Citation Impact
Citing Papers
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
2007 Standout
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
2005 StandoutScience
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
WGCNA: an R package for weighted correlation network analysis
2008 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Diastereoselective Reductive Amination of Aryl Trifluoromethyl Ketones and α‐Amino Esters
2007
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility
2008
Cysteine cathepsin proteases as pharmacological targets in cancer
2007
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
2006
Practical and stereoselective synthesis of β-amino sulfones from alkyl phenyl sulfones and N-(tert-butylsulfinyl) aldimines
2011
Role of malonyl-CoA in heart disease and the hypothalamic control of obesity
2006
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
2020 Standout
A multi-substrate screening approach for the identification of a broadly applicable Diels–Alder catalyst
2019 StandoutNobel
Mitochondria: Dynamic Organelles in Disease, Aging, and Development
2006 Standout
Radiochemical Malonyl-CoA Decarboxylase Assay: Activity and Subcellular Distribution in Heart and Skeletal Muscle
2002
Genetically Altered Expression of Spermidine/Spermine N1-Acetyltransferase Affects Fat Metabolism in Mice via Acetyl-CoA
2006
Mechanisms linking obesity with cardiovascular disease
2006 StandoutNature
Mitochondrial function in normal and diabetic β-cells
2001 Nature
Assay of the Concentration and 13C-Isotopic Enrichment of Malonyl–Coenzyme A by Gas Chromatography–Mass Spectrometry
2001
The Failing Heart — An Engine Out of Fuel
2007 Standout
AMPK alterations in cardiac physiology and pathology: enemy or ally?
2006
Targeting proteases: successes, failures and future prospects
2006
Catalysis for fluorination and trifluoromethylation
2011 StandoutNature
Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion
2009
Fluorine in Medicinal Chemistry
2015
Insulin antagonizes AMP‐activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides
2001
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
2014 StandoutNature
Drug discovery for a new generation of covalent drugs
2012
The Trifluoroethylamine Function as Peptide Bond Replacement
2007
Myocardial Substrate Metabolism in the Normal and Failing Heart
2005 Standout
Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle
2006
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise
2003
Malonyl-CoA Decarboxylase Is Not a Substrate of AMP-Activated Protein Kinase in Rat Fast-Twitch Skeletal Muscle or an Islet Cell Line
2001
Industrial Applications of the Diels–Alder Reaction
2013
A Multicomponent Reaction Towards N‐(Cyanomethyl)amides
2009
AMP-activated Protein Kinase Is Required for the Lipid-lowering Effect of Metformin in Insulin-resistant Human HepG2 Cells
2004
Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series
2011
Future directions of bone-targeted therapy for metastatic breast cancer
2010
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
2002 StandoutNobel
A Role for Peroxisome Proliferator-activated Receptor α (PPARα) in the Control of Cardiac Malonyl-CoA Levels
2002
Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
2005
The malonyl CoA axis as a potential target for treating ischaemic heart disease
2008
Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors
2008
AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARα and PGC-1
2005
Ψ[CH(CF3)NH]Gly-peptides: synthesis and conformation analysis
2009
Genetic Regulation of Metabolic Pathways in β-Cells Disrupted by Hyperglycemia
2002
Protease inhibitors targeting coronavirus and filovirus entry
2015
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
Absence of Malonyl Coenzyme A Decarboxylase in Mice Increases Cardiac Glucose Oxidation and Protects the Heart From Ischemic Injury
2006
Iron Catalysis in Organic Synthesis
2015 Standout
3d Transition Metals for C–H Activation
2018 Standout
Fluorine in medicinal chemistry
2007 Standout
Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart
2003
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Selective Modification of Pyruvate Dehydrogenase Kinase Isoform Expression in Rat Pancreatic Islets Elicited by Starvation and Activation of Peroxisome Proliferator–Activated Receptor-α
2001
Organic Photoredox Catalysis
2016 Standout
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Nanoscale distribution of mitochondrial import receptor Tom20 is adjusted to cellular conditions and exhibits an inner-cellular gradient
2011 StandoutNobel
Scalable and Highly Diastereo- and Enantioselective Catalytic Diels–Alder Reaction of α,β-Unsaturated Methyl Esters
2018 StandoutNobel
Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates
2010
Myocardial Fatty Acid Metabolism in Health and Disease
2010 Standout
Study of Heterogeneous Catalysis by Iron-Squarate based 3D Metal Organic Framework for the Transformation of Tetrazines to Oxadiazole derivatives
2014
Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet
2002
Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore
2010 Standout
Catalytic Asymmetric [4+2]-Cycloaddition of Dienes with Aldehydes
2017 StandoutNobel
Coordinate Regulation of Malonyl-CoA Decarboxylase,sn-Glycerol-3-phosphate Acyltransferase, and Acetyl-CoA Carboxylase by AMP-activated Protein Kinase in Rat Tissues in Response to Exercise
2002
Increased Uncoupling Protein-2 Levels in β-cells Are Associated With Impaired Glucose-Stimulated Insulin Secretion
2001
The Many Roles for Fluorine in Medicinal Chemistry
2008 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets
2003
Malonyl‐CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5′AMP‐activated protein kinase (AMPK)
2004
Selective trifluoromethylation and alkynylation of tetrahydroisoquinolines using visible light irradiation by Rose Bengal
2012
Rhodium-catalyzed diastereoselective 1,2-addition of arylboronic acids to chiral trifluoroethyl imine
2009
Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level
2004
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Spermidine in health and disease
2018 StandoutScience
Synthesis and Opioid Activity of Tyr1‐ψ[(Z)CF=CH]‐Gly2 and Tyr1‐ψ[(S)/(R)‐CF3CH‐NH]‐Gly2 Leu‐enkephalin Fluorinated Peptidomimetics
2017
Probing the link between citrate and malonyl-CoA in perfused rat hearts
2002
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Mitochondrial Dysfunction and Type 2 Diabetes
2005 StandoutScience
Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity
2002
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
Adaptation and Maladaptation of the Heart in Diabetes: Part II
2002
Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids
2001
Activatable Photosensitizers for Imaging and Therapy
2010 Standout
Electrosynthesis and screening of novel 1,3,4-oxadiazoles as potent and selective antifungal agents
2013
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Aromatic Trifluoromethylation with Metal Complexes
2011 Standout
β-Cell Mitochondria Exhibit Membrane Potential Heterogeneity That Can Be Altered by Stimulatory or Toxic Fuel Levels
2007
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
Malonyl CoA Control of Fatty Acid Oxidation in the Ischemic Heart
2002
Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450 BM3 demethylases
2009 StandoutNobel
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
2013 Standout
Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles: A Review of the Literature from 2000–2012
2012
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Recent Advances in the Synthesis of Fluorinated Amino Acids
2011
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Catalytic Asymmetric Protonation of Silyl Ketene Imines
2013 StandoutNobel
Nutritional regulation of insulin secretion: implications for diabetes.
2012
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
2011 Standout
Works of Frédéric Massé being referenced
The identification of potent, selective, and bioavailable cathepsin S inhibitors
2007
Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell
2000
Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)
2009
Identification of a potent and selective non-basic cathepsin K inhibitor
2006
Activation of Malonyl-CoA Decarboxylase in Rat Skeletal Muscle by Contraction and the AMP-activated Protein Kinase Activator 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside
2000
Investigation of ketone warheads as alternatives to the nitrile for preparation of potent and selective cathepsin K inhibitors
2008
Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease
2010
Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K
2005
Identification of a Nonbasic, Nitrile-Containing Cathepsin K Inhibitor (MK-1256) that is Efficacious in a Monkey Model of Osteoporosis
2008
Lysosomotropism of Basic Cathepsin K Inhibitors Contributes to Increased Cellular Potencies against Off-Target Cathepsins and Reduced Functional Selectivity
2005
A Role for the Malonyl-CoA/Long-Chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli
2004
The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor
2010
β-Substituted Cyclohexanecarboxamide: A Nonpeptidic Framework for the Design of Potent Inhibitors of Cathepsin K
2006