Frédéric Jung

MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel

AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts

Biological Characterization of TAK-901, an Investigational, Novel, Multitargeted Aurora B Kinase Inhibitor

Molecular dynamics and free energy studies on Aurora kinase A and its mutant bound with MLN8054: insight into molecular mechanism of subtype selectivity

Expansive discovery of chemically diverse structured macrocyclic oligoamides

Synthesis of 3-alkoxycarbonyl-1β-methylcarbapenem using palladium-catalyzed amidation of vinyl halide

Quinolines and structurally related heterocycles as antimalarials

The Concept of Synthetic Lethality in the Context of Anticancer Therapy

Enamide Synthesis by Copper‐Catalyzed Cross‐Coupling of Amides and Potassium Alkenyltrifluoroborate Salts

Desymmetrization‐like Catalytic Enantioselective Fluorination of Malonates and Its Application to Pharmaceutically Attractive Molecules

Oncogene addiction: setting the stage for molecularly targeted cancer therapy

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

Cell cycle proteins as promising targets in cancer therapy

Catalytic Three‐Component Ugi Reaction

Thymoquinone: Potential cure for inflammatory disorders and cancer

Rational design of inhibitors that bind to inactive kinase conformations

Selection of boron reagents for Suzuki–Miyaura coupling

Catalysis for fluorination and trifluoromethylation

Introduction of Fluorine and Fluorine‐Containing Functional Groups

Chemo-enzymatic fluorination of unactivated organic compounds

Aurora inhibitor MLN8237 in combination with docetaxel enhances apoptosis and anti-tumor activity in mantle cell lymphoma

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases

Targeting cancer with small molecule kinase inhibitors

Natural products to drugs: natural product-derived compounds in clinical trials

Cell-free nucleic acids as biomarkers in cancer patients

Establishment of a Chemical Synthetic Lethality Screen in Cultured Human Cells

Modulation of kinase‐inhibitor interactions by auxiliary protein binding: Crystallography studies on Aurora A interactions with VX‐680 and with TPX2

Drug repurposing: progress, challenges and recommendations

Translation of new cancer treatments from pet dogs to humans

Mechanisms of drug combinations: interaction and network perspectives

Cascade Reactions in Total Synthesis

Polo and Aurora kinases — lessons derived from chemical biology

Why is cancer drug discovery so difficult?

High-throughput kinase profiling as a platform for drug discovery

Cell cycle, CDKs and cancer: a changing paradigm

Comprehensive analysis of kinase inhibitor selectivity

Paul Ehrlich's magic bullet concept: 100 years of progress

Chemical regulation of epigenetic modifications: Opportunities for new cancer therapy

Search for new pharmacophores for antimalarial activity. Part II: Synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazolines

Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view

Aryl Trifluoroborates in Suzuki–Miyaura Coupling: The Roles of Endogenous Aryl Boronic Acid and Fluoride

Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors

Skepinone-L, a Novel Potent and Highly Selective Inhibitor of p38 MAP Kinase, Effectively Impairs Platelet Activation and Thrombus Formation

A General Strategy for Creating “Inactive-Conformation” Abl Inhibitors

Cell cycle kinases as therapeutic targets for cancer

Aurora kinase inhibitors: Progress towards the clinic

Computational approach to the identification of novel Aurora-A inhibitors

The history and future of targeting cyclin-dependent kinases in cancer therapy

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

Novel Synthesis of Carbapenam by Intramolecular Attack of Lactam Nitrogen toward η¹-Allenyl and η³-Propargylpalladium Complex

Monofluorination of Organic Compounds: 10 Years of Innovation

Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions

Copper-Mediated Coupling Reactions and Their Applications in Natural Products and Designed Biomolecules Synthesis

Chemoselective oxidation of sulfides to sulfones with potassium hydrogen persulfate

Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy

Contribution of Organofluorine Compounds to Pharmaceuticals

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

o-Quinodimethanes:  Efficient Intermediates in Organic Synthesis

Recent developments in sulfone chemistry

The Hitchhiker’s Guide to Flow Chemistry

On the Mechanism of Cu-Catalyzed Enantioselective Extended Conjugate Additions: A Structure-Based Approach

Scope of the Palladium-Catalyzed Aryl Borylation Utilizing Bis-Boronic Acid

Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives

Construction of a carbapenam skeleton using palladium-catalyzed cyclization

Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237

The Many Roles for Fluorine in Medicinal Chemistry

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

Progress in the Synthesis of Canthine Alkaloids and Ring-Truncated Congeners

Desymmetrization‐like Catalytic Enantioselective Fluorination of Malonates and Its Application to Pharmaceutically Attractive Molecules

Mycophenolic Acid:  A One Hundred Year Odyssey from Antibiotic to Immunosuppressant

Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs

Recent advances in electrophilic fluorination

Aurora A Inhibitor (MLN8237) plus Vincristine plus Rituximab Is Synthetic Lethal and a Potential Curative Therapy in Aggressive B-cell Non-Hodgkin Lymphoma

Fluorine in Pharmaceuticals: Looking Beyond Intuition

Switching the Chemoselectivity in the Amination of 4-Chloroquinazolines with Aminopyrazoles

A Computational Model for Overcoming Drug Resistance Using Selective Dual-Inhibitors for Aurora Kinase A and Its T217D Variant

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents

Integrated Cross-Coupling Strategy for an α-Carboline-Based Aurora B Kinase Inhibitor

Assessment of the In vivo Antitumor Effects of ENMD-2076, a Novel Multitargeted Kinase Inhibitor, against Primary and Cell Line–Derived Human Colorectal Cancer Xenograft Models

Olefin inversion

Aerobic Copper-Catalyzed Organic Reactions

Alkyne Elementometalation−Pd-Catalyzed Cross-Coupling. Toward Synthesis of All Conceivable Types of Acyclic Alkenes in High Yields, Efficiently, Selectively, Economically, and Safely: “Green” Way

Chemistry of Biologically Important Synthetic Organoselenium Compounds

Molecular Shape Diversity of Combinatorial Libraries:  A Prerequisite for Broad Bioactivity

Rational Approaches to Improving Selectivity in Drug Design

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

Aromatic Trifluoromethylation with Metal Complexes

Parallel Synthesis of Arrays of Amino-Acid-Derived Isocyanoamides Useful As Starting Materials in IMCR

Transition-Metal-Catalyzed Reactions in Heterocyclic Synthesis

Syntheses a l'aide de sulfones v(+)- methode de synthese generale de doubles liaisons.

Chemistry and Biology Of Multicomponent Reactions

Update 1 of: Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions

Heterocyclic Nanographenes and Other Polycyclic Heteroaromatic Compounds: Synthetic Routes, Properties, and Applications

Orthoquinodimethanes

11- leukotriene C: A naturally occurring slow reacting substance

Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues

Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: Selective inhibitors of Aurora B kinase with potent anti-tumor activity

SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors

Progress in the Development of Selective Inhibitors of Aurora Kinases

Progress in the Development of Selective Inhibitors of Aurora Kinases

Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and .beta.-lactamase stability on the pKa of the C-7 heterocycle

A novel series of non-nucleoside inhibitors of inosine 5′-monophosphate dehydrogenase with immunosuppressive activity§§Abbreviations: β, coefficient of interaction; DTH, delayed-type hypersensitivity; FBS, foetal bovine serum; IMP, inosine 5′-monophosphate; IMPDH, IMP dehydrogenase; K′i, apparent inhibition constant for compound I; Kii, inhibition constant for effect on intercept of Lineweaver–Burk plots; K′x, apparent inhibition constant for compound X; MFT, mycophenolate mofetil; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; MPA, mycophenolic acid; TCA, trichloroacteic acid (10% w/v); v, velocity; v0, uninhibited velocity; and XMP, xanthosine monophosphate.

.beta.-Sultines. Intermediates in a sulfur analog of the Wittig olefin synthesis

Strategic studies in the syntheses of novel 6,7-substituted quinolones and 7- or 6-substituted 1,6- and 1,7-naphthyridones

AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis

Synthesis of 3-fluoro azetidinone by electrophilic fluorination

An efficient large-scale synthesis of alkyl 5-hydroxy-pyridin- and pyrimidin-2-yl acetate

Cephalosporins with C-7-isocyanide dihalides : useful synthons for the introduction of amino heterocycles at C-7 - new routes to the synthesis of amino imidazoles

Decomposition of 3,6-dihydro-1,2-oxathiin 2-oxides to sulfur dioxide and 1,3-dienes. A .pi.4s+.pi.2s cycloreversion

π-Allyl palladium ring closure strategy for the synthesis of a 1β-methylcarbapenem intermediate