Standout Papers
- 6-Mercaptopurine: effects in mouse sarcoma 180 and in normal animals. (1953)
- Hematological Effects of Certain 2,4-Diaminopyrimidines, Antagonists of Folic Acid Metabolism (1954)
Citation Impact
Citing Papers
Cell Death: The Significance of Apoptosis
1980 Standout
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
2001 StandoutScience
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Studies on fatty liver induction by 4-aminopyrazolopyrimidine
1963
Targeting hypoxia in cancer therapy
2011 Standout
Epigenetics in human disease and prospects for epigenetic therapy
2004 StandoutNature
Inhibition of DNA Methylation and Reactivation of Silenced Genes by Zebularine
2003
Cyclophosphamide cystitis in rats: involvement of capsaicin-sensitive primary afferents
1992
Metabolism and action of amino acid analog anti-cancer agents
1990
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
When Checkpoints Fail
1997 StandoutNobel
The guanosine binding site of the Tetrahymena ribozyme
1989 StandoutNatureNobel
The Hallmarks of Cancer
2000 Standout
The biochemistry of apoptosis
2000 StandoutNature
Lethal effect of the anti-Fas antibody in mice
1993 StandoutNature
Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb
1995 StandoutNature
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1998 StandoutNature
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
2006 StandoutNobel
Characterization of the capsaicin‐sensitive component of cyclophosphamide‐induced inflammation in the rat urinary bladder
1994
Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
2006 Standout
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
1988 StandoutNatureNobel
Differential Radiation Response Amongst Proliferating Epithelial Cells
1978
Cellular differentiation, cytidine analogs and DNA methylation
1980 Standout
Antibody Induction and Tolerance
1965 StandoutScienceNobel
Kinetics of the interaction of monophosphates of the antiviral nucleosides 2'-fluoro-1-beta-D-arabinofuranosylpyrimidine and (E)-5-(2-bromovinyl)-2'-deoxyuridine with thymidylate kinases from Vero cells and herpes simplex virus types 1 and 2
1984
Cyclophosphamide cystitis—Identification of acrolein as the causative agent
1979
Mitogenic property of the apical ectodermal ridge
1982
Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis.
1978 StandoutNobel
Prooxidant States and Tumor Promotion
1985 StandoutScience
Structure-activity relationships among purines related to 6-mercaptopurine.
1958 StandoutNobel
Apoptosis in the Pathogenesis and Treatment of Disease
1995 StandoutScience
Temperature-Dependent Surface Changes in Cells Infected or Transformed by a Thermosensitive Mutant of Polyoma Virus
1971 StandoutNobel
The Choice of Animal Tumors for Experimental Studies of Cancer Therapy
1978
Thiation of Nucleosides. I. Synthesis of 2-Amino-6-mercapto-9-β-D-ribofuranosylpurine (“Thioguanosine”) and Related Purine Nucleosides1
1958
Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory Compounds
1957 StandoutNature
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
2012 StandoutNobel
Sequence specificity of heat-labile sites in DNA induced by mitomycin C
1984
Epigenetic Reprogramming in Mammalian Development
2001 StandoutScience
Malignant transformation of cells derived from mouse prostate by epoxides and other derivatives of polycyclic hydrocarbons.
1972
DIFFERENTIAL LETHAL EFFECTS OF BOTH CYTOSINE ARABINOSIDE AND HYDROXYUREA ON JEJUNAL CRYPT CELLS AND TESTOSTERONE‐STIMULATED ACCESSORY SEX GLANDS
1979
2,6-DIAMINOPURINE AS SUBSTRATE AND INHIBITOR OF XANTHINE OXIDASE
1957
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat.
1976 StandoutNobel
Androgen-induced Sexual Differentiation of the Brain is Blocked by Inhibitors of DNA and RNA Synthesis
1974 Nature
A general mechanism for microsomal activation of quinone anticancer agents to free radicals.
1978
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Potentiation by inhibition of drug degradation : 6-substituted purines and xanthine oxidase
1963 StandoutNobel
Ethanol-Induced Apoptotic Neurodegeneration and Fetal Alcohol Syndrome
2000 StandoutScience
Effect of adenosine on cyclic AMP accumulation in ventricular myocardium
1976
The Purine Path to Chemotherapy
1989 ScienceNobel
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
1993 Standout
THE CHEMISTRY AND BIOCHEMISTRY OF PURINE ANALOGS
1954 StandoutNobel
Influence of "feeder cells" and inducers and inhibition of microsomal mixed-function oxidases on hydrocarbon-induced malignant transformation of cells derived from C3H mouse prostate.
1972
The effects of 6-mercaptopurine on Lactobacillus casei
1957 StandoutNobel
An electron‐microscope study of the mode of cell death induced by cancer‐chemotherapeutic agents in populations of proliferating normal and neoplastic cells
1975
Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis
1989 StandoutScience
Targeting of an inducible toxic phenotype in animal cells.
1988
THE FATE OF 6‐MERCAPTOPURINE IN MICE
1954 StandoutNobel
The pathogenesis of cancer metastasis
1980 StandoutNature
Accurate initiation at RNA polymerase II promoters in extracts from Saccharomyces cerevisiae.
1987 StandoutNobel
Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
1999 StandoutScience
Actinomycin D: Effect on the Immune Response
1964 Science
Effects of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat
1971
Hydroxyurea
1967
Purine and Pyrimidine Antagonists
1955 StandoutNobel
Mitochondria and Apoptosis
1998 StandoutScience
Inhibition of ribonucleoside diphosphate reductase by hydroxyurea.
1968
Ornithine Decarboxylase Is Important in Intestinal Mucosal Maturation and Recovery from Injury in Rats
1980 Science
CpG-rich islands and the function of DNA methylation
1986 StandoutNature
The binding of polycyclic aromatic hydrocarbons to the DNA, RNA, and proteins of transformable cells in culture.
1971
Arene Oxides: A New Aspect of Drug Metabolism
1974 StandoutScience
Enzymatic aminoacylation of tRNA with unnatural amino acids
2006 StandoutNobel
6-Chloropurine and 6-Chlorouric Acid as Substrates and Inhibitors of Purine-oxidizing Enzymes
1959
Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA
1964 Science
Sexual Differentiation of the Central Nervous System
1981 StandoutScience
Complex Regulation of Simian Virus 40 Early-Region Transcription from Different Overlapping Promoters
1984 Nobel
The structure of the thymidine kinase gene promoter: Nuclease hypersensitivity correlates with expression
1982 StandoutNobel
AN EVALUATION OF RADIOIODINE‐LABELED 5‐IODO‐2′‐DEOXYURIDINE AS A TRACER FOR MEASURING CELL LOSS FROM SOLID TUMORS*
1971
Apoptosis in AIDS
1993 StandoutScienceNobel
Mechanism of action of hydroxyurea.
1992
The lethal actions of antitumor agents in proliferating cell systems in vivo.
1975
DNA Methylation and Gene Function
1980 StandoutScience
Mechanisms and Genes of Cellular Suicide
1995 StandoutScience
DNA sequence selectivity of guanine–N7 alkylation by nitrogen mustards
1986 StandoutNobel
Works of Frederick S. Philips being referenced
Effects of arabinosylcytosine nucleosides on DNA synthesis in rats.
1970
Metabolic competition studies of 2'-fluoro-5-iodo-1-beta-d-arabinofuranosylcytosine in vero cells and herpes simplex type 1-infected vero cells.
1984
ADENINE INTOXICATION IN RELATION TO IN VIVO FORMATION AND DEPOSITION OF 2,8-DIOXYADENINE IN RENAL TUBULES
1952
Effects of thioguanine in mammals
1956
Biochemical effects of 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil and 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mouse leukemic cells sensitive and resistant to 1-beta-D-arabinofuranosylcytosine.
1982
Cytotoxic effects of 1-beta-D-arabinofuranosyl-5-fluorocytosine and of 1-beta-D-arabinofuranosylcytosine in proliferating tissues in mice.
1969
Metabolism and selective effects of 1-beta-D-arabinofuranosylcytosine in L1210 and Host tissues in vivo.
1975
Binding of [G-3H]-7,12-dimethylbenz(α)anthracene to DNA of normal and of rapidly dividing hepatic cells of rats
1971
Incorporation of metabolites of 2'-fluoro-5-iodo-1-β-d-arabinofuranosylcytosine into deoxyribonucleic acid of neoplastic and normal mammalian tissues
1982
Hydroxyurea: inhibition of deoxyribonucleic acid synthesis in regenerating liver of rats.
1965
6-Mercaptopurine: effects in mouse sarcoma 180 and in normal animals.
1953 StandoutNobel
Mitomycin C: Chemical and Biological Studies on Alkylation
1963 Science
The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis.
1971
PHARMACOLOGY OF MITOMYCIN C. IV. EFFECTS IN VIVO ON NUCLEIC ACID SYNTHESIS; COMPARISON WITH ACTINOMYCIN D.
1963
Pharmacology of mitomycin C. II. Renal excretion and metabolism by tissue hemogenates.
1961
Actinomycin D: effects on Ridgway osteogenic sarcoma in mice.
1966
Uptake, initial effects, and chemotherapeutic efficacy of harringtonine in murine leukemic cells sensitive and resistant to vincristine and other chemotherapeutic agents.
1983
Sarcoma 180 screening data.
1958
THE TOXIC EFFECTS OF 6‐MERCAPTOPURINE AND RELATED COMPOUNDS
1954
EFFECTS OF 6‐MERCAPTOPURINE AND ANALOGS ON EXPERIMENTAL TUMORS
1954
Metabolism and effects of 5-(beta-D-ribofuranosyl)isocytosine in P815 cells.
1979
Hydroxyurea. I. Acute cell death in proliferating tissues in rats.
1967
Production of Fatty Livers by 4-Aminopyrazolo-(3,4-d)-Pyrimidine. Toxicological and Pathological Studies.
1956
Azaserine: Pathological and pharmacological studies
1957
Kinetic properties and inhibition of Acinetobacter glutaminase-asparaginase
1983
Cyclophosphamide and urinary bladder toxicity.
1961
ENZYMATIC DEAMINATION AND VASODEPRESSOR EFFECTS OF ADENOSINE ANALOGS
1952
THE TOXICITY OF ACTINOMYCIN D*
1960