Standout Papers
- Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II (2007)
- The American college of rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials (1993)
- Rheumatoid arthritis (2010)
- American college of rheumatology preliminary definition of improvement in rheumatoid arthritis (1995)
Citation Impact
Citing Papers
ACR and EULAR improvement criteria have comparable validity in rheumatoid arthritis trials. American College of Rheumatology European League of Associations for Rheumatology.
1999
Increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low
2000
Inadequate erythropoietin response to anemia: definition and clinical relevance
1994
Unified Synthesis of Polycyclic Alkaloids by Complementary Carbonyl Activation**
2021 StandoutNobel
Head‐to‐head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: Findings of a phase IIIb, multinational, prospective, randomized study
2012
Doxycycline for osteoarthritis of the knee or hip
2012
Clinical, functional and radiographic consequences of achieving stable low disease activity and remission with adalimumab plus methotrexate or methotrexate alone in early rheumatoid arthritis: 26-week results from the randomised, controlled OPTIMA study
2012
LY2439821, a humanized anti–interleukin‐17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double‐blind, placebo‐controlled, proof‐of‐concept study
2010
Insights into the efficacy of golimumab plus methotrexate in patients with active rheumatoid arthritis who discontinued prior anti-tumour necrosis factor therapy: post-hoc analyses from the GO-AFTER study
2013
Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial
2012
Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study
2009
Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score
2005
Responsiveness to change and reliability of measurement of radiographic joint space width in osteoarthritis of the knee: a systematic review
2011
Discovery of serum proteomic biomarkers for prediction of response to infliximab (a monoclonal anti-TNF antibody) treatment in rheumatoid arthritis: An exploratory analysis
2012
Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent
2001 Standout
A systematic review and meta-analysis of efficacy and toxicity of disease modifying anti-rheumatic drugs and biological agents for psoriatic arthritis
2007
Predictors of joint damage in patients with early rheumatoid arthritis treated with high‐dose methotrexate with or without concomitant infliximab: Results from the ASPIRE trial
2006
Varus malalignment negates the structure-modifying benefits of doxycycline in obese women with knee osteoarthritis
2010
Inflammation and cancer
2002 StandoutNature
A Trial of Etanercept, a Recombinant Tumor Necrosis Factor Receptor:Fc Fusion Protein, in Patients with Rheumatoid Arthritis Receiving Methotrexate
1999 Standout
A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee
2012
Psoriasis
2009 Standout
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
2013 StandoutNature
New therapies for treatment of rheumatoid arthritis
2007
Rheumatoid arthritis
2016 Standout
Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial
2010
Autoimmune Diseases
2001
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
1997 Standout
Summary and recommendations of the OARSI FDA osteoarthritis Assessment of Structural Change Working Group
2011
The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double‐blind, placebo‐controlled phase IIa trial of three dosage levels of CP‐690,550 versus placebo
2009
A simplified disease activity index for rheumatoid arthritis for use in clinical practice
2003
Pathogenesis and therapy of psoriasis
2007 StandoutNature
Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial
2013
Abatacept (CTLA‐4IG) treatment reduces the migratory capacity of monocytes in patients with rheumatoid arthritis
2012
Quality of life bibliography and indexes: 1993 update
1995
Optimisation of a treat-to-target approach in rheumatoid arthritis: strategies for the 3-month time point
2015
Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis
2000 Standout
Adjustment of therapy in rheumatoid arthritis on the basis of achievement of stable low disease activity with adalimumab plus methotrexate or methotrexate alone: the randomised controlled OPTIMA trial
2013
Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice: the Research in Active Rheumatoid Arthritis (ReAct) trial
2007
Combination Therapy with Cyclosporine and Methotrexate in Severe Rheumatoid Arthritis
1995
The association of depression and anxiety with medical symptom burden in patients with chronic medical illness
2007
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
2009 Standout
Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial
1999 Standout
Increase in vastus medialis cross‐sectional area is associated with reduced pain, cartilage loss, and joint replacement risk in knee osteoarthritis
2012
Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double-blind placebo-controlled MASCOT study
2006
Therapies for Active Rheumatoid Arthritis after Methotrexate Failure
2013
Monoclonal expansion of synoviocytes in rheumatoid arthritis
1998
Effects of desferrioxamine therapy on chronic disease anemia associated with rheumatoid arthritis
1996
An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis
2010
Efficacy of B-Cell–Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis
2004 Standout
Lymphoma subtypes in patients with rheumatoid arthritis: Increased proportion of diffuse large B cell lymphoma
2003
A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease
1997 Standout
Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial
2005
Assessment of Quality-of-Life Outcomes
1996 Standout
Tumor Necrosis Factor-α Blockade: A Novel Therapy for Rheumatic Disease
2002
Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis
2015
Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: Conceptual issues and research evidence.
2003 Standout
Quality of Reporting of Observational Longitudinal Research
2005
The Pathogenesis of Rheumatoid Arthritis
2011 Standout
The role of synovitis in osteoarthritis pathogenesis
2012
The effects of drug therapy on radiographic progression of rheumatoid arthritis. results of a 36‐week randomized trial comparing methotrexate and auranofin
1993
Genetic epidemiology of osteoarthritis
2012
Rituximab for rheumatoid arthritis refractory to anti–tumor necrosis factor therapy: Results of a multicenter, randomized, double‐blind, placebo‐controlled, phase III trial evaluating primary efficacy and safety at twenty‐four weeks
2006
Osteoarthritis
2015 Standout
Therapeutic benefit of blocking interleukin‐6 activity with an anti–interleukin‐6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled, dose‐escalation trial
2002
Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study
2002
B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis
2008 Standout
Anti-inflammatory and Upper Gastrointestinal Effects of Celecoxib in Rheumatoid Arthritis
1999
Modified disease activity scores that include twenty-eight-joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis
1995 Standout
Influence of variation in semiflexed knee positioning during image acquisition on separate quantitative radiographic parameters of osteoarthritis, measured by Knee Images Digital Analysis
2012
Treatment for Rheumatoid Arthritis and Risk of Alzheimer’s Disease: A Nested Case-Control Analysis
2016
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis
2001 Standout
Evolving concepts of rheumatoid arthritis
2003 StandoutNature
Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison
1999
Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis
2006
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
1998 StandoutNature
Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis
1994
Interleukin-10-deficient mice develop chronic enterocolitis
1993 Standout
Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States
1998 Standout
Treatment of Active Rheumatoid Arthritis With Leflunomide Compared With Placebo and Methotrexate
1999
Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges
2015
Randomised comparison of initial triple DMARD therapy with methotrexate monotherapy in combination with low-dose glucocorticoid bridging therapy; 1-year data of the tREACH trial
2014
Wegener Granulomatosis: An Analysis of 158 Patients
1992 Standout
Combination therapy in early rheumatoid arthritis: a randomised, controlled, double blind 52 week clinical trial of sulphasalazine and methotrexate compared with the single components
1999
Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications
1996
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis
2000 Standout
Remission induction comparing infliximab and high-dose intravenous steroid, followed by treat-to-target: a double-blind, randomised, controlled trial in new-onset, treatment-naive, rheumatoid arthritis (the IDEA study)
2013
Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial
1999
Inflammatory Bowel Disease
2002 Standout
Should imporvement in rheumatoid arthritis clinical trials be defined as fifty percent or seventy percent improvement in core set measures, rather than twenty percent?
1998
RAPID3 (Routine Assessment of Patient Index Data 3), a Rheumatoid Arthritis Index Without Formal Joint Counts for Routine Care: Proposed Severity Categories Compared to Disease Activity Score and Clinical Disease Activity Index Categories
2008
Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study)
2012
Radiographic outcome of recent-onset rheumatoid arthritis: A 19-year study of radiographic progression
1998
Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
1998
Methotrexate in rheumatoid arthritis. a five‐year prospective multicenter study
1994
Autoantibody profiling in patients with very early rheumatoid arthritis: a follow-up study
2009
The safety profile, tolerability, and effective dose range of rofecoxib in the treatment of rheumatoid arthritis
1999
Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor ? monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
1998
Inflammation and cancer: back to Virchow?
2001 Standout
Mild Traumatic Brain Injury in U.S. Soldiers Returning from Iraq
2008 Standout
The PREMIER study: A multicenter, randomized, double‐blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
2005
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement
2015 Standout
Risk of incident or recurrent malignancies among patients with rheumatoid arthritis exposed to biologic therapy in the German biologics register RABBIT
2010
A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis
2000 Standout
Definition of treatment response in rheumatoid arthritis based on the simplified and the clinical disease activity index
2012
Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial
2009
Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update
2015
Treatment of early seropositive rheumatoid arthritis: Doxycycline plus methotrexate versus methotrexate alone
2006
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies
2007 Standout
Therapeutic strategies for rheumatoid arthritis
2003
Reduction in long‐term disability in patients with rheumatoid arthritis by disease‐modifying antirheumatic drug–based treatment strategies
1996
Long‐Term Prospective Study of Methotrexate in the Treatment of Rheumatoid Arthritis
1992
Baricitinib in Patients with Refractory Rheumatoid Arthritis
2016
Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell–mediated spontaneous autoimmune arthritis in mice
2004 StandoutNobel
Identification of progressors in osteoarthritis by combining biochemical and MRI-based markers
2009
Cartilage and meniscal T2 relaxation time as non-invasive biomarker for knee osteoarthritis and cartilage repair procedures
2013
Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease
2012
Relation of completeness of reporting of health research to journals' endorsement of reporting guidelines: systematic review
2014
Can we improve the performance and reporting of investigator-initiated clinical trials? Rheumatoid arthritis as an example
2014
Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: A randomized, double-blind six-week trial with eighteen-week extension
1999
Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
2002 StandoutNature
Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: Results of the two‐year multinational knee osteoarthritis structural arthritis study
2006
The TNF and TNF Receptor Superfamilies
2001 Standout
Clinical outcome in 22 patients with rheumatoid arthritis treated with B lymphocyte depletion
2002
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
2007 Standout
Antibacterial drug discovery in the resistance era
2016 StandoutNature
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Radiographic outcome after three years of patients with early erosive rheumatoid arthritis treated with intramuscular methotrexate or parenteral gold. Extension of a one‐year double‐blind study in 174 patients
2002
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis
2013
Anemia of Chronic Disease
2005 Standout
Clinical, radiographic and immunogenic effects after 1 year of tocilizumab-based treatment strategies in rheumatoid arthritis: the ACT-RAY study
2014
Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
2004
Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis
2012
Is DAS28 an appropriate tool to assess remission in rheumatoid arthritis?
2005
Interleukin‐6 receptor inhibition with tocilizumab and attainment of disease remission in rheumatoid arthritis: The role of acute‐phase reactants
2010
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Engineering Orthopedic Tissue Interfaces
2009
Progress in understanding the pathogenesis of the anemia of chronic disease [see comments]
1992
Autoimmunity and Anti-TNF-α Agents
2005
Erythropoietin, iron, and erythropoiesis
2000
Anti-Cytokine Therapy for Rheumatoid Arthritis
2000
Comparative evaluation of three semi-quantitative radiographic grading techniques for knee osteoarthritis in terms of validity and reproducibility in 1759 X-rays: report of the OARSI–OMERACT task force
2008
Etanercept Therapy in Rheumatoid Arthritis
1999
Effects of writing about stressful experiences on symptom reduction in patients with asthma or rheumatoid arthritis: a randomized trial.
1999 Standout
Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications
2019 Standout
Rituximab Pharmacokinetics in Patients With Rheumatoid Arthritis: B‐Cell Levels Do Not Correlate With Clinical Response
2007
Inhibition of human erythroid colony-forming units by gamma interferon can be corrected by recombinant human erythropoietin [see comments]
1991
Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes
2001
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Intraarticular Sprifermin (Recombinant Human Fibroblast Growth Factor 18) in Knee Osteoarthritis: A Randomized, Double‐Blind, Placebo‐Controlled Trial
2014
Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study
2009
The Purine Path to Chemotherapy
1989 ScienceNobel
Knee osteoarthritis has doubled in prevalence since the mid-20th century
2017 Standout
Standardization of Uveitis Nomenclature for Reporting Clinical Data. Results of the First International Workshop
2005 Standout
Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis
1996
Iron and the anemia of chronic disease.
2002
Erythropoietin, iron, and erythropoiesis.
2000
Unresolved Questions in Rheumatology: Motion for Debate: Osteoarthritis Clinical Trials Have Not Identified Efficacious Therapies Because Traditional Imaging Outcome Measures Are Inadequate
2013
Erythropoietin, iron, and erythropoiesis
2000
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies
2007 Standout
Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell–mediated spontaneous autoimmune arthritis in mice
2004 StandoutNobel
Privileged Structures: Efficient Chemical “Navigators” toward Unexplored Biologically Relevant Chemical Spaces
2014
STING manifests self DNA-dependent inflammatory disease
2012
Interferon γ Downregulates Stem Cell Factor and Erythropoietin Receptors But Not Insulin-Like Growth Factor-I Receptors in Human Erythroid Colony-Forming Cells
1997
Burden of major musculoskeletal conditions.
2003 Standout
Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein
1997
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Education, self‐care, and outcomes of rheumatic diseases: Further challenges to the “biomedical model” paradigm
1997
Works of Frederick Wolfe being referenced
INFLAMMATORY ACTIVITY, BUT NOT METHOTREXATE OR PREDNISONE USE PREDICTS NON-HODGKINS LYMPHOMA IN RHEUMATOID ARTHRITIS: A 25-YEAR STUDY OF 1,767 RA PATIENTS
1998
An index of the three core data set patient questionnaire measures distinguishes efficacy of active treatment from that of placebo as effectively as the American College of Rheumatology 20% response criteria (ACR20) or the Disease Activity Score (DAS) in a rheumatoid arthritis clinical trial
2003
The american college of rheumatology 1991 revised criteria for the classification of global functional status in rheumatoid arthritis
1992
DOES EXPOSURE TO IMMUNOSUPPRESSIVE THERAPY INCREASE THE 10 YEAR MALIGNANCY AND MORTALITY RISKS IN RHEUMATOID ARTHRITIS? A MATCHED COHORT STUDY
1996
Effects of doxycycline on progression of osteoarthritis: Results of a randomized, placebo‐controlled, double‐blind trial
2005
American college of rheumatology preliminary definition of improvement in rheumatoid arthritis
1995 Standout
The American college of rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials
1993 Standout
Multicenter study of recombinant human erythropoietin in correction of anemia in rheumatoid arthritis
1990
The assessment of rheumatoid arthritis and the acceptability of self‐report questionnaires in clinical practice
2003
Subject retention and adherence in a randomized placebo‐controlled trial of a disease‐modifying osteoarthritis drug
2004
Rheumatoid arthritis
2010 Standout
Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II
2007 Standout
Low‐dose methotrexate compared with auranofin in adult rheumatoid arthritis
1990
Class II human leukocyte antigen genes and T cell receptor polymorphisms in patients with rheumatoid arthritis
1988
Preliminary core set of domains and reporting requirements for longitudinal observational studies in rheumatology.
1999
Radiological progression in rheumatoid arthritis: how many patients are required in a treatment trial to test disease modification?
1993
Methotrexate in rheumatoid arthritis: effects on disease activity in a multicenter prospective study.
1991
Depression is not more common in rheumatoid arthritis: a 10-year longitudinal study of 6,153 patients with rheumatic disease.
1993
Severity of joint pain and Kellgren-Lawrence grade at baseline are better predictors of joint space narrowing than bone scintigraphy in obese women with knee osteoarthritis.
2005
Anxiety and depression in patients with rheumatoid arthritis: a prospective study of 400 patients.
1988