Citation Impact
Citing Papers
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination
2003 StandoutNobel
Preferential localization of IgG memory B cells adjacent to contracted germinal centers
2010
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
2005 StandoutNobel
MutL traps MutS at a DNA mismatch
2015 StandoutNobel
Evolution of new nonantibody proteins via iterative somatic hypermutation
2004 StandoutNobel
Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression
2008
Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch
2004 StandoutScienceNobel
MSH2–MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes
2005
AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts
2002 StandoutScienceNobel
Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase η during copying of a mouse immunoglobulin κ light chain transgene
2002
Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair
2007 StandoutNobel
Cutting Edge: DNA Polymerases μ and λ Are Dispensable for Ig Gene Hypermutation
2002
Cutting Edge: Hypermutation in Ig V Genes from Mice Deficient in the MLH1 Mismatch Repair Protein
1999
Somatic Hypermutation in Muts Homologue (Msh)3-, Msh6-, and Msh3/Msh6-Deficient Mice Reveals a Role for the Msh2–Msh6 Heterodimer in Modulating the Base Substitution Pattern
2000
T Cell-Independent Somatic Hypermutation in Murine B Cells with an Immature Phenotype
2004
Somatic Hypermutation of Immunoglobulin Genes
2002
Linking class-switch recombination with somatic hypermutation
2001 StandoutNobel
Structure of the Histone Acetyltransferase Hat1
1998 StandoutNobel
AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line
2002
Emerging links between hypermutation of antibody genes and DNA polymerases
2001
Uracil in DNA—General mutagen, but normal intermediate in acquired immunity
2006
AID and mismatch repair in antibody diversification
2002
Somatic Hypermutation, Transcription, and DNA Mismatch Repair
1998
Memory B and memory plasma cells
2010
Mechanism of somatic hypermutation: Critical analysis of strand biased mutation signatures at A:T and G:C base pairs
2008
Hypermutation targets a green fluorescent protein-encoding transgene in the presence of immunoglobulin enhancers
1999
Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation
1999
PMS2-deficiency diminishes hypermutation of a λ1 transgene in young but not older mice
1999
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells
2005
DNA polymerase κ deficiency does not affect somatic hypermutation in mice
2002
TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line
1998
Activation-induced Cytosine Deaminase (AID) Is Actively Exported out of the Nucleus but Retained by the Induction of DNA Breaks
2004
Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter
2010
The generation of antibody diversity through somatic hypermutation and class switch recombination
2004
Functions of human DNA polymerases η, κ and ι suggested by their properties, including fidelity with undamaged DNA templates
2003
Towards an understanding of somatic hypermutation
2001
T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses
2015
What role for AID: mutator, or assembler of the immunoglobulin mutasome?
2003
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
2002 Nature
Requirement of Non-canonical Activity of Uracil DNA Glycosylase for Class Switch Recombination
2006 StandoutNobel
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
2001 StandoutNatureNobel
The influence of transcriptional orientation on endogenous switch region function
2003
Somatic hypermutation at A·T pairs: polymerase error versus dUTP incorporation
2005
Activation-Induced Cytidine Deaminase Expression in CD4+ T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age
2011 StandoutNobel
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1–mutant mice
2004
I. VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation
2008
The PU.1 and NF-EM5 binding motifs in the Igκ 3′ enhancer are responsible for directing somatic hypermutations to the intrinsic hotspots in the transgenic Vκ gene
2001
C-Terminal Deletion of AID Uncouples Class Switch Recombination from Somatic Hypermutation and Gene Conversion
2003
The Mismatch Repair Protein Msh6 Influences the In Vivo AID Targeting to the Ig Locus
2006
The Structural Mechanism of Translocation and Helicase Activity in T7 RNA Polymerase
2004 StandoutNobel
Activation-induced deaminase: controversies and open questions
2004
A novel interaction between human DNA polymerase η and MutLα
2009
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Mismatch Recognition and Uracil Excision Provide Complementary Paths to Both Ig Switching and the A/T-Focused Phase of Somatic Mutation
2004
The Translesion DNA Polymerase ζ Plays a Major Role in Ig and bcl-6 Somatic Hypermutation
2001
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Negative regulation of activation-induced cytidine deaminase in B cells
2006 StandoutNobel
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Mammalian DNA Mismatch Repair
1999
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
2011 StandoutNobel
Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes
1999
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
DNA MISMATCH REPAIR AND GENETIC INSTABILITY
2000
A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs
2001 StandoutNobel
Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination
2001 Nobel
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes
2002
Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora
2002 StandoutScienceNobel
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Normal Somatic Hypermutation of Ig Genes in the Absence of 8-Hydroxyguanine-DNA Glycosylase
2003 StandoutNobel
Somatic Hypermutation Is Limited by CRM1-dependent Nuclear Export of Activation-induced Deaminase
2004
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation
2002 StandoutNobel
Cutting Edge: The G-U Mismatch Glycosylase Methyl-CpG Binding Domain 4 Is Dispensable for Somatic Hypermutation and Class Switch Recombination
2003
Two distinctive pathways for recruitment of naïve and primed IgM+B cells to the gut lamina propria
2005 StandoutNobel
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
2004 StandoutNobel
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
2010 StandoutNobel
Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination
2009 StandoutNobel
Computer simulations of protein functions: Searching for the molecular origin of the replication fidelity of DNA polymerases
2005 StandoutNobel
The Targeting of Somatic Hypermutation Closely Resembles That of Meiotic Mutation
2001
In vivoandin vitrostudies of immunoglobulin gene somatic hypermutation
2001 Nobel
Hijacked DNA repair proteins and unchained DNA polymerases
2008
T-Independent Immune Response: New Aspects of B Cell Biology
2000 StandoutScienceNobel
Molecular Mechanisms of Antibody Somatic Hypermutation
2007
Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells
2014
Increased Transcription Levels Induce Higher Mutation Rates in a Hypermutating Cell Line
2001
DNA Double-Strand Breaks
2002 StandoutNobel
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase
2013 StandoutNobel
Mechanism and Regulation of Class Switch Recombination
2008
Different Mismatch Repair Deficiencies All Have the Same Effects on Somatic Hypermutation
1999
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation
2011 StandoutNobel
Severe Attenuation of the B Cell Immune Response in Msh2-deficient Mice
1999
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination
2001 StandoutNobel
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
Somatic Hypermutation in the Absence of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-Pkcs) or Recombination-Activating Gene (Rag)1 Activity
2000
Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein.
1999
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination
2004
Somatic hypermutation of immunoglobulin κ transgenes: Association of mutability with demethylation
2001
Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination
2003
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
2004 StandoutNobel
DNA Breaks in Hypermutating Immunoglobulin Genes: Evidence for a Break-and-Repair Pathway of Somatic Hypermutation
2001
AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization
2002 Nobel
DNA polymerases and somatic hypermutation of immunoglobulin genes
2005
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination
2004 StandoutNobel
DNA Polymerase η Contributes to Strand Bias of Mutations of A versus T in Immunoglobulin Genes
2005
Immunoglobulin Somatic Hypermutation
2007
AID to overcome the limitations of genomic information
2005 StandoutNobel
Works of Frédéric Delbos being referenced
DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
2006
Mismatch Repair Deficiency Interferes with the Accumulation of Mutations in Chronically Stimulated B Cells and Not with the Hypermutation Process
1998
Probing Immunoglobulin Gene Hypermutation with Microsatellites Suggests a Nonreplicative Short Patch DNA Synthesis Process
1998
Multiple layers of B cell memory with different effector functions
2009
Mismatch repair and immunoglobulin gene hypermutation: did we learn something?
1999
Ig gene hypermutation: A mechanism is due
2002
Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouse
2005
Transcription, β–like DNA polymerases and hypermutation
2001