Standout Papers
Citation Impact
Citing Papers
A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas
2012
CDK2-Dependent Phosphorylation of FOXO1 as an Apoptotic Response to DNA Damage
2006 Science
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
2005 StandoutNobel
Comprehensive genomic characterization of head and neck squamous cell carcinomas
2015 StandoutNature
The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins
2004
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The DNA-damage response in human biology and disease
2009 StandoutNature
DNA damage checkpoints: from initiation to recovery or adaptation
2007
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
Mammalian Fe–S cluster biogenesis and its implication in disease
2014
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence
2007
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks
2009
HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
2008
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
2006 Nature
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Cellular senescence: when bad things happen to good cells
2007 Standout
Cell-cycle checkpoints and cancer
2004 StandoutNature
Chk1 and Chk2 kinases in checkpoint control and cancer
2003
Applying the principles of stem-cell biology to cancer
2003
Polycomb silencers control cell fate, development and cancer
2006
The biology and management of non-small cell lung cancer
2018 StandoutNature
Anaplastic lymphoma kinase proteins in growth control and cancer
2004
p53 — a Jack of all trades but master of none
2009
Tying the loose ends together in DNA double strand break repair with 53BP1.
2006
Cancer Metastasis: Building a Framework
2006 Standout
Cancer despite immunosurveillance: immunoselection and immunosubversion
2006
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Using or abusing: viruses and the cellular DNA damage response
2007
Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
2007 StandoutNature
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
2010
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
2009 Standout
DNA repair pathways as targets for cancer therapy
2008
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
ATR: an essential regulator of genome integrity
2008
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability
2008 Nature
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
2006 Nature
Oncogene-Induced Cell Senescence — Halting on the Road to Cancer
2006
Isolation of rare circulating tumour cells in cancer patients by microchip technology
2007 StandoutNature
DNA repair deficiency as a therapeutic target in cancer
2008
Mapping and analysis of chromatin state dynamics in nine human cell types
2011 StandoutNature
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
DNA damage response in human testes and testicular germ cell tumours: biology and implications for therapy
2007
Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence
2008
Mammalian Base Excision Repair: the Forgotten Archangel
2013
Cellular senescence and DNA repair
2006
KLF4, p21 and context-dependent opposing forces in cancer
2005
LIM Protein Ajuba Participates in the Repression of the ATR-Mediated DNA Damage Response
2013
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
2012
γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
2006
Immunity, Inflammation, and Cancer
2010 Standout
Identification and expansion of human colon-cancer-initiating cells
2006 StandoutNature
p53 in health and disease
2007 Standout
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
The DNA damage response, immunity and cancer
2006
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
γH2AX and cancer
2008
Oncogene-induced senescence: the bright and dark side of the response
2010
NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy
2008
Diversity of Genomic Breakpoints in TFG-ALK Translocations in Anaplastic Large Cell Lymphomas
2002
CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?
2007
The ubiquitin ligase APCCdh1 is required to maintain genome integrity in primary human cells
2007
Stem Cells and Cancer
2004 Standout
Non-transcriptional control of DNA replication by c-Myc
2007 Nature
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Cell cycle, CDKs and cancer: a changing paradigm
2009 Standout
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
2005 Nature
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
2005 StandoutNature
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
2009 Nature
Genomic instability — an evolving hallmark of cancer
2010 Standout
The Hallmarks of Aging
2013 Standout
The Causes and Consequences of Polyploidy in Normal Development and Cancer
2011
Identification of human brain tumour initiating cells
2004 StandoutNature
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
2010 StandoutNature
The combined status of ATM and p53 link tumor development with therapeutic response
2009
Breaking down the barriers to cancer immunotherapy
2005 StandoutNobel
DNA Damage Repair and Telomere Length in Normal Breast, Preneoplastic Lesions, and Invasive Cancer
2010
p53 and disease: when the guardian angel fails
2006
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
2007
Cellular senescence: hot or what?
2009
The cancer genome
2009 StandoutNature
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress
2011
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Targeting ALK: Precision Medicine Takes on Drug Resistance
2017
An Oncogene-Induced DNA Damage Model for Cancer Development
2008 Science
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
2011 StandoutScience
Targeting Mdm2 and Mdmx in Cancer Therapy: Better Living through Medicinal Chemistry?
2009
Innate Immune Recognition of Cancer
2015
The Basic Cleft of RPA70N Binds Multiple Checkpoint Proteins, Including RAD9, To Regulate ATR Signaling
2008
Four faces of cellular senescence
2011 Standout
MDM2-Dependent Inhibition of p53 Is Required for Epstein-Barr Virus B-Cell Growth Transformation and Infected-Cell Survival
2009
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
2007 StandoutScience
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Surviving the Breakup: The DNA Damage Checkpoint
2006
DNA Repair Pathways in Clinical Practice: Lessons From Pediatric Cancer Susceptibility Syndromes
2006
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
2008 Standout
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
ATM mutations are associated with inactivation of theARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma
2002
Works of Frederic Tort being referenced
Retinoblastoma Pathway Defects Show Differential Ability to Activate the Constitutive DNA Damage Response in Human Tumorigenesis
2006
Molecular Characterization of a New ALK Translocation Involving Moesin (MSN-ALK) in Anaplastic Large Cell Lymphoma
2001
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Protein expression profiles in patients carrying NFU1 mutations. Contribution to the pathophysiology of the disease
2012
CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas
2002
BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.
2001
ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances
2002
Lipoic acid biosynthesis defects
2014