasome in the ubiquitin pathway.
1992
Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival.
1991
Partial purification and substrate specificity of a ubiquitin hydrolase from Saccharomyces cerevisiae
1991
Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity.
1993
A 26 S protease subunit that binds ubiquitin conjugates.
1994
MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING
1998
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Involvement of the proteasome in various degradative processes in mammalian cells.
1989
In Vivo Stimulation of IκB Phosphorylation Is Not Sufficient To Activate NF-κB
1995
Ubiquitin-mediated protein degradation.
1988 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease
2000
Purification and characterization of a novel protein that is required for degradation of N-alpha-acetylated proteins by the ubiquitin system.
1991 StandoutNobel
PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins.
1993
Molecular Cloning and Expression of a 26 S Protease Subunit Enriched in Dileucine Repeats
1995
Control of mRNA Decay by Heat Shock-Ubiquitin-Proteasome Pathway
1999 Science
Ubiquitin-activating enzyme, E1, is associated with maturation of autophagic vacuoles.
1992 StandoutNobel
Interaction of the Doa4 Deubiquitinating Enzyme with the Yeast 26S Proteasome
1999
Proteasomes: multicatalytic proteinase complexes
1993
Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia
1992 StandoutScienceNobel
Works of G Pratt being referenced
The N Terminus of Antizyme Promotes Degradation of Heterologous Proteins
1996
Multicatalytic and 26 S ubiquitin/ATP‐stimulated proteases in maturing rabbit red blood cells
1991
Human lymphoblast and erythrocyte multicatalytic proteases: differential peptidase activities and responses to the 11S regulator
1995
Proteolysis in Heat-stressed HeLa Cells
1989
The C terminus of mouse ornithine decarboxylase confers rapid degradation on dihydrofolate reductase. Support for the pest hypothesis
1991
Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.
1986
Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease.
1994
Purification of an 11 S regulator of the multicatalytic protease.
1992
Ubiquitin-mediated degradation of histone H3 does not require the substrate-binding ubiquitin protein ligase, E3, or attachment of polyubiquitin chains.
1990
Degradation of structurally characterized proteins injected into HeLa cells
1989
Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family
1992
Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate.
1992
Effects of interferon gamma and major histocompatibility complex-encoded subunits on peptidase activities of human multicatalytic proteases.
1995
Purification of two high molecular weight proteases from rabbit reticulocyte lysate.
1987