Citation Impact
Citing Papers
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
Biochemistry of B Lymphocyte Activation
1993
NF-κB to the rescue: RELs, apoptosis and cellular transformation
1999
Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.
1993
IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System
1993
Comprehensive genomic characterization of head and neck squamous cell carcinomas
2015 StandoutNature
Identification of signal transduction pathways involved in constitutive NF-κB activation in breast cancer cells
2002
Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-β
2001
The Tumor Suppressor Activity of the Lysyl Oxidase Propeptide Reverses the Invasive Phenotype of Her-2/neu–Driven Breast Cancer
2007
In Vivo Regulation of the IκB Homologue cactus during the Immune Response of Drosophila
1998 StandoutNobel
Increased Expression of RelA/Nuclear Factor-κB Protein Correlates with Colorectal Tumorigenesis
2003
Inflammation and cancer
2002 StandoutNature
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
2008 StandoutNature
The NEDD8 Pathway Is Essential for SCFβ-TrCP-mediated Ubiquitination and Processing of the NF-κB Precursor p105
2002 StandoutNobel
MYC on the Path to Cancer
2012 Standout
NF-κB Inhibits Apoptosis in Murine Mammary Epithelia
2000
The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
2010
Disruption of Hsp90 Function Results in Degradation of the Death Domain Kinase, Receptor-interacting Protein (RIP), and Blockage of Tumor Necrosis Factor-induced Nuclear Factor-κB Activation
2000
The Petinoblastoma Tumor Suppressor Protein
1994
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
2003 Standout
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF
2006
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
2004
High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-κB activation
2000
NF-κB in cancer: from innocent bystander to major culprit
2002 Standout
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
2001
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
2011 StandoutNature
The transcription factor NF-κB: control of oncogenesis and cancer therapy resistance
2000
Shared Principles in NF-κB Signaling
2008 Standout
β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
2002
Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
2006
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3
2000
Molecular Events Mediating T Cell Activation
1990
Flow cytometric analysis of apoptotic subpopulations with a combination of Annexin V-FITC, propidium iodide, and SYTO 17
2001
Inhibition of Interleukin-1-stimulated NF-κB RelA/p65 Phosphorylation by Mesalamine Is Accompanied by Decreased Transcriptional Activity
1999
Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
2015 Standout
The role of TGF-β in growth, differentiation, and maturation of B lymphocytes
1999
Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling
2010
Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
1999
Missing Pieces in the NF-κB Puzzle
2002 Standout
Transforming growth factor-β induces development of the TH17 lineage
2006 StandoutNature
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
1995 StandoutNatureNobel
Nuclear factor-κB in cancer development and progression
2006 StandoutNature
Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells
2000
Processing of p105 Is Inhibited by Docking of p50 Active Subunits to the Ankyrin Repeat Domain, and Inhibition Is Alleviated by Signaling via the Carboxyl-terminal Phosphorylation/ Ubiquitin-Ligase Binding Domain
2001 StandoutNobel
Müllerian Inhibiting Substance Inhibits Breast Cancer Cell Growth through an NFκB-mediated Pathway
2000
Sulindac Inhibits Activation of the NF-κB Pathway
1999
Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF‐κB and AP‐1 activation and IL‐8 and VEGF expression in human head and neck squamous cell carcinoma lines
2002
Transient activation of NF-κB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
2003
Immunity, Inflammation, and Cancer
2010 Standout
Chronic immune activation and inflammation in the pathogenesis of aids and cancer
2002
Osteoclast differentiation and activation
2003 StandoutNature
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
2004 Standout
Tyrosine phosphorylation‐dependent activation of NF‐κB
2001
A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice.
1997
TGFβ in Cancer
2008 Standout
NF-κB in cancer: a marked target
2003
Clonal selection and learning in the antibody system
1996 StandoutNature
NF-κB and cell-cycle regulation: the cyclin connection
2001
Drosophila myc Regulates Cellular Growth during Development
1999
Nuclear factor-κB is upregulated in colorectal cancer
2001
Nuclear factor-κB
2004 Standout
Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells
1999
Smad7 Is Induced by CD40 and Protects WEHI 231 B-lymphocytes from Transforming Growth Factor-β-induced Growth Inhibition and Apoptosis
2000
Ah receptor and NF-κB interactions: mechanisms and physiological implications
2002
NF-κB functions as a tumour promoter in inflammation-associated cancer
2004 StandoutNature
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development
2001
Smad3 Potentiates Transforming Growth Factor β (TGFβ)-induced Apoptosis and Expression of the BH3-only Protein Bim in WEHI 231 B Lymphocytes
2003
A requirement for NF-kappa B activation in Bcr-Abl-mediated transformation
1998
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
2009 Standout
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
1999 StandoutNature
A Failure of Transforming Growth Factor-β1 Negative Regulation Maintains Sustained NF-κB Activation in Gut Inflammation
2004
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation
1997
INK4 cell cycle inhibitors direct transcriptional inactivation of NF-κB
1999
Transcription factor NF-κB is constitutively activated in acute lymphoblastic leukemia cells
2000
Transfer of the HSV-tk Gene into Donor Peripheral Blood Lymphocytes for In Vivo Modulation of Donor Anti-Tumor Immunity after Allogeneic Bone Marrow Transplantation. The San Raffaele Hospital, Milan, Italy
1995
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
2002 StandoutNobel
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini
2007
Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.
1993
Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras
1997 Science
Proteasome regulation of activation-induced T cell death
1997 StandoutNobel
The nuclear factor kappa B (NF-κB): A potential therapeutic target for estrogen receptor negative breast cancers
2001
Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells
2000
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis
1995 StandoutScience
Role of NF-κB in the Rescue of Multiple Myeloma Cells From Glucocorticoid-Induced Apoptosis by Bcl-2
1999
Nuclear factor-kappaB protects the liver against genotoxic stress and functions independently of p53.
2003
Repeated observation of breast tumor subtypes in independent gene expression data sets
2003 Standout
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
2004
Leukemic target susceptibility to natural killer cytotoxicity: relationship with BCR-ABL expression
2002
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
2011 StandoutScience
RelB/p52 NF-κB Complexes Rescue an Early Delay in Mammary Gland Development in Transgenic Mice with Targeted Superrepressor IκB-α Expression and Promote Carcinogenesis of the Mammary Gland
2005
NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation
1998 StandoutScience
ch-IAP1, a Member of the Inhibitor-of-Apoptosis Protein Family, Is a Mediator of the Antiapoptotic Activity of the v-Rel Oncoprotein
1997
Functions of Ceramide in Coordinating Cellular Responses to Stress
1996 StandoutScience
NF-κ B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4
2003
Transforming Growth Factor β1 Inhibits Fas Ligand Expression and Subsequent Activation-induced Cell Death in T Cells via Downregulation of c-Myc
1999
The retinoblastoma protein and cell cycle control
1995 Standout
Differential Regulation of the c-myc Oncogene Promoter by the NF-κB Rel Family of Transcription Factors
1994
Multiple Single-Stranded cis Elements Are Associated with Activated Chromatin of the Human c-myc Gene In Vivo
1996
NF-κB inhibition causes spontaneous apoptosis in Epstein–Barr virus-transformed lymphoblastoid cells
2000
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
2005 Standout
Redirection of B cell responsiveness by transforming growth factor β receptor
2003
Differential regulation of the c-myc oncogene promoter by the NF-kappa B rel family of transcription factors.
1994
Associations between gene expressions in breast cancer and patient survival
2002
NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G0/G1-to-S-Phase Transition
1999
Sensitization of tumor cells to Apo2 ligand/TRAIL-induced apoptosis by inhibition of casein kinase II.
2002
A mechanism of suppression of TGF–β/SMAD signaling by NF-κB/RelA
2000
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
2005 StandoutNature
Transcription factor NF-κB participates in regulation of epithelial cell turnover in the colon
2000
TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES
2005 Standout
NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
1999
Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor
2005
Essential role of TAK1 in thymocyte development and activation
2006
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.
1996
A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA.
2000
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.
1996 StandoutNobel
Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe
2009
The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression
2003
c-myc Is Required for Osteoclast Differentiation
2002
The Putative Oncoprotein Bcl-3 Induces Cyclin D1 To Stimulate G1 Transition
2001
A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells
1996
Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9.
2002
Works of G E Sonenshein being referenced
Her-2/neu overexpression induces NF-κB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IκB-α that can be inhibited by the tumor suppressor PTEN
2001
The RelA NF-κB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells
2000
TGFβ1 Inhibits NF-κB/Rel Activity Inducing Apoptosis of B Cells: Transcriptional Activation of IκBα
1996
Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.
1997
The inhibitory effects of transforming growth factor beta1 on breast cancer cell proliferation are mediated through regulation of aberrant nuclear factor-kappaB/Rel expression.
1999
Maintenance of nuclear factor-kappa B/Rel and c-myc expression during CD40 ligand rescue of WEHI 231 early B cells from receptor-mediated apoptosis through modulation of I kappa B proteins.
1996
Nuclear factor-kappaB/Rel blocks transforming growth factor beta1-induced apoptosis of murine hepatocyte cell lines.
1997
Defective T lymphocytes in old mice. Diminished production of mature c-myc RNA after mitogen exposure not attributable to alterations in transcription or RNA stability.
1988
Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes.
1997
NF-kappa B-like factors mediate interleukin 1 induction of c-myc gene transcription in fibroblasts.
1992
Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter.
1990
Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer.
2001
A novel NF-kappa B element within exon 1 of the murine c-myc gene.
1992
Changes in phosphorylation of myc oncogene and RB antioncogene protein products during growth arrest of the murine lymphoma WEHI 231 cell line.
1991