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Exon mutations uncouple 5′ splice site selection from U1 snRNA pairing
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A mutation in the 530 loop ofEscherichia coli16S ribosomal RNA causes resistance to streptomycin
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1998
Mechanism for allosteric inhibition of an ATP-sensitive ribozyme
1998
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Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression
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Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria
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Unambiguous determination of the stereochemistry of nucleotidyl transfer catalyzed by DNA polymerase I from Escherichia coli
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Receptor-specific desensitization of the S49 lymphoma cell adenylyl cyclase. Unaltered behavior of the regulatory component.
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1985 Nobel
Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel
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1986
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Review: A History of Cyclodextrins
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Cell Surface Engineering by a Modified Staudinger Reaction
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1996
Recent advances in the staudinger reaction
1992
On the Mechanism of Ribonuclease A
1974
Experimental evidence for kinetic proofreading in the aminoacylation of tRNA by synthetase.
1977 StandoutNobel
Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2' modifications.
1992
GTP-binding proteins in membranes and the control of adenylate cyclase activity.
1977
Adenine Protonation in Domain B of the Hairpin Ribozyme
2000
Universally conserved and yeast-specific U1 snRNA sequences are important but not essential for U1 snRNP function.
1990 StandoutNobel
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
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1982
Chiral phosphorothioate analogues of B-DNA
1986
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1973
General Acid-Base Catalysis in the Mechanism of a Hepatitis Delta Virus Ribozyme
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In Vitro Selection of Functional Nucleic Acids
1999 StandoutNobel
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1998
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1979
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Isolation of virus-neutralizing RNAs from a large pool of random sequences.
1995
Chemistry of Inositol Lipid Mediated Cellular Signaling
1995
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Recognition of the Codon-Anticodon Helix by Ribosomal RNA
1999 Science
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1985 StandoutNatureNobel
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2000 StandoutNobel
Generation of a Catalytic Antibody by Site-Directed Mutagenesis
1989 Science
Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors.
1988
Conformational Flexibility of Phosphate, Phosphonate, and Phosphorothioate Methyl Esters in Aqueous Solution
1998 StandoutNobel
Bond Order and Charge Localization in Nucleoside Phosphorothioates
1985 Science
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2001 StandoutScienceNobel
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
1988 StandoutNatureNobel
A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site.
1988 StandoutNobel
Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system
1978
Human nucleotide excision nuclease removes thymine dimers from DNA by incising the 22nd phosphodiester bond 5' and the 6th phosphodiester bond 3' to the photodimer.
1992 StandoutNobel
In Vitro Selection of Catalytic Polynucleotides
1997
Cleavage of an Amide Bond by a Ribozyme
1995 Science
Works of Fritz Eckstein being referenced
Investigation of the inhibitory role of phosphorothioate internucleotidic linkages on the catalytic activity of the restriction endonuclease EcoRV
1990
Protection of oligonucleotide primers against degradation by DNA polymerase I
1987
Inter-domain cross-linking and molecular modelling of the hairpin ribozyme
1997
RNA cleavage by small catalytic RNAs
1995
The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction
1993 Nobel
Inhibition of restriction endonuclease hydrolysis by phosphorothioate-containing DNA
1989
A Three-Dimensional Model for the Hammerhead Ribozyme Based on Fluorescence Measurements
1994 Science
Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA
1993 Nobel
Structure-function relationships of hammerhead ribozymes: from understanding to applications
1995
The Structure, Function and Application of the Hammerhead Ribozyme
1997
Two autolytic processing reactions of a satellite RNA proceed with inversion of configuration
1990
Importance of exocyclic base functional groups of central core guanosines for hammerhead ribozyme activity
1993
Properties of 2'-fluorothymidine-containing oligonucleotides: interaction with restriction endonuclease EcoRV
1991
Left-handed DNA: from Synthetic Polymers to Chromosomes
1983
RNA mediated formation of a phosphorothioate diester bond
1988
Inhibition of deoxyribonucleases by phosphorothioate groups in oligodeoxyribonucleotides
1988
Oligonucleotide duplexes containing 2′-amino-2′-deoxycytidines: thermal stability and chemical reactivity
1994
Isoguanosine Substitution of Conserved Adenosines in the Hammerhead Ribozyme
1994
Direct sequencing of polymerase chain reaction amplified DNA fragments through the incorporation of deoxynucleoside α-thiotriphosphates
1988
Translation of 2′-modified mRNAin vitroandin vivo
1994
AUA-Cleaving Hammerhead Ribozymes: Attempted Selection for Improved Cleavage
1994
Study of a hammerhead ribozyme containing 2'-modified adenosine residues
1991
Stereochemistry of a substrate for pancreatic ribonuclease. Crystal and molecular structure of the triethylammonium salt of uridine 2', 3'-0,0-cyclophosphorothioate
1970
The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA
1985
Phosphorothioate analogs of nucleotides
1979
Substrate metal-adenosine 5'-triphosphate chelate structure and stereochemical course of reaction catalyzed by the adenosine triphosphatase from the thermophilic bacterium PS3
1983
MODIFIED OLIGONUCLEOTIDES: Synthesis and Strategy for Users
1998
Phosphorothioates in molecular biology
1989
Assignment of resonances in the phosphorus-31 nuclear magnetic resonance spectrum of poly[d(A-T)] from phosphorothioate substitution
1983
Inhibition of restriction endonuclease Nel I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis
1986
Fluorescent labelling of tRNA and oligodeoxynucleotides using T4 RNA ligase
1984
A dinucleoside phosphorothioate
1967
Stereochemistry of the guanyl nucleotide binding site of transducin probed by phosphorothioate analogs of GTP and GDP
1985
Synthesis and Properties of Diuridine Phosphate Analogues Containing Thio and Amino Modifications
1996
Stereochemistry of internucleotide bond formation by polynucleotide phosphorylase from Micrococcus luteus
1979
Incorporation of phosphorothioate groups into fd and φX174 DNA
1977
Facile synthesis of 2'-amino-2'-deoxyribofuranosylpurines
1979
Friedrich Cramer (1923–2003): Nucleic Acid Chemist and Philosopher
2003
Phosphorus-oxygen bond order in adenosine 5'-O-phosphorothioate dianion
1984
The newt ribozyme is part of a riboprotein complex
1997
Rapid and efficient synthesis of nucleoside 5'-0-(1-thiotriphosphates), 5'-triphosphates and 2',3'-cyclophosphorothioates using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one
1989
Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes
1991 Science
Synthesis of d(GC) and d(CG) octamers containing alternating phosphorothioate linkages: effect of the phosphorothioate group on the B-Z transition
1985
Investigation of Enzyme Mechanisms with Nucleoside Phosphorothioates
1975
Chemically Modified Phenylalanine Transfer Ribonucleic Acid from Yeast. Synthesis and Properties of tRNAPhe-C-C s A and the Effect of Adenosine 5'-O-(1-Thiotriphosphate) on the Activation of Phenylalanine
1970
Synthesis and characterization of diastereomers of guanosine 5'-O-(1-thiotriphosphate) and guanosine 5'-O-(2-thiotriphosphate)
1982
S-Methylated nucleoside phosphorothioates as probes of enzyme metal.cntdot.nucleotide binding sites
1982
DNA and RNA Sequence Determination Based on Phosphorothioate Chemistry
1988 Science
Synthesis and properties of diastereoisomers of adenosine 5'-(O-1-thiotriphosphate) and adenosine 5'-(O-2-thiotriphosphate)
1976
Affinity labeling of the 3'-hydroxy terminal binding site of the ribonucleic acid chain on deoxyribonucleic acid dependent ribonucleic acid polymerase from Escherichia coli
1979
Untersuchung der Wirkungsweise von Enzymen mit Nucleosidphosphorothioaten
1975
Synthesis and characterization of an octanucleotide containing the EcoRI recognition sequence with a phosphorothioate group at the cleavage site
1984
Isolation of Hammerhead Ribozymes with Altered Core Sequences by in Vitro Selection
1997
Diastereomers of 5'-O-adenosyl 3'-O-uridyl phosphorothioate: chemical synthesis and enzymic properties
1979
Phosphorothioate Analogues of Nucleotides—Tools for the Investigation of Biochemical Processes
1983
The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA
1985
Synthesis of dinucleoside monophosphorothioates via addition of sulphur to phosphite triesters.
1978
Polynucleotides containing 2'-amino-2'-deoxyribose and 2'-azido-2'-deoxyribose
1973
Phosphorothioatanaloga von Nucleotiden - Werkzeuge zur Untersuchung biochemischer Prozesse
2006
Crystal and Molecular Structure of Adenosine 5'-O-Phosphorothioate O-p-Nitrophenyl Ester (Sp Diastereomer). Substrate Stereospecificity of Snake Venom Phosphodiesterase
1979
Topology of the GTP‐binding site of adenylyl cyclase from pigeon erythrocytes
1976
Mechanism of Ribose 2‘-Group Discrimination by an RNA Polymerase
1997
Polyribonucleotides Containing a Phosphorothioate Backbone
1970
Mechanistic studies on deoxyribonucleic acid dependent ribonucleic acid polymerase from Escherichia coli using phosphorothioate analog. 1. Initiation and pyrophosphate exchange reactions
1979
Synthesis and configurational analysis of a dinucleoside phosphate isotopically chiral at phosphorus. Stereochemical course of Penicillium citrinum nuclease P1 reaction
1983
Mechanistic studies on deoxyribonucleic acid dependent ribonucleic acid polymerase from Escherichia coli using phosphorothioate analogs. 2. The elongation reaction
1979