Citation Impact
Citing Papers
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Computation and Functional Studies Provide a Model for the Structure of the Zinc Transporter hZIP4
2015 StandoutNobel
Expression Cloning and Pharmacological Characterization of a Human Hippocampal Neuropeptide Y/Peptide YY Y2 Receptor Subtype
1995
Notch signals control the fate of immature progenitor cells in the intestine
2005 Nature
Cloning and Functional Expression of a Human Y4 Subtype Receptor for Pancreatic Polypeptide, Neuropeptide Y, and Peptide YY
1995
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
2004 Standout
β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB
2002
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
2003
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Cyclic AMP‐dependent regulation of K+ transport in the rat distal colon
1996
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
2010 StandoutNature
In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination
2005
High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display
2009
Computational Enzyme Design
2013 StandoutNobel
A highly sensitive selection method for directed evolution of homing endonucleases
2005
The Crystal Structure of the Gene Targeting Homing Endonuclease I-SceI Reveals the Origins of its Target Site Specificity
2003
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
N-myc Downstream-regulated Gene 2, a Novel Estrogen-targeted Gene, Is Involved in the Regulation of Na+/K+-ATPase
2011
Ceramide Biosynthesis Is Required for the Formation of the Oligomeric H+-ATPase Pma1p in the Yeast Endoplasmic Reticulum
2002 StandoutNobel
Nuclear factor-κB in cancer development and progression
2006 StandoutNature
Comprehensive computational design of mCreI homing endonuclease cleavage specificity for genome engineering
2011 StandoutNobel
Massively parallel determination and modeling of endonuclease substrate specificity
2014 StandoutNobel
Control of actin assembly and disassembly at filament ends
2000
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
2005 StandoutNobel
Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate
2009
Directed evolution of homing endonuclease I-SceI with altered sequence specificity
2009
Vascular Signaling in Allogenic Solid Organ Transplantation – The Role of Endothelial Cells
2020
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
2004 Standout
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
Efficient in toto targeted recombination in mouse liver by meganuclease‐induced double‐strand break
2006
Cardiotonic steroids on the road to anti-cancer therapy
2007
NMR Structure and Metal Interactions of the CopZ Copper Chaperone
1999 StandoutNobel
A constitutively open potassium channel formed by KCNQ1 and KCNE3
2000 StandoutNature
Collecting duct–specific gene inactivation of αENaC in the mouse kidney does not impair sodium and potassium balance
2003
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
2011 StandoutNatureNobel
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells
2003
Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia
2015
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
Ubiquitination of Na,K‐ATPase α1 and α2 subunits
1997
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
1999 Standout
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
2012 StandoutNobel
Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction
2003 Standout
Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs
2010 StandoutNobel
Human Menkes X‐chromosome disease and the staphylococcal cadmium‐resistance ATPase: a remarkable similarity in protein sequences
1993
Wnt signalling in stem cells and cancer
2005 StandoutNature
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Crypt stem cells as the cells-of-origin of intestinal cancer
2008 StandoutNature
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
2003
Inducible Gene Knockouts in the Small Intestinal and Colonic Epithelium
1999
Engineered I-CreI Derivatives Cleaving Sequences from the Human XPC Gene can Induce Highly Efficient Gene Correction in Mammalian Cells
2007
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
2003 Standout
Mining Endonuclease Cleavage Determinants in Genomic Sequence Data
2011 StandoutNobel
Functional Significance of E2 State Stabilization by Specific α/β-Subunit Interactions of Na,K- and H,K-ATPase
2008
Mineralocorticoid Receptor Antagonists for the Treatment of Hypertension and Diabetic Nephropathy
2012
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na + channels
2004 StandoutNobel
Pho86p, an endoplasmic reticulum (ER) resident protein in Saccharomyces cerevisiae , is required for ER exit of the high-affinity phosphate transporter Pho84p
2000 StandoutNobel
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases
2001
Targeting of the yeast plasma membrane [H+]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole.
1995
De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine
2004 Science
Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.
1996 StandoutNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
Cell-specific expression of epithelial sodium channel alpha, beta, and gamma subunits in aldosterone-responsive epithelia from the rat: localization by in situ hybridization and immunocytochemistry.
1994
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease
1997 StandoutNobel
Structure, Regulation, and Functional Diversity of Microvilli on the Apical Domain of Epithelial Cells
2015
Mutagenic study of the structure, function and biogenesis of the yeast plasma membrane H+-ATPase
2000
Reprogramming homing endonuclease specificity through computational design and directed evolution
2013 StandoutNobel
Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3
2004
Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis
2007 StandoutScience
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
2014 StandoutNobel
Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes
2020 Standout
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
Enhancing Gene Targeting with Designed Zinc Finger Nucleases
2003 Science
Chronic administration of aldosterone depresses baroreceptor reflex function in the dog.
1994
Endothelial Hypoxia-Inducible Factor-2α Is Required for the Maintenance of Airway Microvasculature
2019 StandoutNobel
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
2003
Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions
2018 StandoutNobel
High-Resolution Crystal Structures of Villin Headpiece and Mutants with Reduced F-Actin Binding Activity,
2005
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
Sodium/Calcium Exchange: Its Physiological Implications
1999 Standout
IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium
2004
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
2005 StandoutNobel
Shear force sensing of epithelial Na + channel (ENaC) relies on N -glycosylated asparagines in the palm and knuckle domains of αENaC
2019
Works of Frédéric Jaisser being referenced
Modulation of the Na,K-pump function by beta subunit isoforms.
1994
Steroidal and Novel Non-steroidal Mineralocorticoid Receptor Antagonists in Heart Failure and Cardiorenal Diseases: Comparison at Bench and Bedside
2016
Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells
2014
Role of β-Subunit Domains in the Assembly, Stable Expression, Intracellular Routing, and Functional Properties of Na,K-ATPase
1998
Aldosterone, mineralocorticoid receptor, and heart failure
2011
Effect of cell sodium on Na+/K+-ATPase-dependent sodium efflux in cortical collecting tubule of rabbits under different aldosterone status
1990
The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling
2018
The Rat Distal Colon P-ATPase α Subunit Encodes a Ouabain-sensitive H+,K+-ATPase
1996
Regulatory Sequences of the Mouse Villin Gene That Efficiently Drive Transgenic Expression in Immature and Differentiated Epithelial Cells of Small and Large Intestines
1999
Characterization of Rat NDRG2 (N-Myc Downstream Regulated Gene 2), a Novel Early Mineralocorticoid-specific Induced Gene
2002
Mineralocorticoid receptor antagonists and kidney diseases: pathophysiological basis
2019
In Vivo, Villin Is Required for Ca2+-Dependent F-Actin Disruption in Intestinal Brush Borders
1999
The Absence of Endothelial Sodium Channel α (αENaC) Reduces Renal Ischemia/Reperfusion Injury
2019
Mechanisms of urinary K+ and H+ excretion: primary structure and functional expression of a novel H,K-ATPase.
1993
I-SceI-Induced Gene Replacement at a Natural Locus in Embryonic Stem Cells
1998
Mutation of a conserved proline residue in the beta-subunit ectodomain prevents Na(+)-K(+)-ATPase oligomerization
1993
Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Protects Against Acute Kidney Injury–Mediated Chronic Kidney Disease
2017
Phosphorylation of the Na,K-ATPase alpha-subunit by protein kinase A and C in vitro and in intact cells. Identification of a novel motif for PKC-mediated phosphorylation.
1994
Inducible Gene Expression and Gene Modification in Transgenic Mice
2000
Role of the transmembrane and extracytoplasmic domain of beta subunits in subunit assembly, intracellular transport, and functional expression of Na,K-pumps.
1993
A putative H(+)-K(+)-ATPase is selectively expressed in surface epithelial cells of rat distal colon
1993
Primary sequence and functional expression of a novel ouabain-resistant Na,K-ATPase. The beta subunit modulates potassium activation of the Na,K-pump.
1992
Mineralocorticoid Receptor and Cardiovascular Disease
2018