Standout Papers
- Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form (2002)
- The role of modifications in codon discrimination by tRNALysUUU (2004)
- Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon (2005)
- Structure of a purine-purine wobble base pair in the decoding center of the ribosome (2004)
- Structure of the 70 S Ribosome Complexed with mRNA and tRNA (2006)
- The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA (2009)
- Mechanism for expanding the decoding capacity of transfer RNAs by modification of uridines (2007)
- Atomic Structures of the 30S Subunit and Its Complexes with Ligands and Antibiotics (2001)
- GTPase activation of elongation factor EF‐Tu by the ribosome during decoding (2009)
Citation Impact
Citing Papers
Rχ-01, a New Family of Oxazolidinones That Overcome Ribosome-Based Linezolid Resistance
2008
Crystal Structure of the Eukaryotic 40 S Ribosomal Subunit in Complex with Initiation Factor 1
2010 Science
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70 S Ribosome
2009 StandoutScienceNobel
Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity
2007 StandoutNobel
Simulating movement of tRNA into the ribosome during decoding
2005
Structure of the Yeast Mitochondrial Large Ribosomal Subunit
2014 ScienceNobel
Crystal Structure of the Eukaryotic Ribosome
2010 Science
Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome
2008 StandoutScienceNobel
Structures of the Bacterial Ribosome at 3.5 A Resolution
2005 Science
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
2020 StandoutScienceNobel
Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes
2008
The Ribosome as a Conveying Thermal Ratchet Machine
2009
RELION: Implementation of a Bayesian approach to cryo-EM structure determination
2012 Standout
Distortion of tRNA upon Near-cognate Codon Recognition on the Ribosome
2011
High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy
2013 StandoutNobel
The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
2009 StandoutNobel
Scaffolding as an Organizing Principle in Trans-translation
2006 StandoutNobel
Structure of the signal recognition particle interacting with the elongation-arrested ribosome
2004 StandoutNatureNobel
tRNA selection and kinetic proofreading in translation
2004 Nobel
How Initiation Factors Maximize the Accuracy of tRNA Selection in Initiation of Bacterial Protein Synthesis
2006
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Interactions of elongation factor EF‐P with the Escherichia coli ribosome
2008
A Uniform Response to Mismatches in Codon-Anticodon Complexes Ensures Ribosomal Fidelity
2006
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
The Structure and Function of the Eukaryotic Ribosome
2012
The ribosome in focus: new structures bring new insights
2007
Decoding the genome: a modified view
2004
A sequence element that tunes Escherichia coli tRNAAlaGGC to ensure accurate decoding
2009
Cleavage of the A Site mRNA Codon during Ribosome Pausing Provides a Mechanism for Translational Quality Control
2003
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Hibernating Bears, Antibiotics, and the Evolving Ribosome (Nobel Lecture)
2010 Nobel
Atomic structures of the eukaryotic ribosome
2012
Interactions of the Release Factor RF1 with the Ribosome as Revealed by Cryo-EM
2006 StandoutNobel
Crosslinking of Translation Factor EF-G to Proteins of the Bacterial Ribosome Before and After Translocation
2007
Mutational analysis reveals two independent molecular requirements during transfer RNA selection on the ribosome
2006
Kinetically Competent Intermediates in the Translocation Step of Protein Synthesis
2007
Structural studies of elongation and release factors
2008
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
Functional conformations of the L11–ribosomal RNA complex revealed by correlative analysis of cryo-EM and molecular dynamics simulations
2006 StandoutNobel
The Spliceosome: Design Principles of a Dynamic RNP Machine
2009 Standout
Suppression of Multiple Substrate Mutations by Spliceosomal prp8 Alleles Suggests Functional Correlations with Ribosomal Ambiguity Mutants
2004
The Ribosomal Peptidyl Transferase
2007
Natural amino acids do not require their native tRNAs for efficient selection by the ribosome
2009
Accommodation of aminoacyl-tRNA into the ribosome involves reversible excursions along multiple pathways
2010
Structural basis for aminoglycoside inhibition of bacterial ribosome recycling
2007
In Vitro Reconstitution of Eukaryotic Translation Reveals Cooperativity between Release Factors eRF1 and eRF3
2006
Structural aspects of translation termination on the ribosome
2011
A structural view of translation initiation in bacteria
2008
Mechanical Studies of Single Ribosome/mRNA Complexes
2005
The sarcin–ricin loop of 23S rRNA is essential for assembly of the functional core of the 50S ribosomal subunit
2008
Phylogenetic distribution of translational GTPases in bacteria
2007
A flexible loop in yeast ribosomal protein L11 coordinates P-site tRNA binding
2010
Understanding Discrimination by the Ribosome: Stability Testing and Groove Measurement of Codon–Anticodon Pairs
2003
Contribution of 16S rRNA nucleotides forming the 30S subunit A and P sites to translation inEscherichia coli
2005
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
2009 Standout
Exploring conformational modes of macromolecular assemblies by multiparticle cryo-EM
2009
Ribosomal RNAs are tolerant toward genetic insertions: evolutionary origin of the expansion segments
2008
Coupling of Ribosomal L1 Stalk and tRNA Dynamics during Translation Elongation
2008
A Model for How Ribosomal Release Factors Induce Peptidyl-tRNA Cleavage in Termination of Protein Synthesis
2007
Elongation factors on the ribosome
2005
Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit
2013 StandoutNatureNobel
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
A hierarchical model for evolution of 23S ribosomal RNA
2009 Nature
Streptomycin interferes with conformational coupling between codon recognition and GTPase activation on the ribosome
2004
A fast dynamic mode of the EF‐G‐bound ribosome
2009
Molecular dynamics of EF‐G during translocation
2011 StandoutNobel
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
2008
Mechanism of tetracycline resistance by ribosomal protection protein Tet(O)
2013 StandoutNobel
Structural insights into cognate versus near‐cognate discrimination during decoding
2011 StandoutNobel
Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome
2009 StandoutNobel
Viral IRES RNA structures and ribosome interactions
2008
Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy
2010 Nature
Eukaryotic class 1 translation termination factor eRF1 − the NMR structure and dynamics of the middle domain involved in triggering ribosome‐dependent peptidyl‐tRNA hydrolysis
2007
Insights into the decoding mechanism from recent ribosome structures
2003 StandoutNobel
A structural understanding of the dynamic ribosome machine
2008 StandoutNobel
Site-specific labeling of the ribosome for single-molecule spectroscopy
2005
Structure of the mammalian ribosomal pre-termination complex associated with eRF1•eRF3•GDPNP
2013 StandoutNobel
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
Correlating ribosome function with high-resolution structures
2008 StandoutNobel
Simulation and analysis of single-ribosome translation
2009
Release Factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalorimetric studies
2007
Aminoglycoside activity observed on single pre-translocation ribosome complexes
2009
Structural dynamics of the ribosome
2008
Recognition and selection of tRNA in translation
2004
Navigating the ribosome's metastable energy landscape
2009
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Unraveling the Structure of the Ribosome (Nobel Lecture)
2010 Nobel
Structural rearrangements of the ribosome at the tRNA proofreading step
2010
Insights into the mechanisms of splicing: more lessons from the ribosome: Figure 1.
2005
Evolution of nonstop, no-go and nonsense-mediated mRNA decay and their termination factor-derived components
2008
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Structure of the ternary initiation complex aIF2–GDPNP–methionylated initiator tRNA
2012
Structural basis of highly conserved ribosome recycling in eukaryotes and archaea
2012 Nature
Modified Uridines with C5-methylene Substituents at the First Position of the tRNA Anticodon Stabilize U·G Wobble Pairing during Decoding
2008 StandoutNobel
Roles of 5-substituents of tRNA wobble uridines in the recognition of purine-ending codons
2003
Assembly and Analysis of Eukaryotic Translation Initiation Complexes
2007
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Mutational Analysis of S12 Protein and Implications for the Accuracy of Decoding by the Ribosome
2007
Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNAMet and AUG selection
2008
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Structural basis for translation termination by archaeal RF1 and GTP-bound EF1α complex
2012
The Ribosomal Stalk Binds to Translation Factors IF2, EF-Tu, EF-G and RF3 via a Conserved Region of the L12 C-terminal Domain
2006
Observation of Intersubunit Movement of the Ribosome in Solution Using FRET
2007
The ribosome’s response to codon–anticodon mismatches
2006
A short guide for molecular dynamics simulations of RNA systems
2008
An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination
2007
Flexible Fitting of Atomic Structures into Electron Microscopy Maps Using Molecular Dynamics
2008 StandoutNobel
RF3 Induces Ribosomal Conformational Changes Responsible for Dissociation of Class I Release Factors
2007 StandoutNobel
Two-step model of stop codon recognition by eukaryotic release factor eRF1
2013
Visualization of the Hybrid State of tRNA Binding Promoted by Spontaneous Ratcheting of the Ribosome
2008 StandoutNobel
Structure of the Dom34–Hbs1 complex and implications for no-go decay
2010
Identification of Two Distinct Hybrid State Intermediates on the Ribosome
2007
Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements
2006
Dynamics of the base of ribosomal A-site finger revealed by molecular dynamics simulations and Cryo-EM
2009 StandoutNobel
Peptide‐Bond Synthesis on the Ribosome: No Free Vicinal Hydroxy Group Required on the Terminal Ribose Residue of Peptidyl‐tRNA
2008
Cryo-EM Visualization of a Viral Internal Ribosome Entry Site Bound to Human Ribosomes
2004 StandoutNobel
Kinetic Determinants of High-Fidelity tRNA Discrimination on the Ribosome
2004
Alignment/misalignment hypothesis for tRNA selection by the ribosome
2006
Spontaneous Intersubunit Rotation in Single Ribosomes
2008
Macromolecular structure modeling from 3D EM using VolRover 2.0
2012
Spontaneous reverse movement of mRNA-bound tRNA through the ribosome
2007
The Role of L1 Stalk–tRNA Interaction in the Ribosome Elongation Cycle
2010
Likelihood-based classification of cryo-EM images using FREALIGN
2013
tRNA’s Wobble Decoding of the Genome: 40 Years of Modification
2006
Genetic evidence against the 16S ribosomal RNA helix 27 conformational switch model
2003
Heterogeneity of Large Macromolecular Complexes Revealed by 3D Cryo-EM Variance Analysis
2008
Role of the individual domains of translation termination factor eRF1 in GTP binding to eRF3
2007
The role of tRNA as a molecular spring in decoding, accommodation, and peptidyl transfer
2004 StandoutNobel
Comparison of characteristics and function of translation termination signals between and within prokaryotic and eukaryotic organisms
2006
Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu
2009 StandoutNobel
Translation factors direct intrinsic ribosome dynamics during translation termination and ribosome recycling
2009
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA
2005 StandoutNatureNobel
Reverse Translocation of tRNA in the Ribosome
2006
Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation
2004 StandoutNobel
Crystal structure of the ribosome recycling factor bound to the ribosome
2007 StandoutNobel
Structural basis for messenger RNA movement on the ribosome
2006 Nature
Multiple stages in codon–anticodon recognition:double-trigger mechanisms and geometric constraints☆
2006
Deletion of a Conserved, Central Ribosomal Intersubunit RNA Bridge
2006
Conformations of Flanking Bases in HIV-1 RNA DIS Kissing Complexes Studied by Molecular Dynamics
2007
Two Distinct Components of Release Factor Function Uncovered by Nucleophile Partitioning Analysis
2007
Antibacterial drug discovery in the resistance era
2016 StandoutNature
Structure of the no-go mRNA decay complex Dom34–Hbs1 bound to a stalled 80S ribosome
2011
Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit
2003 StandoutNobel
Interaction of Helix D of Elongation Factor Tu with Helices 4 and 5 of Protein L7/12 on the Ribosome
2004
Crystal Structure of the 70S Ribosome Bound with the Q253P Mutant Form of Release Factor RF2
2013
Structure of the 30S translation initiation complex
2008 Nature
Following translation by single ribosomes one codon at a time
2008 Nature
A signal relay between ribosomal protein S12 and elongation factor EF-Tu during decoding of mRNA
2008
The antibiotic viomycin traps the ribosome in an intermediate state of translocation
2007
Structural basis for translation termination on the 70S ribosome
2008 Nature
Kinetic Analysis of Interaction of Eukaryotic Release Factor 3 with Guanine Nucleotides
2006
tRNA–mRNA mimicry drives translation initiation from a viral IRES
2007
Elastic properties of ribosomal RNA building blocks: molecular dynamics of the GTPase-associated center rRNA
2007
Termination and post-termination events in eukaryotic translation
2012
Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit
2008 StandoutNobel
Structure and Dynamics of a Processive Brownian Motor: The Translating Ribosome
2010 StandoutNobel
What we have learned from ribosome structures
2008 StandoutNobel
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-Å resolution
2010
Comprehensive genetic selection revealed essential bases in the peptidyl-transferase center
2006 StandoutNobel
Structures of the Ribosome in Intermediate States of Ratcheting
2009 Science
Converting structural information into an allosteric-energy-based picture for elongation factor Tu activation by the ribosome
2011 StandoutNobel
A Click Chemistry Approach to Pleuromutilin Conjugates with Nucleosides or Acyclic Nucleoside Derivatives and Their Binding to the Bacterial Ribosome
2008
Integrity of the P-site is probed during maturation of the 60S ribosomal subunit
2012 StandoutNobel
Spontaneous formation of the unlocked state of the ribosome is a multistep process
2009
Crystal structure of a translation termination complex formed with release factor RF2
2008
An Arc of Unpaired “Hinge Bases” Facilitates Information Exchange among Functional Centers of the Ribosome
2006
Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM
2008 StandoutNobel
Initiation of Protein Synthesis in Bacteria
2005
Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1α complex
2010
Interactions and dynamics of the Shine–Dalgarno helix in the 70S ribosome
2007
Structural basis for mRNA and tRNA positioning on the ribosome
2006
Ribosomal Translocation: One Step Closer to the Molecular Mechanism
2009
Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease
2004
The Mechanism for Activation of GTP Hydrolysis on the Ribosome
2010 ScienceNobel
Peptide Release on the Ribosome: Mechanism and Implications for Translational Control
2008
Deleterious mutations in small subunit ribosomal RNA identify functional sites and potential targets for antibiotics
2005
Structural basis for TetM-mediated tetracycline resistance
2012
Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles
2013
The role of fluctuations in tRNA selection by the ribosome
2007 Nobel
The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State
2009 StandoutScienceNobel
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
2014 StandoutNobel
Irreversible chemical steps control intersubunit dynamics during translation
2008
Transfer RNA in the hybrid P/E state: Correlating molecular dynamics simulations with cryo-EM data
2007 StandoutNobel
Structural basis for cross-resistance to ribosomal PTC antibiotics
2008 StandoutNobel
Crystal Structure of the Eukaryotic 60 S Ribosomal Subunit in Complex with Initiation Factor 6
2011 Science
Following movement of the L1 stalk between three functional states in single ribosomes
2009
X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli
2003
Cryo-EM structure of the mammalian eukaryotic release factor eRF1–eRF3-associated termination complex
2012 StandoutNobel
Role of Ribosomal Protein L27 in Peptidyl Transfer
2008
Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine
2004
Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosome
2010
The process of mRNA–tRNA translocation
2007 StandoutNobel
Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination
2007
RNA Structure: Reading the Ribosome
2005 Science
The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
2008
Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit
2008 StandoutNobel
An Active Role for tRNA in Decoding Beyond Codon:Anticodon Pairing
2005 Science
Acquisition of a natural resistance gene renders a clinical strain of methicillin‐resistantStaphylococcus aureusresistant to the synthetic antibiotic linezolid
2007
STRUCTURAL INSIGHTS INTO TRANSLATIONAL FIDELITY
2005 StandoutNobel
Fidelity at the Molecular Level: Lessons from Protein Synthesis
2009
Stop Codon Recognition by Release Factors Induces Structural Rearrangement of the Ribosomal Decoding Center that Is Productive for Peptide Release
2007
Allosteric collaboration between elongation factor G and the ribosomal L1 stalk directs tRNA movements during translation
2009
Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance
2003
Works of F.V. Murphy being referenced
Structure of the 70 S Ribosome Complexed with mRNA and tRNA
2006 StandoutScienceNobel
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA
2009 StandoutScienceNobel
A structural basis for streptomycin-induced misreading of the genetic code
2013
The role of modifications in codon discrimination by tRNALysUUU
2004 StandoutNobel
GTPase activation of elongation factor EF‐Tu by the ribosome during decoding
2009 StandoutNobel
Structure of a purine-purine wobble base pair in the decoding center of the ribosome
2004 StandoutNobel
Mechanism for expanding the decoding capacity of transfer RNAs by modification of uridines
2007 StandoutNobel
Atomic Structures of the 30S Subunit and Its Complexes with Ligands and Antibiotics
2001 StandoutNobel
Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form
2002 StandoutNobel
Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon
2005 StandoutNobel