Frédéric Villard

Coronavirus biology and replication: implications for SARS-CoV-2

Mechanisms, regulation and functions of the unfolded protein response

Naturally occurring NS3 resistance-associated variants in hepatitis C virus genotype 1: Their relevance for developing countries

Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly

Automated technologies and novel techniques to accelerate protein crystallography for structural genomics

Structural basis of cytokine-mediated activation of ALK family receptors

Improving de novo protein binder design with deep learning

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

Microseed matrix screening for optimization in protein crystallization: what have we learned?

Improved low-resolution crystallographic refinement with Phenix and Rosetta

PROTAC targeted protein degraders: the past is prologue

The Rise of Molecular Glues

Strategies and challenges for the next generation of antibody–drug conjugates

Application of DEN refinement and automated model building to a difficult case of molecular-replacement phasing: the structure of a putative succinyl-diaminopimelate desuccinylase from Corynebacterium glutamicum

Improving the Accuracy of Macromolecular Structure Refinement at 7 Å Resolution

The SWISS-MODEL Repository and associated resources

Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants

mScarlet: a bright monomeric red fluorescent protein for cellular imaging

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

Advances, Interactions, and Future Developments in the CNS, Phenix, and Rosetta Structural Biology Software Systems

Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor

Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes

Internal Disequilibria and Phenotypic Diversification during Replication of Hepatitis C Virus in a Noncoevolving Cellular Environment

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

Structural Determinants of MALT1 Protease Activity

An automated microseed matrix-screening method for protein crystallization

A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target