Citation Impact
Citing Papers
Pathophysiology of Migraine: A Disorder of Sensory Processing
2017 Standout
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
2005 StandoutScience
Amino Acid Variants in the Human Leptin Receptor: Lack of Association to Juvenile Onset Obesity
1997
Chronic leptin administration promotes lipid utilization until fat mass is greatly reduced and preserves lean mass of normal female rats
2000
The role of leptin in progression of non-alcoholic fatty liver disease
2005
Acute stimulation of glucose metabolism in mice by leptin treatment
1997 Nature
Hyperleptinemia of Pregnancy Associated with the Appearance of a Circulating Form of the Leptin Receptor
1997
Identification of targets of leptin action in rat hypothalamus.
1996
Expression of Ob Receptor in Normal Human Adrenals: Differential Regulation of Adrenocortical and Adrenomedullary Function by Leptin1
1998
Chemokines and leukocyte traffic
1998 StandoutNature
Hypothalamic regulation of sleep and circadian rhythms
2005 StandoutNature
Demonstration of a Leptin Binding Factor in Human Serum
1997
Receptor-mediated regional sympathetic nerve activation by leptin.
1997
Leptin Receptor Gene Variation and Obesity: Lack of Association in a White British Male Population
1997
Absence of Soluble Leptin Receptor in Plasma fromdbPas/dbPas and Otherdb/db Mice
1998
The Protein Data Bank
2000 Standout
Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis
1999
Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
2011
Central nervous system control of food intake and body weight
2006 StandoutNature
Congenital leptin deficiency is associated with severe early-onset obesity in humans
1997 StandoutNature
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
2001 StandoutNature
Mechanisms linking obesity with cardiovascular disease
2006 StandoutNature
The effects of leptin on REM sleep and slow wave deltain rats are reversed by food deprivation
1999
Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.
1998
Selective deletion of leptin receptor in neurons leads to obesity
2001
Relatively low plasma leptin concentrations precede weight gain in Pima Indians
1997
Leptin enters the brain by a saturable system independent of insulin
1996
Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma.
1996
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
2012 StandoutNature
Ghrelin: An orexigenic and somatotrophic signal from the stomach
2001
The weight of leptin in immunity
2004
Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice
1996
Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
1996
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
The Leptin Receptor
1997
Leptin: a review of its peripheral actions and interactions
2002
Adipose tissue as an endocrine organ
2009
Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene
1997
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
1997 StandoutNature
Obesity, diabetes and the central nervous system
1998
Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice
1997 Standout
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Leptin's Actions on the Reproductive Axis: Perspectives and Mechanisms
1999
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
2007 StandoutNature
PPARs and the complex journey to obesity
2004
Leptin Receptor (OB-R) Signaling
1997
A human leptin mutant induces weight gain in normal mice
1997
Pathophysiological Significance of theObeseGene Product, Leptin, in Ventromedial Hypothalamus (VMH)-Lesioned Rats: Evidence for Loss of Its Satiety Effect in VMH-Lesioned Rats1
1997
Leptin and inflammation-associated cachexia in chronic kidney disease
2006
Leptin Directly Activates SF1 Neurons in the VMH, and This Action by Leptin Is Required for Normal Body-Weight Homeostasis
2006
The Need to Feed
2002
Crystal structure of the obese protein Ieptin-E100
1997 Nature
The arcuate nucleus as a primary site of satiety effect of leptin in rats
1997
Mechanism of leptin removal from the circulation by the kidney
1997
Ghrelin induces adiposity in rodents
2000 StandoutNature
Central nervous system control of food intake
2000 StandoutNature
Feeding and body-weight regulation by hypothalamic neuropeptides—mediation of the actions of leptin
1999
Leptin induces functional activation of cyclooxygenase‐2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells
2008
Neuroendocrine Regulation and Actions of Leptin
1999
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation
1997 Nature
Leptin Regulation of the Mesoaccumbens Dopamine Pathway
2006
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
2010 StandoutNature
Surprising similarities in structure comparison
1996
A role for ghrelin in the central regulation of feeding
2001 StandoutNature
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
1998 StandoutNature
Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis
2004
Leptin accelerates the onset of puberty in normal female mice.
1997
Cerebrospinal Fluid Leptin in Anorexia Nervosa: Correlation with Nutritional Status and Potential Role in Resistance to Weight Gain1
1997
Leptin effects on feeding-related hypothalamic and peripheral neuronal activities in normal and obese rats
1999
Abnormal splicing of the leptin receptor in diabetic mice
1996 StandoutNature
Adipogenesis and Obesity: Rounding Out the Big Picture
1996
Leptin and the adrenal gland
2000
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
2006
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
1997 Standout
The hormone resistin links obesity to diabetes
2001 StandoutNature
The biology of leptin: a review.
1998
Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding
1997
The stomach is a source of leptin
1998 Nature
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
1998 StandoutNature
From Lesions to Leptin
1999
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
1997 Nature
Atherosclerosis
2000 StandoutNature
Leptin and the regulation of body weight in mammals
1998 StandoutNature
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Hypothalamic CART is a new anorectic peptide regulated by leptin
1998 Nature
Unraveling the central nervous system pathways underlying responses to leptin
1998
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
1996
Role of leptin in the neuroendocrine response to fasting
1996 StandoutNature
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
1996
Leptin stimulates proliferation and TGF-β expression in renal glomerular endothelial cells: Potential role in glomerulosclerosis
1999
The molecular neurobiology of depression
2008 StandoutNature
Leptin, Leptin Receptors, and the Control of Body Weight
2009
Obesity Wars
2004
Body weight is regulated by the brain: a link between feeding and emotion
2005
Matrix Elasticity Directs Stem Cell Lineage Specification
2006 Standout
Adipose tissue as an endocrine and paracrine organ
1998
Leptin regulated calcium channels of neuropeptide Y and proopiomelanocortin neurons by activation of different signal pathways
2008
Adipose Tissue as an Endocrine Organ
2004 Standout
Leptin Inhibits Bone Formation through a Hypothalamic Relay
2000 Standout
Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow
2006
Genetics of body-weight regulation
2000 Nature
Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice
1996 Standout
Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity
2001
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
1996
Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor
1996 Science
Using mouse models to dissect the genetics of obesity
2002
Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity
2001
Whole body leptin kinetics and renal metabolism in vivo
1997
Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities
1999
Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes
1997
Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring
1999 StandoutScience
Role of the kidney in human leptin metabolism
1997
Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities
1999
The adipoinsular axis: effects of leptin on pancreatic β-cells
2000
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
1997
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
1998
Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor
1997
Distributions of leptin receptor mRNA isoforms in the rat brain
1998
STATs and Gene Regulation
1997 StandoutScience
The Central Melanocortin System and Energy Homeostasis
1999
Evidence for a Novel Peripheral Action of Leptin as a Metabolic Signal to the Adrenal Gland: Leptin Inhibits Cortisol Release Directly
1997
Localization of Leptin Receptor (Ob-R) Messenger Ribonucleic Acid in the Rodent Hindbrain*
1998
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
2000 StandoutScienceNobel
Defective STAT signaling by the leptin receptor in diabetic mice.
1996
Central leptin modulates behavioral and neural responsivity to CCK
1999
The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.
1996
Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor
1998
Effects of Leptin on Insulin Sensitivity in Normal Rats*
1997
Evidence for Leptin Binding to Proteins in Serum of Rodents and Humans: Modulation With Obesity
1996
Prolactin: Structure, Function, and Regulation of Secretion
2000 Standout
Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia
1997
Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin
1997
Leptin Receptor‐ and STAT3‐Immunoreactivities in Hypocretin/Orexin Neurones of the Lateral Hypothalamus1
1999
The Function of Leptin in Nutrition, Weight, and Physiology
2002
Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein
1997 StandoutScience
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Fine Structure of the Murine Leptin Receptor Gene: Splice Site Suppression Is Required to Form Two Alternatively Spliced Transcripts
1997
A structural census of the current population of protein sequences
1997 StandoutNobel
A unified statistical framework for sequence comparison and structure comparison
1998 StandoutNobel
Selective deletion of leptin receptor in neurons leads to obesity
2001
A Solid-Phase Approach to Mouse Melanocortin Receptor Agonists Derived from a Novel Thioether Cyclized Peptidomimetic Scaffold
2002 StandoutNobel
Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
1998
Leptin Inhibits Directly Glucocorticoid Secretion by Normal Human and Rat Adrenal Gland**This work was supported by a grant from the Swiss National Science Foundation (No. 3100–050748.97/1).
1998
Gut hormone PYY3-36 physiologically inhibits food intake
2002 StandoutNature
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
1997
Expression and Characterization of a Putative High Affinity Human Soluble Leptin Receptor
1997
Chemical characterization of leptin-activated neurons in the rat brain
2000
Expression of Leptin Receptor Isoforms in Rat Brain Microvessels
1998
Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity
2002
Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation
1997
Leptin actions on food intake and body temperature are mediated by IL-1
1999
Works of Frederick Clark being referenced
Identification and expression cloning of a leptin receptor, OB-R
1995 Standout