Citation Impact
Citing Papers
Metabolic Signatures of Insulin Resistance in 7,098 Young Adults
2012
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
2005 StandoutScience
mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling
2011
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
2008 StandoutScience
TOR Signaling in Growth and Metabolism
2006 Standout
Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
2022 StandoutNobel
Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation
2014
Nutrient Regulation of Insulin Secretion and β-Cell Functional Integrity
2010
mTOR Signaling in Growth Control and Disease
2012 Standout
Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels
2010
A view on drug resistance in cancer
2019 StandoutNature
mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes
2005
The Tuberous Sclerosis Complex
2006 Standout
Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase
2016
Growing roles for the mTOR pathway
2005
AKT/PKB Signaling: Navigating Downstream
2007 Standout
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt
2006
mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
2011
The genetics of ageing
2010 StandoutNature
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
2013 StandoutNature
Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice
2010
The metabolic syndrome
2010 Standout
Hypoxia and Inflammation
2011 Standout
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
2010 Standout
Rapamycin: One Drug, Many Effects
2014 Standout
Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis
2008
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
2009 Standout
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
2012
GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
2010 Standout
Immunoregulatory functions of mTOR inhibition
2009
Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease
2011
Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
2010
Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment
2016
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
The metabolic syndrome
2005 Standout
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12
2012
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
2009 StandoutNature
Immunity, Inflammation, and Cancer
2010 Standout
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
2008
JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes
2005
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
The VHL/HIF axis in clear cell renal carcinoma
2012 StandoutNobel
Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism
2011
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
2006 Standout
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
2015 Standout
Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
2010
Increased Activation of the Mammalian Target of Rapamycin Pathway in Liver and Skeletal Muscle of Obese Rats: Possible Involvement in Obesity-Linked Insulin Resistance
2004
MicroRNA-137/181c Regulates Serine Palmitoyltransferase and In Turn Amyloid β, Novel Targets in Sporadic Alzheimer's Disease
2011
Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
2001
Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice
2014
Fatty Acid Infusion Selectively Impairs Insulin Action on Akt1 and Protein Kinase C λ/ζ but Not on Glycogen Synthase Kinase-3
2002
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
2004 Nature
Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression
2010
An expanding role for mTOR in cancer
2005
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
2006
Insulin signaling pathways in cortical dysplasia and TSC‐tubers: Tissue microarray analysis
2004
AKT/PKB Signaling: Navigating the Network
2017 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
2007
The Hallmarks of Aging
2013 Standout
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
2006 Standout
The PI3K Pathway in Human Disease
2017 Standout
S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2
2008
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Dynamics and diversity in autophagy mechanisms: lessons from yeast
2009 StandoutNobel
mTOR and cancer: insights into a complex relationship
2006
Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase
2011
Termination of autophagy and reformation of lysosomes regulated by mTOR
2010 StandoutNature
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
Signaling pathways controlling skeletal muscle mass
2013
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
2009 StandoutNobel
Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance
2012
Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction
2006
Nutrients Suppress Phosphatidylinositol 3-Kinase/Akt Signaling via Raptor-Dependent mTOR-Mediated Insulin Receptor Substrate 1 Phosphorylation
2005
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
2005
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms
2007
Turnover of the Active Fraction of IRS1 Involves Raptor-mTOR- and S6K1-Dependent Serine Phosphorylation in Cell Culture Models of Tuberous Sclerosis
2006
Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults
2012
Interplay and Effects of Temporal Changes in the Phosphorylation State of Serine-302, -307, and -318 of Insulin Receptor Substrate-1 on Insulin Action in Skeletal Muscle Cells
2008
Balancing Akt with S6K
2004
Activation of Akt and eIF4E Survival Pathways by Rapamycin-Mediated Mammalian Target of Rapamycin Inhibition
2005 Standout
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
2010 Nobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
40 YEARS OF IGF1: Role of IGF-binding proteins in regulating IGF responses to changes in metabolism
2018
Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells
2010
Human Fatty Liver Disease: Old Questions and New Insights
2011 StandoutScience
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
2004 StandoutScience
Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality
2016
mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes
2008
Meat consumption, health, and the environment
2018 StandoutScience
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans
2013
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness
2012
Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
2009
Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
2010
Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 Kinase/Akt Regulation of Glut1 Activity and Trafficking
2007
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases
2014
When Translation Meets Metabolism: Multiple Links to Diabetes
2003
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
2011
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
2020 StandoutNobel
Works of Frédéric Tremblay being referenced
Modulation of insulin action by dietary proteins and amino acids: role of the mammalian target of rapamycin nutrient sensing pathway
2005
Activation of the Mammalian Target of Rapamycin Pathway Acutely Inhibits Insulin Signaling to Akt and Glucose Transport in 3T3-L1 and Human Adipocytes
2004
Amino Acid and Insulin Signaling via the mTOR/p70 S6 Kinase Pathway
2001
Dietary Cod Protein Restores Insulin-Induced Activation of Phosphatidylinositol 3-Kinase/Akt and GLUT4 Translocation to the T-Tubules in Skeletal Muscle of High-Fat-Fed Obese Rats
2003
Overactivation of S6 Kinase 1 as a Cause of Human Insulin Resistance During Increased Amino Acid Availability
2005
Defective Insulin-Induced GLUT4 Translocation in Skeletal Muscle of High Fat–Fed Rats Is Associated With Alterations in Both Akt/Protein Kinase B and Atypical Protein Kinase C (ζ/λ) Activities
2001
Role of Dietary Proteins and Amino Acids in the Pathogenesis of Insulin Resistance
2007
Prevention of skeletal muscle insulin resistance by dietary cod protein in high fat-fed rats
2001
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
2007
Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth
2017