Citation Impact
Citing Papers
Improvement of comparative model accuracy by free-energy optimization along principal components of natural structural variation
2004 StandoutNobel
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
2015 Science
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing
2017 StandoutNobel
CRISPR/Cpf1-mediated DNA-free plant genome editing
2017
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase
2016 StandoutNobel
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design
2005
Phage display as a tool for the directed evolution of enzymes
2003
High‐Throughput Screening for Terpene‐Synthase‐Cyclization Activity and Directed Evolution of a Terpene Synthase
2013 StandoutNobel
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
Genome-Editing Technologies: Principles and Applications
2016
Computational Enzyme Design
2013 StandoutNobel
AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication
2014
Multiplex pairwise assembly of array-derived DNA oligonucleotides
2015 StandoutNobel
Thoroughly sampling sequence space: Large‐scale protein design of structural ensembles
2002
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
High Frequency Targeted Mutagenesis Using Engineered Endonucleases and DNA-End Processing Enzymes
2013
Directed Evolution as a Method To Create Enantioselective Cyclohexanone Monooxygenases for Catalysis in Baeyer–Villiger Reactions
2004
Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
2015 StandoutNobel
Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions
2010
Comprehensive computational design of mCreI homing endonuclease cleavage specificity for genome engineering
2011 StandoutNobel
Massively parallel determination and modeling of endonuclease substrate specificity
2014 StandoutNobel
Opportunities and challenges for a sustainable energy future
2012 StandoutNatureNobel
DNA‐Based Asymmetric Catalysis
2005 StandoutNobel
Kemp elimination catalysts by computational enzyme design
2008 StandoutNatureNobel
Expanding the Range of Substrate Acceptance of Enzymes: Combinatorial Active‐Site Saturation Test
2005
Enantioselective Enzymes by Computational Design and In Silico Screening
2015 StandoutNobel
Learning from Directed Evolution: Further Lessons from Theoretical Investigations into Cooperative Mutations in Lipase Enantioselectivity
2006
A Simple Enantioconvergent and Chemoenzymatic Synthesis of Optically Active α‐Substituted Amides
2011 StandoutNobel
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
2011 StandoutNatureNobel
Directed evolution drives the next generation of biocatalysts
2009
Enantioselective Friedel–Crafts Reactions in Water Using a DNA‐Based Catalyst
2009 StandoutNobel
Recent advances in enzyme assays
2004
A FRET‐Based Fluorogenic Phosphine for Live‐Cell Imaging with the Staudinger Ligation
2008 StandoutNobel
Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
2005
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
2012 StandoutNobel
Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs
2010 StandoutNobel
Constructing and Analyzing the Fitness Landscape of an Experimental Evolutionary Process
2008
DNA‐Based Catalytic Enantioselective Michael Reactions in Water
2007 StandoutNobel
Simulating enzyme reactions: Challenges and perspectives
2001
Enhancing the Thermal Robustness of an Enzyme by Directed Evolution: Least Favorable Starting Points and Inferior Mutants Can Map Superior Evolutionary Pathways
2011
Molecular engineering of epoxide hydrolase and its application to asymmetric and enantioconvergent hydrolysis
2007
Heritable targeted mutagenesis in maize using a designed endonuclease
2009
Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds
2009
Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation
2008
Genome-editing Technologies for Gene and Cell Therapy
2016
Mining Endonuclease Cleavage Determinants in Genomic Sequence Data
2011 StandoutNobel
Engineering the third wave of biocatalysis
2012 StandoutNature
Exploitation of binding energy for catalysis and design
2009 StandoutNatureNobel
Genome Editing B.C. (Before CRISPR): Lasting Lessons from the “Old Testament”
2018
Computational Design of an α-Gliadin Peptidase
2012 StandoutNobel
Directed Evolution as a Method To Create Enantioselective Cyclohexanone Monooxygenases for Catalysis in Baeyer–Villiger Reactions
2004
Controlling the enantioselectivity of enzymes by directed evolution: Practical and theoretical ramifications
2004
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3
2006 StandoutNobel
Solute Solvent Dynamics and Energetics in Enzyme Catalysis: The SN2 Reaction of Dehalogenase as a General Benchmark
2004 StandoutNobel
In the light of directed evolution: Pathways of adaptive protein evolution
2009 StandoutNobel
A new paradigm for electrostatic catalysis of radical reactions in vitamin B 12 enzymes
2007 StandoutNobel
Directed evolution of enantioselective hybrid catalysts: a novel concept in asymmetric catalysis
2007
Development of a Practical Biocatalytic Process for (R)-2-Methylpentanol
2009
Apparent NAC Effect in Chorismate Mutase Reflects Electrostatic Transition State Stabilization
2003 StandoutNobel
Highly Enantioselective Reduction of a Small Heterocyclic Ketone: Biocatalytic Reduction of Tetrahydrothiophene-3-one to the Corresponding (R)-Alcohol
2009
Reprogramming homing endonuclease specificity through computational design and directed evolution
2013 StandoutNobel
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
2014 StandoutNobel
Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
2003 StandoutScienceNobel
Gerichtete Evolution stereoselektiver Enzyme: Eine ergiebige Katalysator‐Quelle für asymmetrische Reaktionen
2010
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Asymmetric Catalysis of the Carbonyl-Amine Condensation: Kinetic Resolution of Primary Amines
2017 StandoutNobel
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
Recursive construction of perfect DNA molecules from imperfect oligonucleotides
2008
Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections
2012
Development of a Biocatalytic Process as an Alternative to the (−)-DIP-Cl-Mediated Asymmetric Reduction of a Key Intermediate of Montelukast
2009
The Catalytic Asymmetric Fischer Indolization
2011 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Conversion of a maltose receptor into a zinc biosensor by computational design
2001
Biocatalytic Synthesis of Chiral Alcohols and Amino Acids for Development of Pharmaceuticals
2013
Frozen Density Functional Free Energy Simulations of Redox Proteins: Computational Studies of the Reduction Potential of Plastocyanin and Rusticyanin
2003 StandoutNobel
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Application of Designed Enzymes in Organic Synthesis
2011
Works of Frédéric Cédrone being referenced
Improved soybean oil quality by targeted mutagenesis of the fatty acid desaturase 2 gene family
2014
Improving cold storage and processing traits in potato through targeted gene knockout
2015
Colorimetric Assays for Quantitative Analysis and Screening of Epoxide Hydrolase Activity
2005
Generation and Analysis of Mesophilic Variants of the Thermostable Archaeal I-DmoI Homing Endonuclease
2007
Tailoring new enzyme functions by rational redesign
2000
Meganuclease-mediated Inhibition of HSV1 Infection in Cultured Cells
2011
Gene Correction of a Duchenne Muscular Dystrophy Mutation by Meganuclease-Enhanced Exon Knock-In
2013
Directed Evolution of Biocatalysts
2006
Directed Evolution of the Epoxide Hydrolase fromAspergillus niger
2003