Standout Papers
Citation Impact
Citing Papers
Regulated import and degradation of a cytosolic protein in the yeast vacuole
1991 StandoutNatureNobel
Structure of the signal recognition particle interacting with the elongation-arrested ribosome
2004 StandoutNatureNobel
A chimeric mitochondrial precursor protein with internal disulfide bridges blocks import of authentic precursors into mitochondria and allows quantitation of import sites.
1988
Secretion in yeast: Reconstitution of the translocation and glycosylation of α-factor and invertase in a homologous cell-free system
1986
Functional architecture of an intracellular membrane t-SNARE
2000 StandoutNatureNobel
A yeast mitochondrial outer membrane protein essential for protein import and cell viability
1990 Nature
Destabilization of the complete protein secondary structure on binding to the chaperone GroEL
1994 StandoutNatureNobel
Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane.
1995
Protein targeting to and translocation across the membrane of the endoplasmic reticulum
1992
A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation
1992
The signal recognition particle in S. cerevisiae
1991
Identification of a receptor for protein import into mitochondria
1990 StandoutNatureNobel
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
1988 StandoutNatureNobel
Transmembrane domain-dependent sorting of proteins to the ER and plasma membrane in yeast
1997
The Engagement of Sec61p in the ER Dislocation Process
1999 StandoutNobel
SHR3: A novel component of the secretory pathway specifically required for localization of amino acid permeases in yeast
1992
YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism
1992
Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation
1997
Evolutionary conservation of components of the protein translocation complex
1994 Nature
Translocation of proteins across the endoplasmic reticulum
1993
Mechanism of Polypeptide Translocation into the Endoplasmic Reticulum
1996 StandoutNobel
Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation
1996
The outer membrane of yeast mitochondria: isolation of outside-out sealed vesicles
1983
The Nuclear Envelope of the Yeast Saccharomyces cerevisiae
1992
The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins
1999
BiP Acts as a Molecular Ratchet during Posttranslational Transport of Prepro-α Factor across the ER Membrane
1999
Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway
1990 StandoutNobel
Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex
1991 StandoutNatureNobel
Protein folding in the cell
1992 StandoutNature
SNAP receptors implicated in vesicle targeting and fusion
1993 StandoutNatureNobel
Approaching the mechanism of protein transport across the ER membrane
1996
Structure of the E. coli protein-conducting channel bound to a translating ribosome
2005 StandoutNatureNobel
The C. elegans genome sequencing project: a beginning
1992 StandoutNatureNobel
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
2000 StandoutNatureNobel
Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane
1993
DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70
1994
COPII–cargo interactions direct protein sorting into ER-derived transport vesicles
1998 StandoutNatureNobel
Biogenesis of Polytopic Membrane Proteins: Membrane Segments Assemble within Translocation Channels prior to Membrane Integration
1996
A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum
1993 Nature
SRH1 protein, the yeast homologue of the 54 kDa subunit of signal recognition particle, is involved in ER translocation of secretory proteins
1991
The binding cascade of SecB to SecA to SecYE mediates preprotein targeting to the E. coli plasma membrane
1990
Chapter 1 A Hitchhiker's Guide to Analysis of the Secretory Pathway in Yeast
1989 StandoutNobel
SEC21 is a gene required for ER to Golgi protein transport that encodes a subunit of a yeast coatomer
1992 StandoutNatureNobel
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
A 42K outer-membrane protein is a component of the yeast mitochondrial protein import site
1989 Nature
SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER
1993 StandoutNatureNobel
70K heat shock related proteins stimulate protein translocation into microsomes
1988 StandoutNatureNobel
Yeast Sec proteins interact with polypeptides traversing the endoplasmic reticulum membrane
1992
Mitochondrial Hsp70/MIM44 complex facilitates protein import
1994 Nature
Binding of Secretory Precursor Polypeptides to a Translocon Subcomplex Is Regulated by BiP
1997 StandoutNobel
Isolation and biochemical characterization of organelles from the yeast, Saccharomyces cerevisiae
1995
Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint.
1993 StandoutNobel
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
1999 StandoutNature
Sec61p and BiP directly facilitate polypeptide translocation into the ER
1992 StandoutNobel
COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast
1995 StandoutNobel
Secretion in yeast: translocation and glycosylation of prepro-α-factor in vitro can occur via an ATP-dependent post-translational mechanism
1986
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p
1995
Structure of the yeast endoplasmic reticulum: Localization of ER proteins using immunofluorescence and immunoelectron microscopy
1991
Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein
1990 StandoutNatureNobel
Role of the Nuclear Transport Factor p10 in Nuclear Import
1996 StandoutScienceNobel
Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins.
1993
Electrospray Ionization Tandem Mass Spectrometry (Esi-Ms/Ms) Analysis of the Lipid Molecular Species Composition of Yeast Subcellular Membranes Reveals Acyl Chain-Based Sorting/Remodeling of Distinct Molecular Species En Route to the Plasma Membrane
1999
Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic Hsc70.
1993 StandoutNobel
Post-translational insertion of fragment of the glucose transporter into microsomes requires phosphoanhydride bond cleavage
1986 Nature
Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum.
1992 StandoutNobel
Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins
1996 StandoutScienceNobel
SSC1, an essential member of the yeast HSP70 multigene family, encodes a mitochondrial protein.
1989
Transport of Proteins Across the Endoplasmic Reticulum Membrane
1992 Science
Both ATP and an energized inner membrane are required to import a purified precursor protein into mitochondria.
1987
Peroxisome Biogenesis
2001
Structural and functional characterization of Sec66p, a new subunit of the polypeptide translocation apparatus in the yeast endoplasmic reticulum.
1993 StandoutNobel
Nonlethal sec71-1 and sec72-1 mutations eliminate proteins associated with the Sec63p-BiP complex from S. cerevisiae.
1994
The cleavable prepiece of an imported mitochondrial protein is sufficient to direct cytosolic dihydrofolate reductase into the mitochondrial matrix
1984
Genes required for completion of import of proteins into the endoplasmic reticulum in yeast.
1984 StandoutNobel
Determination of the Transmembrane Topology of Yeast Sec61p, an Essential Component of the Endoplasmic Reticulum Translocation Complex
1996
Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery.
1990 StandoutNobel
A member of the Hsp70 family is localized in mitochondria and resembles Escherichia coli DnaK.
1989
The Lumenal Domain of Sec63p Stimulates the ATPase Activity of BiP and Mediates BiP Recruitment to the Translocon in Saccharomyces cerevisiae
1997 StandoutNobel
Import of an incompletely folded precursor protein into isolated mitochondria requires an energized inner membrane, but no added ATP.
1987
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Polypeptide translocation across the endoplasmic reticulum membrane.
1992 StandoutNobel
A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.
1992
Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation.
1992 StandoutNobel
In vitro import of cytochrome c peroxidase into the intermembrane space: release of the processed form by intact mitochondria.
1989
Bacterial leader peptidase, a membrane protein without a leader peptide, uses the same export pathway as pre-secretory proteins
1984
SSC1, an Essential Member of the Yeast HSP70 Multigene Family, Encodes a Mitochondrial Protein
1989
Single-amino-acid substitutions within the signal sequence of yeast prepro-alpha-factor affect membrane translocation.
1988
Unfolding and refolding of a purified precursor protein during import into isolated mitochondria.
1988
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
ATP is essential for protein translocation into Escherichia coli membrane vesicles.
1985
A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae.
1996
Coat Proteins and Vesicle Budding
1996 StandoutScienceNobel
A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast.
1992
Requirement for a GTPase-Activating Protein in Vesicle Budding from the Endoplasmic Reticulum
1993 StandoutScienceNobel
Characterization of YDJ1: a yeast homologue of the bacterial dnaJ protein.
1991
BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum.
1995 StandoutNobel
The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum.
1993
A yeast mutant temperature-sensitive for mitochondrial assembly is deficient in a mitochondrial protease activity that cleaves imported precursor polypeptides.
1985
The amino terminus of the yeast F1-ATPase beta-subunit precursor functions as a mitochondrial import signal.
1986
Binding protein BiP is required for translocation of secretory proteins into the endoplasmic reticulum in Saccharomyces cerevisiae.
1991
The Promoter Region of the Yeast KAR2 (BiP) Gene Contains a Regulatory Domain that Responds to the Presence of Unfolded Proteins in the Endoplasmic Reticulum
1993
A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s.
1995
Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria
1986 Nature
Sequences distal to the mitochondrial targeting sequences are necessary for the maturation of the F1-ATPase beta-subunit precursor in mitochondria.
1987
Isolation and characterization of nuclear envelopes from the yeast Saccharomyces.
1995 StandoutNobel
The most abundant small cytoplasmic RNA of Saccharomyces cerevisiae has an important function required for normal cell growth.
1989
A zinc finger-like domain of the molecular chaperone DnaJ is involved in binding to denatured protein substrates.
1996
Sec61p is adjacent to nascent type I and type II signal-anchor proteins during their membrane insertion.
1993
Sec72p contributes to the selective recognition of signal peptides by the secretory polypeptide translocation complex.
1994 StandoutNobel
Mitochondrial protein import: Nucleoside triphosphates are involved in conferring import-competence to precursors
1987
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
Structural and Functional Dissection of Sec62p, a Membrane-Bound Component of the Yeast Endoplasmic Reticulum Protein Import Machinery
1990 StandoutNobel
Subunit IV of yeast cytochrome c oxidase: cloning and nucleotide sequencing of the gene and partial amino acid sequencing of the mature protein.
1984
Cell biology: An unfolding story of protein translocation
1986 StandoutNatureNobel
Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum.
1993
Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence.
1993
A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein.
1990
The SLP1 gene of Saccharomyces cerevisiae is essential for vacuolar morphogenesis and function.
1990
A purified precursor polypeptide requires a cytosolic protein fraction for import into mitochondria.
1984
SSS1 encodes a stabilizing component of the Sec61 subcomplex of the yeast protein translocation apparatus.
1994 StandoutNobel
Characterization of translocation contact sites involved in the import of mitochondrial proteins.
1987
Regulation of Hsp70 function by a eukaryotic DnaJ homolog.
1992
Phosphodiester bond cleavage outside mitochondria is required for the completion of protein import into the mitochondrial matrix
1987
The role of protein structure in the mitochondrial import pathway. Unfolding of mitochondrially bound precursors is required for membrane translocation.
1987
Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.
1990
SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum.
1989 StandoutNobel
Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus.
1993
A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome.
1993 StandoutNobel
Nucleation of COPII Vesicular Coat Complex by Endoplasmic Reticulum to Golgi Vesicle SNAREs
1998 StandoutScienceNobel
In vitro protein translocation across the yeast endoplasmic reticulum: ATP-dependent post-translational translocation of the prepro-α-factor
1986
Alignment of Conduits for the Nascent Polypeptide Chain in the Ribosome-Sec61 Complex
1997 StandoutScienceNobel
The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor
2011 StandoutScienceNobel
Transport of proteins into mitochondria: Translocational intermediates spanning contact sites between outer and inner membranes
1985
Single-Amino-Acid Substitutions within the Signal Sequence of Yeast Prepro-α-Factor Affect Membrane Translocation
1988
Signal sequences specify the targeting route to the endoplasmic reticulum membrane.
1996
A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein.
1989
Protein import into mitochondria: ATP-dependent protein translocation activity in a submitochondrial fraction enriched in membrane contact sites and specific proteins.
1989
Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression.
1994
Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae.
1995 StandoutNobel
Two nuclear mutations that block mitochondrial protein import in yeast.
1984
Characterization of SIS1, a Saccharomyces cerevisiae homologue of bacterial dnaJ proteins.
1991
ER translocation intermediates are adjacent to a nonglycosylated 34-kD integral membrane protein.
1991
Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44.
1994
Protein import into yeast mitochondria is inhibited by antibodies raised against 45-kd proteins of the outer membrane.
1987
A novel pathway of import of alpha-mannosidase, a marker enzyme of vacuolar membrane, in Saccharomyces cerevisiae.
1990
The role of protein structure in the mitochondrial import pathway. Analysis of the soluble F1-ATPase beta-subunit precursor.
1987
Protein Translocation Across Biological Membranes
2005 StandoutScienceNobel
Prepro-carboxypeptidase Y and a truncated form of pre-invertase, but not full-length pre-invertase, can be posttranslationally translocated across microsomal vesicle membranes from Saccharomyces cerevisiae.
1988
SED4 encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation.
1995
Sequential action of mitochondrial chaperones in protein import into the matrix.
1991
Works of G. Daum being referenced
Association between the endoplasmic reticulum and mitochondria of yeast facilitates interorganelle transport of phospholipids through membrane contact
1999
Mitochondrial membrane contact sites of yeast. Characterization of lipid components and possible involvement in intramitochondrial translocation of phospholipids
1991
Import of proteins into mitochondria. Cytochrome b2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondria.
1982
Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast.
1989 StandoutNobel
Subcellular and submitochondrial localization of phospholipid-synthesizing enzymes in Saccharomyces cerevisiae
1986
Intramitochondrial transfer of phospholipids in the yeast, Saccharomyces cerevisiae.
1990
Import of proteins into mitochondria. Energy-dependent, two-step processing of the intermembrane space enzyme cytochrome b2 by isolated yeast mitochondria.
1982
Import of proteins into mitochondria. Energy-dependent uptake of precursors by isolated mitochondria.
1982
Sterol composition of yeast organelle membranes and subcellular distribution of enzymes involved in sterol metabolism
1993