Standout Papers
Citation Impact
Citing Papers
Similarity of reverse transcriptase-like sequences of viruses, transposable elements, and mitochondrial introns.
1988
[57] Sequencing end-labeled DNA with base-specific chemical cleavages
1980 StandoutNobel
Mutational Analysis of Trp-229 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Identifies This Amino Acid Residue as a Prime Target for the Rational Design of New Non-Nucleoside RT Inhibitors
2000
Efficient transcription of RNA into DNA by avian sarcoma virus polymerase
1976
Distinct prion proteins in short and long scrapie incubation period mice
1987 StandoutNobel
Site-specific mutagenesis of PRD1 DNA polymerase: Mutations in highly conserved regions of the family B DNA polymerase
1990
2.3 Å crystal structure of the catalytic domain of DNA polymerase β
1994
Structures of MLSBK Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance
2005 StandoutNobel
Expression, Purification, and Crystallization of the HIV-1 Reverse Transcriptase (RT)
1990
Primer Terminus Stabilization at the φ29 DNA Polymerase Active Site
1995
Use of organic cosmotropic solutes to crystallize flexible proteins: application to T7 RNA polymerase and its complex with the inhibitor T7 lysozyme
1997 StandoutNobel
Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant Mutant
1996
Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69
1997 StandoutNobel
Mapping of nucleic acid binding in proteolytic domains of HIV-1 reverse transcriptase
1993
Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanisms
1996
Structure of the Replicating Complex of a Pol α Family DNA Polymerase
2001 StandoutNobel
Structural Mechanisms of HIV Drug Resistance
1996
Identification of a new human immunodeficiency virus type 1 distinct from group M and group O
1998 StandoutNobel
Structural basis for initiation of transcription from an RNA polymerase–promoter complex
1999 StandoutNatureNobel
An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae
1989 StandoutNatureNobel
The dynamic disulphide relay of quiescin sulphydryl oxidase
2012 StandoutNatureNobel
A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles
1994 StandoutNobel
Telomere states and cell fates
2000 StandoutNatureNobel
Building a Replisome from Interacting Pieces
1999 StandoutNobel
Site-directed mutagenesis of the YCDTDS amino acid motif of the Φ29 DNA polymerase
1990
Transcription factor b (TFIIH) is required during nucleotide-excision repair in yeast
1994 StandoutNatureNobel
Crystal structure of Thermus aquaticus DNA polymerase
1995 StandoutNatureNobel
Structural Basis for the Resilience of Efavirenz (DMP-266) to Drug Resistance Mutations in HIV-1 Reverse Transcriptase
2000
Interaction of Retroviral Reverse Transcriptase with Template–Primer Duplexes during Replication
1997
Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques
1989 StandoutNobel
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance 1 1Edited by J. Karn
1998
Secondary Structure of Vertebrate Telomerase RNA
2000 StandoutNobel
Many crystal forms of human immunodeficiency virus reverse transcriptase
1991
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors 1 1Edited by J. Karn
2001
The complete nucleotide sequence of the left very early region of Escherichia coli bacteriophage PRD1 coding for the terminal protein and the DNA polymerase
1987
Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase
1995
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors
1995
The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design
1995
Antiretroviral Drug Resistance: Mechanisms, Pathogenesis, Clinical Significance
1996
Structure of Taq polymerase with DNA at the polymerase active site
1996 StandoutNatureNobel
Amino acid changes coded by bacteriophage T4 DNA polymerase mutator mutants
1988
Crystal structure of a thermostable Bacillus DNA polymerase l large fragment at 2.1 Å resolution
1997
Crystal structure of an HIV-binding recombinant fragment of human CD4
1990 StandoutNatureNobel
The effects of nucleoside analogs on telomerase and telomeres inTetrahymena
1994 StandoutNobel
Structures of DNA and RNA polymerases and their interactions with nucleic acid substrates
1995
Switching and Signaling at the Telomere
2001 StandoutNobel
An open and closed case for all polymerases
1999
Phenylethylthiazolylthiourea (PETT) Non-nucleoside Inhibitors of HIV-1 and HIV-2 Reverse Transcriptases
2000
Mutagenesis of conserved region I in the DNA polymerase from human adenovirus serotype 2
1991
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors
1995
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance
2001
HIV reverse transcriptase structure-function relationships
1991
Combination Therapy with Zidovudine and Didanosine Selects for Drug-Resistant Human Immunodeficiency Virus Type 1 Strains with Unique Patterns of pol Gene Mutations
1994
Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions
1997
Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Å resolution
1998
A general structure for DNA-dependent DNA polymerases
1991
Rapid purification of homodimer and heterodimer HIV‐1 reverse transcriptase by metal chelate affinity chromatography
1990
Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template
2004 StandoutNatureNobel
Double-strand breaks at an initiation site for meiotic gene conversion
1989 StandoutNatureNobel
The telomerase reverse transcriptase: components and regulation
1998
Binding of the Second Generation Non-nucleoside Inhibitor S-1153 to HIV-1 Reverse Transcriptase Involves Extensive Main Chain Hydrogen Bonding
2000
Rapid Changes in Human Immunodeficiency Virus Type 1 RNA Load and Appearance of Drug-Resistant Virus Populations in Persons Treated with Lamivudine (3TC)
1995
Lysine Methylation as a Routine Rescue Strategy for Protein Crystallization
2006
The CCA-adding Enzyme Has a Single Active Site
1998
Can DNA polymerase I (Klenow fragment) serve as a model for other polymerases?
1991
Resistance to ddI and Sensitivity to AZT Induced by a Mutation in HIV-1 Reverse Transcriptase
1991 Science
The catalytic subunit of yeast telomerase
1997
Intraspecies transfer via total cellular DNA of the gene for hypoxanthine phosphoribosyltransferase into cultured mouse cells
1979
Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus
1984 StandoutNatureNobel
Linkage of prion protein and scrapie incubation time genes
1986 StandoutNobel
Phi 29 DNA polymerase active site. Mutants in conserved residues Tyr254 and Tyr390 are affected in dNTP binding.
1992
Molecular Targets for AIDS Therapy
1990 Science
Altering Genotype and Phenotype by DNA-Mediated Gene Transfer
1980 StandoutScienceNobel
A herpes simplex virus 1 integration site in the mouse genome defined by somatic cell genetic analysis
1978
Human immunodeficiency virus reverse transcriptase. Substrate and inhibitor kinetics with thymidine 5'-triphosphate and 3'-azido-3'-deoxythymidine 5'-triphosphate
1990
Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitors.
1991
Transformation of mammalian cells with genes from procaryotes and eucaryotes
1979 StandoutNobel
Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.
1993
Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study.
1993
Localization of Sed5, a putative vesicle targeting molecule, to the cis-Golgi network involves both its transmembrane and cytoplasmic domains.
1994
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene
1983 StandoutNobel
Expression of a chicken chromosomal ovalbumin gene injected into frog oocyte nuclei
1980 StandoutNatureNobel
Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases.
1988
Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor
1992 StandoutScience
Ovalbumin is synthesized in mouse cells transformed with the natural chicken ovalbumin gene.
1980
Initiation of Minus-Strand DNA Synthesis by Human Immunodeficiency Virus Type 1 Reverse Transcriptase
1999
Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract x-rays to 3.5-A resolution.
1991
A general model for genetic recombination.
1975
Primary structure of T4 DNA polymerase. Evolutionary relatedness to eucaryotic and other procaryotic DNA polymerases.
1988
Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine
1994
High-Frequency Transfer of Cloned Herpes Simplex Virus Type 1 Sequences to Mammalian Cells by Protoplast Fusion
1981
Separation of the complementary strands of DNA fragments on polyacrylamide gels
1977
A DNA glycosylase from Escherichia coli that releases free urea from a polydeoxyribonucleotide containing fragments of base residues
1980 StandoutNobel
High-frequency transfer of cloned herpes simplex virus type 1 sequences to mammalian cells by protoplast fusion.
1981
HIV-1 reverse transcriptase specifically interacts with the anticodon domain of its cognate primer tRNA.
1989 StandoutNobel
Correlation between a Coat Protein Amino-terminal Sequence and a Ribosome-binding DNA Sequence from φX 174
1973
Structural Relationship of Bacterial RecA Proteins to Recombination Proteins from Bacteriophage T4 and Yeast
1993 StandoutScienceNobel
Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution
2001 StandoutScienceNobel
Human immunodeficiency virus type 1 pol gene mutations which cause decreased susceptibility to 2',3'-dideoxycytidine
1992
Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase.
1991
Selection, recombination, and G----A hypermutation of human immunodeficiency virus type 1 genomes
1991
Reconstitution in vitro of RNase H activity by using purified N-terminal and C-terminal domains of human immunodeficiency virus type 1 reverse transcriptase.
1991
Structure, sequence and expression of the hepatitis delta (δ) viral genome
1986 StandoutNatureNobel
Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance
1998 StandoutScience
STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP
1994
Proteolytic release and crystallization of the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase
1991
Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Nonnucleoside Inhibitors
1995 Science
Crystal Structure of the Ribonuclease H Domain of HIV-1 Reverse Transcriptase
1991 Science
Substrate Binding in Human Immunodeficiency Virus Reverse Transcriptase
1989
Implication of the tRNA Initiation Step for Human Immunodeficiency Virus Type 1 Reverse Transcriptase in the Mechanism of 3‘-Azido-3‘-deoxythymidine (AZT) Resistance
1998
Point mutations which drastically affect the polymerization activity of encephalomyocarditis virus RNA-dependent RNA polymerase correspond to the active site of Escherichia coli DNA polymerase I.
1992
Reverse transcriptase of human immunodeficiency virus type 1: functionality of subunits of the heterodimer in DNA synthesis
1992
REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase
1989
High efficiency transformation by direct microinjection of DNA into cultured mammalian cells
1980 StandoutNobel
Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell
1980
Crystal Structure of Rat DNA Polymerase β: Evidence for a Common Polymerase Mechanism
1994 Science
3′-Azido-3′-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes
1998
Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents
1982 StandoutNatureNobel
Combination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89
1997
Reversible Chemical Modification of the Scrapie Agent
1981 StandoutScienceNobel
Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not.
1994
DNA polymerase I gene of Saccharomyces cerevisiae: nucleotide sequence, mapping of a temperature-sensitive mutation, and protein homology with other DNA polymerases.
1988
DNA sequence at the C termini of the overlapping genes A and B in bacteriophage φX174
1977 StandoutNatureNobel
Structure of DNA Polymerase I Klenow Fragment Bound to Duplex DNA
1993 StandoutScienceNobel
DNA- and RNA-dependent DNA polymerases
1993 StandoutNobel
Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity.
1989
Motif A of bacteriophage T4 DNA polymerase: role in primer extension and DNA replication fidelity. Isolation of new antimutator and mutator DNA polymerases.
1994
Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3‘-azido-3‘-deoxythymidine.
1992
Cleavage map of bacteriophage X174 RF DNA by restriction enzymes
1976
Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)
1989 Science
Subunit specificity of mutations that confer resistance to nonnucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase
1994
Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors
2004 StandoutNobel
Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli.
1992
A cellular gene encodes scrapie PrP 27-30 protein
1985 StandoutNobel
The double-strand-break repair model for recombination
1983 StandoutNobel
Potential Mechanism for Sustained Antiretroviral Efficacy of AZT-3TC Combination Therapy
1995 Science
Diethyl Pyrocarbonate in Nucleic Acid Research
1976
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids
1999
Complexes of HIV-1 Reverse Transcriptase with Inhibitors of the HEPT Series Reveal Conformational Changes Relevant to the Design of Potent Non-Nucleoside Inhibitors
1996
Structures of Ternary Complexes of Rat DNA Polymerase β, a DNA Template-Primer, and ddCTP
1994 Science
Bacteriophage PRD1 DNA polymerase: evolution of DNA polymerases.
1987
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
1986 StandoutNobel
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Identification of the primer binding domain in human immunodeficiency virus reverse transcriptase
1992
Phi 29 DNA polymerase active site. Residue ASP249 of conserved amino acid motif “Dx2SLYP” is critical for synthetic activities.
1993
Assembly of an Active Group II Intron−Maturase Complex by Protein Dimerization
2004 StandoutNobel
Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine.
1992
Identification of four conserved motifs among the RNA-dependent polymerase encoding elements.
1989
Single-Step Kinetics of HIV-1 Reverse Transcriptase Mutants Responsible for Virus Resistance to Nucleoside Inhibitors Zidovudine and 3-TC
1997
LAV Revisited: Origins of the Early HIV-1 Isolates from Institut Pasteur
1991 StandoutScienceNobel
Prevention of HIV-1 Infection and Preservation of CD4 Function by the Binding of CPFs to gp120
1990 Science
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor
1978 StandoutNobel
Biochemical transformation of mouse cells by fragments of herpes simplex virus DNA
1977
Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities.
1991
Crystal Structures of Zidovudine- or Lamivudine-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptases Containing Mutations at Codons 41, 184, and 215
2002
Characterization of the binding site for nevirapine (BI-RG-587), a nonnucleoside inhibitor of human immunodeficiency virus type-1 reverse transcriptase
1991
Transformation of the gene for hypoxanthine phosphoribosyltransferase
1979
Nucleotide sequence of bacteriophage φX174 DNA
1977 StandoutNatureNobel
Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor
1990 Science
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor
1997
Works of G. Darby being referenced
Zidovudine sensitivity of human immunodeficiency viruses from high-risk, symptom-free individuals during therapy
1990
Ordered Appearance of Zidovudine Resistance Mutations during Treatment of 18 Human Immunodeficiency Virus-Positive Subjects
1992
Characterization of a DNA Polymerase Mutant of Herpes Simplex Virus from a Severely Immunocompromised Patient Receiving Acyclovir
1989
The multifunctional folic acid sythesis fas gene of Pneumocystis carinii appears to encode dihydropteroate synthase and hydroxymethyldihydropterin pyrophosphokinase
1992
HIV-1 reverse transcriptase: crystallization and analysis of domain structure by limited proteolysis
1988
High resolution structures of HIV-1 RT from four RT–inhibitor complexes
1995
HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy
1989 StandoutScience
The Structure of Tobacco Rattle Virus Ribonucleic Acids: Nature of the 3'-Terminal Nucleosides
1972
The replication of bacteriophage ФX174 DNA in vitro
1971
Characterization of human immunodeficiency virus type 1 reverse transcriptase by using monoclonal antibodies: role of the C terminus in antibody reactivity and enzyme function
1988
The detection of virus DNA sequences in a herpes type 2 transformed hamster cell line (333‐8‐9)
1976
Chemical Degradation of DMA oxidized by Permanganate
1967 Nature
Evidence that the 'Active Centre' of the Herpes Simplex Virus Thymidine Kinase Involves an Interaction between Three Distinct Regions of the Polypeptide
1986
Site-specific mutagenesis of AIDS virus reverse transcriptase
1987 Nature
AIDS virus reverse transcriptase defined by high level expression in Escherichia coli.
1987
Introduction of the herpes simplex virus thymidine kinase gene into mouse cells using virus DNA or transformed cell DNA
1978
A Study of Sequence Homology between Tobacco Rattle Virus Ribonucleic Acids
1973
The structure of the DNA of bacteriophage φX174
1970
Related functional domains in virus DNA polymerases.
1987