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Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
2012 Science
Leptin therapy in insulin-deficient type I diabetes
2010
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Origins and evolution of the Western diet: health implications for the 21st century1,2
2005 Standout
Evidence That Glucose Metabolism Regulates Leptin Secretion from Cultured Rat Adipocytes*
1998
Mechanism of free fatty acid-induced insulin resistance in humans.
1996
Ceramides in insulin resistance and lipotoxicity
2005
Contributions of Insulin-Resistance and Insulin-Secretory Defects to the Pathogenesis of Type 2 Diabetes Mellitus
2003
Signalling aspects of insulin resistance in skeletal muscle
2000
Pathogenesis of type 2 diabetes mellitus
2004
Abdominal obesity and metabolic syndrome
2006 StandoutNature
Normal Fasting Plasma Glucose Levels and Type 2 Diabetes in Young Men
2005
Gastric Bypass Surgery Improves Metabolic and Hepatic Abnormalities Associated With Nonalcoholic Fatty Liver Disease
2006
Clinical importance of insulin secretion and its interaction with insulin resistance in the treatment of type 2 diabetes mellitus and its complications
2001
Inflammation and metabolic disorders
2006 StandoutNature
Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
2013
The FGF family: biology, pathophysiology and therapy
2009 Standout
Leptin revisited: its mechanism of action and potential for treating diabetes
2012
Receptor-mediated regional sympathetic nerve activation by leptin.
1997
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity
1999
Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes
2001
Mechanisms linking obesity with cardiovascular disease
2006 StandoutNature
Increased lipolysis in non‐obese pregnant women studied in the third trimester
2005
A Role for Ceramide, but Not Diacylglycerol, in the Antagonism of Insulin Signal Transduction by Saturated Fatty Acids
2003
Mechanisms modifying glucose oxidation in diabetes mellitus
1994
The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia
2012
Relationship Between Body Fat Mass and Free Fatty Acid Kinetics in Men and Women
2009
Interactions Between Glucose and FFA Metabolism in Man
1996
Autophagy regulates lipid metabolism
2009 StandoutNature
The metabolic syndrome
2010 Standout
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
2008 Standout
Nonalcoholic Fatty Liver Disease
2002 Standout
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
2005 Standout
Insulin Resistance — Mechanisms, Syndromes, and Implications
1991
Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease
2001
Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk
2016
Energy intake is associated with endotoxemia in apparently healthy men
2008
Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus.
1992
Obesity, diabetes and the central nervous system
1998
The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes
2013
Insulin sensitivity: modulation by nutrients and inflammation
2008
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
2002
Leptin's Actions on the Reproductive Axis: Perspectives and Mechanisms
1999
Adiponectin: A Novel Adipokine Linking Adipocytes and Vascular Function
2004
Obesity and Nonalcoholic Fatty Liver Disease: Biochemical, Metabolic, and Clinical Implications
2009 Standout
Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin
2002
Molecular insights into insulin action and secretion
2002
13C and 31P NMR Studies on the Effects of Increased Plasma Free Fatty Acids on Intramuscular Glucose Metabolism in the Awake Rat
1997
TLR4 links innate immunity and fatty acid–induced insulin resistance
2006 Standout
The metabolic syndrome
2005 Standout
Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance
2007
Hepatic fuel selection
1995
A central role for JNK in obesity and insulin resistance
2002 StandoutNature
Increased Levels of Plasma Acylcarnitines in Obesity and Type 2 Diabetes and Identification of a Marker of Glucolipotoxicity
2010
Central nervous system control of food intake
2000 StandoutNature
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Resting energy expenditure, body composition, and excess weight in the obese
1988
Nonalcoholic Steatohepatitis: Summary of An Aasld Single Topic Conference
2003 Standout
Dysfunctional fat cells, lipotoxicity and type 2 diabetes
2004
Global and societal implications of the diabetes epidemic
2001 StandoutNature
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
1998 StandoutNature
Phosphorylation of IRS proteins, insulin action, and insulin resistance
2008
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Fatty acids, lipotoxicity and insulin secretion
1999
Lipin, a lipodystrophy and obesity gene
2005
Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes
2004
The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones
2003
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Mechanisms of fatty acid-induced inhibition of glucose uptake.
1994 Standout
cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance
2010
The evolution of β‐cell dysfunction and insulin resistance in type 2 diabetes
2002
The hormone resistin links obesity to diabetes
2001 StandoutNature
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Impaired adipose tissue lipid storage, but not altered lipolysis, contributes to elevated levels of NEFA in type 2 diabetes. Degree of hyperglycemia and adiposity are important factors
2016
Free Fatty Acids and Pathogenesis of Type 2 Diabetes Mellitus
2000
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
2001
Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia
2001 Standout
Lipid overload and overflow: metabolic trauma and the metabolic syndrome
2003
Inflammation, Atherosclerosis, and Coronary Artery Disease
2005 Standout
Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review
2006
Troglitazone action is independent of adipose tissue.
1997
Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects—experiences from relatives and twin studies
2003
Leptin and the regulation of body weight in mammals
1998 StandoutNature
Lipolysis: pathway under construction
2005
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Prevention of fat-induced insulin resistance by salicylate
2001
Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits
2014 Standout
PKC-θ knockout mice are protected from fat-induced insulin resistance
2004
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
2004
Chronic effects of different fatty acids and leptin in INS-1 cells
2001
Intramyocellular lipids and insulin resistance
2004
Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
1998
Dietary Fat and Carbohydrates Differentially Alter Insulin Sensitivity During Caloric Restriction
2009
Role of the glucosamine pathway in fat-induced insulin resistance.
1997
A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
1998 Nature
Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state
2005
Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with Type II diabetes
2001
Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin
1998
Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling
2005
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
2009 Standout
Neurotensin in the rat anterior pituitary gland
1982 Nature
Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM
1996
The Role of Voltage-Gated Calcium Channels in Pancreatic β-Cell Physiology and Pathophysiology
2006
Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans
2004
PAI-1 and the Metabolic Syndrome
2006
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Type 2 diabetes: principles of pathogenesis and therapy
2005 Standout
Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets
2002
Signals That Regulate Food Intake and Energy Homeostasis
1998 Science
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation
2002
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
2001 Standout
Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance
2003
Pioglitazone Reduces Islet Triglyceride Content and Restores Impaired Glucose-Stimulated Insulin Secretion in Heterozygous Peroxisome Proliferator–Activated Receptor-γ–Deficient Mice on a High-Fat Diet
2004
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Effect of a Sustained Reduction in Plasma Free Fatty Acid Concentration on Intramuscular Long-Chain Fatty Acyl-CoAs and Insulin Action in Type 2 Diabetic Patients
2005
Changes in Plasma Leptin during the Treatment of Diabetic Ketoacidosis
1999
Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach
2004
Effects of preoptic injections of gastrin, cholecystokinin, secretin, vasoactive intestinal peptide and PHI on the secretion of luteinizing hormone and prolactin in ovariectomized estrogen-primed rats
1987
Central Role of the Adipocyte in the Metabolic Syndrome
2001
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
2008 StandoutNobel
Dose-Response Effect of Pioglitazone on Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes
2002
Inhibition of Insulin Sensitivity by Free Fatty Acids Requires Activation of Multiple Serine Kinases in 3T3-L1 Adipocytes
2004
Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor.
1995 StandoutNobel
How Obesity Causes Diabetes: Not a Tall Tale
2005 Science
Malonyl-CoA, fuel sensing, and insulin resistance
1999
Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus
2001
Increase in Endoplasmic Reticulum Stress–Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals
2008
Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
2008
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
2002 Standout
Rosiglitazone Improves Downstream Insulin Receptor Signaling in Type 2 Diabetic Patients
2003
A new predictive equation for resting energy expenditure in healthy individuals
1990 Standout
Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications.
1992
Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
2002
Lipotoxicity in Human Pancreatic Islets and the Protective Effect of Metformin
2002
Lipolysis in the Absence of Hormone-Sensitive Lipase
2002
Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron
2012 StandoutNobel
Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome
2000 Standout
PKC-θ knockout mice are protected from fat-induced insulin resistance
2004
The PPARs: From Orphan Receptors to Drug Discovery
2000 Standout
The Genetic Basis of Type 2 Diabetes Mellitus: Impaired Insulin Secretion versus Impaired Insulin Sensitivity
1998
The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala Polymorphism
2002
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role ofPGC1andNRF1
2003 Standout
Prolactin: Structure, Function, and Regulation of Secretion
2000 Standout
Mitochondrial Dysfunction and Type 2 Diabetes
2005 StandoutScience
Effect of PPAR-γ Activation and Inhibition on Glucose-Stimulated Insulin Release in INS-1e Cells
2004
Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity
2002
Inflammatory Mechanisms in Obesity
2011 Standout
Syndromes of Autoimmunity and Hypoglycemia: Autoantibodies Directed Against insulinand Its Receptor
1989
Turning down insulin signaling
2001
Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat
1999
Pancreatic β-Cell Lipotoxicity Induced by Overexpression of Hormone-Sensitive Lipase
2003
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
1993 StandoutScience
Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice
2011
Interactions Between Glucose and FFA Metabolism in Man
1996
Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance
2017
Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance
2009
Banting Lecture 2001
2002
Metabolic Syndrome: A Clinical and Molecular Perspective
2004
The Metabolic Syndrome
2008 Standout
Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
2004 StandoutScience
A reappraisal of the caloric requirements of men
1987
Effects of Acute Changes of Plasma Free Fatty Acids on Intramyocellular Fat Content and Insulin Resistance in Healthy Subjects
2001
Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance
2014
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
1999
Understanding the Physiology of FGF21
2015
Computer Simulation Studies of the Catalytic Mechanism of Human Aldose Reductase
2000 StandoutNobel
Free Fatty Acids Reduce Splanchnic and Peripheral Glucose Uptake in Patients With Type 2 Diabetes
2002
Pancreatic β-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
2004
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness
2012
Rat Small Intestine Is an Insulin-Sensitive Gluconeogenic Organ
2001
Improved Glucose and Lipid Metabolism in Genetically Obese Mice Lacking aP2
2000
The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents
2014
Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α
2002
Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance.
2000
Insulin Resistance and Atherosclerosis
2006
Plasma gonadotropin, prolactin levels and hypothalamic tyrosine hydroxylase activity following intraventricular bombesin and secretin in ovariectomized conscious rats
1983
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
2000
A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes
2003
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
2002
Fasting for 72 h increases intramyocellular lipid content in nondiabetic, physically fit men
2002
Works of G. Boden being referenced
Circulating FGF-21 Levels in Normal Subjects and in Newly Diagnose Patients with Type 2 Diabetes Mellitus
2007
Effects of Free Fatty Acids (FFA) on Glucose Metabolism: Significance for Insulin Resistance and Type 2 Diabetes
2003
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction
2002
Nonbinding inhibitory antiinsulin receptor antibodies. A new type of autoantibodies in human diabetes.
1988
Effects of fat on insulin-stimulated carbohydrate metabolism in normal men.
1991
Metabolic effects of darglitazone, an insulin sensitizer, in NIDDM subjects
1995
Effects of glucagon on plasma amino acids.
1984
A reappraisal of caloric requirements in healthy women
1986
Effect of hyperinsulinemia on urea pool size and substrate oxidation rates
1988
Quantitation of glycolysis and skeletal muscle glycogen synthesis in humans
1993
Disruption of circadian insulin secretion is associated with reduced glucose uptake in first-degree relatives of patients with type 2 diabetes.
1999
Effects of lipid on basal carbohydrate metabolism in normal men
1991
Long-term effects of dietary fiber on glucose tolerance and gastric emptying in noninsulin-dependent diabetic patients
1983
In Vivoandin VitroEffects of Antiinsulin Receptor Antibodies*
1984
Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects.
1998
Energy Metabolism in Feasting and Fasting
1979
Effect of insulin on fat metabolism during and after normal pregnancy.
1999
Elevated serum human growth hormone and decreased serum insulin in prediabetic males after intravenous tolbutamide and glucose
1968
Hepatic, gut, and renal substrate flux rates in patients with hepatic cirrhosis.
1981
Effects of oleate and fatty acids from omental adipocytes on insulin uptake in rat liver cells.
1993
Effects of Therapy on the Nature and Quantity of Fuels Oxidized During Diabetic Ketoacidosis
1980
Rapid Intravenous Sodium Acetoacetate Infusion in Man METABOLIC AND KINETIC RESPONSES
1973
Identification, characterization, and distribution of secretin immunoreactivity in rat and pig brain.
1981
Abnormal serum growth hormone responses in genetically potential-diabetic male patients with normal oral glucose tolerance: Evidence for an insulin-like action of growth hormone in vivo
1973
Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes.
1999
Effects of Anti-Insulin Receptor Antibodies (AIRA) on Downregulation and Turnover of Insulin Receptors on Cultured Hepatocytes
1986
Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.
1999
Effects of a 48-h fat infusion on insulin secretion and glucose utilization
1995
Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes
2003
Acetone Metabolism During Diabetic Ketoacidosis
1982
Nature and quantity of fuels consumed in patients with alcoholic cirrhosis.
1983
Effects of insulin on fatty acid reesterification in healthy subjects
1993
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
1997
Effect of fasting on serum leptin in normal human subjects.
1996
Effects of prolonged glucose infusion on insulin secretion, clearance, and action in normal subjects
1996
Hepatic and renal metabolism before and after portasystemic shunts in patients with cirrhosis.
1985