Standout Papers
Citation Impact
Citing Papers
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks
2013
Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch
2004 StandoutScienceNobel
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
2015 Science
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9
2014 Nobel
Short Telomeres in Yeast Are Highly Recombinogenic
2001
Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases
2007
Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos
2007
Coevolution of a Homing Endonuclease and Its Host Target Sequence
2007
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
2011
Comprehensive analysis of the specificity of transcription activator-like effector nucleases
2014
Non-specific protein–DNA interactions control I-CreI target binding and cleavage
2012
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Native homing endonucleases can target conserved genes in humans and in animal models
2011
In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination
2005
Gene editing: not just for translation anymore
2011
TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain
2010
High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display
2009
AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication
2014
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy
2015
Telomerase-Mediated Telomere Addition In Vivo Requires DNA Primase and DNA Polymerases α and δ
1999
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
2014 Nature
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
2013 Standout
Tracking genome engineering outcome at individual DNA breakpoints
2011
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
Mismatch repair proteins: key regulators of genetic recombination
2004
Regulation of DNA double-strand break repair pathway choice
2007
Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
2016
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Repair of Strand Breaks by Homologous Recombination
2013
The Structure of I-CeuI Homing Endonuclease: Evolving Asymmetric DNA Recognition from a Symmetric Protein Scaffold
2006
Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model
2012 Nobel
Regulation of DNA repair throughout the cell cycle
2008
From Monomeric to Homodimeric Endonucleases and Back: Engineering Novel Specificity of LAGLIDADG Enzymes
2006
DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining
2000
Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes
2000 Nature
Comprehensive computational design of mCreI homing endonuclease cleavage specificity for genome engineering
2011 StandoutNobel
A role for Saccharomyces cerevisiae histone H2A in DNA repair
2000 Nature
Homing endonuclease structure and function
2005
Massively parallel determination and modeling of endonuclease substrate specificity
2014 StandoutNobel
Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space
2012
Directed evolution of homing endonuclease I-SceI with altered sequence specificity
2009
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
CRISPR-Cas systems for editing, regulating and targeting genomes
2014 Standout
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
Gene therapy for primary immunodeficiencies: Looking ahead, toward gene correction
2011
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
Switching and Signaling at the Telomere
2001 StandoutNobel
Homing endonuclease I-CreI derivatives with novel DNA target specificities
2006
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
2011 StandoutNatureNobel
Improved Modeling of Side-Chain–Base Interactions and Plasticity in Protein–DNA Interface Design
2012 StandoutNobel
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells
2003
Mismatch repair and immunoglobulin gene hypermutation: did we learn something?
1999
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSα
1998 StandoutNobel
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Highly efficient endogenous human gene correction using designed zinc-finger nucleases
2005 Nature
Telomerase-Independent Lengthening of Yeast Telomeres Occurs by an Abrupt Rad50p-Dependent, Rif-Inhibited Recombinational Process
2000
An improved zinc-finger nuclease architecture for highly specific genome editing
2007
DNA-binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases
2007
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
2012 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Branch Migration and Holliday Junction Resolution Catalyzed by Activities from Mammalian Cells
2001
Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs
2010 StandoutNobel
Comprehensive homing endonuclease target site specificity profiling reveals evolutionary constraints and enables genome engineering applications
2011
Structure-Based DNA-Binding Prediction and Design
2010
DNA double strand break repair in mammalian cells
2000
A TALE nuclease architecture for efficient genome editing
2010 Standout
DNA recombination: the replication connection
1999
Altered target site specificity variants of the I-PpoI His-Cys box homing endonuclease
2007
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA Modification
2011
Heritable targeted mutagenesis in maize using a designed endonuclease
2009
Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins
2009
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
Progress and prospects: Zinc-finger nucleases as gene therapy agents
2008
Motif‐directed flexible backbone design of functional interactions
2009 StandoutNobel
Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation
2008
RNA-dependent DNA endonuclease Cas9 of the CRISPR system: Holy Grail of genome editing?
2013
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 StandoutNobel
Mining Endonuclease Cleavage Determinants in Genomic Sequence Data
2011 StandoutNobel
Exploitation of binding energy for catalysis and design
2009 StandoutNatureNobel
Genome-editing revolution: My whirlwind year with CRISPR
2015 StandoutNatureNobel
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells
2012
Outcrossed sex allows a selfish gene to invade yeast populations
2001
RecBCD Enzyme and the Repair of Double-Stranded DNA Breaks
2008
Chemical and biological approaches to improve the efficiency of homologous recombination in human cells mediated by artificial restriction DNA cutter
2012
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Roles of the Two Drosophila CRYPTOCHROME Structural Domains in Circadian Photoreception
2004 StandoutScienceNobel
Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases
2001
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
TELOMERES AND THEIR CONTROL
2000 StandoutNobel
CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems
2015
Quality Control by DNA Repair
1999 StandoutScienceNobel
Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning
2015 StandoutScienceNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease
2009
Genetic Steps of Mammalian Homologous Repair with Distinct Mutagenic Consequences
2004
Genome Engineering With Zinc-Finger Nucleases
2011
Reprogramming homing endonuclease specificity through computational design and directed evolution
2013 StandoutNobel
The connection between transcription and genomic instability
2002
Mammalian Sirtuins: Biological Insights and Disease Relevance
2010 Standout
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
2014 StandoutNobel
DNA Repair in Drosophila
2000
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
Tapping natural reservoirs of homing endonucleases for targeted gene modification
2011
In vitro and in vivo nucleotide exchange directed by chimeric RNA/DNA oligonucleotides in Saccharomyces cerevisae
2001
Male‐sterile maize plants produced by targeted mutagenesis of the cytochrome P 450‐like gene (MS 26) using a re‐designed I–C reI homing endonuclease
2013
Homing endonucleases: DNA scissors on a mission
2012
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections
2012
Swi1 Prevents Replication Fork Collapse and Controls Checkpoint Kinase Cds1
2003
Human DNA Repair Genes
2001 StandoutScienceNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
A Sense of the End
2000 Science
Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination
2003
Targeting DNA Double-Strand Breaks with TAL Effector Nucleases
2010
IDENTIFICATION OF CONSERVED FEATURES OF LAGLIDADG HOMING ENDONUCLEASES
2010
Regulation of Homologous Recombination in Eukaryotes
2010
Works of Frédéric Pâques being referenced
Context dependence between subdomains in the DNA binding interface of the I-CreI homing endonuclease
2011
Generation and Analysis of Mesophilic Variants of the Thermostable Archaeal I-DmoI Homing Endonuclease
2007
Robust Cell Line Development Using Meganucleases
2008
Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences
2008
High Frequency Targeted Mutagenesis Using Engineered Endonucleases and DNA-End Processing Enzymes
2013
Targeted approaches for gene therapy and the emergence of engineered meganucleases
2009
Coupling endonucleases with DNA end–processing enzymes to drive gene disruption
2012
Meganuclease-mediated Inhibition of HSV1 Infection in Cultured Cells
2011
Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases
2008 Nature
Meganucleases and DNA Double-Strand Break-Induced Recombination: Perspectives for Gene Therapy
2007
Meganucleases can restore the reading frame of a mutated dystrophin
2010
Engineering of Large Numbers of Highly Specific Homing Endonucleases that Induce Recombination on Novel DNA Targets
2005
Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths
1999
Efficient in toto targeted recombination in mouse liver by meganuclease‐induced double‐strand break
2006
Efficient gene targeting mediated by a lentiviral vector-associated meganuclease
2011
The C-terminal loop of the homing endonuclease I-CreI is essential for site recognition, DNA binding and cleavage
2007
A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences
2006
Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy
2011
Rearrangements Involving Repeated Sequences Within a P Element Preferentially Occur Between Units Close to the Transposon Extremities
1996
The I-CreI meganuclease and its engineered derivatives: applications from cell modification to gene therapy
2010
Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds
2009
Engineered I-CreI Derivatives Cleaving Sequences from the Human XPC Gene can Induce Highly Efficient Gene Correction in Mammalian Cells
2007
Gene Correction of a Duchenne Muscular Dystrophy Mutation by Meganuclease-Enhanced Exon Knock-In
2013
Two Pathways for Removal of Nonhomologous DNA Ends during Double-Strand Break Repair in Saccharomyces cerevisiae
1997
Identification of Genes Regulating Gene Targeting by a High-Throughput Screening Approach
2011
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
1999 Standout
Removal of One Nonhomologous DNA End During Gene Conversion by a RAD1- and MSH2-Independent Pathway
1999
Crystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineering
2008
Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination
1997
Expansions and Contractions in a Tandem Repeat Induced by Double-Strand Break Repair
1998
Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease
2009
Factors Affecting Double-Strand Break-Induced Homologous Recombination in Mammalian Cells
2005