Standout Papers
- Observations on the brains of demented old people (1970)
- The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects (1968)
- Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. (1978)
Citation Impact
Citing Papers
Patients with hippocampal amnesia cannot imagine new experiences
2007 StandoutNobel
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
Delirium in the Intensive Care Unit: Occurrence and Clinical Course in Older Patients
2003
NORMAL AGEING, IMPAIRED COGNITIVE FUNCTION, AND SENILE DEMENTIA OF THE ALZHEIMER'S TYPE: A CONTINUUM?
1988
Diagnostic Criteria for Vascular Cognitive Disorders
2014
Alzheimer 100 – highlights in the history of Alzheimer research
2006
Pharmacology of nootropics and metabolically active compounds in relation to their use in dementia
1990
The impact of delirium in the intensive care unit on hospital length of stay
2001 Standout
Assessing Patient Dependence in Alzheimer's Disease
1994
t-loops at trypanosome telomeres
2001
Vascular dementia
2015 Standout
Whole Genome Sequences of a Male and Female Supercentenarian, Ages Greater than 114 Years
2012
Combined cholinergic and serotonergic denervation of the forebrain produces severe deficits in a spatial learning task in the rat
1988
Immunohistochemical verification of senile and kuru plaques in Creutzfeldt‐Jakob disease and the allied disease
1988
Evaluation of delirium in critically ill patients: Validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
2001 Standout
Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4695 mRNA is predominantly produced in rat and human brain
1990
Cerebrospinal fluid protein biomarkers for Alzheimer’s disease
2004
Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease
1988
Prions and Neurodegenerative Diseases
1987 StandoutNobel
The prevalence and causes of dementia in people under the age of 65 years
2003
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
1995 StandoutNatureNobel
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
1997 Standout
Alzheimer's disease versus dementia with Lewy bodies: Cerebral metabolic distinction with autopsy confirmation
2001
Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit
2004 Standout
Abnormality of Gait as a Predictor of Non-Alzheimer's Dementia
2002
Ischemic stress induces deposition of amyloid ? immunoreactivity in human brain
1995
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
1999
The Prognostic Significance of Delirium in Older Hospital Patients
1997
Is Binding to Nicotinic Acetylcholine and Dopamine Receptors Related to Working Memory in Rats?
1997
Nurses' Recognition of Delirium and Its Symptoms
2001
Leisure Activities and the Risk of Dementia in the Elderly
2003 Standout
THE PROGRESSION OF THE PATHOLOGICAL CHANGES OF ALZHEIMER'S DISEASE IN FRONTAL AND TEMPORAL NEOCORTEX EXAMINED BOTH AT BIOPSY AND AT AUTOPSY
1988
Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals
1988
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
L‐Deprenyl in the Treatment of Mild Dementia of the Alzheimer Type: Results of a 15–Month Trial
1993
Development of dementing illnesses in an 80‐year‐old volunteer cohort
1989
Research Evaluation and Prospective Diagnosis of Dementia With Lewy Bodies
2002
Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease
1989
Toward a pathological definition of vascular dementia
2010
Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence
1991
Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice
2001
Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles
1992 StandoutNobel
The risk of dementia and death after delirium
1999
Memory Deficits in Aged Cebus Monkeys and Facilitation With Central Cholinomimetics
1980
A critique of instruments and methods to detect, diagnose, and rate delirium
1995
Tangles and plaques in nondemented aging and ?preclinical? Alzheimer's disease
1999
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
1988 Nature
Alzheimer's disease
2006 Standout
Randomized Clinical Trial of Daily Aspirin Therapy in Multi‐Infarct Dementia
1989
Effect of Vascular Lesions on Cognition in Alzheimer's Disease: A Community‐Based Study
2004
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
COMPARISON OF SEVEN STAINING METHODS FOR SENILE PLAQUES AND NEUROFIBRILLARY TANGLES IN A PROSPECTIVE SERIES OF 15 ELDERLY PATIENTS
1989
Switching and Signaling at the Telomere
2001 StandoutNobel
Arisugacins, selective acetylcholinesterase inhibitors of microbial origin
1997 StandoutNobel
Do MCI criteria in drug trials accurately identify subjects with predementia Alzheimer's disease?
2005
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
1991 Standout
Transmissible and non-transmissible amyloidoses: autocatalytic post-translational conversion of host precursor proteins to β-pleated sheet configurations
1988 Nobel
Vascular dementia: Different forms of vessel disorders contribute to the development of dementia in the elderly brain
2012
Prognosis after Hospital Discharge of Older Medical Patients with Delirium
1992
Pathology and pathogenesis of vascular cognitive impairment—a critical update
2013
Hippocampal Complexin Proteins and Cognitive Dysfunction in Schizophrenia
2005
A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
1999 Standout
The Hallmarks of Aging
2013 Standout
Identification of Alzheimer and vascular lesion thresholds for mixed dementia
2007
The Pathobiology of Vascular Dementia
2013 Standout
Tau pathology in Alzheimer disease and other tauopathies
2004
Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage
1989
Hippocampal formation glucose metabolism and volume losses in MCI and AD
2001
Memory and mental status correlates of modified Braak staging
1999
Brain angiotensin receptor subtypes in the control of physiological and behavioral responses
1994
Delirium in Mechanically Ventilated Patients
2001 Standout
Does amyloid precede paired helical filaments in the senile plaque? A study of 15 cases with graded intellectual status in aging and Alzheimer disease
1988
Clinico‐Neuropathological Correlation of Alzheimer's Disease in a Community‐Based Case Series
1999
The Free Radical Theory of Aging
2003
Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway
1999 StandoutNobel
Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
1998 StandoutNobel
Precipitating Factors for Delirium in Hospitalized Elderly Persons
1996
Dementia of the Alzheimer Type
1980
Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing
1990 Science
SUBUNIT STRUCTURE OF THE ALZHEIMER TANGLE
1986
Human Memory and the Cholinergic System
1974
Alzheimer's paired helical filaments share epitopes with neurofilament side arms.
1986
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.
1988 StandoutNobel
Regional mapping of prion proteins in brain.
1992 StandoutNobel
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model
2008 StandoutNobel
Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease
1983
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate.
1989
Alzheimer's Disease: Insolubility of Partially Purified Paired Helical Filaments in Sodium Dodecyl Sulfate and Urea
1982 Science
Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation
1997 StandoutNobel
The cerebral cortex in presenil dementia
1973
Transneuronal transport of peroxidase-conjugated wheat germ agglutinin (WGA-HRP) from the olfactory epithelium to the brain of the adult rat
1986
Some morphometric aspects of the brain in senile dementia of the alzheimer type
1981
The Pharmacology of Memory: A Neurobiological Perspective
1981
Postmortem stability of α-bungarotoxin binding sites in mouse and human brain
1981
The Behavior Rating Scale for Dementia of the Consortium to Establish a Registry for Alzheimer's Disease. The Behavioral Pathology Committee of the Consortium to Establish a Registry for Alzheimer's Disease
1995
Possible biochemical basis of memory disorder in Alzheimer disease
1978
Computerised tomography and intellectual impairment in the elderly.
1976
Image reconstruction of the Alzheimer paired helical filament.
1985
Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease
1987 Science
A Century of Alzheimer's Disease
2006 StandoutScience
A new rating scale for Alzheimer's disease
1984 Standout
Expression of the human beta-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice.
1991
NINDS AIREN neuroimaging criteria do not distinguish stroke patients with and without dementia
2004
Changes in the Monoamine Containing Neurones of the Human Cns in Senile Dementia
1980
Normal cortical concentration of cholecystokinin-like immunoreactivity with reduced choline acetyltransferase activity in senile dementia of Alzheimer type
1981
[ 11 C]PIB in a nondemented population
2006
Neurotransmitter enzyme abnormalities in senile dementia
1977
Amyloid and senile plaques and cerebral blood vessels
1982
Research subject recruitment for gerontological studies of pharmacological agents
1982
Nervous system distribution of the serotonin 5-HT3 receptor mRNA.
1993 StandoutNobel
Plaques, tangles and dementia
1982
Total Synthesis of α-Pyrone Meroterpenoids, Novel Bioactive Microbial Metabolites
2005 StandoutNobel
Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A quantitative study
1978
Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading
1981
Choline uptake in patients with Alzheimer pre-senile dementia
1981
Age-Related Changes in Passive Avoidance Retention: Modulation with Dietary Choline
1980 Science
Age-related alterations in the rodent brain cholinergic system and behavior
1980
Molecular Biology of Learning: Modulation of Transmitter Release
1982 StandoutScienceNobel
A Prospective Study of Delirium in Hospitalized Elderly
1990
Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease
1997 StandoutNobel
Selective vulnerability of neurones in organic dementia
1977 Nature
Reduced corticol choline acetyltransferase activity in senile dementia of Alzheimer type is not accompanied by changes in vasoactive intestinal polypeptide
1980
Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type
1980
Dementia in Parkinson disease
1979
Alzheimer's Disease and Down's Syndrome*
1982
Perivascular deposits of serum proteins in cerebral cortex in vascular dementia
1985
Biochemical changes in the cholinergic system of the ageing brain and in senile dementia
1980
Neurotransmitter-related enzymes in senile dementia of the alzheimer type
1979
Three Cases of Enduring Memory Impairment after Bilateral Damage Limited to the Hippocampal Formation
1996
Donepezil in vascular dementia
2003
Cholinergic Innervation in Neuritic Plaques
1982 Science
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
2004 StandoutNobel
Prevalence and Malignancy of Alzheimer Disease
1976
The Prevalence and Malignancy of Alzheimer Disease
1976
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
1992 StandoutNobel
Development and Application of the Extended Scale for Dementia
1979
Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia
1981
Cell counts in human cerebral cortex in normal adults throughout life using an image analysing computer
1980
Cholinergic receptor loss in brains of aging mice
1980
Paired helical filaments from Alzheimer disease patients contain cytoskeletal components.
1985
Object-memory evaluation for prospective detection of dementia in normal functioning elderly: Predictive and normative data
1990
GLUCOSE METABOLISM AND ACETYLCHOLINE SYNTHESIS IN RELATION TO NEURONAL ACTIVITY IN ALZHEIMER'S DISEASE
1980
Neuropeptides in Alzheimer's disease, depression and schizophrenia
1981
Presynaptic cholinergic mechanisms in brain of aged rats with memory impairments
1981
Pathological verification of ischemic score in differentiation of dementias
1980
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.
1988 StandoutNobel
Choline chloride effects on memory in the elderly☆
1980
Biochemistry of Alzheimer's Dementia
1982
Changes in the Brain Catecholamines in Patients with Dementia of Alzheimer Type
1979
Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus
1987 Science
Cortical somatostatin-like immunoreactivity in cases of Alzheimer's disease and senile Dementia of the Alzheimer type
1981
A New Clinical Scale for the Staging of Dementia
1982 Standout
Influence of leisure activity on the incidence of Alzheimer’s Disease
2001
Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease
1989 Science
Coenzyme a-acetylating enzymes in Alzheimer's disease: Possible cholinergic ‘compartment’ of pyruvate dehydrogenase
1980
Brain Function, Intellectual Impairment and Education in the Aged
1978
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
1982 StandoutScience
Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein.
1994 StandoutNobel
Neuropeptide deficits in schizophrenia vs. Alzheimer's disease cerebral cortex
1996
Subunit structure of paired helical filaments in Alzheimer's disease.
1985
Basal forebrain neurons in the dementia of Parkinson disease
1983
Senile dementia of the Alzheimer type
1983
Neuropathological and biochemical observations on the noradrenergic system in Alzheimer's disease
1981
Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation
1984 StandoutScience
Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study.
2000 Standout
Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type
1989
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
1983 Standout
A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease
1987
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Alzheimer's disease: a correlative study.
1986
NEUROFIBRILLARY TANGLES AND THE PATHOGENESIS OF DEMENTIA: A QUANTITATIVE STUDY
1976
Neurotransmitter metabolites, enzymes and receptors in experimental scrapie
1985
Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme
1996
Physostigmine and its effect on six patients with dementia
1981
Age and neurochemical correlates of radial maze performance in rats
1981
Parkinson disease, dementia, and alzheimer disease: Clinicopathological correlations
1980
Nicotine for Alzheimer's disease
2001
Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats
1981
Clinical diagnosis of Alzheimer's disease
1984 Standout
ALZHEIMER'S PRESENILE DEMENTIA, SENILE DEMENTIA OF ALZHEIMER TYPE AND DOWN'S SYNDROME IN MIDDLE AGE FORM AN AGE RELATED CONTINUUM OF PATHOLOGICAL CHANGES
1984
Some Speculations about Prions, Amyloid, and Alzheimer's Disease
1984 StandoutNobel
Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.
1988 StandoutNobel
Antibodies to a scrapie prion protein
1984 StandoutNatureNobel
Deconstructing complexin function in activating and clamping Ca 2+ -triggered exocytosis by comparing knockout and knockdown phenotypes
2013 StandoutNobel
Prion protein preamyloid and amyloid deposits in Gerstmann-Sträussler-Scheinker disease, Indiana kindred.
1992 StandoutNobel
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent
2005
Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation
1983 StandoutScience
A genetic approach to trace neural circuits
1999 StandoutNobel
Cerebral Blood Flow in Dementia
1975 Standout
Works of G. Blessed being referenced
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.
1978 Standout
Reduced dopamine-beta-hydroxylase activity in Alzheimer's disease
1981
The Diagnosis of Dementia in the Elderly a Comparison of CAMCOG (the Cognitive Section of CAMDEX), the AGECAT Program, DSM–III, the Mini-Mental State Examination and Some Short Rating Scales
1991
Correlation between the 37-Item Mental Test Score and Abbreviated 10-Item Mental Test Score by Psychogeriatric Day Patients
1987
Topography, Extent, and Clinical Relevance of Neurochemical Deficits in Dementia of Lewy Body Type, Parkinson's Disease, and Alzheimer's Disease
1991
CONFUSION RATINGS AND ABBREVIATED MENTAL TEST PERFORMANCE: A COMPARISON
1986
Correlation between Scores for Dementia and Counts of ‘Senile Plaques’ in Cerebral Grey Matter of Elderly Subjects
1966 Nature
Cell loss in the locus coeruleus in senile dementia of Alzheimer type
1981
Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.
1985
Extensive loss of choline acetyltransferase activity is not reflected by neuronal loss in the nucleus of meynert in Alzheimer's disease
1982
CHANGES IN BRAIN CHOLINESTERASES IN SENILE DEMENTIA OF ALZHEIMER TYPE
1978
ALUMINOSILICATES AND SENILE PLAQUE FORMATION IN ALZHEIMER'S DISEASE
1986
Observations on the brains of non-demented old people
1968
Nicotinic receptor abnormalities in Alzheimer's and Parkinson's diseases.
1987
The relationship between quantitative measures of dementia and of degenerative changes in the cerebral grey matter of elderly subjects.
1967
Observations on the brains of demented old people
1970 Standout
Hippocampal Free Amino Acids in Alzheimer's Disease
1980
The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects
1968 Standout
Pathological changes in the nucleus of meynert in Alzheimer's and Parkinson's diseases
1983
Aspects of Psychiatry in the Elderly
1967
Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes
1981