Citation Impact
Citing Papers
Identification of a New Component of the Agonist Binding Site of the Nicotinic α7 Homooligomeric Receptor
1995
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Structural Basis for Gating and Activation of RyR1
2016 StandoutNobel
Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label
1991
Water-soluble Nicotinic Acetylcholine Receptor Formed by α7 Subunit Extracellular Domains
1998
Acetylcholine receptor channel imaged in the open state
1995 Nature
GABAA receptor needs two homologous domains of the & beta;-subunit for activation by GABA but not by pentobarbital
1993 Nature
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis
1992
Improved Secondary Structure Predictions for a Nicotinic Receptor Subunit: Incorporation of Solvent Accessibility and Experimental Data into a Two-Dimensional Representation
1999
Neurotransmitter action: Opening of ligand-gated ion channels
1993
Functional architecture of the nicotinic acetylcholine receptor: A prototype of ligand-gated ion channels
1993
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Structure of nicotinic acetylcholine receptors
1993
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
Crystal structure and mechanism of a calcium-gated potassium channel
2002 StandoutNatureNobel
Contribution of Aromatic Moieties of Tyrosine 133 and of the Anionic Subsite Tryptophan 86 to Catalytic Efficiency and Allosteric Modulation of Acetylcholinesterase
1995
Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels
1993 Nature
The TiPS lecture the nicotinic acetylcholine receptor: an allosteric protein prototype of ligand-gated ion channels
1990
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
1995 StandoutNature
Subcellular Localization of Presenilins: Association with a Unique Membrane Pool in Cultured Cells
2000
Localization of agonist and competitive antagonist binding sites on nicotinic acetylcholine receptors
2000
Mutational analysis of the glycine-binding site of the NMDA receptor: Structural similarity with bacterial amino acid-binding proteins
1994
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
1993 StandoutNobel
Effects of mutations of Torpedo acetylcholine receptor .alpha.1 subunit residues 184-200 on .alpha.-bungarotoxin binding in a recombinant fusion protein
1993
Membrane protein folding and oligomerization: the two-stage model
1990
Stereochemistry of charged nitrogen-aromatic interactions and its involvement in ligand-receptor binding
1993
Chemical synaptic transmission in the cochlea
1995
The Contributions of Aspartyl Residues in the Acetylcholine Receptor γ and δ Subunits to the Binding of Agonists and Competitive Antagonists
1996
Probing conformational changes in the nicotinic acetylcholine receptor by Fourier transform infrared difference spectroscopy
1992
Actions of neurotoxins (bungarotoxins, neosurugatoxin and lophotoxins) on insect and nematode nicotinic acetylcholine receptors
1995
Receptor classes and the transmitter-gated ion channels
1992
Ivermectin: A Positive Allosteric Effector of the α7 Neuronal Nicotinic Acetylcholine Receptor
1998
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
Identification of genes expressed in C. elegans touch receptor neurons
2002 StandoutNatureNobel
A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans
1995 StandoutNobel
Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities
1993 Nature
Acetylcholine interactions with tryptophan‐184 of the α‐subunit of the nicotinic acetylcholine receptor revealed by transferred nuclear Overhauser effect
1991
Microfluidic device for stem cell differentiation and localized electroporation of postmitotic neurons
2014
Homologous .kappa.-neurotoxins exhibit residue-specific interactions with the .alpha.3 subunit of the nicotinic acetylcholine receptor: A comparison of the structural requirements for .kappa.-bungarotoxin and .kappa.-flavitoxin binding
1993
Regulation of receptor function by cholesterol
2000
Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins
1995
Neuroligin 1: A splice site-specific ligand for β-neurexins
1995 StandoutNobel
Radioligand Binding and Photoaffinity Labelling Studies Show a Direct Interaction of Phenothiazines at 5-HT 3 Receptors
1997
Substitution of Torpedo acetylcholine receptor .alpha.1-subunit residues with snake .alpha.1- and rat nerve .alpha.3-subunit residues in recombinant fusion proteins: effect on .alpha.-bungarotoxin binding
1992
Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic
1992 Nature
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Acetylcholine Binding by a Synthetic Receptor: Implications for Biological Recognition
1990 Science
Mechanism of calcium gating in small-conductance calcium-activated potassium channels
1998 Nature
Neuronal nicotinic receptors: from structure to pathology
2004
The Diversity of Neuronal Nicotinic Acetylcholine Receptors
1993
Transverse distance between the membrane and the agonist binding sites on the Torpedo acetylcholine receptor: a fluorescence study
1994
Homeodomain-DNA recognition
1994 StandoutNobel
Crystal and molecular structure of human annexin V after refinement
1992 Nobel
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
2001 StandoutNature
Ion channels: molecular basis of ion selectivity
1993
Annexin VI is required for budding of clathrin-coated pits
1992 StandoutNobel
Stratification of the channel domain in neurotransmitter receptors
1993
Ligand—receptor interactions in the nicotinic acetylcholine receptor probed using multiple substitutions at conserved tyrosines on the α subunit
1994
Allosteric Receptors after 30 Years
1998
Fourier transform infrared difference spectroscopy of the nicotinic acetylcholine receptor: evidence for specific protein structural changes upon desensitization
1993
Trp279 is involved in the binding of quaternary ammonium at the peripheral site of Torpedo marmorata acetylcholinesterase
1994
Nuclear Magnetic Resonance (NMR) Analysis of Ligand Receptor Interactions: The Cholinergic System — A Model
1996
Toward high-resolution prediction and design of transmembrane helical protein structures
2007 StandoutNobel
Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit
2008 StandoutNobel
Cys-Loop Neuroreceptors: Structure to the Rescue?
2008
Competitive antagonists bridge the alpha-gamma subunit interface of the acetylcholine receptor through quaternary ammonium-aromatic interactions
1994
A catechol- O -methyltransferase that is essential for auditory function in mice and humans
2008 StandoutNobel
Two subsites in the binding domain of the acetylcholine receptor: an aromatic subsite and a proline subsite.
1995
Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants
1992 Science
Acid potentiation of the capsaicin receptor determined by a key extracellular site
2000 StandoutNobel
Phenyl−Perfluorophenyl Stacking Interactions: Topochemical [2+2] Photodimerization and Photopolymerization of Olefinic Compounds
1998 StandoutNobel
Acetylcholinesterase: structure and use as a model for specific cation—protein interactions
1992
Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: structure and proteolysis by tetanus toxin and botulinal neurotoxins type D and F.
1994 StandoutNobel
From ab initio quantum mechanics to molecular neurobiology: A cation–π binding site in the nicotinic receptor
1998
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
2004 StandoutNobel
Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel
1991 StandoutScienceNobel
Postsynaptic Membrane Fusion and Long-Term Potentiation
1998 StandoutScienceNobel
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Lophotoxins: Irreversible active‐site‐directed inhibitors of nicotinic acetylcholine receptors
1991
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Localization of the high and low affinity [3H]ryanodine binding sites on the skeletal muscle Ca2+ release channel.
1994
Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein
1991 StandoutScience
Nicotinic Receptors at the Amino Acid Level
2000
Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.
1993
MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans
2000 StandoutNatureNobel
Inactivation of a Serotonin-Gated Ion Channel by a Polypeptide Toxin from Marine Snails
1998 StandoutScienceNobel
Cation-π bonding and amino-aromatic interactions in the biomolecular recognition of substituted ammonium ligands
1996
Molecular dissection of subunit interfaces in the acetylcholine receptor: Identification of determinants of α-Conotoxin M1 selectivity
1995
Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor.
1992
Cell Surface Engineering by a Modified Staudinger Reaction
2000 StandoutScienceNobel
The Cation−π Interaction
1997 Standout
Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp
1996 StandoutScience
Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium
1993
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
2017 StandoutNobel
Neural Science
2000 StandoutNobel
Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.
1992
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor.
1992
Characterization of d-tubocurarine binding site of Torpedo acetylcholine receptor
1994
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
2004 StandoutNobel
Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. A negatively charged region of the delta subunit within 0.9 nm of the alpha subunit binding site disulfide.
1991
Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate
1993
A structural view of evolutionary divergence
1999 StandoutNobel
Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha 7 nicotinic receptor.
1993
Two functionally dependent acetylcholine subunits are encoded in a single Caenorhabditis elegans operon
1998 StandoutNobel
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Mutation of Glycine Receptor Subunit Creates β-Alanine Receptor Responsive to GABA
1993 Science
Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants.
1992
A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle
2010 StandoutNobel
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
A Photoactivatable Push−Pull Fluorophore for Single-Molecule Imaging in Live Cells
2008 StandoutNobel
Neurotransmitter-gated ion channels as unconventional allosteric proteins
1994
Negatively charged amino acid residues in the nicotinic receptor delta subunit that contribute to the binding of acetylcholine.
1993
Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite.
1991
Ab initio and AM1 calculations on model systems of Acctylcholine binding: complexes of tetramethylammonium with aromatics, neutral and ionic formic acid
1993
Origin of the Catalytic Power of Acetylcholinesterase: Computer Simulation Studies
1998 StandoutNobel
Two Identical Noninteracting Sites in an Ion Channel Revealed by Proton Transfer
1994 StandoutScienceNobel
Recent Trends in Photoaffinity Labeling
1995
Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells
1995 Science
Caenorhabditis elegansLevamisole Resistance Geneslev-1,unc-29, andunc-38Encode Functional Nicotinic Acetylcholine Receptor Subunits
1997 StandoutNobel
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
Works of Frédéric Revah being referenced
Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites.
1990
Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site‐directed mutagenesis
1991
The noncompetitive blocker [3H]chlorpromazine labels segment M2 but not segment M 1 of the nicotinic acetylcholine receptor α‐subunit
1989
Functional Architecture of the Nicotinic Acetylcholine Receptor: From Electric Organ to Brain
1991
Immunohistochemical analysis of presenilin‐1 expression in the mouse brain
1996
Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor
1991 Nature
Adenovirus in the brain: recent advances of gene therapy for neurodegenerative diseases
1998
Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.
1992
Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand.
1991
The acetylcholine receptor molecule: allosteric sites and the ion channel
1987
The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.
1990