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SIRIUS
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1994
Crystal structure of an uncleaved α1‐antitrypsin reveals the conformation of its inhibitory reactive loop
1995
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1998
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1996
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1999
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2001
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1996
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1996
Refined X-ray crystallographic structure of the poliovirus 3C gene product 1 1Edited By D. Rees
1997
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1999
Improvements in protein secondary structure prediction by an enhanced neural network
1990
Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1
1995
Implications for function and therapy of a 2.9 å structure of binary-complexed antithrombin
1998
Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation
2000
Hydrophobic stabilization in T4 lysozyme determined directly by multiple substitutions of Ile 3
1988 Nature
Topology of the Stable Serpin-Protease Complexes Revealed by an Autoantibody That Fails to React with the Monomeric Conformers of Antithrombin
1999
Crystal structure of the apoptotic suppressor CrmA in its cleaved form
2000
Structural determinants of water permeation through aquaporin-1
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Histidine-aromatic interactions in barnase
1992
Visualizing the mechanical activation of Src
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Ivermectin: A Positive Allosteric Effector of the α7 Neuronal Nicotinic Acetylcholine Receptor
1998
The Z type variation of human α1-antitrypsin causes a protein folding defect
1995
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2000
Accurate modeling of protein conformation by automatic segment matching
1992
Heparin Enhances the Specificity of Antithrombin for Thrombin and Factor Xa Independent of the Reactive Center Loop Sequence
2001
The Fold of Human Aquaporin 1
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Serpin α1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy
1996
Helix D Elongation and Allosteric Activation of Antithrombin
2002
Weakly Polar Interactions In Proteins
1988
The native strains in the hydrophobic core and flexible reactive loop of a serine protease inhibitor: crystal structure of an uncleaved α1-antitrypsin at 2.7 å
1996
Structural basis of the allosteric behaviour of phosphofructokinase
1990 Nature
Aromatic rings act as hydrogen bond acceptors
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Arginine substitutions in the hinge region of antichymotrypsin affect serpin β-sheet rearrangement
1996
Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage
2000
Partitioning of Serpin-Proteinase Reactions between Stable Inhibition and Substrate Cleavage Is Regulated by the Rate of Serpin Reactive Center Loop Insertion into β-Sheet A
2000
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Role of Arginine 129 in Heparin Binding and Activation of Antithrombin
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Surface, subunit interfaces and interior of oligomeric proteins
1988
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Human Carboxyhemoglobin at 2.2 Å Resolution: Structure and Solvent Comparisons of R-State, R2-State and T-State Hemoglobins
1998
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Structure of form III crystals of bovine pancreatic trypsin inhibitor
1987
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1997
Heterologous Expression of Three Plant Serpins with Distinct Inhibitory Specificities
1996
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools
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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
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1998
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1998
Water Molecules Hydrogen Bonding to Aromatic Acceptors of Amino Acids: the Structure of Tyr-Tyr-Phe Dihydrate and a Crystallographic Database Study on Peptides
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What do dysfunctional serpins tell us about molecular mobility and disease?
1995
Why ion pair reversal by protein engineering is unlikely to succeed
1988 StandoutNatureNobel
Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide
1998
Inhibitory conformation of the reactive loop of α1-antitrypsin
1996
Database of homology‐derived protein structures and the structural meaning of sequence alignment
1991
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides
1992 NatureNobel
Formation of the Covalent Chymotrypsin·Antichymotrypsin Complex Involves No Large-scale Movement of the Enzyme
2001
Role of Arginine 132 and Lysine 133 in Heparin Binding to and Activation of Antithrombin
1996
Accurate prediction of the stability and activity effects of site-directed mutagenesis on a protein core
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Cryo-EM structure of a type IV secretion system
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Detection of common three‐dimensional substructures in proteins
1991
Allosteric Receptors after 30 Years
1998
Prion (PrPSc)-specific epitope defined by a monoclonal antibody
1997 StandoutNatureNobel
Wild-type α1-antitrypsin is in the canonical inhibitory conformation
1998
Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop
1994
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
Evolutionarily conserved networks of residues mediate allosteric communication in proteins
2002
Determinants of a protein fold
1987
Significance of secondary structure predictions on the reactive center loop region of seprins: a model for the folding of serpins into a metastable state
1996
Major proteinase movement upon stable serpin–proteinase complex formation
1997
The anticoagulant activation of antithrombin by heparin
1997
Accurate design of megadalton-scale two-component icosahedral protein complexes
2016 StandoutScienceNobel
Gene duplications in the structural evolution of chymotrypsin
1979
Volume changes in protein evolution
1994
Structure of erythrocruorin in different ligand states refined at 1·4 Å resolution
1979
Sugar and Signal-Transducer Binding Sites of the Escherichia coli Galactose Chemoreceptor Protein
1988 Science
Protein Structure Determination in Solution by Nuclear Magnetic Resonance Spectroscopy
1989 StandoutScienceNobel
Serpin Structure, Mechanism, and Function
2002 Standout
Macroscopic models for studies of electrostatic interactions in proteins: limitations and applicability.
1984 StandoutNobel
Envelope structure of Semliki Forest virus reconstructed from cryo-electron micrographs
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Molecular dynamics simulation of photodissociation of carbon monoxide from hemoglobin.
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Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
2000
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
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One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
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Investigation of Synthetic Hosts That Model Cation-π Sites Found at Protein Binding Domains
2002
Serpin reactive center loop mobility is required for inhibitor function but not for enzyme recognition.
1994
MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans
2000 StandoutNatureNobel
Molecular surface recognition: determination of geometric fit between proteins and their ligands by correlation techniques.
1992
The protein products of the myc and myb oncogenes and adenovirus E1a are structurally related
1983 StandoutNatureNobel
Assignment of asparagine-44 side-chain primary amide proton NMR resonances and the peptide amide N1H resonance of glycine-37 in basic pancreatic trypsin inhibitor
1987
Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells.
1996
Theoretical Study of Alkyl-π and Aryl-π Interactions. Reconciling Theory and Experiment
2002
Energy-structure correlation in metalloporphyrins and the control of oxygen binding by hemoglobin.
1977 StandoutNobel
Structural Relationship of Bacterial RecA Proteins to Recombination Proteins from Bacteriophage T4 and Yeast
1993 StandoutScienceNobel
Automatic identification of secondary structure in globular proteins
1977 StandoutNobel
Hemoglobin tertiary structural change on ligand binding its role in the co-operative mechanism
1983
Protein folding
1977
Simple Cation−π Interaction between a Phenyl Ring and a Protonated Amine Stabilizes an α-Helix in Water
2002
Molecular evolution of plasminogen activator inhibitor-1 functional stability.
1995
The Cation−π Interaction
1997 Standout
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1991 StandoutScienceNobel
Quaternary structures and low frequency molecular vibrations of haems of deoxy and oxyhaemoglobin studied by resonance Raman scattering
1980
Inactive conformation of the serpin α1-antichymotrypsin indicates two-stage insertion of the reactive loop: Implications for inhibitory function and conformational disease
2000
Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp
1996 StandoutScience
Haemoglobin: The structural changes related to ligand binding and its allosteric mechanism
1979
A Density Functional Study of the Receptor−Ligand Interaction: Stabilization Energy in Ammonium Salt−Aromatic Interactions
1998
Inactivation of papain by antithrombin due to autolytic digestion: a model of serpin inactivation of cysteine proteinases
1998
Amino‐aromatic interactions in proteins
1986
Complexes of benzene with formamide and methanethiol as models for interactions of protein substructures
1989
Crystal Structure of DNA Photolyase from Escherichia coli
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Cation−π Interaction in Model α-Helical Peptides
2002
Progress in Modeling of Protein Structures and Interactions
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Structure of a complex between yeast hexokinase A and glucose
1980 StandoutNobel
Protein Structure Prediction and Structural Genomics
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The necrotic Gene in Drosophila Corresponds to One of a Cluster of Three Serpin Transcripts Mapping at 43A1.2
2000
Status of empirical methods for the prediction of protein backbone topography
1976
Constraints on the assembly of spherical virus particles
1984
How different amino acid sequences determine similar protein structures: The structure and evolutionary dynamics of the globins
1980
A Mechanism for Ion Selectivity in Potassium Channels: Computational Studies of Cation-π Interactions
1993 Science
Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)
1994
Semiempirical calculations of model deoxyheme. Variation of calculated electromagnetic properties with electronic configuration and distance of iron from the plane
1978
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Helix movements in proteins
1985
The process of infection with bacteriophage φX174
1962
Neural Computing in Cancer Drug Development: Predicting Mechanism of Action
1992 StandoutScienceNobel
Virus-Specific Double-Stranded RNA in Poliovirus-Infected Cells
1964 StandoutScienceNobel
Cation-π interactions in structural biology
1999 Standout
The Internal Dynamics of Globular Protein
1981
Conformational flexibility in protein molecules
1979 StandoutNatureNobel
Energetic Analysis of an Engineered Cation−π Interaction in Staphylococcal Nuclease
1998
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Refined crystal structure of deoxyhemoglobin S. II. Molecular interactions in the crystal.
1985
The Cation−π Interaction
2012
The relation between the divergence of sequence and structure in proteins.
1986 Standout
Origin of the Attraction and Directionality of the NH/π Interaction: Comparison with OH/π and CH/π Interactions
2000
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism
2002
Works of G. Fermi being referenced
Haemoglobin and myoglobin
1981
Stereochemistry of Cooperative Mechanisms in Hemoglobin
1987
Indirect allosteric effects of a neutral mutation
1988
New effectors of human hemoglobin: structure and function
1990
A Novel Allosteric Mechanism in Haemoglobin
1993
Three-dimensional fourier synthesis of human deoxyhaemoglobin at 2·5 Å resolution: Refinement of the atomic model
1975
Protein synthesis and the onset of intracellular bacteriophage growth
1962
Biological implications of a 3 å structure of dimeric antithrombin
1994
Structure of deoxyhemoglobin Cowtown [His HC3(146) beta----Leu]: origin of the alkaline Bohr effect and electrostatic interactions in hemoglobin.
1984
LR16, a compound with potent effects on the oxygen affinity of hemoglobin, on blood cholesterol, and on low density lipoprotein.
1988
The crystal structure of human deoxyhaemoglobin at 1.74 Å resolution
1984
Influence of quaternary structure of the globin on thermal spin equilibria in different methemoglobin derivatives
1978
ChemInform Abstract: Hemoglobin as a Receptor of Drugs and Peptides: X‐Ray Studies of the Stereochemistry of Binding.
1986
Stereochemistry of cooperative mechanisms in hemoglobin
1987
Hemoglobin as a receptor of drugs and peptides: x-ray studies of the stereochemistry of binding
1986
Structure of human fluoromethaemoglobin with inositol hexaphosphate
1977