Standout Papers
Citation Impact
Citing Papers
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
SHP-2 Tyrosine Phosphatase as an Intracellular Target of Helicobacter pylori CagA Protein
2002 Science
Heterogeneity in the Helicobacter pylori vacA and cagA genes: association with gastroduodenal disease in South Africa?
1999
Major virulence factors, VacA and CagA, are commonly positive in Helicobacter pylori isolates in Japan
1998
Analysis of the genome sequence of the flowering plant Arabidopsis thaliana
2000 StandoutNature
In Vivo Regulation of the IκB Homologue cactus during the Immune Response of Drosophila
1998 StandoutNobel
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex
1997
A Toll-like receptor recognizes bacterial DNA
2000 StandoutNature
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Corrected Identity of Isolates of Helicobacter Pylori Reference Strain NCTC11637
1997
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
1997 StandoutNature
Variability of gene order in different Helicobacter pylori strains contributes to genome diversity
1996
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
1990 StandoutNature
An Induced Proximity Model for Caspase-8 Activation
1998
Lack of gastritis and of an adaptive immune response in interferon regulatory factor-1-deficient mice infected withHelicobacter pylori
2001
T1/ST2 Signaling Establishes It as a Member of an Expanding Interleukin-1 Receptor Family
1996
Toll-like Receptors and Innate Immunity
2001
Cells’ Perception of Position in a Concentration Gradient
1998 StandoutNobel
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
2013 StandoutNature
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori
2000
Emergence of recombinant strains ofHelicobacter pyloriduring human infection
1999
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
2001 StandoutNature
Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin
1998 StandoutNobel
Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin.
1998
Studies on the contribution of c-fos/AP-1 to arthritic joint destruction.
1997
Quasispecies Development ofHelicobacter pyloriObserved in Paired Isolates Obtained Years Apart from the Same Host
2000
Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant
1998
Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori
1998
Presence of the cagA Gene in the Majority of Helicobacter pylori Strains Is Independent of Whether the Individual Has Duodenal Ulcer or Asymptomatic Gastritis
1996
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
1996 StandoutNobel
Genetic organization of a small cryptic plasmid of Helicobacter pylori
1995
The biochemistry of apoptosis
2000 StandoutNature
Analysis of the type IV secretion system-dependent cell motility of Helicobacter pylori-infected epithelial cells
2004
Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori
1995
Evolving concepts of rheumatoid arthritis
2003 StandoutNature
The Interrelationship between Cytotoxin-Associated Gene A, Vacuolating Cytotoxin, and Helicobacter pylori-Related Diseases
1996
The product of the tobacco mosaic virus resistance gene N: Similarity to toll and the interleukin-1 receptor
1994
Toll-like receptors in the induction of the innate immune response
2000 StandoutNature
Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin‐101
2001
Oncogenic mechanisms of the Helicobacter pylori CagA protein
2004
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Density of Helicobacter pylori Infection In Vivo as Assessed by Quantitative Culture and Histology
1996
Involvement of the Ca2+-dependent Phosphatase Calcineurin in Gene Transcription That Is Stimulated by cAMP through cAMP Response Elements
1995
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
1997 StandoutNature
The immune response of Drosophila
2003 StandoutNatureNobel
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
2001 StandoutNature
Genetic and functional characterization of the alpAB gene locus essential for the adhesion of Helicobacter pylori to human gastric tissue
1999
Analyses of the cag pathogenicity island of Helicobacter pylori
1998
c‐Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs
2002
Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
1992 StandoutNature
Expression of mRNA for Interferon-Gamma, Interleukin-10, and Interleukin-12 (p40) in Normal Gastric Mucosa and in Mucosa Infected withHelicobacter pylori
1997
Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori
2004
Bacterial Lipopolysaccharide Activates Nuclear Factor-κB through Interleukin-1 Signaling Mediators in Cultured Human Dermal Endothelial Cells and Mononuclear Phagocytes
1999
Helicobacter pylori CagA Containing ITAM‐Like Sequences Localized to Lipid Rafts Negatively Regulates VacA‐Induced Signaling In Vivo
2003
A revised annotation and comparative analysis of Helicobacter pylori genomes
2003
The vacuolating cytotoxin of Helicobacter pylori
1996
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
1998 Nature
Prospects for the Development of a Vaccine Against Helicobacter pylori
1996
Attenuation of Helicobacter pylori CagA·SHP-2 Signaling by Interaction between CagA and C-terminal Src Kinase
2003
Ordered cosmid library and high‐resolution physical—genetic map of Helicobacter pylori strain NCTC11638
1994
Recombination and clonal groupings within Helicobacter pylori from different geographical regions
1999
Functional analysis of iceA1, a CATG-recognizing restriction endonuclease gene in Helicobacter pylori
2002
Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors—Insight into Heterotrimeric IL-1 Signaling Complexes
2009
Analysis of iceA1 transcription in Helicobacter pylori
2000
Association between TNF- promoter polymorphism and Helicobacter pylori cagA subtype infection
2001
Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
2002 StandoutNature
Association of Helicobacter pylori genotype with gastroesophageal reflux disease and other upper gastrointestinal diseases
2000
Src Is the Kinase of the Helicobacter pylori CagA Protein in Vitro and in Vivo
2002
pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo
1993
Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers
1999
Regulation of transcription in Helicobacter pylori: simple systems or complex circuits?
2001
Correlation between Variation of the 3′ Region of thecagAGene inHelicobacter pyloriand Disease Outcome in Japan
2002
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Innate Immune Receptors
2016
Pathogen Recognition and Innate Immunity
2006 Standout
The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation
2003
Vacuolating Toxin Production in Clinical Isolates of Helicobacter pylori with Different vacA Genotypes
1998
Inflammasomes in health and disease
2012 StandoutNature
The immunopathogenesis of sepsis
2002 StandoutNature
The Functional Status of the Helicobacter pylori sabB Adhesin Gene as a Putative Marker for Disease Outcome
2004
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
IL‐1: Discoveries, controversies and future directions
2010
Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype.
1995
The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)
1998
Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection
1997
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1998 StandoutScienceNobel
Virulence Factors of Helicobacter pylori Responsible for Gastric Diseases in Mongolian Gerbil
2000
Interleukin-8 response of gastric epithelial cell lines to Helicobacter pylori stimulation in vitro
1995
Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.
1994
PLANT DISEASE RESISTANCE GENES
1997 Standout
Tyrosine phosphorylation of theHelicobacter pyloriCagA antigen aftercag-driven host cell translocation
2000
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation.
2001
Infection withHelicobacter pyloriExpressing thecagAGene Is Not Associated with an Increased Risk of Developing Peptic Ulcer Diseases in Korean Patients
1998
Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion
1998
Serologic detection of infection with cagA+ Helicobacter pylori strains
1995
A Conventional Beagle Dog Model for Acute and Chronic Infection withHelicobacter pylori
1999
Adaptive mutation and cocolonization during Helicobacter pylori infection of gnotobiotic piglets
1995
Cloning and Characterization of Two Toll/Interleukin-1 Receptor–Like Genes TIL3 and TIL4: Evidence for a Multi-Gene Receptor Family in Humans
1998
A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-kappa B.
1993
cag , a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
1996 Standout
Mutation of the cytotoxin-associated cagA gene does not affect the vacuolating cytotoxin activity of Helicobacter pylori
1994
Helicobacter pylori - a conundrum of genetic diversity
1998
A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway
1996
Occurrence of gastric ulcers in gnotobiotic piglets colonized by Helicobacter pylori
1995
The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products
2000
Polymorphisms of Helicobacter pylori HP0638 Reflect Geographic Origin and Correlate with cagA Status
2002
Host Cell Responses to Genotypically SimilarHelicobacter pyloriIsolates from United States and Japan
2002
NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation
1998 StandoutScience
Proteins Encoded by thecagPathogenicity Island ofHelicobacter pyloriAre Required for NF-κB Activation
1998
Death Receptors: Signaling and Modulation
1998 StandoutScience
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin
1995
Pathogenesis ofHelicobacter pyloriInfection
2006 Standout
Detection ofHelicobacter species in the liver of patients with and without primary liver carcinoma
2000
Vacuolating Cytotoxin of Helicobacter pylori Plays a Role during Colonization in a Mouse Model of Infection
2001
Evaluation of the Association of NineHelicobacter pyloriVirulence Factors with Strains Involved in Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
2004
Integrin Signaling
1999 StandoutScience
Detection of Helicobacter species in the liver of patients with and without primary liver carcinoma.
2000
IRAK: A Kinase Associated with the Interleukin-1 Receptor
1996 Science
Expanding Allelic Diversity of Helicobacter pylori vacA
1998
CagA/cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines.
1994
Development of a Mouse Model of Helicobacter pylori Infection that Mimics Human Disease
1995 Science
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
A family of human receptors structurally related to Drosophila Toll
1998 Standout
Identification and characterization of an operon of Helicobacter pylori that is involved in motility and stress adaptation
1997
The Danger Model: A Renewed Sense of Self
2002 StandoutScience
Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging
1998 StandoutScience
Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions.
1990
Helicobacter pylori-Induced Mucosal Inflammation Is Th1 Mediated and Exacerbated in IL-4, But Not IFN-γ, Gene-Deficient Mice
2000
Helicobacter pylori Virulence and Genetic Geography
1999 StandoutScience
Determination of the Structures of Symmetric Protein Oligomers from NMR Chemical Shifts and Residual Dipolar Couplings
2011 StandoutNobel
Metabolism and Genetics of Helicobacter pylori : the Genome Era
1999
Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA.
1988
cagA -Positive Helicobacter pylori Populations in China and The Netherlands Are Distinct
1998
Helicobacter pylori Caga Protein Can Be Tyrosine Phosphorylated in Gastric Epithelial Cells
2000
Regulation of development and differentiation by the extracellular matrix
1993
Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants ofDrosophila
2000 StandoutNobel
Vacuolating Toxin Gene Polymorphism amongHelicobacter pyloriClinical Isolates and Its Association with m1, m2, or ChimericvacAMiddle Types
1998
Role of the Helicobacter pylori virulence factors vacuolating cytotoxin, CagA, and urease in a mouse model of disease
1995
TheHelicobacter pyloriplasticity region locusjhp0947âjhp0949is associated with duodenal ulcer disease and interleukin-12 production in monocyte cells
2004
Experimental Infection of Mongolian Gerbils with Wild-Type and Mutant Helicobacter pylori Strains
1998
Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.
1991
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
1997 StandoutScience
pH-Regulated Gene Expression of the Gastric PathogenHelicobacter pylori
2003
Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
2002
The New Path to Preventing Ulcers
1995 Science
Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan
1997
Structure of cag pathogenicity island in Japanese Helicobacter pyloriisolates
1999
Spiral Bacteria in the Human Stomach: The Gastric Helicobacters
1995
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes
1998 StandoutNobel
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
Caspases: Enemies Within
1998 StandoutScience
The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll
1994
Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.
1994
The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity
1998
Induction of interleukin-8 secretion from gastric epithelial cells by a cagA negative isogenic mutant of Helicobacter pylori.
1995
Distinct Variants of Helicobacter pylori cagA Are Associated with vacA Subtypes
1999
Chemical Glycoproteomics
2016 StandoutNobel
Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin
1999
Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high‐affinity ferrous iron transporter
2000
Works of G Macchia being referenced
Mapping of receptor binding sites on IL-1 beta by reconstruction of IL-1ra-like domains.
1995
Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer.
1993 Standout
Amino acids conserved in interleukin-1 receptors (IL-1Rs) and the Drosophila toll protein are essential for IL-1R signal transduction.
1992
The murine interleukin 1β gene: structure and evolution
1986
Cyclosporin A blocks calcium-dependent pathways of gene activation.
1991
A role for protein kinase C activity in interleukin-1 (IL-1) induction of IL-2 gene expression but not in IL-1 signal transduction.
1990