Citation Impact
Citing Papers
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
2004 StandoutScience
Nmd3 is a structural mimic of eIF 5A, and activates the cp GTP ase Lsg1 during 60S ribosome biogenesis
2017 StandoutNobel
Atopic Dermatitis
2008 Standout
Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid β42 Production by Direct Modulation of γ-Secretase Activity
2003
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases
2011
C-terminal ECFP Fusion Impairs Synaptotagmin 1 Function
2004 StandoutNobel
aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation
2002
Nicastrin binds to membrane-tethered Notch
2001
TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity
2006 Nature
Dendritic cells: versatile controllers of the immune system
2007 StandoutNobel
Presenilin: Running with Scissors in the Membrane
2007
γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?
2002
Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP
2005
Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
2009 StandoutNobel
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
Controlled microwave heating in modern organic synthesis: highlights from the 2004–2008 literature
2009
Covalent protein modification: the current landscape of residue-specific electrophiles
2014
Covalent organic frameworks (COFs): from design to applications
2012 Standout
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation
2004 StandoutNobel
Endogenous β-amyloid production in presenilin-deficient embryonic mouse fibroblasts
2001
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Alzheimer's disease
2006 Standout
Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease
2011 StandoutNobel
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
2002
Alzheimer's Disease
2010 Standout
Implication of APP Secretases in Notch Signaling
2001
Synthesis of novel 3-(aryl)benzothieno[2,3-c]pyran-1-ones from Sonogashira products and intramolecular cyclization: Antitumoral activity evaluation
2008
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1
2002
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
2017 StandoutNobel
Processing of β-Amyloid Precursor-like Protein-1 and -2 by γ-Secretase Regulates Transcription
2002
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Notch and Presenilin: a proteolytic mechanism emerges
2001
Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch
2001
Structure and function of γ-secretase
2008
Catalytic, asymmetric reactions of ketenes and ketene enolates
2009
Genetically engineered mouse models of neurodegenerative diseases
2002
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Intramembrane Proteolysis
2009
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
3d Transition Metals for C–H Activation
2018 Standout
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Synthesis of Heterocycles via Electrophilic Cyclization of Alkynes Containing Heteroatom
2011 Standout
Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub
2017 StandoutNobel
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Solid-Phase Synthesis of Isocoumarins: A Traceless Halocyclization Approach
2009
SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates
2018 StandoutNobel
Ynamides: A Modern Functional Group for the New Millennium
2010 Standout
Lanthanide- and Actinide-Mediated Terminal Alkyne Hydrothiolation for the Catalytic Synthesis of Markovnikov Vinyl Sulfides
2010
Phosphine Organocatalysis
2018 Standout
Studies toward the Unique Pederin Family Member Psymberin: Full Structure Elucidation, Two Alternative Total Syntheses, and Analogs
2012
A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor
2019
Waste-Free Synthesis of Condensed Heterocyclic Compounds by Rhodium-Catalyzed Oxidative Coupling of Substituted Arene or Heteroarene Carboxylic Acids with Alkynes
2009
Metal-Catalyzed Decarboxylative C–H Functionalization
2017 Standout
The Complementary Competitors: Palladium and Copper in C–N Cross-Coupling Reactions
2012
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
2019 StandoutNobel
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Cu-Catalyzed Mild C(sp2)–H Functionalization Assisted by Carboxylic Acids en Route to Hydroxylated Arenes
2013
Regulation of APP-Dependent Transcription Complexes by Mint/X11s: Differential Functions of Mint Isoforms
2002 StandoutNobel
Synthesis of Amidines Using N-Allyl Ynamides. A Palladium-Catalyzed Allyl Transfer through an Ynamido−π-Allyl Complex
2009
Transition-Metal-Catalyzed C−S, C−Se, and C−Te Bond Formation via Cross-Coupling and Atom-Economic Addition Reactions
2011 Standout
Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates
2016 StandoutNobel
Copper catalyzed room temperature lactonization of aromatic C–H bond: a novel and efficient approach for the synthesis of dibenzopyranones
2014
Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization
2012 Standout
Dendritic cells are specialized accessory cells along with TGF-β for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3− precursors
2007 StandoutNobel
Gold-catalyzed intermolecular oxidation of chiral homopropargyl sulfonamides: a reliable access to enantioenriched pyrrolidin-3-ones
2014
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Biogenesis of γ-secretase early in the secretory pathway
2007 StandoutNobel
Tolerogenic Dendritic Cells
2003 StandoutNobel
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Synthesis of 4-halophosphaisocoumarins via halocyclization of 2-(1-alkynyl)phenylphosphonates
2005
Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ
2001
Sampling the conformational space of the catalytic subunit of human γ-secretase
2015
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
2017 StandoutNobel
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity
2015 Standout
Works of Frédéric Bihel being referenced
Trisubstitution of pyridine through sequential and regioselective palladium cross-coupling reactions affording analogs of known GPR54 antagonists
2013
New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties
2004
Novel synthesis of 3,4-dihydro-5-bromo[1,4]oxazin-2-one derivatives, new protease inhibitor scaffold
2003
New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage
2001
Microwave-assisted cyclic amidine synthesis using TiCl4
2006
Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new β-amyloid peptide production inhibitors and their activities on various classes of protease
2003
The initial substrate-binding site of γ-secretase is located on presenilin near the active site
2005
Synthesis and Antiviral Activity of New Anti-HIV Amprenavir Bioisosteres
2002
Direct Guanidinylation of Aryl and Heteroaryl Halides via Copper-Catalyzed Cross-Coupling Reaction
2011
6-endo-dig Cyclization of heteroarylesters to alkynes promoted by Lewis acid catalyst in the presence of Brønsted acid
2007
Fully Regiocontrolled Polyarylation of Pyridine
2014
Discovery of a Subnanomolar Helical d -Tridecapeptide Inhibitor of γ-Secretase
2004
Design of potential new HIV protease inhibitors: enantioconvergent synthesis of new pyrrolidin-3-ol, and pyrrolidin-3-one peptide conjugates
2001